M Kitamura

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The concept of glomerular self-defense
    M Kitamura
    Department of Medicine, University College London Medical School, England, United Kingdom
    Kidney Int 55:1639-71. 1999
  2. ncbi request reprint Renal transfer of genetically engineered cells
    M Kitamura
    Department of Medicine, University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, London, United Kingdom
    J Am Soc Nephrol 11:S154-8. 2000
  3. ncbi request reprint Adoptive transfer of nuclear factor-kappaB-inactive macrophages to the glomerulus
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, London, United Kingdom
    Kidney Int 57:709-16. 2000
  4. ncbi request reprint Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid
    M Kitamura
    Department of Medicine, University College London Medical School, England, United Kingdom
    Kidney Int 56:1223-9. 1999
  5. ncbi request reprint NF-kappaB-mediated self defense of macrophages faced with bacteria
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, GB
    Eur J Immunol 29:1647-55. 1999
  6. ncbi request reprint Transfer of genetically engineered cells to the glomerulus
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, The Rayne Institute, London, UK
    Exp Nephrol 7:259-66. 1999
  7. ncbi request reprint The antioxidant N-acetylcysteine induces mesangial cells to create three-dimensional cytoarchitecture that underlies cellular differentiation
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, United Kingdom
    J Am Soc Nephrol 10:746-51. 1999
  8. ncbi request reprint Bystander macrophages silence transgene expression driven by the retroviral long terminal repeat
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, 5 University Street, London, WC1E 6JJ, United Kingdom
    Biochem Biophys Res Commun 257:74-8. 1999
  9. ncbi request reprint Transgene regulation by the tetracycline-controlled transactivation system
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, Rayne Institute, London, UK
    Exp Nephrol 6:576-80. 1998
  10. ncbi request reprint Gene transfer into the adult kidney for unravelling disease processes
    M Kitamura
    Department of Medicine, University College London Medical School, Rayne Institute, London, UK
    Exp Nephrol 6:429-37. 1998

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The concept of glomerular self-defense
    M Kitamura
    Department of Medicine, University College London Medical School, England, United Kingdom
    Kidney Int 55:1639-71. 1999
    ..This article outlines how the glomerulus, when faced with injurious cells or exposed to pathogenic mediators, defends itself via the intrinsic machinery that is brought into play in resident glomerular cells...
  2. ncbi request reprint Renal transfer of genetically engineered cells
    M Kitamura
    Department of Medicine, University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, London, United Kingdom
    J Am Soc Nephrol 11:S154-8. 2000
    ..This article summarizes current experience with the adoptive transfer of engineered cells to the glomerulus for investigation of and therapy for glomerular diseases...
  3. ncbi request reprint Adoptive transfer of nuclear factor-kappaB-inactive macrophages to the glomerulus
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, London, United Kingdom
    Kidney Int 57:709-16. 2000
    ..As a prototypal investigation, this study examines a role for nuclear factor-kappaB (NF-kappaB) in effector actions of macrophages within the glomerular microenvironment...
  4. ncbi request reprint Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid
    M Kitamura
    Department of Medicine, University College London Medical School, England, United Kingdom
    Kidney Int 56:1223-9. 1999
    ..In the second part, we address a novel potential of bioflavonoid quercetin as an inhibitor of apoptosis in glomerular cells. Possible mechanisms for the antiapoptotic action of quercetin and its therapeutic utility are discussed...
  5. ncbi request reprint NF-kappaB-mediated self defense of macrophages faced with bacteria
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, GB
    Eur J Immunol 29:1647-55. 1999
    ..These data suggest a critical role for NF-kappaB in the survival of macrophages at the site of bacterial infection...
  6. ncbi request reprint Transfer of genetically engineered cells to the glomerulus
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, The Rayne Institute, London, UK
    Exp Nephrol 7:259-66. 1999
    ..This article summarizes current experience with adoptive transfer of engineered cells to the glomerulus and addresses its potential application to kidney research...
  7. ncbi request reprint The antioxidant N-acetylcysteine induces mesangial cells to create three-dimensional cytoarchitecture that underlies cellular differentiation
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, United Kingdom
    J Am Soc Nephrol 10:746-51. 1999
    ..These results indicate that, by a redox-sensitive mechanism, NAC induces mesangial cells to create three-dimensional cytoarchitecture that underlies cellular differentiation...
  8. ncbi request reprint Bystander macrophages silence transgene expression driven by the retroviral long terminal repeat
    M Kitamura
    Department of Medicine, University College London Medical School, The Rayne Institute, 5 University Street, London, WC1E 6JJ, United Kingdom
    Biochem Biophys Res Commun 257:74-8. 1999
    ..These results raise a possibility that expression of transgenes driven by the MLV-LTR may be silenced in vivo when the retrovirally-transduced cells are co-localized with activated macrophages...
  9. ncbi request reprint Transgene regulation by the tetracycline-controlled transactivation system
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, Rayne Institute, London, UK
    Exp Nephrol 6:576-80. 1998
    ..This article briefly outlines the concept of the tetracycline-regulated gene expression systems and addresses the current experience in kidney research...
  10. ncbi request reprint Gene transfer into the adult kidney for unravelling disease processes
    M Kitamura
    Department of Medicine, University College London Medical School, Rayne Institute, London, UK
    Exp Nephrol 6:429-37. 1998
    ..This article summarizes current experience with renal gene transfer and addresses its potential impacts on the understanding of renal function in vivo...
  11. ncbi request reprint TGF-beta1 as an endogenous defender against macrophage-triggered stromelysin gene expression in the glomerulus
    M Kitamura
    Department of Medicine, University College London Medical School, United Kingdom
    J Immunol 160:5163-8. 1998
    ..This induction was substantially repressed in those glomeruli producing active TGF-beta1. These results reinforce the idea that TGF-beta1 is an endogenous defender that attenuates certain actions of infiltrating Mphi in the glomerulus...
  12. ncbi request reprint Evidence for TGF-beta-mediated 'defense' of the glomerulus: a blackguard molecule rehabilitated?
    M Kitamura
    Department of Medicine, University College London Medical School, UK
    Exp Nephrol 6:1-6. 1998
    ..The aim of this article is to summarize the potentially beneficial action of TGF-beta in the glomerulus and to address its 'bright side' in glomerular inflammation...
  13. ncbi request reprint Three-dimensional matrix primes mesangial cells to down-regulation of alpha-smooth muscle actin via deactivation of CArG box elements
    M Kitamura
    Department of Medicine, University College London Medical School, England, United Kingdom
    Kidney Int 53:690-7. 1998
    ..These data suggested that three-dimensional ECM primes mesangial cells to down-regulation of alpha-smooth muscle actin via deactivation of CArG box elements...
  14. pmc Creation of an In vivo cytosensor using engineered mesangial cells. Automatic sensing of glomerular inflammation controls transgene activity
    M Kitamura
    Glomerular Bioengineering Unit, Department of Medicine, University College London Medical School, The Rayne Institute, London WC1E 6JJ, United Kingdom
    J Clin Invest 100:1394-9. 1997
    ....
  15. ncbi request reprint Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-beta 1
    M Kitamura
    Department of Medicine, University College London Medical School, United Kingdom
    J Immunol 159:1404-11. 1997
    ..These data demonstrate that TGF-beta 1 functions as an inhibitor of MCP-1 expression in macrophages possibly via down-regulation of c-Jun/activator protein-1...
  16. ncbi request reprint Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid
    T Konta
    Renal Bioengineering Unit, Department of Medicine, Royal Free and University College Medical School, University College London, United Kingdom
    J Biol Chem 276:12697-701. 2001
    ..These data elucidated that the antiapoptotic effect of t-RA is mediated by both nuclear receptor-dependent and -independent mechanisms...
  17. ncbi request reprint Suppression of constitutive but not Il-1beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway
    J Lucio-Cazana
    Department of Medicine, Royal Free and University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, Mortimer Street, London W1T 3AA, United Kingdom
    J Am Soc Nephrol 12:688-94. 2001
    ....
  18. ncbi request reprint Unexpected transcriptional induction of monocyte chemoattractant protein 1 by proteasome inhibition: involvement of the c-Jun N-terminal kinase-activator protein 1 pathway
    K Nakayama
    Department of Medicine, Royal Free and University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, Mortimer Street, London W1T 3AA, UK
    J Immunol 167:1145-50. 2001
    ..These data revealed that proteasome inhibition triggered the expression of MCP-1 and other genes via the multistep induction of the JNK-c-Jun/AP-1 pathway...
  19. pmc Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo
    M Kitamura
    Department of Medicine, University College London Medical School, United Kingdom
    J Clin Invest 94:497-505. 1994
    ..The mesangial cell vector system thus achieves site-specific delivery of an exogenous gene into the glomerulus and is amenable to in situ amplification and sustained expression by preconditioning of the target site...
  20. ncbi request reprint Expression, regulation, and function of inhibitor of apoptosis family genes in rat mesangial cells
    A Furusu
    Department of Medicine, Royal Free and University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, London, England, United Kingdom
    Kidney Int 60:579-86. 2001
    ..IAPs can contribute to the survival of rat mesangial cells, but unexpectedly, these molecules are not involved in the TNF-alpha--induced, NF-kappa B--dependent cytoprotection in this cell type...
  21. ncbi request reprint Explanted glomeruli: utility and limitations
    M Kitamura
    Department of Medicine, Royal Free and University College Medical School, University College London, Jules Thorn Institute, Middlesex Hospital, London, UK
    Exp Nephrol 9:349-54. 2001
    ..In this article, we summarize our current findings and discuss the utility and limitations of explanted glomeruli...
  22. ncbi request reprint Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis
    A Mooney
    Department of Medicine, University Hospital, Nottingham, United Kingdom
    J Immunol 159:3949-60. 1997
    ..Finally, the data show that Fas ligation can override cytokine survival signaling, emphasizing a candidate role for this molecule in the undesirable apoptotic loss of mesangial cells during the progression of glomerular scarring...