T B L Kirkwood

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Tools for the SBML Community
    Colin S Gillespie
    School of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioinformatics 22:628-9. 2006
  2. doi request reprint Understanding ageing from an evolutionary perspective
    T B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    J Intern Med 263:117-27. 2008
  3. pmc Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach
    Carole J Proctor
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom
    Mol Neurodegener 7:32. 2012
  4. pmc A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
    Mark T Mc Auley
    Campus for Ageing and Vitality, Newcastle University, Henry Wellcome Biogerontology Building, Newcastle upon Tyne NE4 5PL, United Kingdom
    BMC Syst Biol 6:130. 2012
  5. doi request reprint The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support
    Thomas B L Kirkwood
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Bioessays 34:692-700. 2012
  6. pmc The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    BMC Geriatr 7:14. 2007
  7. pmc A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks
    María Moreno-Villanueva
    Lehrstuhl Molekulare Toxikologie, Fachbereich Biologie, Universitat Konstanz, Konstanz, Germany
    BMC Biotechnol 9:39. 2009
  8. ncbi request reprint Understanding the odd science of aging
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, United Kingdom
    Cell 120:437-47. 2005
  9. ncbi request reprint What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Mech Ageing Dev 126:439-43. 2005
  10. ncbi request reprint Intrinsic ageing of gut epithelial stem cells
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 125:911-5. 2004

Detail Information

Publications55

  1. ncbi request reprint Tools for the SBML Community
    Colin S Gillespie
    School of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioinformatics 22:628-9. 2006
    ..The rationale for this is to reduce the amount of repeated work carried out within the community and to create tools that offer a greater number of features to the end-user...
  2. doi request reprint Understanding ageing from an evolutionary perspective
    T B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    J Intern Med 263:117-27. 2008
    ..g. food supply. Evolutionary understanding can also help to understand important features of the human life history such as menopause...
  3. pmc Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach
    Carole J Proctor
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom
    Mol Neurodegener 7:32. 2012
    ..In light of the tool's utility, we developed computer simulation models to examine Aß₄₂ turnover and its aggregation in detail and to test the effect of immunization against Aß dimers...
  4. pmc A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
    Mark T Mc Auley
    Campus for Ageing and Vitality, Newcastle University, Henry Wellcome Biogerontology Building, Newcastle upon Tyne NE4 5PL, United Kingdom
    BMC Syst Biol 6:130. 2012
    ..The model integrates both current and previously published data relating to molecular biology, physiology, ageing and nutrition in an integrated fashion...
  5. doi request reprint The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support
    Thomas B L Kirkwood
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Bioessays 34:692-700. 2012
    ..Finally, the expectation that free-radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free-radical theory is just one of the multiple mechanisms driving the ageing process...
  6. pmc The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    BMC Geriatr 7:14. 2007
    ....
  7. pmc A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks
    María Moreno-Villanueva
    Lehrstuhl Molekulare Toxikologie, Fachbereich Biologie, Universitat Konstanz, Konstanz, Germany
    BMC Biotechnol 9:39. 2009
    ..The 'Fluorimetric Detection of Alkaline DNA Unwinding (FADU)' method [Birnboim HC, Jevcak JJ. Cancer Res (1981) 41:1889-1892] is a sensitive procedure to quantify DNA strand breaks, yet it is very tedious to perform...
  8. ncbi request reprint Understanding the odd science of aging
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, United Kingdom
    Cell 120:437-47. 2005
    ..To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay...
  9. ncbi request reprint What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Mech Ageing Dev 126:439-43. 2005
    ..In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age...
  10. ncbi request reprint Intrinsic ageing of gut epithelial stem cells
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 125:911-5. 2004
    ..This paper reviews what is currently known about intrinsic ageing of gut epithelial stem cells and its functional consequences...
  11. ncbi request reprint Food restriction, evolution and ageing
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 126:1011-6. 2005
    ..It will then be important to investigate how these are organised and whether the same or different factors are at play in the various species in which food restriction extends life span...
  12. pmc Time of our lives. What controls the length of life?
    Thomas B L Kirkwood
    Institute for Ageing and Health, The University of Newcastle, Newcastle upon Tyne, UK
    EMBO Rep 6:S4-8. 2005
  13. doi request reprint A systematic look at an old problem
    Thomas B L Kirkwood
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Nature 451:644-7. 2008
  14. doi request reprint Global aging and the brain
    Thomas B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Nutr Rev 68:S65-9. 2010
    ..Growing evidence indicates that the global aging process is more malleable than used to be thought. This needs to be taken into account in efforts to improve health and retention of mental capital across the life course...
  15. pmc Systems biology of ageing and longevity
    Thomas B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Philos Trans R Soc Lond B Biol Sci 366:64-70. 2011
    ..This connection is informed by actions of natural selection on the determinants of ageing and longevity...
  16. doi request reprint On the programmed/non-programmed nature of ageing within the life history
    Thomas B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Curr Biol 21:R701-7. 2011
    ..In acknowledging that, at least in theory, ageing might occasionally be adaptive, however, the high barriers to validating actual instances of adaptive ageing are made clear...
  17. ncbi request reprint Genes that shape the course of ageing
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Trends Endocrinol Metab 14:345-7. 2003
    ..An elegant new study of genes acting downstream of these signals in the nematode worm Caenorhabditis elegans reveals a plethora of information about the complex network of mechanisms that modulate the ageing process...
  18. pmc The most pressing problem of our age
    Thomas B L Kirkwood
    University of Newcastle Institute for Ageing and Health, Henry Wellcome Laboratory for Biogerontology Research, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
    BMJ 326:1297-9. 2003
  19. doi request reprint The connections between general and reproductive senescence and the evolutionary basis of menopause
    Thomas B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 1204:21-9. 2010
    ..This is most striking in the case of the human menopause, for which a particular combination of biological and sociobiological factors appear to be responsible...
  20. ncbi request reprint Changing complexity in aging: a metric not an hypothesis
    Thomas B L Kirkwood
    Department of Gerontology, University of Newcastle upon Tyne, Institute for Ageing and Health, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, United Kingdom
    Neurobiol Aging 23:21-2. 2002
  21. ncbi request reprint Sex and ageing
    T B Kirkwood
    Department of Gerontology, Institute for the Health of the Elderly, Wolfson Research Centre, University of Newcastle, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    Exp Gerontol 36:413-8. 2001
    ....
  22. ncbi request reprint New science for an old problem
    Thomas B L Kirkwood
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK NE4 6BE
    Trends Genet 18:441-2. 2002
  23. ncbi request reprint Somatic mutations and ageing in silico
    Thomas B L Kirkwood
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Mech Ageing Dev 124:85-92. 2003
    ....
  24. ncbi request reprint Evolution of ageing
    Thomas B L Kirkwood
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Mech Ageing Dev 123:737-45. 2002
    ....
  25. ncbi request reprint Molecular gerontology
    T B L Kirkwood
    University of Newcastle, Department of Gerontology, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Inherit Metab Dis 25:189-96. 2002
    ..Recognition that ageing results from accumulation of damage also points to a role for lifestyle interventions (e.g. nutrition and exercise) to help prevent damage or promote repair...
  26. pmc Modelling the checkpoint response to telomere uncapping in budding yeast
    C J Proctor
    Institute for Ageing and Health, and School of Clinical Medical Sciences Gerontology, Centre for Integrated Systems Biology of Ageing and Nutrition, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    J R Soc Interface 4:73-90. 2007
    ..The model can be used to carry out a variety of in silico experiments in which different genes are knocked out and the results of simulation are compared to experimental data. Possible extensions to the model are also discussed...
  27. ncbi request reprint The Institute for Ageing and Health, University of Newcastle, UK
    J A Edwardson
    Institute for Ageing and Health, University of Newcastle, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Exp Gerontol 37:749-56. 2002
    ..An ambitious strategy for future research on ageing and age-related disorders is based on the synergy between these complementary approaches...
  28. ncbi request reprint Modelling cellular senescence as a result of telomere state
    Carole J Proctor
    SCMS, Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Aging Cell 2:151-7. 2003
    ..By letting the probability of uncapping depend upon telomere length, we show that the hypothesized model provides a good fit to experimental data...
  29. pmc Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study
    Joanna Collerton
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL
    BMJ 339:b4904. 2009
    ....
  30. ncbi request reprint Mitochondria and ageing: winning and losing in the numbers game
    Joao F Passos
    Centre for Integrated Systems Biology of Ageing and Nutrition, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Bioessays 29:908-17. 2007
    ....
  31. pmc Testing evolutionary theories of menopause
    Daryl P Shanley
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 6BE, UK
    Proc Biol Sci 274:2943-9. 2007
    ..Our results point to the distinctive (and perhaps unique) role of menopause in human evolution and provide important support for the hypothesized evolutionary significance of grandmothers...
  32. ncbi request reprint Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans
    Daryl P Shanley
    Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences Gerontology, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Biogerontology 7:165-8. 2006
    ..Although calorie restriction does not increase lifespan in all species, it remains a fascinating and valuable tool to study ageing at the whole organism level...
  33. ncbi request reprint Modelling the actions of chaperones and their role in ageing
    Carole J Proctor
    Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences Gerontology, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 126:119-31. 2005
    ....
  34. ncbi request reprint A mathematical model of ageing in yeast
    Colin S Gillespie
    Henry Wellcome Laboratory for Biogerontology Research, SCMS Gerontology, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Theor Biol 229:189-96. 2004
    ....
  35. ncbi request reprint Modelling telomere shortening and the role of oxidative stress
    Carole J Proctor
    Department of Gerontology, University of Newcastle, Institute for Ageing and Health, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Mech Ageing Dev 123:351-63. 2002
    ..We suggest that theoretical models of this kind are valuable tools to bridge the gap between the verbal statements of hypotheses and their rigorous experimental test...
  36. ncbi request reprint Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions
    Fotios Drenos
    School of Clinical Medical Sciences Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    Biogerontology 7:287-95. 2006
    ....
  37. ncbi request reprint Towards an e-biology of ageing: integrating theory and data
    Thomas B L Kirkwood
    Institute for Ageing and Heath, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Nat Rev Mol Cell Biol 4:243-9. 2003
    ..We describe how a new web-based modelling initiative is seeking to integrate data and hypotheses from diverse biological sources...
  38. pmc Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
    Joao F Passos
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Biol 5:e110. 2007
    ..X foci. We propose that mitochondrial ROS is a major determinant of telomere-dependent senescence at the single-cell level that is responsible for cell-to-cell variation in replicative lifespan...
  39. pmc A mathematical model of aging-related and cortisol induced hippocampal dysfunction
    Mark T McAuley
    Henry Wellcome Building, Biogerontology Building, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, England, NE4 6BE, UK
    BMC Neurosci 10:26. 2009
    ..We further challenged the model with biologically based interventions to ascertain if cortisol associated hippocampal dysfunction could be abrogated...
  40. ncbi request reprint Clones, Stem Cells and Immortality?
    T B L Kirkwood
    Department of Gerontology, University of Newcastle
    Med Leg J 70:71-9. 2002
  41. ncbi request reprint p53 and ageing: too much of a good thing?
    Thomas B L Kirkwood
    Department of Gerontology, Institute for Ageing and Health, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Bioessays 24:577-9. 2002
    ..But other work shows that there is a strong positive association between DNA repair-mediated protection against cancer and ageing. So what are we to make of the new data with regard to overall understanding of the mechanisms of ageing?..
  42. pmc Mitochondrial DNA mutations in human colonic crypt stem cells
    Robert W Taylor
    Department of Neurology, The Medical School, University of Newcastle upon Tyne, United Kingdom
    J Clin Invest 112:1351-60. 2003
    ..These studies have important consequences not only for understanding of the finding of mtDNA mutations in aging tissues and tumors, but also for determining the frequency of mtDNA mutations within a cell...
  43. pmc Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
    Marco Nooteboom
    Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Aging Cell 9:96-9. 2010
    ..We show for the first time in aging human tissue that RC deficiency attenuates cell proliferation and increases apoptosis in the progeny of RC deficient stem cells, leading to decreased crypt cell population...
  44. pmc Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo
    Satoshi Ishizuka
    School of Clinical Medical Sciences Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    Nucleic Acids Res 31:6198-205. 2003
    ..Our results thus establish that PARP-1 acts as a survival factor for intestinal stem cells in vivo and suggest a functional link with early p53 and p21(CIP1/WAF1) responses...
  45. ncbi request reprint Modelling the disposable soma theory of ageing
    Fotios Drenos
    School of Clinical Medical Sciences Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK
    Mech Ageing Dev 126:99-103. 2005
    ..We also describe how the optimal investment in maintenance is affected by varying the parameters that specify the schedules of reproduction and mortality...
  46. ncbi request reprint Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells
    Armin Rashidi
    Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mech Ageing Dev 130:216-21. 2009
    ..The unusual antioxidant status of beta-cells may thus be explained as an instance of co-evolution of the brain, cortisol and corticosteroid receptors, and beta-cells in the endocrine pancreas...
  47. pmc Ten commandments for the future of ageing research in the UK: a vision for action
    Oscar H Franco
    BMC Geriatr 7:10. 2007
    ....
  48. ncbi request reprint Ageing: the old worm turns more slowly
    Thomas B L Kirkwood
    Nature 419:794-5. 2002
  49. ncbi request reprint Telomere-driven replicative senescence is a stress response
    Thomas von Zglinicki
    Nat Biotechnol 21:229-30. 2003
  50. doi request reprint Gerontology: Healthy old age
    Thomas B L Kirkwood
    Nature 455:739-40. 2008
  51. doi request reprint Medical challenges of improving the quality of a longer life
    Jean Pierre Michel
    Department of Geriatrics and Rehabilitation, University of Geneva, Hopital des 3 Chêne Ch Pont Bochet, Thonex Geneva, Switzerland
    JAMA 299:688-90. 2008
  52. ncbi request reprint The National Service Framework--suggestions about priorities for policy development welcome
    Thomas B L Kirkwood
    Age Ageing 31:409, 411; author reply 411-2. 2002
  53. ncbi request reprint LINK-AGE: coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology
    Olivier Toussaint
    Mech Ageing Dev 127:761-2. 2006
  54. ncbi request reprint Asymmetry and the origins of ageing
    Thomas B L Kirkwood
    Mech Ageing Dev 126:533-4. 2005
  55. ncbi request reprint Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
    Gro V Amdam
    Department of Animal Science, Centre for Integrative Genetics, Agricultural University of Norway, P O Box 5025, 1432 Aas, Norway
    Exp Gerontol 39:767-73. 2004
    ..Our results therefore suggest that in terms of maintenance of the cellular immune system, senescence of the honeybee worker is under social control...