Simon Kilvington

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom
    Simon Kilvington
    Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom
    Invest Ophthalmol Vis Sci 45:165-9. 2004
  2. ncbi Encystment of Acanthamoeba during incubation in multipurpose contact lens disinfectant solutions and experimental formulations
    Simon Kilvington
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Eye Contact Lens 34:133-9. 2008
  3. ncbi Antimicrobial efficacy of multi-purpose contact lens disinfectant solutions following evaporation
    Simon Kilvington
    Abbott Medical Optics Inc, Santa Ana, CA 92705 4933, USA
    Cont Lens Anterior Eye 34:183-7. 2011
  4. ncbi Acidified nitrite enhances hydrogen peroxide disinfection of Acanthamoeba, bacteria and fungi
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, PO Box 138, University Road, Leicester LE1 9HN, UK
    J Antimicrob Chemother 65:1207-14. 2010
  5. ncbi Acanthamoeba polyphaga strain age and method of cyst production influence the observed efficacy of therapeutic agents and contact lens disinfectants
    Reanne Hughes
    Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Antimicrob Agents Chemother 47:3080-4. 2003
  6. ncbi A comparison of regimen methods for the removal and inactivation of bacteria, fungi and Acanthamoeba from two types of silicone hydrogel lenses
    Simon Kilvington
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Cont Lens Anterior Eye 32:73-7. 2009
  7. ncbi The disinfection efficacy of MeniCare soft multipurpose solution against Acanthamoeba and viruses using stand-alone biocidal and regimen testing
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Eye Contact Lens 36:90-5. 2010
  8. ncbi Antimicrobial activity of simulated solar disinfection against bacterial, fungal, and protozoan pathogens and its enhancement by riboflavin
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, P O Box 138, University Road, Leicester LE1 9HN, United Kingdom
    Appl Environ Microbiol 76:6010-2. 2010
  9. ncbi The efficacy of simulated solar disinfection (SODIS) against Ascaris, Giardia, Acanthamoeba, Naegleria, Entamoeba and Cryptosporidium
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom
    Acta Trop 119:138-43. 2011
  10. ncbi Activity of the amidoamine myristamidopropyl dimethylamine against keratitis pathogens
    Reanne Hughes
    Department of Microbiology and Immunology, University of Leicester, Medical Sciences Building, P.O. Box 138, University Road, Leicester LE1 9HN, UK
    J Antimicrob Chemother 51:1415-8. 2003

Collaborators

Detail Information

Publications17

  1. ncbi Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom
    Simon Kilvington
    Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom
    Invest Ophthalmol Vis Sci 45:165-9. 2004
    ..To investigate reasons for this higher frequency, a study of the role of domestic tap water as a potential source of AK was undertaken...
  2. ncbi Encystment of Acanthamoeba during incubation in multipurpose contact lens disinfectant solutions and experimental formulations
    Simon Kilvington
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Eye Contact Lens 34:133-9. 2008
    ..In this study the physiologic response of Acanthamoeba trophozoites to incubation in various contact lens solutions was investigated...
  3. ncbi Antimicrobial efficacy of multi-purpose contact lens disinfectant solutions following evaporation
    Simon Kilvington
    Abbott Medical Optics Inc, Santa Ana, CA 92705 4933, USA
    Cont Lens Anterior Eye 34:183-7. 2011
    ..To address this, impact of partial evaporation on the antimicrobial efficacy of multipurpose contact lens care solutions was investigated...
  4. ncbi Acidified nitrite enhances hydrogen peroxide disinfection of Acanthamoeba, bacteria and fungi
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, PO Box 138, University Road, Leicester LE1 9HN, UK
    J Antimicrob Chemother 65:1207-14. 2010
    ..In this study, the efficacy of hydrogen peroxide (H2O2) and acidified nitrite (NaNO2) alone and in combination was compared against a variety of bacteria, fungi and protozoa...
  5. ncbi Acanthamoeba polyphaga strain age and method of cyst production influence the observed efficacy of therapeutic agents and contact lens disinfectants
    Reanne Hughes
    Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Antimicrob Agents Chemother 47:3080-4. 2003
    ..01). These observations have important implications for the standardization and interpretation of Acanthamoeba disinfectant and therapeutic agent testing...
  6. ncbi A comparison of regimen methods for the removal and inactivation of bacteria, fungi and Acanthamoeba from two types of silicone hydrogel lenses
    Simon Kilvington
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Cont Lens Anterior Eye 32:73-7. 2009
    ..To compare the antimicrobial efficacy of commercial contact lens solutions when used according to the manufacturers' recommended regimens with two types of silicone hydrogel lenses...
  7. ncbi The disinfection efficacy of MeniCare soft multipurpose solution against Acanthamoeba and viruses using stand-alone biocidal and regimen testing
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Eye Contact Lens 36:90-5. 2010
    ..To assess the disinfection efficacy of MeniCare Soft contact lens multipurpose solution against Acanthamoeba and viruses in suspension and when inoculated on to contact lenses and subjected to rub-and-rinse or no-rub-and-rinse care regimes...
  8. ncbi Antimicrobial activity of simulated solar disinfection against bacterial, fungal, and protozoan pathogens and its enhancement by riboflavin
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, P O Box 138, University Road, Leicester LE1 9HN, United Kingdom
    Appl Environ Microbiol 76:6010-2. 2010
    ..001). With A. polyphaga cysts, the kill (3.5 log(10) after 6 h) was obtained only in the presence of riboflavin and 250 W m(-2) irradiance...
  9. ncbi The efficacy of simulated solar disinfection (SODIS) against Ascaris, Giardia, Acanthamoeba, Naegleria, Entamoeba and Cryptosporidium
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom
    Acta Trop 119:138-43. 2011
    ..However, care must be taken as Ascaris larvae continue to develop inside the ova after exposure to SODIS and Cryptosporidium remain impermeable to propidium iodide staining indicating they may still be infectious...
  10. ncbi Activity of the amidoamine myristamidopropyl dimethylamine against keratitis pathogens
    Reanne Hughes
    Department of Microbiology and Immunology, University of Leicester, Medical Sciences Building, P.O. Box 138, University Road, Leicester LE1 9HN, UK
    J Antimicrob Chemother 51:1415-8. 2003
    ..MAPD may represent a broad-spectrum therapeutic antimicrobial for keratitis and surgical prophylaxis and deserves further evaluation in these roles...
  11. ncbi The efficacy of simulated solar disinfection (SODIS) against coxsackievirus, poliovirus and hepatitis A virus
    Wayne Heaselgrave
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building PO Box 138, University Road, Leicester LE1 9HN, UK
    J Water Health 10:531-8. 2012
    ..However, further verification studies need to be performed using natural sunlight in the region where the SODIS technology is to be employed to validate our results...
  12. ncbi Enhanced killing of Acanthamoeba cysts with a plant peroxidase-hydrogen peroxide-halide antimicrobial system
    Reanne Hughes
    Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Appl Environ Microbiol 69:2563-7. 2003
    ..Our observations could result in significant improvement in the efficacy of H(2)O(2) contact lens disinfection systems against Acanthamoeba cysts and prevention of acanthamoeba keratitis...
  13. ncbi Development of a rapid DNA extraction method and one-step nested PCR for the detection of Naegleria fowleri from the environment
    Arine Fadzlun Ahmad
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, PO Box 138, University Road, Leicester LE1 9HN, UK
    Water Res 45:5211-7. 2011
    ..The availability of a rapid, reliable and sensitive one-step nested PCR method for the direct detection of N. fowleri from the environment may aid ecological studies and enable intervention to prevent PAM cases...
  14. ncbi Activities of therapeutic agents and myristamidopropyl dimethylamine against Acanthamoeba isolates
    Simon Kilvington
    Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom
    Antimicrob Agents Chemother 46:2007-9. 2002
    ..MAPD minimum cysticidal concentrations were 6.25 to 25 microg/ml; 10 to 30 microg/ml gave at least a 3-log cyst kill after 6 h, and 50 and 100 microg/ml gave at least a 3-log cyst kill within 2 and 1 h, respectively...
  15. ncbi Development of a nested PCR for environmental detection of the pathogenic free-living amoeba Balamuthia mandrillaris
    Arine F Ahmad
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, PO Box 138, University Road, Leicester, LE1 9HN, United Kingdom
    J Eukaryot Microbiol 58:269-71. 2011
    ..Sixteen of 17 Californian soil samples were positive compared with 0/44 from the United Kingdom. This approach will enable a greater understanding of B. mandrillaris ecology, geographic distribution, and public health risk...
  16. ncbi Effect of a multipurpose contact lens solution on the survival and binding of Acanthamoeba species on contact lenses examined with a no-rub regimen
    Roya N Borazjani
    Research, Development and Engineering, Research Group, Bausch and Lomb, Rochester NY 14609, USA
    Eye Contact Lens 31:39-45. 2005
    ..To determine the effect of a multipurpose contact lens solution (ReNu MultiPlus Multi-Purpose Solution [RMP]) on the relative survival and binding of trophozoites and cysts of Acanthamoeba on hydrogel lenses with a no-rub regimen...
  17. ncbi Persistently culture positive acanthamoeba keratitis: in vivo resistance and in vitro sensitivity
    Juan J Perez-Santonja
    Cornea and External Disease Service, Moorfields Eye Hospital, London, UK
    Ophthalmology 110:1593-600. 2003
    ..To characterize the risk factors, clinical course, treatment outcome and the association between in vivo resistance and in vitro sensitivity for subjects with persistently culture-positive Acanthamoeba keratitis...