- Tumour necrosis factor-mediated macrophage activation in the target organ is critical for clinical manifestation of uveitisT K Khera
School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
Clin Exp Immunol 168:165-77. 2012..We conclude that sTNF is required for inflammatory cell infiltration into target tissue, but at the tissue site inhibition of both sTNF and tmTNF is required to inhibit macrophage activation and to protect from tissue damage...
- Fragile X-related protein FXR1 controls post-transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-alpha production by transforming growth factor-beta1Tarnjit K Khera
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, UK
FEBS J 277:2754-65. 2010..In summary, TGF-beta1 opposes LPS-induced stabilization of TNF-alpha mRNA and reduces the amount of TNF-alpha protein, through induction of expression of the mRNA-binding protein FXR1...
- Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteinsTarnjit K Khera
School of Cellular and Molecular Medicine, University Walk, Bristol, UK
Prog Retin Eye Res 29:610-21. 2010..The study of mRNA stability remains essential for the understanding of intracellular regulatory pathways and molecular mechanisms of pathology for infection, inflammation and degeneration...