K-T Khaw

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium
    J Y Park
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Br J Cancer 103:747-56. 2010
  2. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
  3. pmc Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 13:133. 2012
  4. pmc Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, 8001 Zurich, Switzerland
    BMC Med 11:63. 2013
  5. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
  6. pmc Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study
    Kay Tee Khaw
    Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 9:e1001255. 2012
  7. pmc Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study
    Heather Ward
    MRC Centre for Nutrition and Cancer, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 10:R32. 2008
  8. pmc The association of education with body mass index and waist circumference in the EPIC-PANACEA study
    Silke Hermann
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    BMC Public Health 11:169. 2011
  9. pmc Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 8:112. 2008
  10. pmc Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and women
    Emily McFadden
    Institute of Public Health, University of Cambridge, UK
    BMC Public Health 8:230. 2008

Detail Information

Publications119 found, 100 shown here

  1. pmc Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium
    J Y Park
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Br J Cancer 103:747-56. 2010
    ..Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent...
  2. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
    ....
  3. pmc Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 13:133. 2012
    ..The aims of this analysis were i) to determine the influence of IP on QUS measurements at the heel and, ii) among those with IP to determine the influence of disease related factors on these measurements...
  4. pmc Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, 8001 Zurich, Switzerland
    BMC Med 11:63. 2013
    ..The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  5. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
    ..We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established...
  6. pmc Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study
    Kay Tee Khaw
    Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 9:e1001255. 2012
    ..The lack of association found in several cohort studies between dietary saturated fat and coronary heart disease (CHD) risk has renewed debate over the link between dietary fats and CHD...
  7. pmc Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study
    Heather Ward
    MRC Centre for Nutrition and Cancer, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 10:R32. 2008
    ..Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies...
  8. pmc The association of education with body mass index and waist circumference in the EPIC-PANACEA study
    Silke Hermann
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    BMC Public Health 11:169. 2011
    ..To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  9. pmc Socioeconomic position and risk of short-term weight gain: prospective study of 14,619 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 8:112. 2008
    ..The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK...
  10. pmc Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and women
    Emily McFadden
    Institute of Public Health, University of Cambridge, UK
    BMC Public Health 8:230. 2008
    ..We investigate the association between occupational social class and self-rated health (SRH) at different ages in men and women...
  11. pmc Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort
    Lianna S Ishihara
    Department of Public Health and Primary Care, University of Cambridge, Forvie Site, Cambridge CB2 2SR, UK
    BMC Neurol 5:15. 2005
    ..The objective of the study was to determine the self-reported prevalence of parkinsonian symptoms from a questionnaire, and to examine their association with age and self-reported Parkinson's disease in a large cohort...
  12. pmc Accuracy of death certification and hospital record linkage for identification of incident stroke
    Shubhada Sinha
    West Suffolk Hospital, Hardwick Lane, Bury St Edmunds, IP33 2QZ, Suffolk, UK
    BMC Med Res Methodol 8:74. 2008
    ..We examined the accuracy of these routine record linkage approaches for identifying incident stroke cases in a large UK population-based study, the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort...
  13. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
    ..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...
  14. ncbi request reprint Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk
    Kay Tee Khaw
    University of Cambridge, School of Clinical Medicine, Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Intern Med 141:413-20. 2004
    ..Increasing evidence suggests a continuous relationship between blood glucose concentrations and cardiovascular risk, even below diagnostic threshold levels for diabetes...
  15. pmc Epidemiology of coronary heart disease in women
    K T Khaw
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital Box 251, Cambridge CB2 2QQ, UK
    Heart 92:iii2-4. 2006
  16. ncbi request reprint Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition
    K T Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK
    Lancet 357:657-63. 2001
    ..We aimed to assess the relation between plasma ascorbic acid and subsequent mortality due to all causes, cardiovascular disease, ischaemic heart disease, and cancer...
  17. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  18. ncbi request reprint Comment on Miettinen: Rose revisited
    Kay Tee Khaw
    School of Clinical Medicine, University of Cambridge, Cambridge, UK
    Eur J Epidemiol 19:745-8. 2004
  19. ncbi request reprint Glycated hemoglobin as a marker of cardiovascular risk
    Kay Tee Khaw
    School of Clinical Medicine, University of Cambridge, UK
    Curr Opin Lipidol 17:637-43. 2006
    ..Diabetes mellitus is an established risk factor for cardiovascular disease. This review examines glycated hemoglobin, an indicator of long-term average blood glucose concentrations, in risk prediction for cardiovascular disease...
  20. ncbi request reprint Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Lancet 363:197-202. 2004
    ..We aimed to assess quantitative ultrasound of the calcaneum and fracture incidence in a prospective observational population study...
  21. ncbi request reprint Blood pressure and urinary sodium in men and women: the Norfolk Cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    Am J Clin Nutr 80:1397-403. 2004
    ..A key issue is whether differences in usual sodium intake within the range feasible in free-living populations have clinical or public health relevance...
  22. pmc How many, how old, how soon?
    K T Khaw
    Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrookes Hospital, Cambridge CB2 2QQ
    BMJ 319:1350-2. 1999
    ..Understanding and identification of the causes and prevention of conditions that could result to serious disabilities must be a high priority...
  23. ncbi request reprint Work and leisure time physical activity assessed using a simple, pragmatic, validated questionnaire and incident cardiovascular disease and all-cause mortality in men and women: The European Prospective Investigation into Cancer in Norfolk prospective pop
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK
    Int J Epidemiol 35:1034-43. 2006
    ..This may be partly related to different methods for assessing physical activity. Most studies have focused on leisure time physical activity...
  24. ncbi request reprint Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study
    Kay Tee Khaw
    Depqartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:915-9. 2004
    ..Increasing evidence suggests that abnormal glucose metabolism may be associated with increased risk of colorectal cancer...
  25. ncbi request reprint Occupational social class, educational level and area deprivation independently predict plasma ascorbic acid concentration: a cross-sectional population based study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)
    S Shohaimi
    Institute of Public Health, University of Cambridge, UK
    Eur J Clin Nutr 58:1432-5. 2004
    ..To investigate the independent association between three different measures of socioeconomic status and plasma ascorbic acid level...
  26. ncbi request reprint Respiratory function and self-reported functional health: EPIC-Norfolk population study
    P K Myint
    Room 311, Strangeways Research Laboratory, Wort s Causeway, Cambridge, CB1 8RN, UK
    Eur Respir J 26:494-502. 2005
    ..00; 95% CI 0.82-1.22). In conclusion, forced expiratory volume in one second independently predicts self perceived physical well being in a general population across the whole normal distribution of respiratory function...
  27. ncbi request reprint Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study
    R W Jakes
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Cambridge, UK
    Eur J Clin Nutr 57:1089-96. 2003
    ..This study describes the associations between sedentary behaviour (television viewing) and participation in vigorous recreational activity with obesity and with biomarkers of cardiovascular disease (CVD) risk profile...
  28. ncbi request reprint Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, United Kingdom
    Am J Clin Nutr 87:64-9. 2008
    ..Although clinical trials showed no significant benefit of vitamin C supplementation in reducing stroke risk, they were not able to examine the relation between plasma vitamin C concentrations and stroke risk in a general population...
  29. ncbi request reprint Psychological distress, major depressive disorder, and risk of stroke
    P G Surtees
    Strangeways Research Laboratory, University of Cambridge, Department of Public Health and Primary Care, Cambridge, CB1 8RN, UK
    Neurology 70:788-94. 2008
    ..We investigated this association based upon a large population-based prospective cohort study...
  30. pmc Dietary antioxidants and asthma in adults
    B D Patel
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge, UK
    Thorax 61:388-93. 2006
    ..Several antioxidant nutrients have been reported to be inversely associated with asthma. A study was undertaken to assess the independent associations of these nutrients with asthma in adults...
  31. ncbi request reprint Effect of age on the relationship of occupational social class with prevalence of modifiable cardiovascular risk factors and cardiovascular diseases. A population-based cross-sectional study from European Prospective Investigation into Cancer - Norfolk (E
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Gerontology 52:51-8. 2006
    ..Previous studies on cardiovascular risk profile in different socioeconomic status were focused on younger populations and many of them have not been able to take into account age and sex differences...
  32. ncbi request reprint Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population
    Shubhada Sinha
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Cardiovasc Prev Rehabil 12:144-50. 2005
    ..Cigarette smoking is a well-recognized determinant of plasma fibrinogen however it remains unclear how fibrinogen levels relate to the degree and duration of smoking, or to time since smoking cessation...
  33. pmc Residential area deprivation predicts smoking habit independently of individual educational level and occupational social class. A cross sectional study in the Norfolk cohort of the European Investigation into Cancer (EPIC-Norfolk)
    S Shohaimi
    Institute of Public Health, University of Cambridge, UK MRC Dunn Human Nutrition Unit, Cambridge, UK
    J Epidemiol Community Health 57:270-6. 2003
    ..To investigate the independent association between individual and area based measures of socioeconomic status and cigarette smoking habit...
  34. ncbi request reprint Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age
    S Kaptoge
    Strangeways Research Laboratory, University of Cambridge, Worts Causeway, CB1 8RN Cambridge, UK
    Osteoporos Int 14:418-28. 2003
    ..The protective effect of vitamin C in women needs to be further investigated in other prospective cohort or intervention studies...
  35. ncbi request reprint Physical health-related quality of life predicts stroke in the EPIC-Norfolk
    P K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neurology 69:2243-8. 2007
    ..To examine the relationship between Short Form (SF)-36 physical functional health-related quality of life and incident stroke...
  36. ncbi request reprint Modifiable lifestyle behaviors and functional health in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Prev Med 44:109-16. 2007
    ..To examine the association between modifiable lifestyle behaviors and functional health...
  37. ncbi request reprint Microalbuminuria, cardiovascular risk factors and cardiovascular morbidity in a British population: the EPIC-Norfolk population-based study
    Matthew F Yuyun
    Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Robinson Way, Cambridge CB2 2SR, UK
    Eur J Cardiovasc Prev Rehabil 11:207-13. 2004
    ..We examined the prevalence of microalbuminuria and its relationship to cardiovascular risk factors and cardiovascular morbidity in the UK general population...
  38. ncbi request reprint Habitual fish consumption and glycated haemoglobin: the EPIC-Norfolk study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 58:277-84. 2004
    ..To investigate the association between habitual fish consumption and a continuous measure of glycaemia...
  39. ncbi request reprint Geographic and other determinants of BMD change in European men and women at the hip and spine. a population-based study from the Network in Europe for Male Osteoporosis (NEMO)
    S Kaptoge
    Strangeways Research Laboratory, Department of Medicine, University of Cambridge, Wort s Causeway Cambridge, UK
    Bone 40:662-73. 2007
    ....
  40. ncbi request reprint Microalbuminuria and stroke in a British population: the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    M F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    J Intern Med 255:247-56. 2004
    ..To examine the relationship between microalbuminuria and incident stroke in the general population...
  41. ncbi request reprint Obesity, confidant support and functional health: cross-sectional evidence from the EPIC-Norfolk cohort
    P G Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK
    Int J Obes Relat Metab Disord 28:748-58. 2004
    ..To investigate the association between body mass index (BMI) and functional health according to age and the support available from a close confidant...
  42. ncbi request reprint Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Circulation 116:2933-43. 2007
    ..Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain...
  43. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  44. ncbi request reprint Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65
    Stephen Kaptoge
    Strangeways Research Laboratory, Institute of Public Health, Cambridge CB2 2QQ, UK stephen srl cam ac uk
    Bone 32:561-70. 2003
    ..Faster expansion in the female femoral neck may in turn lead to greater fragility if wider diameter and thinner cortices become locally unstable...
  45. ncbi request reprint Habitual fish consumption and risk of incident stroke: the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, UK
    Public Health Nutr 9:882-8. 2006
    ..To examine the association between fish consumption and stroke risk...
  46. pmc Childhood smoking is an independent risk factor for obstructive airways disease in women
    B D Patel
    Department of Public Health and Primary Care, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Thorax 59:682-6. 2004
    ..To assess whether starting to smoke in childhood increases the risk of obstructive airways disease (OAD) in adult life...
  47. ncbi request reprint Sex hormone status may modulate rate of expansion of proximal femur diameter in older women alongside other skeletal regulators
    S Kaptoge
    Institute of Public Health and Department of Medicine, University of Cambridge, Cambridge CB1 8RN, United Kingdom
    J Clin Endocrinol Metab 92:304-13. 2007
    ..Little is known of associations between hip geometry and skeletal regulators. This is important because geometry is a determinant of both hip function and resistance to fracture...
  48. ncbi request reprint Combined work and leisure physical activity and risk of stroke in men and women in the European prospective investigation into Cancer-Norfolk Prospective Population Study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Neuroepidemiology 27:122-9. 2006
    ..70, 95% CI: 0.49-0.99, p = 0.024) compared to those who were inactive. This highlights the fact that efforts to increase physical activity in both the work place and in leisure time should be encouraged...
  49. ncbi request reprint Physical activity and mammographic breast density in the EPIC-Norfolk cohort study
    Tricia M Peters
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Epidemiol 167:579-85. 2008
    ..The lack of an association between physical activity and percentage breast density suggests that an association between physical activity and breast cancer risk is unlikely to be mediated through an effect on mammographic breast density...
  50. ncbi request reprint Obesity indices and self-reported functional health in men and women in the EPIC-Norfolk
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Obesity (Silver Spring) 14:884-93. 2006
    ..To investigate the association between two indices of obesity, BMI and waist-to-hip ratio (WHR), and self-reported physical and mental functional health...
  51. ncbi request reprint Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study
    Mei Fen Chan
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:900-5. 2007
    ..However, the relationship between usual daily physical activity and endogenous hormones in postmenopausal women in the general population is still uncertain...
  52. ncbi request reprint Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship?
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Stroke 38:271-5. 2007
    ..The relationship between blood glucose concentration and stroke in people without established diabetes has been studied less extensively...
  53. ncbi request reprint Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study
    A H Harding
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 56:882-90. 2002
    ..To investigate the association between total level and type of alcohol consumed and glycaemia...
  54. pmc Residential area deprivation predicts fruit and vegetable consumption independently of individual educational level and occupational social class: a cross sectional population study in the Norfolk cohort of the European Prospective Investigation into Canc
    Shamarina Shohaimi
    Institute of Public Health, University of Cambridge, UK
    J Epidemiol Community Health 58:686-91. 2004
    ..To investigate the independent association between individual and area based socioeconomic measures and fruit and vegetable consumption...
  55. ncbi request reprint Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men
    Yen Ling Low
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    J Nutr 135:2680-6. 2005
    ..In this first study on phytoestrogen-gene associations in men, we conclude that enterolactone and equol are positively associated with plasma androgen concentrations, and interactions with CYP19 gene may be involved...
  56. ncbi request reprint Microalbuminuria independently predicts all-cause and cardiovascular mortality in a British population: The European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
    Matthew F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, UK
    Int J Epidemiol 33:189-98. 2004
    ..We therefore undertook this study to examine the relationship between albuminuria and all-cause, cardiovascular disease (CVD) and non-CVD mortality in the general population...
  57. ncbi request reprint A prospective study of microalbuminuria and incident coronary heart disease and its prognostic significance in a British population: the EPIC-Norfolk study
    Matthew F Yuyun
    Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    Am J Epidemiol 159:284-93. 2004
    ..61 (95% CI: 1.19, 2.07). Microalbuminuria may be useful in identifying persons at increased risk of CHD and subsequent death in the general population...
  58. ncbi request reprint Fruit and vegetable consumption and self-reported functional health in men and women in the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk): a population-based cross-sectional study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, UK
    Public Health Nutr 10:34-41. 2007
    ..To investigate the association between fruit and vegetable consumption and self-reported physical and mental functional health measured by an anglicised short-form 36-item questionnaire (UK SF-36)...
  59. ncbi request reprint Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and women
    Lisa R Purslow
    MRC Epidemiology Unit, Institute of Medical Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Epidemiol 167:188-92. 2008
    ..Redistribution of daily energy intake, so that more energy is consumed at breakfast and less energy is consumed later in the day, may help to reduce weight gain in middle-aged adults...
  60. ncbi request reprint Dietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk study
    Anne Helen Harding
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    Am J Epidemiol 159:73-82. 2004
    ..81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors...
  61. ncbi request reprint Urine pH is an indicator of dietary acid-base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study
    Ailsa A Welch
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Br J Nutr 99:1335-43. 2008
    ..As urine pH relates to dietary acid-base load its use to monitor change in consumption of fruit and vegetables, in individuals, warrants further investigation...
  62. pmc Healthy lifestyle choices: could sense of coherence aid health promotion?
    Nicholas W J Wainwright
    Strangeways Research Laboratory and University of Cambridge Department of Public Health and Primary Care, Worts Causeway, Cambridge, UK
    J Epidemiol Community Health 61:871-6. 2007
    ..A research framework based on the personal characteristic defined by a sense of coherence (SOC) focuses on the effective use of resources to maintain good health...
  63. ncbi request reprint Medical training in the UK: sleepwalking to disaster
    Morris Brown
    University of Cambridge, Cambridge CB2 2QQ, UK
    Lancet 369:1673-5. 2007
  64. pmc LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  65. ncbi request reprint Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes
    Morris Brown
    University of Cambridge, Cambridge CB2 2QQ, UK
    Lancet 369:967-8. 2007
  66. ncbi request reprint Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort study
    Paul G Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Am J Psychiatry 165:515-23. 2008
    ..The authors investigated the association between major depressive disorder, including its clinical course, and mortality from ischemic heart disease...
  67. ncbi request reprint Self-reported birth weight and subsequent risk of colorectal cancer
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge CB2 2SR, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:935-8. 2002
    ..There is a J-shape relation between self-reported birth weight and subsequent risk of colorectal cancer. Babies born with macrosomia appear to have the greatest risk...
  68. ncbi request reprint Association of depression with peripheral leukocyte counts in EPIC-Norfolk--role of sex and cigarette smoking
    Paul Surtees
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Worts Causeway, England, UK
    J Psychosom Res 54:303-6. 2003
    ..To investigate the associations among depression, smoking behaviour and enumerative measures of immunity in a population-based cohort study...
  69. ncbi request reprint Are imprecise methods obscuring a relation between fat and breast cancer?
    Sheila A Bingham
    MRC Dunn Human Nutrition Unit, Welcome Trust MRC Building, Hills Road, CB2 2XY, Cambridge, UK
    Lancet 362:212-4. 2003
    ..10 [0.94-1.29], p=0.23). Dietary measurement error might explain the absence of a significant association between dietary fat and breast-cancer risk in cohort studies...
  70. ncbi request reprint Smoking status and differential white cell count in men and women in the EPIC-Norfolk population
    Megan R Smith
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, Cambridge CB2 2SR, UK
    Atherosclerosis 169:331-7. 2003
    ..The apparent almost immediate reversibility of effects of smoking on inflammation, as indicated by the WBC count, may help motivate efforts to stop smoking...
  71. ncbi request reprint Functional health status, chronic medical conditions and disorders of mood
    Paul G Surtees
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, UK
    Br J Psychiatry 183:299-303. 2003
    ..Understanding of the impact of depressive and anxiety disorders on functional health status in the context of chronic medical illness has been gained almost exclusively from the study of patient populations...
  72. ncbi request reprint Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood
    Paul Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK
    Int J Behav Med 10:251-68. 2003
    ..Caution is needed in the interpretation of these findings that require replication but they may be seen to aid understanding of the mechanisms through which early environmental exposures act...
  73. ncbi request reprint Sense of coherence and mortality in men and women in the EPIC-Norfolk United Kingdom prospective cohort study
    Paul Surtees
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Epidemiol 158:1202-9. 2003
    ..76, p=0.002). Results suggest that a strong sense of coherence may confer some resilience to the risk of chronic disease...
  74. ncbi request reprint Occupational social class, educational level, smoking and body mass index, and cause-specific mortality in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort
    Emily McFadden
    Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Wort s Causeway, Cambridge, UK
    Eur J Epidemiol 23:511-22. 2008
    ....
  75. ncbi request reprint How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography?
    Masako Kataoka
    Department of Radiology, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    AJR Am J Roentgenol 187:73-80. 2006
    ..The purpose of this study was to examine the relationship between breast arterial calcification (BAC), commonly found on mammography, and cardiovascular disease and its risk factors...
  76. ncbi request reprint Measured height loss predicts fractures in middle-aged and older men and women: the EPIC-Norfolk prospective population study
    Alireza Moayyeri
    Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    J Bone Miner Res 23:425-32. 2008
    ..Serial measurement of height is, therefore, recommended among the elderly people...
  77. ncbi request reprint Adaptation to social adversity is associated with stroke incidence: evidence from the EPIC-Norfolk prospective cohort study
    Paul G Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
    Stroke 38:1447-53. 2007
    ..We test the hypothesis that sense of coherence (SOC), a marker of social stress adaptive capacity, is associated with incident stroke in a population-based prospective cohort study...
  78. ncbi request reprint Physical activity and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Cancer Epidemiol Biomarkers Prev 16:36-42. 2007
    ..This study provides additional evidence for a protective effect of physical activity on breast cancer risk...
  79. ncbi request reprint Prospective cohort study of hostility and the risk of cardiovascular disease mortality
    Paul G Surtees
    Strangeways Research Laboratory and Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Int J Cardiol 100:155-61. 2005
    ..Recent literature reviews have questioned hostility as a risk factor for heart disease. However, controversy persists due to the rarity of large-scale prospective cohort studies of initially healthy populations...
  80. ncbi request reprint Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions
    Yen Ling Low
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:213-20. 2005
    ..We conclude that higher isoflavone exposure is associated with lower plasma estradiol in postmenopausal women and that this preliminary study is suggestive of the involvement of diet-gene interactions...
  81. ncbi request reprint Cigarette smoking and fat distribution in 21,828 British men and women: a population-based study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Obes Res 13:1466-75. 2005
    ..To examine the relationship between cigarette smoking habits and fat distribution in a population-based cohort of men and women...
  82. ncbi request reprint Relation between self-reported physical functional health and chronic disease mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study
    Phyo K Myint
    Department of Public Health and Primary Care, University of Cambridge, UK
    Ann Epidemiol 16:492-500. 2006
    ..To explore the relationship between self-reported physical functional health and mortality...
  83. ncbi request reprint Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, MRC Dunn Human Nutrition Unit, Cambridge and MRC Epidemiology Unit, Cambridge, UK
    J Hypertens 22:2067-74. 2004
    ..To determine the relation between fat distribution and blood pressure, independent of body mass index...
  84. ncbi request reprint Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: results from the EPIC-Norfolk population-based cohort study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Strangeway s Site, Worts Causeway, Cambridge CB1 8RN, United Kingdom
    Atherosclerosis 189:420-7. 2006
    ..We examine whether lipid levels vary between central and peripheral fat distribution in the general population...
  85. ncbi request reprint INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, UK
    Diabetes 54:2812-5. 2005
    ..These data suggest that INS VNTR class is not an important determinant of size and body weight regulation in middle-aged men and women...
  86. ncbi request reprint EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
    John Danesh
    EPIC Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Eur J Epidemiol 22:129-41. 2007
    ..Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors...
  87. ncbi request reprint Resilience, misfortune, and mortality: evidence that sense of coherence is a marker of social stress adaptive capacity
    Paul G Surtees
    Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
    J Psychosom Res 61:221-7. 2006
    ..The purpose of this study is to test the hypothesis that sense of coherence (SOC) distinguishes adaptive capacity to adverse event experience...
  88. ncbi request reprint Plasma ascorbic acid concentrations and fat distribution in 19,068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Am J Clin Nutr 82:1203-9. 2005
    ..Excess fat may promote fatty acid oxidation and increase free radical concentrations, which could result in increased antioxidant use. Whether plasma ascorbic acid concentrations are associated with fat distribution remains unclear...
  89. ncbi request reprint Mastery, sense of coherence, and mortality: evidence of independent associations from the EPIC-Norfolk Prospective Cohort Study
    Paul G Surtees
    Strangeways Research Laboratory, Cambridge, United Kingdom
    Health Psychol 25:102-10. 2006
    ..These results may aid future study of coping resources as determinants of persistent well-being...
  90. ncbi request reprint Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort
    Sabina Rinaldi
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 118:2832-9. 2006
    ..Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG...
  91. ncbi request reprint Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population
    Ute Nöthlings
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, 14558 Germany
    J Nutr 138:775-81. 2008
    ....
  92. ncbi request reprint Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk
    Philip B Grace
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:698-708. 2004
    ..024) for serum equol, and 1.22 (1.01-1.48; P = 0.044) for serum daidzein]. These estimates of risk are similar to those established for estrogens and androgens in postmenopausal breast cancer but need confirmation in larger studies...
  93. ncbi request reprint Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition DIfE, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Natl Cancer Inst 98:920-31. 2006
    ..This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women...
  94. ncbi request reprint Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    Stefan F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:2064-70. 2006
    ..The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V...
  95. ncbi request reprint Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
    Christine Friedenreich
    Division of Population Health and Information, Alberta Cancer Board, T2N 4N2, Calgary, Alberta, Canada
    Cancer Causes Control 18:399-413. 2007
    ..To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups...
  96. pmc Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition
    Teresa Norat
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69 372 Lyon cedex 08, France
    J Natl Cancer Inst 97:906-16. 2005
    ..Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing...
  97. pmc Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Naomi E Allen
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK
    Endocr Relat Cancer 15:485-97. 2008
    ..In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women...
  98. ncbi request reprint Dietary patterns among older Europeans: the EPIC-Elderly study
    Christina Bamia
    Department of Hygiene and Epidemiology, University of Athens Medical School, M Asias 75, Athens 11527, Greece
    Br J Nutr 94:100-13. 2005
    ..Our study contributes to the identification of groups of elderly who are likely to have different prospects for long-term disease occurrence and survival...
  99. ncbi request reprint Serum C-peptide levels and breast cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Martijn Verheus
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 119:659-67. 2006
    ..Nevertheless, among older, postmenopausal women, hyperinsulinemia might contribute to increasing breast cancer risk...
  100. ncbi request reprint Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Int J Cancer 118:728-38. 2006
    ..Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases...
  101. ncbi request reprint Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events?
    Rebecca K Simmons
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, England
    Arch Intern Med 168:1209-16. 2008
    ..There is a continuous relationship between glycated hemoglobin (HbA(1c)) and coronary heart disease (CHD) risk, even below diagnostic thresholds for diabetes mellitus...