Research Topics
Species | Naeem KhanSummaryAffiliation: University of Birmingham Country: UK Publications
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Detail Information
Publications
Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infectionNaeem Khan
CR U K Institute for Cancer Studies, Vincent Drive, Edgbaston, University of Birmingham, Birmingham, United Kingdom
J Immunol 173:7481-9. 2004..These results suggest that carriage of CMV may be detrimental to the immunocompetent host by suppressing heterologous virus-specific immunity during aging...
Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genesNaeem Khan
CR UK Institute for Cancer Studies, Vincent Dr, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
J Virol 79:2869-79. 2005....- Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individualsNaeem Khan
Cancer Research U.K. Institute for Cancer Studies and Department of Geriatric Medicine, University of Birmingham, Edgbaston, United Kingdom
J Immunol 169:1984-92. 2002..Such a dramatic accumulation of virus-specific effector CTL might impair the ability to respond to heterologous infection and may underlie the negative influence of CMV seropositivity on survival in the very elderly... - Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infectionDelphine Sauce
CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Virol 83:9068-78. 2009.... 
Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrowUmaimainthan Palendira
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
Blood 112:3293-302. 2008..These observations identify a novel bone marrow homing phenotype for CD8(+) memory T cells, which necessitates a reevaluation of the magnitude of antigen-specific populations within the lymphoid system...- CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individualsLaura Crompton
Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
Blood 111:2053-61. 2008..In addition, these TCR sequences are highly homologous to those observed in HLA-DR7(+) patients with CD4(+) T-cell large granular lymphocytosis and implicate cytomegalovirus as a likely antigenic stimulus for this disorder... - The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoireBatoul Pourgheysari
C R U K Institute for Cancer Studies, Vincent Drive, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
J Virol 81:7759-65. 2007..This memory inflation of CMV-specific CD4(+) T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals... - Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balanceAndrew D Hislop
Institute for Cancer Studies and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
J Clin Invest 115:2546-55. 2005..We suggest that efficient control of EBV infection requires appropriate CD8+ T cell homing to oropharyngeal sites... - Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex moleculesRichard D Antrobus
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
J Infect Dis 191:1842-53. 2005..Furthermore, they suggest that a potential immunoregulatory function of UL18 may be to preferentially target highly differentiated HCMV-specific effector memory T cells during persistent infection... - CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burdenOliver Goodyear
CR UK Institute for Cancer Studies and Department of Haematology, Queen Elizabeth Hospital, Birmingham
Blood 106:4217-24. 2005..Functional T cells specific for CGAgs are therefore present in a proportion of patients with multiple myeloma and offer the possibility of a novel approach for immunotherapy in this disease... - Cytomegalovirus is associated with depression and anxiety in older adultsAnna C Phillips
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Brain Behav Immun 22:52-5. 2008..This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response... - Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotypeNaeem Khan
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK B15 2TA
J Infect Dis 185:1025-34. 2002..The results confirm that, although pp65 is a major target for CD8+ T cells, the IE-1 protein may itself stimulate comparable responses in some persons... - Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cellsMatthew D Morgan
Renal Immunobiology, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Immunology 130:64-73. 2010..This information is of value in understanding the pathogenesis and potential treatment of this disease... - B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cellsAndreas Moosmann
Department of Otorhinolaryngology, Ludwig Maximilians Universitat, Munich, Germany
Blood 100:1755-64. 2002..We conclude that the pp65 mini-EBV is an attractive tool for CMV-specific adoptive immunotherapy. Mini-EBVs could also facilitate the generation of T cells specific for various other antigens of interest... - Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramersMark Cobbold
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, England, UK
J Exp Med 202:379-86. 2005..This novel approach to adoptive transfer has considerable potential for antigen-specific T cell therapy... - Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell linesKarl S Peggs
Royal Free and University College London Medical School, London, UK
Lancet 362:1375-7. 2003..Our findings indicate that application of CMV-specific cell lines is both feasible and effective in a clinical environment... - HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirusShelley F Stone
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
AIDS 19:555-62. 2005..To assess the frequency and phenotype of cytomegalovirus (CMV)-specific CD8 T cells in previously immunocompromised HIV patients with stable undetectable HIV viremia due to highly active antiretroviral therapy (HAART)... - T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infectionNaeem Khan
Division of Immunology, School of Infection and Host Defense, University of Liverpool, Duncan Building, Daulby Street, Liverpool, UK
J Immunol 178:4455-65. 2007.... - The immunological burden of human cytomegalovirus infectionNaeem Khan
Division of Immunology, School of Infection and Host Defence, University of Liverpool, UK
Arch Immunol Ther Exp (Warsz) 55:299-308. 2007..This review also discusses our current understanding of how virus carriage may skew lymphocyte populations in immunocompetent subjects and the association of CMV-seropositivity with immunosenescence... - Reconstitution of T-cell repertoire after autologous stem cell transplantation: influence of CD34 selection and cytomegalovirus infectionKarl S Peggs
Department of Haematology, University College London, London, United Kingdom
Biol Blood Marrow Transplant 9:198-205. 2003.... - The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndromeFiona J Plunkett
Department of Immunology and Molecular Pathology, Royal Free and University College Medical School, London, UK
Mech Ageing Dev 126:855-65. 2005..This may contribute to the defective immunity found in XLP patients who survive acute EBV infection who develop EBV-related B cell lymphomas before the fourth decade of life... - Palliative surgery for advance osteosarcoma of shoulder regionAyesha Asghar
Department of Paediatric Surgery, Children Hospital, PIMS, Islamabad, Pakistan
J Coll Physicians Surg Pak 13:352-4. 2003..All patients had complete loss of movement. Five patients underwent fore quarter amputation. Extensive amputation although a major mutilating procedure, provides patients a dramatic relief for the period that he survives...