Naeem Khan

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint The immunological burden of human cytomegalovirus infection
    Naeem Khan
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, UK
    Arch Immunol Ther Exp (Warsz) 55:299-308. 2007
  2. pmc Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions
    Naeem Khan
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Daulby Street, Liverpool, UK
    Immunology 131:537-48. 2010
  3. ncbi request reprint T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection
    Naeem Khan
    Division of Immunology, School of Infection and Host Defense, University of Liverpool, Duncan Building, Daulby Street, Liverpool, UK
    J Immunol 178:4455-65. 2007
  4. doi request reprint Cytomegalovirus-specific CD8+ T cells do not develop in all renal transplant patients at risk of virus infection
    Stephen E Christmas
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    Transpl Immunol 22:99-104. 2009
  5. pmc Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers
    Mark Cobbold
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, England, UK
    J Exp Med 202:379-86. 2005
  6. ncbi request reprint HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirus
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
    AIDS 19:555-62. 2005
  7. pmc Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes
    Naeem Khan
    CR UK Institute for Cancer Studies, Vincent Dr, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
    J Virol 79:2869-79. 2005
  8. ncbi request reprint Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
    Naeem Khan
    CR U K Institute for Cancer Studies, Vincent Drive, Edgbaston, University of Birmingham, Birmingham, United Kingdom
    J Immunol 173:7481-9. 2004
  9. ncbi request reprint Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    Naeem Khan
    Cancer Research U K Institute for Cancer Studies and Department of Geriatric Medicine, University of Birmingham, Edgbaston, United Kingdom
    J Immunol 169:1984-92. 2002
  10. ncbi request reprint Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype
    Naeem Khan
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK B15 2TA
    J Infect Dis 185:1025-34. 2002

Collaborators

  • Graham S Taylor
  • Stephen E Christmas
  • P A H Moss
  • A C Phillips
  • S Mackinnon
  • Ma French
  • Thomas R Jones
  • Patricia Price
  • K Peggs
  • S F Stone
  • Arne N Akbar
  • Andrew D Hislop
  • Alan B Rickinson
  • Umaimainthan Palendira
  • Batoul Pourgheysari
  • Mark Cobbold
  • Laura Crompton
  • Laxman Nayak
  • Christopher D Buckley
  • Karen Piper
  • Guy Pratt
  • Fiona J Plunkett
  • Oliver Goodyear
  • Richard D Antrobus
  • Andreas Moosmann
  • Wajid Raza
  • Rajiv Khanna
  • Richard Steyn
  • Rosanna Chinn
  • Lee Machado
  • Andrew Bell
  • Rachel Bruton
  • Donna Best
  • Benjamin E Willcox
  • John Goldman
  • Prem Mahendra
  • Colin Steward
  • Charles Craddock
  • Sudhir Tauro
  • Lee I Garner
  • Michael Kuo
  • Andrew I Bell
  • Husam Osman
  • Ronjon Chakraverty
  • Malcom H A Rustin
  • Jean M Fletcher
  • Adrian B Drake-Lee
  • David Webster
  • Premini Mahendra
  • Judith M Timms
  • Ornella Franzese
  • Damien Montamat-Sicotte
  • Mario Assenmacher
  • Lavina L Belaramani
  • Jane Starczynski
  • Wolfgang Bergler
  • Mike Salmon
  • Eduardo Olavarria
  • Reza Sharifi
  • Nicolas Hammerschmitt
  • Andrea Cara
  • H Bobby Gaspar
  • Alison M Leese
  • Dorothy McDonald
  • Kimberly C Gilmour
  • Lucinda Billingham
  • Charles Crawley
  • Wolfgang Hammerschmidt
  • Debbie Croom-Carter
  • Caroline Zentz
  • Henri Jacques Delecluse
  • Gabi Hollweck
  • Barbara Wollenberg
  • Neil W Blake
  • Reinhard Zeidler

Detail Information

Publications21

  1. ncbi request reprint The immunological burden of human cytomegalovirus infection
    Naeem Khan
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, UK
    Arch Immunol Ther Exp (Warsz) 55:299-308. 2007
    ..This review also discusses our current understanding of how virus carriage may skew lymphocyte populations in immunocompetent subjects and the association of CMV-seropositivity with immunosenescence...
  2. pmc Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions
    Naeem Khan
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Daulby Street, Liverpool, UK
    Immunology 131:537-48. 2010
    ....
  3. ncbi request reprint T cell recognition patterns of immunodominant cytomegalovirus antigens in primary and persistent infection
    Naeem Khan
    Division of Immunology, School of Infection and Host Defense, University of Liverpool, Duncan Building, Daulby Street, Liverpool, UK
    J Immunol 178:4455-65. 2007
    ....
  4. doi request reprint Cytomegalovirus-specific CD8+ T cells do not develop in all renal transplant patients at risk of virus infection
    Stephen E Christmas
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    Transpl Immunol 22:99-104. 2009
    ..Those without CMV disease did not show any T cell response while most patients with detectable CMV developed specific CD8+ T cells...
  5. pmc Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers
    Mark Cobbold
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, England, UK
    J Exp Med 202:379-86. 2005
    ..This novel approach to adoptive transfer has considerable potential for antigen-specific T cell therapy...
  6. ncbi request reprint HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirus
    Shelley F Stone
    Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia
    AIDS 19:555-62. 2005
    ..To assess the frequency and phenotype of cytomegalovirus (CMV)-specific CD8 T cells in previously immunocompromised HIV patients with stable undetectable HIV viremia due to highly active antiretroviral therapy (HAART)...
  7. pmc Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes
    Naeem Khan
    CR UK Institute for Cancer Studies, Vincent Dr, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
    J Virol 79:2869-79. 2005
    ....
  8. ncbi request reprint Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection
    Naeem Khan
    CR U K Institute for Cancer Studies, Vincent Drive, Edgbaston, University of Birmingham, Birmingham, United Kingdom
    J Immunol 173:7481-9. 2004
    ..These results suggest that carriage of CMV may be detrimental to the immunocompetent host by suppressing heterologous virus-specific immunity during aging...
  9. ncbi request reprint Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    Naeem Khan
    Cancer Research U K Institute for Cancer Studies and Department of Geriatric Medicine, University of Birmingham, Edgbaston, United Kingdom
    J Immunol 169:1984-92. 2002
    ..Such a dramatic accumulation of virus-specific effector CTL might impair the ability to respond to heterologous infection and may underlie the negative influence of CMV seropositivity on survival in the very elderly...
  10. ncbi request reprint Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype
    Naeem Khan
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK B15 2TA
    J Infect Dis 185:1025-34. 2002
    ..The results confirm that, although pp65 is a major target for CD8+ T cells, the IE-1 protein may itself stimulate comparable responses in some persons...
  11. ncbi request reprint Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
    Karl S Peggs
    Royal Free and University College London Medical School, London, UK
    Lancet 362:1375-7. 2003
    ..Our findings indicate that application of CMV-specific cell lines is both feasible and effective in a clinical environment...
  12. pmc Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance
    Andrew D Hislop
    Institute for Cancer Studies and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Clin Invest 115:2546-55. 2005
    ..We suggest that efficient control of EBV infection requires appropriate CD8+ T cell homing to oropharyngeal sites...
  13. ncbi request reprint Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecules
    Richard D Antrobus
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    J Infect Dis 191:1842-53. 2005
    ..Furthermore, they suggest that a potential immunoregulatory function of UL18 may be to preferentially target highly differentiated HCMV-specific effector memory T cells during persistent infection...
  14. doi request reprint Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow
    Umaimainthan Palendira
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Blood 112:3293-302. 2008
    ..These observations identify a novel bone marrow homing phenotype for CD8(+) memory T cells, which necessitates a reevaluation of the magnitude of antigen-specific populations within the lymphoid system...
  15. ncbi request reprint B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells
    Andreas Moosmann
    Department of Otorhinolaryngology, Ludwig Maximilians Universitat, Munich, Germany
    Blood 100:1755-64. 2002
    ..We conclude that the pp65 mini-EBV is an attractive tool for CMV-specific adoptive immunotherapy. Mini-EBVs could also facilitate the generation of T cells specific for various other antigens of interest...
  16. ncbi request reprint CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals
    Laura Crompton
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Blood 111:2053-61. 2008
    ..In addition, these TCR sequences are highly homologous to those observed in HLA-DR7(+) patients with CD4(+) T-cell large granular lymphocytosis and implicate cytomegalovirus as a likely antigenic stimulus for this disorder...
  17. ncbi request reprint Cytomegalovirus is associated with depression and anxiety in older adults
    Anna C Phillips
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Brain Behav Immun 22:52-5. 2008
    ..This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response...
  18. ncbi request reprint The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
    Fiona J Plunkett
    Department of Immunology and Molecular Pathology, Royal Free and University College Medical School, London, UK
    Mech Ageing Dev 126:855-65. 2005
    ..This may contribute to the defective immunity found in XLP patients who survive acute EBV infection who develop EBV-related B cell lymphomas before the fourth decade of life...
  19. ncbi request reprint Reconstitution of T-cell repertoire after autologous stem cell transplantation: influence of CD34 selection and cytomegalovirus infection
    Karl S Peggs
    Department of Haematology, University College London, London, United Kingdom
    Biol Blood Marrow Transplant 9:198-205. 2003
    ....
  20. ncbi request reprint CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden
    Oliver Goodyear
    CR UK Institute for Cancer Studies and Department of Haematology, Queen Elizabeth Hospital, Birmingham
    Blood 106:4217-24. 2005
    ..Functional T cells specific for CGAgs are therefore present in a proportion of patients with multiple myeloma and offer the possibility of a novel approach for immunotherapy in this disease...
  21. pmc The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire
    Batoul Pourgheysari
    C R U K Institute for Cancer Studies, Vincent Drive, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
    J Virol 81:7759-65. 2007
    ..This memory inflation of CMV-specific CD4(+) T cells contributes to evidence that CMV infection may be damaging to immune function in elderly individuals...