Faisel Khan

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Chemical synthesis and microvascular effects of new nitric oxide donors in humans
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Clin Sci (Lond) 105:577-84. 2003
  2. ncbi request reprint Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Clin Sci (Lond) 106:183-9. 2004
  3. ncbi request reprint Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans
    Faisel Khan
    Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Appl Physiol 97:883-7. 2004
  4. doi request reprint Allopurinol treatment reduces arterial wave reflection in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Cardiovasc Ther 26:247-52. 2008
  5. doi request reprint Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography
    Faisel Khan
    Institute of Cardiovascular Research, University Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 115:295-300. 2008
  6. ncbi request reprint Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Hypertension 46:1123-8. 2005
  7. doi request reprint The role of endothelial function and its assessment in rheumatoid arthritis
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Nat Rev Rheumatol 6:253-61. 2010
  8. ncbi request reprint Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children
    F Khan
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Int Angiol 25:268-73. 2006
  9. doi request reprint The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Atherosclerosis 200:374-9. 2008
  10. doi request reprint The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Med 14:137-42. 2009

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Chemical synthesis and microvascular effects of new nitric oxide donors in humans
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Clin Sci (Lond) 105:577-84. 2003
    ..Since such compounds release NO in a non-enzymic manner following topical application, they might produce an attractive therapeutic source of localized NO delivery without inducing systemic side effects...
  2. ncbi request reprint Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Clin Sci (Lond) 106:183-9. 2004
    ....
  3. ncbi request reprint Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans
    Faisel Khan
    Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Appl Physiol 97:883-7. 2004
    ..Deionized water is a better iontophoresis vehicle for the assessment of microvascular function in skin when using ACh and SNP...
  4. doi request reprint Allopurinol treatment reduces arterial wave reflection in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Cardiovasc Ther 26:247-52. 2008
    ..A further larger study is warranted to look at whether a therapeutic intervention with allopurinol will impact positively on mortality and morbidity in stroke survivors...
  5. doi request reprint Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography
    Faisel Khan
    Institute of Cardiovascular Research, University Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 115:295-300. 2008
    ..446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects...
  6. ncbi request reprint Changes in endothelial function precede the clinical disease in women in whom preeclampsia develops
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Hypertension 46:1123-8. 2005
    ..These changes precede the onset of clinical disease and might be related to a compensatory increased sensitivity of the microcirculation to nitric oxide...
  7. doi request reprint The role of endothelial function and its assessment in rheumatoid arthritis
    Faisel Khan
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Nat Rev Rheumatol 6:253-61. 2010
    ..Given the increase in cardiovascular mortality associated with RA, effective management must involve prevention of cardiovascular risk, in addition to control of disease activity and inflammation...
  8. ncbi request reprint Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children
    F Khan
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Int Angiol 25:268-73. 2006
    ..The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness...
  9. doi request reprint The association between serum urate levels and arterial stiffness/endothelial function in stroke survivors
    Faisel Khan
    The Institute for Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Atherosclerosis 200:374-9. 2008
    ..A therapeutic intervention trial of lowering of serum urate is required to see whether this will impact positively on mortality and morbidity in patients with high-risk of strokes...
  10. doi request reprint The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Vasc Med 14:137-42. 2009
    ..30, p = 0.006). The risk of later cardiovascular disease may be reduced by exclusively breastfeeding during infancy. These findings have potential public health implications, and support policies aimed at promoting breastfeeding...
  11. ncbi request reprint Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Clin Physiol Funct Imaging 23:282-5. 2003
    ....
  12. doi request reprint Relationship between maternal arterial wave reflection, microvascular function and fetal growth in normal pregnancy
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Microcirculation 17:608-14. 2010
    ..In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum...
  13. doi request reprint Assessment of endothelial function as a marker of cardiovascular risk in patients with rheumatoid arthritis
    Faisel Khan
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Int J Rheum Dis 13:189-95. 2010
    ..The purpose of this review is to give a brief overview of some of the commonly used techniques for assessment of endothelial function, and in particular on those that have been used in studies of patients with rheumatoid arthritis...
  14. ncbi request reprint Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes
    F Khan
    University Department of Medicine, Child Health Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Diabetes Care 23:215-20. 2000
    ....
  15. pmc Impaired microvascular function in normal children: effects of adiposity and poor glucose handling
    Faisel Khan
    Vascular Diseases Research Unit, Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    J Physiol 551:705-11. 2003
    ..These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life...
  16. doi request reprint Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis
    Bernat Galarraga
    The Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Rheumatology (Oxford) 48:1418-23. 2009
    ..The second objective was to establish any effect anti-rheumatic treatment may have on augmentation index...
  17. doi request reprint Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
    ..With its increasing use by other groups, it is anticipated that further published studies will help to provide a better understanding of the development and progression of cardiovascular disease...
  18. pmc B-type natriuretic peptide is an independent predictor of endothelial function in man
    Maheshwar Pauriah
    Centre for Cardiovascular and Lung Biology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Clin Sci (Lond) 123:307-12. 2012
    ..In a strategy using several biomarkers to relate to endothelial function, plasma BNP was found to be an independent predictor of endothelial function as assessed by endothelium-dependent vasodilatation in response to ACH...
  19. ncbi request reprint Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome
    Vance A Spence
    Vascular and Inflammatory Diseases Research Unit, Institute for Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 114:561-6. 2008
    ..Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group...
  20. doi request reprint Therapeutic development in cardiac syndrome X: a need to target the underlying pathophysiology
    Tiong K Lim
    Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
    Cardiovasc Ther 27:49-58. 2009
    ....
  21. doi request reprint Biochemical and vascular aspects of pediatric chronic fatigue syndrome
    Gwen Kennedy
    Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Arch Pediatr Adolesc Med 164:817-23. 2010
    ..To evaluate the biochemical and vascular aspects of pediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)...
  22. doi request reprint The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin
    M P Dias
    Vascular Diseases Research Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Anaesthesia 63:151-5. 2008
    ..001). Local anaesthetics may therefore be useful in the suppression of inflammation and the prevention of postoperative hyperalgesia...
  23. ncbi request reprint Differences in endothelial function and vascular reactivity between Scottish and Arabic populations
    K E Elherik
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee
    Scott Med J 48:85-7. 2003
    ..Environmental, dietary, but also genetic factors might affect endothelial cell function and vascular activity...
  24. ncbi request reprint The effect of adjuvant epinephrine concentration on the vasoactivity of the local anesthetics bupivacaine and levobupivacaine in human skin
    David J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Dundee, United Kingdom
    Reg Anesth Pain Med 29:307-11. 2004
    ..The aim of our study was to determine the lowest effective vasoconstrictor concentration of epinephrine in human skin for a range of doses of bupivacaine and its less-vasodilatory S(-) isomer, levobupivacaine...
  25. ncbi request reprint Circadian variation in vascular tone and endothelial cell function in normal males
    Khalid Elherik
    University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, UK
    Clin Sci (Lond) 102:547-52. 2002
    ..These circadian variations in endothelial activity might play an important role in the occurrence of acute cardiovascular events at this time, which are precipitated through the interplay between ET-1, NO and vascular function...
  26. ncbi request reprint Vasoactive properties of lignocaine administered by iontophoresis in human skin
    David J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 104:87-92. 2003
    ..It might be worth considering the use of alternative, non-vasoactive preservatives in local anaesthetic preparations, or avoiding the use of additives altogether, when this is feasible...
  27. ncbi request reprint Mechanisms contributing to the vaso-active effects of prilocaine in human skin
    D J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Dundee DD1 9SY, UK
    Anaesthesia 58:6-10. 2003
    ....
  28. ncbi request reprint The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects
    Faisel Khan
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Cardiovasc Res 59:955-62. 2003
    ..Evaluation of the effects of supplementation of n-3 and n-6 fatty acids on vascular tone and endothelial function in healthy men and women aged 40 to 65 years...
  29. doi request reprint Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo
    Jill J F Belch
    Vascular and Inflammatory Diseases Research Unit, Dundee, DD1 9SY, Scotland
    Microvasc Res 85:86-92. 2013
    ..Longitudinal assessments of skin microvascular function in mice could provide a useful translatable model for assessing early endothelial dysfunction...
  30. doi request reprint Clinical improvement in rheumatoid arthritis is associated with healthier microvascular function in patients who respond to antirheumatic therapy
    Bernat Galarraga
    Vascular and Inflammatory Diseases Research Unit, Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland
    J Rheumatol 37:521-8. 2010
    ..We assessed the effect of antirheumatic treatment on microvascular endothelial function in patients with RA, particularly to examine responders versus nonresponders to therapy...
  31. ncbi request reprint Investigation of cutaneous microvascular activity and flare response in patients with fibromyalgia syndrome
    A W Al-Allaf
    Rheumatic Disease Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Rheumatology (Oxford) 40:1097-101. 2001
    ..57). CONCLUSION: There are no significant differences in cutaneous microvascular reactivity between patients with FMS and control subjects...
  32. doi request reprint C-reactive protein: the underlying cause of microvascular dysfunction in rheumatoid arthritis
    B Galarraga
    Institute of Cardiovascular Research, Vascular and Inflammatory Diseases Research Unit, University Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Rheumatology (Oxford) 47:1780-4. 2008
    ..We therefore assessed forearm microvascular endothelial function in patients with RA and determined its relationship to RA disease activity and inflammation...
  33. doi request reprint Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure
    Matlooba A AlZadjali
    University of Dundee, Ninewells Hospital and Medical School, United Kingdom
    J Am Coll Cardiol 53:747-53. 2009
    ....
  34. ncbi request reprint Vascular endothelial growth factor in patients with critical limb ischemia before and after amputation
    M McLaren
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    Int Angiol 21:165-8. 2002
    ..However growth factors are also implicated in the development of vascular disease by smooth muscle cell proliferation...
  35. ncbi request reprint Improvement in systemic endothelial condition following amputation in patients with critical limb ischemia
    D J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK
    Int Angiol 27:408-12. 2008
    ..We looked at whether markers of endothelial function improve after amputation of the ischemic limb, when this potential source of toxins has been removed...
  36. ncbi request reprint Endothelial activation and response in patients with hand arm vibration syndrome
    G Kennedy
    Section of Vascular Medicine and Biology, University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Eur J Clin Invest 29:577-81. 1999
    ..Cytokines and cell adhesion molecules both play an important role in this interaction, and basal vascular tone and vasodilatation are regulated by nitric oxide...
  37. ncbi request reprint Endothelin-1 levels predict 3-year survival in patients who have amputation for critical leg ischaemia
    D J Newton
    Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Surg 92:1377-81. 2005
    ..The aim of this study was to investigate whether any markers of endothelial function could predict death in these patients...
  38. ncbi request reprint Pilot study of the effects of local pressure on microvascular function in the diabetic foot
    D J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, University of Dundee, Dundee, Scotland, UK
    Diabet Med 22:1487-91. 2005
    ..The aim of the study was to determine whether areas of the diabetic foot that experience high pressures during normal activity also demonstrate reductions in cutaneous microvascular flow and/or endothelial function...
  39. ncbi request reprint Mechanisms influencing the vasoactive effects of lidocaine in human skin
    D J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University Department of Anaesthesia, Dundee DD1 9SY, UK
    Anaesthesia 62:146-50. 2007
    ..No reduction in response was seen after blocking the cyclo-oxygenase or beta-adrenoceptor pathways. Nitric oxide release contributes to the vasoactivity of lidocaine in human skin...
  40. ncbi request reprint Intensive insulin therapy improves endothelial function and microvascular reactivity in young people with type 1 diabetes
    V L Franklin
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Diabetologia 51:353-60. 2008
    ..The aim of this study was to determine whether introducing intensive diabetes management [intensive insulin therapy (IIT) and 'Sweet Talk' text-messaging support] produces measurable improvements in endothelial function...
  41. ncbi request reprint Vasoactive characteristics of bupivacaine and levobupivacaine with and without adjuvant epinephrine in peripheral human skin
    D J Newton
    Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Anaesth 94:662-7. 2005
    ..The aim of this study was to characterize fully the vasoactive effects of these anaesthetics, using an objective measure of blood flow, and to assess the influence of adding epinephrine...
  42. ncbi request reprint Assessment of microvascular endothelial function in human skin
    D J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 101:567-72. 2001
    ....
  43. doi request reprint Effects of Vitamin D supplementation on markers of vascular function after myocardial infarction-A randomised controlled trial
    Miles D Witham
    Ageing and Health, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, United Kingdom Electronic address
    Int J Cardiol 167:745-9. 2013
    ..We tested whether vitamin D supplementation could improve endothelial function and other markers of vascular function in patients with a history of myocardial infarction...
  44. ncbi request reprint Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome
    V A Spence
    Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Prostaglandins Leukot Essent Fatty Acids 70:403-7. 2004
    ..There are several mechanisms that might lead to ACh endothelial sensitivity in CFS patients and various experiments have been designed to unravel the enigma. These are reported here...
  45. ncbi request reprint Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy
    D J Newton
    Peripheral Vascular Diseases Research Group, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    J Foot Ankle Surg 41:233-7. 2002
    ..The changes in blood flow observed in this pilot study might reflect angiogenesis in the newly formed granulation tissue and/or vasodilatation of existing vessels, processes that are possibly enhanced by the intervention...
  46. doi request reprint Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion
    Sriram Vaidyanathan
    Asthma and Allergy Research Group, Centre for Cardiovascular and Lung Biology, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Am J Respir Crit Care Med 182:19-24. 2010
    ..Chronic use of intranasal decongestants, such as oxymetazoline, leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenoceptor mediated down-regulation and desensitization of response...
  47. doi request reprint Commentary on viewpoint: the human cutaneous circulation as a model of generalized microvascular function
    Faisel Khan
    J Appl Physiol 105:385; author reply 389. 2008