Stephen M Keyse

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint Protein phosphatases and cancer. Preface
    Stephen M Keyse
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
    Cancer Metastasis Rev 27:121-2. 2008
  2. doi request reprint DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5
    Rebecca S Arkell
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK
    Cell Signal 20:836-43. 2008
  3. doi request reprint Dual-specificity MAP kinase phosphatases (MKPs) and cancer
    Stephen M Keyse
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
    Cancer Metastasis Rev 27:253-61. 2008
  4. pmc Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
    Maria Ekerot
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Biochem J 412:287-98. 2008
  5. pmc Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
    Christopher J Staples
    CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 285:25928-40. 2010
  6. pmc Distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae
    Lorena Palacios
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ramón y Cajal de Investigaciones Sanitarias, 28040 Madrid, Spain
    J Biol Chem 286:42037-50. 2011
  7. pmc Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
    Robin J Dickinson
    CR UK Stress Response Laboratory, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    J Biol Chem 286:38018-26. 2011
  8. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
  9. ncbi request reprint Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos
    Terence Gordon Smith
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 580:4242-5. 2006
  10. ncbi request reprint Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal
    Maria Karlsson
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 279:41882-91. 2004

Collaborators

  • Kate G Storey
  • Anton Gartner
  • Juan Jose Sanz-Ezquerro
  • Andrew C B Cato
  • Marios P Stavridis
  • Jana V Maier
  • Mona Johannessen
  • Ugo Moens
  • Cheryll Tickle
  • Sylvain Meloche
  • Robin J Dickinson
  • Christopher J Staples
  • Mark P Didmon
  • Maxwell C Eblaghie
  • Ole Morten Seternes
  • Margret Mandl
  • Maria Karlsson
  • Rachael Rutkowski
  • Graeme Stewart
  • Lorena Palacios
  • Laurent Delavaine
  • David M Owens
  • Anna Kucharska
  • Christopher Staples
  • Maria Ekerot
  • Rebecca S Arkell
  • Iain D Keenan
  • Terence Gordon Smith
  • Espen Aberg
  • Graham R Christie
  • Elizabeth R Farrell
  • J Simon Lunn
  • Bjarne Johansen
  • Fiona MacIsaac
  • David J Williams
  • Joanne Mathers
  • David N Slack
  • Michelle Collister
  • Antonio García Trinidad
  • Rafael Pulido
  • Maria Jose Marin
  • Almudena Sacristán-Reviriego
  • Robin Dickinson
  • Marianne Schimpl
  • Rocío Cejudo-Marín
  • Andres Alonso
  • Humberto Martín
  • Maria Molina
  • Ashley Craig
  • Nick A Morrice
  • Linda K Rushworth
  • Simon J Cook
  • Matthew Squires
  • Shaista Hayat
  • Michael P Mitchell
  • Maria Perander
  • Catherine Julien
  • Ian Rosewell
  • Andrea E Münsterberg
  • Neil Q MacDonald
  • Gillian M Morriss-Kay
  • Beate Hegge
  • Michael J Stark
  • Jill Williamson

Detail Information

Publications20

  1. doi request reprint Protein phosphatases and cancer. Preface
    Stephen M Keyse
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
    Cancer Metastasis Rev 27:121-2. 2008
  2. doi request reprint DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5
    Rebecca S Arkell
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK
    Cell Signal 20:836-43. 2008
    ..These results demonstrate that even upon over-expression DUSP6 fails to inactivate ERK5, confirming that it is indeed an ERK1/2-specific DUSP...
  3. doi request reprint Dual-specificity MAP kinase phosphatases (MKPs) and cancer
    Stephen M Keyse
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
    Cancer Metastasis Rev 27:253-61. 2008
    ..This review summarises the current evidence implicating the dual-specificity MKPs in the initiation and development of cancer and also on the outcome of treatment...
  4. pmc Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
    Maria Ekerot
    Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Biochem J 412:287-98. 2008
    ..These findings identify a conserved Ets-factor-dependent mechanism by which ERK signalling activates DUSP6/MKP-3 transcription to deliver ERK1/2-specific negative-feedback control of FGF signalling...
  5. pmc Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
    Christopher J Staples
    CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 285:25928-40. 2010
    ..Our results demonstrate that cross-talk between the p38alpha and JNK pathways mediated by induction of DUSP1/MKP-1 regulates the cellular response to UV radiation...
  6. pmc Distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae
    Lorena Palacios
    Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ramón y Cajal de Investigaciones Sanitarias, 28040 Madrid, Spain
    J Biol Chem 286:42037-50. 2011
    ..This binding flexibility may allow MAPK pathways to exploit additional regulatory controls in order to provide fine modulation of both pathway activity and specificity...
  7. pmc Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
    Robin J Dickinson
    CR UK Stress Response Laboratory, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    J Biol Chem 286:38018-26. 2011
    ..We conclude that DUSP9/MKP-4 is a bona fide target of PKA signaling and that attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38α in vivo...
  8. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..Our results suggest that this enzyme may have a critical role in regulating the activity of MAPK signalling during early development and organogenesis...
  9. ncbi request reprint Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos
    Terence Gordon Smith
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 580:4242-5. 2006
    ..We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of FGF-induced ERK activity...
  10. ncbi request reprint Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal
    Maria Karlsson
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 279:41882-91. 2004
    ..Our results reinforce the idea that regulatory proteins such as MKP-3 may play a key role in the spatio-temporal regulation of MAP kinase activity...
  11. pmc The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development
    Graham R Christie
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:8323-33. 2005
    ....
  12. pmc Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
    Margret Mandl
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:1830-45. 2005
    ..In addition, our data indicate that the cytoplasm may not be an exclusive site of MAP kinase activation...
  13. ncbi request reprint Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
    Anna Kucharska
    Cancer Research UK Stress Response Laboratory, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
    Cell Signal 21:1794-805. 2009
    ..We conclude that DUSP5 is stabilised by complex formation with its physiological substrate and that this may reinforce its activity as both a phosphatase and nuclear anchor for ERK2...
  14. ncbi request reprint Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4
    Espen Aberg
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway, and Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK
    J Biol Chem 281:35499-510. 2006
    ..We conclude that MK5 activation is dependent on both ERK3 and ERK4 in these cells and that these atypical MAPKs are both physiological regulators of MK5 activity...
  15. ncbi request reprint YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae
    Michelle Collister
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, DD1 9SY, Dundee, UK
    FEBS Lett 527:186-92. 2002
    ..We conclude that the physiological target of YIL113p is Slt2/Mpk1p...
  16. ncbi request reprint Diverse physiological functions for dual-specificity MAP kinase phosphatases
    Robin J Dickinson
    Cancer Research UK Stress Response Laboratory, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    J Cell Sci 119:4607-15. 2006
    ..Interestingly, these functions may reflect both restricted subcellular MKP activity and changes in the levels of signalling through multiple MAPK pathways...
  17. ncbi request reprint Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, United Kingdom
    Curr Biol 13:1009-18. 2003
    ..High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known...
  18. pmc Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling
    Rachael Rutkowski
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 7:e1002238. 2011
    ..Since apoptosis is also restricted to pachytene stage cells in mammalian germlines, analogous mechanisms regulating p53 family members are likely to be conserved throughout evolution...
  19. ncbi request reprint Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis
    Robin J Dickinson
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee, DD1 9SY, UK
    Mech Dev 113:193-6. 2002
    ..Most of these have been characterised as sites of FGF/FGFR signalling...
  20. pmc Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress
    Ole Morten Seternes
    Department of Biochemistry Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Mol Cell Biol 22:6931-45. 2002
    ....