Research Topics
Genomes and Genes | Stephen M KeyseSummaryAffiliation: University of Dundee Country: UK Publications
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Publications
Protein phosphatases and cancer. PrefaceStephen M Keyse
Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
Cancer Metastasis Rev 27:121-2. 2008
DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5Rebecca S Arkell
Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK
Cell Signal 20:836-43. 2008..These results demonstrate that even upon over-expression DUSP6 fails to inactivate ERK5, confirming that it is indeed an ERK1/2-specific DUSP...- Dual-specificity MAP kinase phosphatases (MKPs) and cancerStephen M Keyse
Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, UK
Cancer Metastasis Rev 27:253-61. 2008..This review summarises the current evidence implicating the dual-specificity MKPs in the initiation and development of cancer and also on the outcome of treatment... - Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPKAnna Kucharska
Cancer Research UK Stress Response Laboratory, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
Cell Signal 21:1794-805. 2009..We conclude that DUSP5 is stabilised by complex formation with its physiological substrate and that this may reinforce its activity as both a phosphatase and nuclear anchor for ERK2... 
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoterMaria Ekerot
Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Biochem J 412:287-98. 2008..These findings identify a conserved Ets-factor-dependent mechanism by which ERK signalling activates DUSP6/MKP-3 transcription to deliver ERK1/2-specific negative-feedback control of FGF signalling...- Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4Espen Aberg
Department of Pharmacology, Institute of Medical Biology, University of Troms, N-9037 Troms, Norway, and Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK
J Biol Chem 281:35499-510. 2006..We conclude that MK5 activation is dependent on both ERK3 and ERK4 in these cells and that these atypical MAPKs are both physiological regulators of MK5 activity... - Diverse physiological functions for dual-specificity MAP kinase phosphatasesRobin J Dickinson
Cancer Research UK Stress Response Laboratory, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
J Cell Sci 119:4607-15. 2006..Interestingly, these functions may reflect both restricted subcellular MKP activity and changes in the levels of signalling through multiple MAPK pathways... - Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5Margret Mandl
Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Mol Cell Biol 25:1830-45. 2005..In addition, our data indicate that the cytoplasm may not be an exclusive site of MAP kinase activation... - The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic developmentGraham R Christie
Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Mol Cell Biol 25:8323-33. 2005.... - Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiationChristopher J Staples
CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
J Biol Chem 285:25928-40. 2010..Our results demonstrate that cross-talk between the p38alpha and JNK pathways mediated by induction of DUSP1/MKP-1 regulates the cellular response to UV radiation... - Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signalMaria Karlsson
Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 279:41882-91. 2004..Our results reinforce the idea that regulatory proteins such as MKP-3 may play a key role in the spatio-temporal regulation of MAP kinase activity... - YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiaeMichelle Collister
Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, DD1 9SY, Dundee, UK
FEBS Lett 527:186-92. 2002..We conclude that the physiological target of YIL113p is Slt2/Mpk1p... - Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryosTerence Gordon Smith
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
FEBS Lett 580:4242-5. 2006..We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of FGF-induced ERK activity... - Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stressOle Morten Seternes
Department of Biochemistry Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
Mol Cell Biol 22:6931-45. 2002.... - Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphataseRobin J Dickinson
Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
Biochem J 364:145-55. 2002..Our results suggest that this enzyme may have a critical role in regulating the activity of MAPK signalling during early development and organogenesis...