Keith M Kerr
Affiliation: University of Aberdeen
- Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinomaKeith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen, UK
J Pathol 203:638-44. 2004..Loss of MMP-2 and TIMP-2 in stromally invasive tumour may reflect a particular role for MMP-2 at the BAC stage, with later down-regulation of this particular enzyme...
- The role of DNA methylation in the development and progression of lung adenocarcinomaKeith M Kerr
Department of Pathology, Aberdeen Royal Infirmary, Link Building, Foresterhill, Aberdeen, AB25 2ZN, UK
Dis Markers 23:5-30. 2007....
- Classification of lung cancer: proposals for change?Keith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
Arch Pathol Lab Med 136:1190-3. 2012..The huge increase in data on the molecular biology of lung cancer has improved our understanding of these diseases, has driven improved therapy for some patients, and must be reflected in the way lung cancer is classified...
- Personalized medicine for lung cancer: new challenges for pathologyKeith M Kerr
Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Histopathology 60:531-46. 2012..This extended diagnostic requirement from increasingly limited material provided by minimally invasive biopsy techniques poses major challenges for pathology...
- Pulmonary preinvasive neoplasiaK M Kerr
Department of Pathology, Aberdeen Royal Infirmary and Aberdeen University Medical School, Foresterhill, Aberdeen AB25 2ZD, UK
J Clin Pathol 54:257-71. 2001....
- Pulmonary adenocarcinomas: classification and reportingKeith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Histopathology 54:12-27. 2009..The emerging clinical and prognostic relevance of a number of histological features in these complex tumours strengthens the argument in favour of including quantitative detail of pattern sub-types in reports on resected tumours...
- Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimensPeh Sun Loo
Department of Pathology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
J Thorac Oncol 5:442-7. 2010..Histochemical staining for mucin and immunohistochemical (IHC) identification of NSCLC subtype-associated markers could help predict the final subtype of resected NSCLCs diagnosed as NSCLC-NOS on preoperative bronchial biopsy samples...
- Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trialMarianne C Nicolson
Thoracic Oncology, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom
J Thorac Oncol 8:930-9. 2013..This phase II study explored this association prospectively at the protein and mRNA-expression level...
- Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical applicationRussell D Petty
Department of Oncology, Aberdeen and Oncology Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
Clin Cancer Res 10:3237-48. 2004..Taken together, these advances hold the promise of an improved understanding of the molecular biology of NSCLC and its treatment, which in turn will lead to improved outcomes for this deadly disease...
- Quantitative analysis of tumor in bronchial biopsy specimensCaroline L Coghlin
Department of Pathology, Aberdeen Royal Infirmary and Aberdeen University Medical School, Aberdeen, United Kingdom
J Thorac Oncol 5:448-52. 2010..We analyzed a series of 100 bronchial biopsy specimens in lung cancer patients to assess the frequency and quantity of tumor present in biopsy samples...
- Serpin b3 is associated with poor survival after chemotherapy and is a potential novel predictive biomarker in advanced non-small-cell lung cancerGordon Urquhart
School of Medicine and Dentistry, University of Aberdeen, Foresterhill Healthcare Campus, Foresterhill, Aberdeen, Scotland, United Kingdom and Departments of Oncology and Pathology Aberdeen Royal Infirmary, Foresterhill Healthcare Campus, Foresterhill, Aberdeen, Scotland, United Kingdom
J Thorac Oncol 8:1502-9. 2013..This independent prospective study was designed to confirm the predictive utility of SB3...
- Spontaneous dissection of an anomalous systemic artery in the lung during pregnancy: a rare cause of hemoptysisShafaque Shaikh
Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
Ann Thorac Surg 82:725-6. 2006..This article aims to discuss the clinical presentation, diagnostic curiosity, management using a minimally invasive technique (video-assisted thoracoscopic lobectomy), and finally the histopathologic findings...
- Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancerRussell D Petty
Oncology Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, School of Medicine, University of Aberdeen, Aberdeen, nited Kingdom
J Clin Oncol 24:1729-44. 2006..Insight into clinical response to platinum-based chemotherapy (PBC) in non-small-cell lung cancer (NSCLC)...
- Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissueJill M Kolesar
School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53706 1515, USA
Int J Oncol 21:1119-24. 2002..007), suggesting NQO1 may be important in chemosensitivity as well as the pathogenesis of lung cancer and NQO1 genotyping may be a useful component of pharmacogenetic strategies for the treatment of NSCLC...
- Changing trends in incidence of lung cancer by histologic type in ScotlandElaine F Harkness
ARC Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Int J Cancer 102:179-83. 2002..Changes in histologic types are unlikely to be solely due to diagnostic advances. Rates of adenocarcinoma have increased steadily over time, and this may be due to changes in cigarette design during the 1950s...