Keith M Kerr
Affiliation: University of Aberdeen
- Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinomaKeith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen, UK
J Pathol 203:638-44. 2004..Loss of MMP-2 and TIMP-2 in stromally invasive tumour may reflect a particular role for MMP-2 at the BAC stage, with later down-regulation of this particular enzyme...
- The role of DNA methylation in the development and progression of lung adenocarcinomaKeith M Kerr
Department of Pathology, Aberdeen Royal Infirmary, Link Building, Foresterhill, Aberdeen, AB25 2ZN, UK
Dis Markers 23:5-30. 2007....
- Classification of lung cancer: proposals for change?Keith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
Arch Pathol Lab Med 136:1190-3. 2012..The huge increase in data on the molecular biology of lung cancer has improved our understanding of these diseases, has driven improved therapy for some patients, and must be reflected in the way lung cancer is classified...
- Personalized medicine for lung cancer: new challenges for pathologyKeith M Kerr
Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Histopathology 60:531-46. 2012..This extended diagnostic requirement from increasingly limited material provided by minimally invasive biopsy techniques poses major challenges for pathology...
- Pulmonary preinvasive neoplasiaK M Kerr
Department of Pathology, Aberdeen Royal Infirmary and Aberdeen University Medical School, Foresterhill, Aberdeen AB25 2ZD, UK
J Clin Pathol 54:257-71. 2001....
- Pulmonary adenocarcinomas: classification and reportingKeith M Kerr
Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Histopathology 54:12-27. 2009..The emerging clinical and prognostic relevance of a number of histological features in these complex tumours strengthens the argument in favour of including quantitative detail of pattern sub-types in reports on resected tumours...
- Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimensPeh Sun Loo
Department of Pathology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
J Thorac Oncol 5:442-7. 2010..Histochemical staining for mucin and immunohistochemical (IHC) identification of NSCLC subtype-associated markers could help predict the final subtype of resected NSCLCs diagnosed as NSCLC-NOS on preoperative bronchial biopsy samples...
- Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trialMarianne C Nicolson
Thoracic Oncology, Aberdeen Royal Infirmary, University of Aberdeen, Aberdeen, United Kingdom
J Thorac Oncol 8:930-9. 2013..This phase II study explored this association prospectively at the protein and mRNA-expression level...
- Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical applicationRussell D Petty
Department of Oncology, Aberdeen and Oncology Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
Clin Cancer Res 10:3237-48. 2004..Taken together, these advances hold the promise of an improved understanding of the molecular biology of NSCLC and its treatment, which in turn will lead to improved outcomes for this deadly disease...
- In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinomaErik Thunnissen
From the Departments of Pathology Drs Thunnissen and Beliën, Radiology Dr Lely, and Surgery Dr Hartemink, VU University Medical Center, Amsterdam, the Netherlands the Department of Pathology, Aberdeen Royal Infirmary, Aberdeen University Medical School, Aberdeen, Scotland Dr Kerr the Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Dr Chung the Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania Dr Flieder the Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan Dr Noguchi the Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan Dr Yatabe the Department of Pathology, University Health Network Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada Drs Hwang and Tsao and the Department of Pathology, Symbiant Medical Center Alkmaar, Alkmaar, the Netherlands Dr Meijer Jorna
Arch Pathol Lab Med 137:1792-7. 2013..Surgical removal and pathologic handling of lung tissue has a compressive effect upon its architecture. The effect of surgical atelectasis on morphology has not been examined in depth, especially with respect to lung adenocarcinomas...
- Quantitative analysis of tumor in bronchial biopsy specimensCaroline L Coghlin
Department of Pathology, Aberdeen Royal Infirmary and Aberdeen University Medical School, Aberdeen, United Kingdom
J Thorac Oncol 5:448-52. 2010..We analyzed a series of 100 bronchial biopsy specimens in lung cancer patients to assess the frequency and quantity of tumor present in biopsy samples...
- Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver studyErik Thunnissen
Departments of Pathology and Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands Department of Pathology, Faculty of Medicine, Tsukuba, Japan Rutgers New Jersey Medical School, Newark, New Jersey Department of Pathology, Mount Sinai Medical Center, New York, New York Elisabeth Brambilla, CHU Albert Michallon, Institut de Biologie, Département d Anatomie et Cytologie Pathologiques, Grenoble Cedex, France Brigham and Women s Hospital, Boston, Massachusetts Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania Piedmont Pathology Associates, Hickory, North Carolina, and University of North Carolina, Chapel Hill, North Carolina Department of Medicine and Pathology, University of Colorado Cancer Center, Aurora, Colorado Division of Pathology, The Cancer Institute, Japanese Foundation Cancer Research, Tokyo, Japan Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom Department of Pathology, CHU A Michallon
J Thorac Oncol 9:1354-62. 2014....
- EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic surveyYasushi Yatabe
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom KalGen Laboratory, Stem cell and Cancer Institute SCI, Jakarta, Indonesia School of Medicine, Monash University Malaysia and Sime Darby Medical Center, Kuala Lumpur, Malaysia Center for Gene and Protein Research, Hanoi Medical University, Hanoi, Vietnam Department of Pathology, Fudan University Shanghai Cancer Center Institute of Pathology, Fudan University, Shanghai, China Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Research and Biotechnology Division, St Luke s Medical Center, Quezon City and COS CENSER, De La Salle University, Manila, Philippines Department of Pathology, National Cancer Center, Goyang si, Gyeonggi Do, Korea Department of Pathology, Singapore General Hospital, Singapore, Singapore Chulalongkorn GenePRO Center, Chulalongkorn Hospital, Bangkok, Thailand Seoul National University Bundang Hospital, Seoul, Ibaraki 304-8506
J Thorac Oncol 10:438-45. 2015..Although EGFR mutation testing has been adopted by many laboratories in Asia, data are lacking on the proportion of NSCLC patients tested in each country, and the most commonly used testing methods...
- Serpin b3 is associated with poor survival after chemotherapy and is a potential novel predictive biomarker in advanced non-small-cell lung cancerGordon Urquhart
School of Medicine and Dentistry, University of Aberdeen, Foresterhill Healthcare Campus, Foresterhill, Aberdeen, Scotland, United Kingdom and Departments of Oncology and Pathology Aberdeen Royal Infirmary, Foresterhill Healthcare Campus, Foresterhill, Aberdeen, Scotland, United Kingdom
J Thorac Oncol 8:1502-9. 2013..This independent prospective study was designed to confirm the predictive utility of SB3...
- Spontaneous dissection of an anomalous systemic artery in the lung during pregnancy: a rare cause of hemoptysisShafaque Shaikh
Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
Ann Thorac Surg 82:725-6. 2006..This article aims to discuss the clinical presentation, diagnostic curiosity, management using a minimally invasive technique (video-assisted thoracoscopic lobectomy), and finally the histopathologic findings...
- Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancerRussell D Petty
Oncology Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, School of Medicine, University of Aberdeen, Aberdeen, nited Kingdom
J Clin Oncol 24:1729-44. 2006..Insight into clinical response to platinum-based chemotherapy (PBC) in non-small-cell lung cancer (NSCLC)...
- Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissueJill M Kolesar
School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53706 1515, USA
Int J Oncol 21:1119-24. 2002..007), suggesting NQO1 may be important in chemosensitivity as well as the pathogenesis of lung cancer and NQO1 genotyping may be a useful component of pharmacogenetic strategies for the treatment of NSCLC...
- Changing trends in incidence of lung cancer by histologic type in ScotlandElaine F Harkness
ARC Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Int J Cancer 102:179-83. 2002..Changes in histologic types are unlikely to be solely due to diagnostic advances. Rates of adenocarcinoma have increased steadily over time, and this may be due to changes in cigarette design during the 1950s...