I D Kerr

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint The translocation mechanism of P-glycoprotein
    Richard Callaghan
    Nuffield Department of Clinical Laboratory Sciences, Level 4, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom
    FEBS Lett 580:1056-63. 2006
  2. ncbi request reprint Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein
    Janet Storm
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Biochemistry 46:9899-910. 2007
  3. doi request reprint Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    FEBS J 277:550-63. 2010
  4. ncbi request reprint Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Eur Biophys J 32:644-54. 2003
  5. ncbi request reprint Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition
    Ian D Kerr
    Centre for Biochemistry and Cell Biology, School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 315:166-73. 2004
  6. ncbi request reprint ABC proteins and antibiotic drug resistance: is it all about transport?
    I D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Soc Trans 33:1000-2. 2005
  7. pmc The ABCG family of membrane-associated transporters: you don't have to be big to be mighty
    Ian D Kerr
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham
    Br J Pharmacol 164:1767-79. 2011
  8. ncbi request reprint Principles of proteomics and its applications in cancer
    S Chuthapisith
    Department of Surgery, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, England, UK
    Surgeon 5:14-22. 2007
  9. ncbi request reprint Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs
    Suebwong Chuthapisith
    Department of Surgery, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Int J Oncol 30:1545-51. 2007
  10. pmc New insight into the biochemical mechanisms regulating auxin transport in plants
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem J 401:613-22. 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The translocation mechanism of P-glycoprotein
    Richard Callaghan
    Nuffield Department of Clinical Laboratory Sciences, Level 4, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom
    FEBS Lett 580:1056-63. 2006
    ..The present review attempts to utilise the available data to generate a detailed sequence of events in the translocation pathway for this dexterous protein...
  2. ncbi request reprint Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein
    Janet Storm
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Biochemistry 46:9899-910. 2007
    ..Homology modeling of P-glycoprotein indicated that the G346C mutation caused a steric interaction between TM5 and TM6, thereby precluding a helical movement required to support ATP hydrolysis...
  3. doi request reprint Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    FEBS J 277:550-63. 2010
    ....
  4. ncbi request reprint Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Eur Biophys J 32:644-54. 2003
    ..We have interpreted our results in terms of homology models, which suggest that the N-terminal NBD of P-glycoprotein can be produced as a stable, correctly folded, isolate domain with judicious design of the expression construct...
  5. ncbi request reprint Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition
    Ian D Kerr
    Centre for Biochemistry and Cell Biology, School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 315:166-73. 2004
    ....
  6. ncbi request reprint ABC proteins and antibiotic drug resistance: is it all about transport?
    I D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Soc Trans 33:1000-2. 2005
    ..Pertinent data in support of these two hypotheses are discussed in this paper...
  7. pmc The ABCG family of membrane-associated transporters: you don't have to be big to be mighty
    Ian D Kerr
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham
    Br J Pharmacol 164:1767-79. 2011
    ..We summarize here data on all five human ABCG transporters and provide a current perspective on their roles in human health and disease...
  8. ncbi request reprint Principles of proteomics and its applications in cancer
    S Chuthapisith
    Department of Surgery, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, England, UK
    Surgeon 5:14-22. 2007
    ..These technologies, particularly when combined with genomic analyses, will provide valuable insights into the molecular basis of carcinogenesis and the development of more effective anti-cancer therapies...
  9. ncbi request reprint Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs
    Suebwong Chuthapisith
    Department of Surgery, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Int J Oncol 30:1545-51. 2007
    ....
  10. pmc New insight into the biochemical mechanisms regulating auxin transport in plants
    Ian D Kerr
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem J 401:613-22. 2007
    ..In this review we will appraise the recent transport data and highlight likely future research directions, including the characterization of auxiliary proteins necessary for the regulation of auxin transporters...
  11. ncbi request reprint Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein
    J Lawson
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Biochim Biophys Acta 1778:376-91. 2008
    ..Consequently, this will enable testable predictions to be made that will result in further in-roads into our understanding of this clinically important drug pump...
  12. ncbi request reprint Modelling the restoration of wild-type dynamic behaviour in DeltaF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine
    Daniel J Warner
    Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK
    J Mol Graph Model 26:691-9. 2007
    ....
  13. pmc The binding of auxin to the Arabidopsis auxin influx transporter AUX1
    David J Carrier
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Plant Physiol 148:529-35. 2008
    ..Determination of the parameters describing the initial interaction between a plant transporter and its hormone ligand provides novel quantitative data for modeling auxin fluxes...
  14. doi request reprint Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling
    Janet Storm
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, United Kingdom
    Biochemistry 47:3615-24. 2008
    ..Covalent modification of the cytosolic segment of TM6 did, however, attenuate drug stimulation of ATP hydrolysis and demonstrates an important role for this segment in coupling drug binding to ATP hydrolysis during translocation...
  15. doi request reprint Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
    Christopher A McDevitt
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, UK
    FEBS J 275:4354-62. 2008
    ..The data indicate that, like ABCB1 and ABCC1, the 'power stroke' for translocation in ABCG2 R482G is the binding of nucleotide...
  16. ncbi request reprint Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2
    Christopher A McDevitt
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom
    Structure 14:1623-32. 2006
    ..We interpret the tetrameric structure as comprising four homodimeric ABCG2(R482G) complexes...
  17. ncbi request reprint The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling
    Georgina Berridge
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Biochem 270:1483-92. 2003
    ..Any observed functional asymmetry in the intact transporter presumably reflects different rates of hydrolysis at the two NBDs or interdomain communications...
  18. ncbi request reprint Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508
    Mark P Gabriel
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, UK
    Biochemistry 42:7780-9. 2003
    ..The results imply that the accessibility of residue 508, located in the alpha-helical subdomain of NBD1 in Pgp, is altered by the conformational changes that occur during ATP hydrolysis...
  19. ncbi request reprint An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling
    Daniella R Stenham
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    FASEB J 17:2287-9. 2003
    ..This model will be important for understanding the mechanism of P-glycoprotein and other ABC transporters...
  20. ncbi request reprint The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein
    Alice Rothnie
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    J Biol Chem 279:34913-21. 2004
    ..Our data are reconciled with a recent atomic scale model of P-gp and are consistent with a tilting of TM6 in response to nucleotide binding and ATP hydrolysis...
  21. ncbi request reprint Structure and association of ATP-binding cassette transporter nucleotide-binding domains
    Ian D Kerr
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4, John Radcliffe Hospital, OX3 9DS, UK
    Biochim Biophys Acta 1561:47-64. 2002
    ..This review evaluates both these data and the conflicting implications they have for domain communication in ABC transporters. Areas of biochemical research that attempt to resolve these conflicts will be discussed...
  22. pmc Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain
    Jeff D Campbell
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Biophys J 87:3703-15. 2004
    ..These results support the mechanism for ATP-induced conformational transitions derived from the crystal structures of other NBDs...
  23. pmc Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1
    Ranjan Swarup
    School of Biosciences, Sutton Bonington Campus, University of Nottingham, United Kingdom
    Plant Cell 16:3069-83. 2004
    ..Whereas almost all partial-loss-of-function and null alleles cluster in the core permease region, the sole conditional allele aux1-7 modifies the function of the external C-terminal domain...
  24. ncbi request reprint The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment
    Alice Rothnie
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    FEBS Lett 579:3984-90. 2005
    ..However, covalent modification of this residue appears to prevent conformational changes that lead to drug stimulation of ATP hydrolysis...
  25. ncbi request reprint P-glycoprotein: so many ways to turn it on
    Richard Callaghan
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Clin Pharmacol 48:365-78. 2008
    ..This review also describes the mechanism underlying ABCB1 expression in noncancerous tissue, a process that does not involve the stress response...