Affiliation: University of Birmingham
- Is there a relationship between attention deficit hyperactivity disorder and bipolar disorder?Lindsey Kent
Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
J Affect Disord 73:211-21. 2003..However, several fundamental methodological issues require rectification in future research in order to further elucidate the relationship between these disorders...
- Recent advances in the genetics of attention deficit hyperactivity disorderLindsey Kent
Developmental Psychiatry Section, University of Cambridge, Douglas House, Cambridge CB2 2AH, UK
Curr Psychiatry Rep 6:143-8. 2004..Current challenges in this field are to identify the actual functional variant(s) in these genes conferring susceptibility and other genetic and environmental risk factors for ADHD...
- Maternal and child psychological sequelae in paediatric burn injuriesL Kent
Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Mindelsohn Way, Edgbaston, Birmingham, UK
Burns 26:317-22. 2000..Following paediatric burn injury mothers appear to be at higher risk than children for developing psychological sequelae, which may have longer term implications for the child's outcome such as affecting compliance with treatment...
- Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorderL Kent
Department of Psychiatry, University of Birmingham, UK
Psychiatr Genet 11:37-40. 2001..35). The continuing sample collection will enable further study of other potential nicotinic system polymorphisms in ADHD in more powerful samples...
- No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorderL Kent
Department of Psychiatry, Division of Neuroscience, University of Birmingham, Birmingham, UK
Am J Med Genet 105:686-9. 2001..However, it remains possible that the CHRNA7 gene and other nicotinic system genes may be involved in conferring susceptibility to ADHD...
- Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysisL Kent
Molecular Psychiatry Group, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham B15 2QZ, UK
Mol Psychiatry 7:908-12. 2002..18, 3 df, P = 0.004) and the 10 repeat of the VNTR (chi(2) = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD...
- The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorderElise E DeVito
Department of Psychiatry, University of Cambridge, Cambridge, UK
Biol Psychiatry 64:636-9. 2008..The objectives of the study were to assess the effects of stimulant medication on decision making in ADHD and compare performance on the Cambridge Gamble Task between boys with and without ADHD...
- Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD)Elise E DeVito
Department of Psychiatry, University of Cambridge, P O Box 189, Addenbrooke s Hospital, Cambridge CB22QQ, UK
Psychopharmacology (Berl) 202:531-9. 2009..However, impulsivity is a multi-factorial construct and the degree to which different forms of impulsivity contribute to impairments in ADHD or respond to pharmacological treatments remains unclear...
- An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHDZahoor Syed
Addenbrookes Hospital, Cambridge, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 144:375-8. 2007..69, odds ratio (OR) = 1.65, P = 0.05). Although this SNP is located in the 5' pro-NGF sequence and not the mature NGF protein, it may affect intracellular processing and secretion of NGF...
- Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorderJonathan Mill
Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
Am J Med Genet 114:269-71. 2002..Within-family tests of linkage and association confirmed these findings. Further work is needed to ascertain the role of SNAP-25 in ADHD and assess the functional significance of this polymorphism...
- Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypesNaomi Lowe
Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 74:348-56. 2004..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
- Insights into the control of attentional set in ADHD using the attentional blink paradigmDeanna J Mason
School of Psychology, University of Exeter, UK
J Child Psychol Psychiatry 46:1345-53. 2005..This study compared ADHD to control children on a temporal search task using Rapid Serial Visual Presentation (RSVP). In addition, the effects of irrelevant singleton distractors on search performance were examined...
- No association between TPH2 gene polymorphisms and ADHD in a UK sampleKaren Sheehan
Neuropsychiatric Genetics, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
Neurosci Lett 412:105-7. 2007..A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD...
- Beckwith Weidemann syndrome: a behavioral phenotype-genotype studyLindsey Kent
Bute Medical School, University of St Andrews, St Andrews, Scotland, UK
Am J Med Genet B Neuropsychiatr Genet 147:1295-7. 2008..These findings suggest a potential role for the 11p15.5 imprinted gene cluster in ASD and indicate a need for further investigations of neurobehavioral phenotypes in BWS...