Research Topics
| B KennySummaryAffiliation: University of Bristol Country: UK Publications
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Detail Information
Publications
The enteropathogenic Escherichia coli (EPEC) Map effector is imported into the mitochondrial matrix by the TOM/Hsp70 system and alters organelle morphologyPanagiotis Papatheodorou
, , D-70593 Stuttgart-Hohenheim, Germany
Cell Microbiol 8:677-89. 2006..Changes in mitochondrial morphology have been linked to alterations in the ability of these organelles to regulate cellular processes providing a possible additional role for Map import into mitochondria...- Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modificationsB Kenny
Department of Pathology and Microbiology, School of Medical Sciences, Bristol, UK
Mol Microbiol 31:1229-41. 1999..The data also suggest a mechanism for Tir insertion into the host membrane, as well as providing clues to the mode of intimin-integrin interaction... 
Enteropathogenic Escherichia coli (EPEC) Tir receptor molecule does not undergo full modification when introduced into host cells by EPEC-independent mechanismsB Kenny
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England
Infect Immun 69:1444-53. 2001..CesT was found to be an efficiency factor which was not required, unlike in EPEC, for Tir stability, indicating that it may function to guide Tir to the translocation apparatus or maintain it in a secretion-competent form...- Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondriaB Kenny
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol, UK
Cell Microbiol 2:579-90. 2000..This is the first example of a type III secreted protein targeted to mitochondria; it is probable that homologues (present in EPEC and Shigella species) and other bacterial effectors will also target this organelle... - The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueB Kenny
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Cell Microbiol 3:499-510. 2001..An EHEC-induced phosphotyrosine dephosphorylation activity is also identified... - Enteropathogenic Escherichia coli (EPEC)-- a crafty subversive little bugBrendan Kenny
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Microbiology 148:1967-78. 2002 - Mechanism of action of EPEC type III effector moleculesBrendan Kenny
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol, UK
Int J Med Microbiol 291:469-77. 2002..The third, EspF disrupts intestinal barrier function and can induce host cell death by unknown mechanisms. Recent data relating to the mechanism by which Tir and Map function within host cells is discussed... - Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector moleculesBrendan Kenny
Departmentof Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol, UK
Mol Microbiol 44:1095-1107. 2002..Possible implications of the multifunctional nature of EPEC effector molecules in pathogenesis are discussed... - Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface proteinPaul Dean
Department of Pathology and Microbiology, Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
Mol Microbiol 54:665-75. 2004..This work demonstrates that EPEC uses multiple multifunctional proteins to elicit specific responses in intestinal cells and that EPEC can control the activity of its injected effector molecules from its extracellular location... - Phosphoserine modification of the enteropathogenic Escherichia coli Tir molecule is required to trigger conformational changes in Tir and efficient pedestal elongationJ Warawa
Department of Pathology and Microbiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Mol Microbiol 42:1269-80. 2001.... - Effect of protein kinase A-mediated phosphorylation on the structure and association properties of the enteropathogenic Escherichia coli Tir virulence proteinAyman Hawrani
Departments of Pathology and Microbiology and Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 278:25839-46. 2003.... - Role of sipA in the early stages of Salmonella typhimurium entry into epithelial cellsM A Jepson
Cell Imaging Facility and Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK
Cell Microbiol 3:417-26. 2001..It thus appears that the secreted effector protein SipA promotes invasion by a previously unrecognized mechanism separate from the induction of membrane ruffling per se... - Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cellsMark A Jepson
Department of Biochemistry, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Cell Microbiol 5:773-83. 2003..This synergism, which is in stark contrast to the antagonistic actions of Map and Tir in regulating filopodia and pedestal formation, further illustrates the complex interplay between EPEC effectors... - CesT is a bivalent enteropathogenic Escherichia coli chaperone required for translocation of both Tir and MapElizabeth A Creasey
Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College, London SW7 2AZ, UK
Mol Microbiol 47:209-21. 2003..Although other chaperones are reported to have a bivalent binding specificity, CesT is the first member of its family that chaperones more than one protein for translocation... 
Enteropathogenic Escherichia coli (EPEC) inactivate innate immune responses prior to compromising epithelial barrier functionMarie Helene Ruchaud Sparagano
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Cell Microbiol 9:1909-21. 2007..Thus, these findings also lend themselves to a plausible mechanism to explain the absence of a strong inflammatory response in EPEC-infected humans...- The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targetingSabine Quitard
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Cell Microbiol 8:972-81. 2006..Moreover, loss of PI-3 kinase-dependent phosphorylation of Akt and gross changes in host phosphotyrosine protein profiles could not be linked to inhibition of the PI-3 kinase-dependent uptake process... - Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteinsPaul Dean
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
Proc Natl Acad Sci U S A 103:1876-81. 2006..Moreover, the identification of effector activities that alter microvilli structure and SGLT-1 function provides new tools for studying the underlying regulatory processes... - Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model systemMarc Maresca
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE24HH, UK
Cell Microbiol 7:1749-62. 2005..Our study also provides insights into the nature of NO production in response to bacterial infection as well as the role of the locus of enterocyte effacement (LEE)-encoded effector molecules in inhibiting iNOS expression... - EPEC's weapons of mass subversionPaul Dean
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE24HH, UK
Curr Opin Microbiol 8:28-34. 2005..Furthermore, new virulence-associated factors are continually being uncovered that are encoded outside the LEE pathogenicity island, some of which are not injected into host cells... - Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture modelsStephanie Schüller
Centre for Paediatric Gastroenterology, Royal Free and University College Medical School, London, UK
Cell Microbiol 9:1352-64. 2007.... - "Neural networks" in bacteria: making connectionsJudith P Armitage
Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, United Kingdom
J Bacteriol 187:26-36. 2005