Peter Ge Kennedy

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Human African trypanosomiasis: in and out of Africa
    Peter G E Kennedy
    Neurology 66:962-3. 2006
  2. ncbi request reprint Latent Varicella-zoster virus in human dorsal root ganglia
    P G Kennedy
    Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, G51 4TF, Scotland, United Kingdom
    Virology 258:451-4. 1999
  3. ncbi request reprint Absence of detection of varicella-zoster virus DNA in temporal artery biopsies obtained from patients with giant cell arteritis
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Govan Road, G51 4TF Glasgow, UK
    J Neurol Sci 215:27-9. 2003
  4. ncbi request reprint Neurological infection
    Peter G E Kennedy
    University of Glasgow Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, Scotland, UK
    Lancet Neurol 3:13. 2004
  5. pmc Human African trypanosomiasis of the CNS: current issues and challenges
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, United Kingdom
    J Clin Invest 113:496-504. 2004
  6. pmc Viral encephalitis: causes, differential diagnosis, and management
    P G E Kennedy
    Department of Neurology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, UK
    J Neurol Neurosurg Psychiatry 75:i10-5. 2004
  7. doi request reprint Diagnosing central nervous system trypanosomiasis: two stage or not to stage?
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Trans R Soc Trop Med Hyg 102:306-7. 2008
  8. ncbi request reprint Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeys
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
    Virus Genes 28:273-6. 2004
  9. ncbi request reprint Animal models of human African trypanosomiasis--very useful or too far removed?
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Trans R Soc Trop Med Hyg 101:1061-2. 2007
  10. ncbi request reprint Diagnostic and neuropathogenesis issues in human African trypanosomiasis
    Peter G E Kennedy
    Division of Clinical Neurosciences, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, Glasgow G51 4TF, Scotland, UK
    Int J Parasitol 36:505-12. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Human African trypanosomiasis: in and out of Africa
    Peter G E Kennedy
    Neurology 66:962-3. 2006
  2. ncbi request reprint Latent Varicella-zoster virus in human dorsal root ganglia
    P G Kennedy
    Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, G51 4TF, Scotland, United Kingdom
    Virology 258:451-4. 1999
    ..Thus more than one region of the VZV genome is present in neurons during VZV ganglionic latency, and the presence of both a VZV gene and its corresponding RNA transcript can be shown to occur in the same localised region of DRG tissue...
  3. ncbi request reprint Absence of detection of varicella-zoster virus DNA in temporal artery biopsies obtained from patients with giant cell arteritis
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Govan Road, G51 4TF Glasgow, UK
    J Neurol Sci 215:27-9. 2003
    ....
  4. ncbi request reprint Neurological infection
    Peter G E Kennedy
    University of Glasgow Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, Scotland, UK
    Lancet Neurol 3:13. 2004
  5. pmc Human African trypanosomiasis of the CNS: current issues and challenges
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, United Kingdom
    J Clin Invest 113:496-504. 2004
    ..This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease...
  6. pmc Viral encephalitis: causes, differential diagnosis, and management
    P G E Kennedy
    Department of Neurology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, UK
    J Neurol Neurosurg Psychiatry 75:i10-5. 2004
  7. doi request reprint Diagnosing central nervous system trypanosomiasis: two stage or not to stage?
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Trans R Soc Trop Med Hyg 102:306-7. 2008
    ..Whilst some clinicians use the WHO CSF criteria, others use alternative findings to define late-stage disease. Novel analyses in CSF of patients are urgently required for more accurate diagnostic staging...
  8. ncbi request reprint Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeys
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
    Virus Genes 28:273-6. 2004
    ..These findings parallel the detection of varicella zoster virus in neurons of latently infected human ganglia. Natural exposure to SVV provides a model system to study varicella latency...
  9. ncbi request reprint Animal models of human African trypanosomiasis--very useful or too far removed?
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Trans R Soc Trop Med Hyg 101:1061-2. 2007
    ....
  10. ncbi request reprint Diagnostic and neuropathogenesis issues in human African trypanosomiasis
    Peter G E Kennedy
    Division of Clinical Neurosciences, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, Glasgow G51 4TF, Scotland, UK
    Int J Parasitol 36:505-12. 2006
    ....
  11. ncbi request reprint Viral encephalitis
    Peter G E Kennedy
    Department of Neurology, Southern General Hospital, Institute of Neurological Sciences, Glasgow G51 4TF Scotland, UK
    J Neurol 252:268-72. 2005
    ..This review outlines the general management approach in patients suspected of having viral encephalitis...
  12. ncbi request reprint Human African trypanosomiasis-neurological aspects
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow Southern General Hospital, Institute of Neurological Sciences, Glasgow G51 4TF, Scotland, UK
    J Neurol 253:411-6. 2006
    ..However, control of the disease will also require more effective measures of reducing man/fly contact and also the allocation of much greater financial and infrastructural resources than are currently available in Africa...
  13. pmc Neurovirological methods and their applications
    P G E Kennedy
    Division of Clinical Neurosciences, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:1016-22. 2003
    ....
  14. ncbi request reprint Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Brain 126:1683-90. 2003
    ..These findings could be exploited to develop novel anti-inflammatory therapies in Human African trypanosomiasis by modulating the NK1 receptor as well as the parasite...
  15. ncbi request reprint The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis
    P G Kennedy
    Glasgow University Department of Neurology, Southern General Hospital, South Glasgow University Hospitals NHS Trust, Scotland, UK
    J Neuroimmunol 100:36-41. 1999
    ..Continued use of this mouse model should lead to further enhancement of our understanding of the pathogenesis of the PTRE and to improved drug regimes to prevent and/or treat it...
  16. pmc Varicella-zoster virus gene expression in latently infected and explanted human ganglia
    P G Kennedy
    Glasgow University Department of Neurology, Southern General Hospital, Glasgow, United Kingdom
    J Virol 74:11893-8. 2000
    ..Taken together, these data provide further support for the notion of significant and restricted viral gene expression in VZV latency...
  17. ncbi request reprint Varicella-Zoster virus gene expression in latently infected rat dorsal root ganglia
    P G Kennedy
    Glasgow University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, Scotland, United Kingdom
    Virology 289:218-23. 2001
    ....
  18. doi request reprint Varicella-zoster virus human ganglionic latency: a current summary
    Peter G E Kennedy
    Department of Neurology, Glasgow University, Southern General Hospital, Glasgow, Scotland, UK
    J Neurovirol 16:411-8. 2010
    ....
  19. ncbi request reprint Varicella-zoster virus latency in human ganglia
    Peter G E Kennedy
    Glasgow University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
    Rev Med Virol 12:327-34. 2002
    ..Whether gene expression at both the transcriptional and translational levels is more extensive than currently reported will require much more work and probably new molecular technology...
  20. doi request reprint Herpes simplex virus type 1 and Bell's palsy-a current assessment of the controversy
    Peter Ge Kennedy
    Department of Neurology, Division of Clinical Neurosciences, Faculty of Medicine, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
    J Neurovirol 16:1-5. 2010
    ....
  21. ncbi request reprint Key issues in varicella-zoster virus latency
    Peter G E Kennedy
    Department of Neurology, Glasgow University, and Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, United Kingdom
    J Neurovirol 8:80-4. 2002
    ..Advances in this difficult field may be expected to arise from both newly developed molecular technology and more refined animal models of VZV latency...
  22. doi request reprint Cytokines in central nervous system trypanosomiasis: cause, effect or both?
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Trans R Soc Trop Med Hyg 103:213-4. 2009
    ..Because of the practical difficulties of obtaining serial measurements in patients, it has proved difficult to assign either cause or effect properties to measured cytokines, but mechanistic animal modelling studies are proving helpful...
  23. doi request reprint The continuing problem of human African trypanosomiasis (sleeping sickness)
    Peter G E Kennedy
    Department of Neurology, Division of Clinical Neurosciences, Faculty of Medicine, University of Glasgow Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
    Ann Neurol 64:116-26. 2008
    ..There is a pressing need for an effective, safe oral drug for both stages of the disease, but this will require a significant increase in investment for new drug discovery from Western governments and the pharmaceutical industry...
  24. ncbi request reprint Transcriptomal analysis of varicella-zoster virus infection using long oligonucleotide-based microarrays
    Peter G E Kennedy
    Glasgow University Department of Neurology, Southern General Hospital, Institute of Neurological Sciences, Glasgow G51 4TF, UK
    J Gen Virol 86:2673-84. 2005
    ....
  25. pmc Diagnosis and treatment of viral encephalitis
    A Chaudhuri
    Department of Clinical Neurosciences, University of Glasgow, Glasgow, Scotland, UK
    Postgrad Med J 78:575-83. 2002
    ..Vaccination and vector control measures are useful preventive strategies in certain arboviral and zoonotic encephalitis. However, we need better antiviral therapy to meet the challenge of acute viral encephalitis more effectively...
  26. doi request reprint Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
    Peter Ge Kennedy
    Department of Neurology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Lancet Neurol 12:186-94. 2013
    ..Eflornithine combined with nifurtimox is the first-line treatment for late-stage T b gambiense. New drugs are in the pipeline for treatment of CNS human African trypanosomiasis, giving rise to cautious optimism...
  27. ncbi request reprint Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology
    Jeremy M Sternberg
    School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Neuroimmunol 167:81-9. 2005
    ....
  28. ncbi request reprint Sleeping sickness: new drugs from old? [corrected]
    Peter G E Kennedy
    Lancet 359:1695-6. 2002
  29. ncbi request reprint Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen
    Frank W Jennings
    Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Parasitol Int 51:381-8. 2002
    ..Thus, there is strong evidence that injected suramin and topical melarsoprol should be given almost simultaneously to achieve the most effective combination of the two drugs...
  30. ncbi request reprint Herpes simplex virus-1 and varicella-zoster virus latency in ganglia
    Bradley M Mitchell
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    J Neurovirol 9:194-204. 2003
    ..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
  31. pmc Varicella-zoster virus gene 66 transcription and translation in latently infected human Ganglia
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:6660-5. 2003
    ....
  32. ncbi request reprint Varicella-Zoster virus proteins encoded by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat model
    Esther Grinfeld
    Department of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
    Virology 323:85-90. 2004
    ..Transcripts for the late gene 40 were never detected. We conclude that VZV ORFs 14 and 67 are dispensable for the establishment of a latent infection in this model...
  33. pmc Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response
    Lorna MacLean
    School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, Scotland
    J Infect Dis 196:1620-8. 2007
    ..The identification of trypanosome isolates with differing disease progression phenotypes provides the first field-based genetic evidence for virulence variants in T. brucei rhodesiense...
  34. ncbi request reprint The neurotropic herpes viruses: herpes simplex and varicella-zoster
    Israel Steiner
    Neurological Sciences Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    Lancet Neurol 6:1015-28. 2007
    ..We review the biological, medical, and neurological aspects of acute, latent, and reactivated infections with the neurotropic herpes viruses...
  35. ncbi request reprint Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis
    Jean Rodgers
    Division of Infection and Immunity, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK
    Parasitol Int 56:321-4. 2007
    ..This lack of any additional or unexpected CNS toxicity in the mouse model of CNS HAT provides valuable safety data for the future possible use of this drug combination in patients with late-stage HAT...
  36. ncbi request reprint Translation of varicella-zoster virus genes during human ganglionic latency
    Esther Grinfeld
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Scotland, UK
    Virus Genes 29:317-9. 2004
    ..These proteins were detected mainly in the neuronal cytoplasm, are likely to be present in low abundance during VZV latency, and mirror the profile of VZV gene transcription...
  37. ncbi request reprint Varicella-Zoster virus gene expression at variable periods following death in a rat model of ganglionic infection
    Esther Grinfeld
    Division of Clinical Neurosciences, Institute of Neurological Sciences, University of Glasgow, Southern General Hospital, Glasgow, G51 4TF, Scotland, UK
    Virus Genes 35:29-32. 2007
    ....
  38. ncbi request reprint An attempt to investigate the presence of Epstein Barr virus in multiple sclerosis and normal control brain tissue
    Margaret L Opsahl
    University of Glasgow, Dept of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences Southern General Hospital, Glasgow G51 4TF Scotland, UK
    J Neurol 254:425-30. 2007
    ..Nevertheless, the limited data obtained did not provide any positive evidence of EBV involvement...
  39. ncbi request reprint The pattern of viral persistence in monkeys intra-tracheally infected with Simian varicella virus
    Esther Grinfeld
    Department of Neurology, Institute of Neurological Sciences, University of Glasgow, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Virus Genes 35:289-92. 2007
    ..There was no evidence for transcription of SVV ORFs 63 and 21 in the ganglia of the one IT infected and 2 naturally infected monkeys investigated using RNA ISH...
  40. ncbi request reprint Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter
    Margaret L Opsahl
    University of Glasgow Department of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Brain 128:516-27. 2005
    ..The frequent high level of HHV-6 infection in multiple sclerosis samples suggests a possible role in pathogenesis...