R N Kelsh

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. pmc The INT6 cancer gene and MEK signaling pathways converge during zebrafish development
    Michal Grzmil
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e959. 2007
  2. ncbi The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives
    R N Kelsh
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 127:515-25. 2000
  3. ncbi Sorting out Sox10 functions in neural crest development
    Robert N Kelsh
    Centre for Regenerative Medicine, University of Bath, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, UK
    Bioessays 28:788-98. 2006
  4. pmc Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis
    Carrie Anderson
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, UKBA2 7AY
    Mol Biosyst 3:51-9. 2007
  5. pmc Leukocyte tyrosine kinase functions in pigment cell development
    Susana S Lopes
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    PLoS Genet 4:e1000026. 2008
  6. pmc A systematic survey of expression and function of zebrafish frizzled genes
    Masataka Nikaido
    Department of Biology and Biochemistry, University of Bath, Claverton Down, United Kingdom
    PLoS ONE 8:e54833. 2013
  7. pmc An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development
    Emma R Greenhill
    Department of Biology and Biochemistry and Centre for Regenerative Medicine, University of Bath, Bath, United Kingdom
    PLoS Genet 7:e1002265. 2011
  8. pmc An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10
    James R Dutton
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    BMC Dev Biol 8:105. 2008
  9. ncbi Genetic analysis of melanophore development in zebrafish embryos
    R N Kelsh
    Max Planck Institute für Entwicklungsbiologie, Abteilung III, Spemannstrasse 35, Tubingen, D 72076, Germany
    Dev Biol 225:277-93. 2000
  10. pmc Stripes and belly-spots -- a review of pigment cell morphogenesis in vertebrates
    Robert N Kelsh
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Semin Cell Dev Biol 20:90-104. 2009

Collaborators

Detail Information

Publications51

  1. pmc The INT6 cancer gene and MEK signaling pathways converge during zebrafish development
    Michal Grzmil
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e959. 2007
    ..INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking...
  2. ncbi The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives
    R N Kelsh
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 127:515-25. 2000
    ..The combination of pigmentation and enteric nervous system defects makes colourless mutations a model for two human neurocristopathies, Waardenburg-Shah syndrome and Hirschsprung's disease...
  3. ncbi Sorting out Sox10 functions in neural crest development
    Robert N Kelsh
    Centre for Regenerative Medicine, University of Bath, Department of Biology and Biochemistry, Claverton Down, Bath BA2 7AY, UK
    Bioessays 28:788-98. 2006
    ..Here, I discuss this controversy and argue that these functions are, in part, molecularly interrelated...
  4. pmc Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis
    Carrie Anderson
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, UKBA2 7AY
    Mol Biosyst 3:51-9. 2007
    ....
  5. pmc Leukocyte tyrosine kinase functions in pigment cell development
    Susana S Lopes
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    PLoS Genet 4:e1000026. 2008
    ..In summary, we have discovered a novel signalling pathway in NCC development and demonstrate fate specification of iridophores as the first identified role for Ltk...
  6. pmc A systematic survey of expression and function of zebrafish frizzled genes
    Masataka Nikaido
    Department of Biology and Biochemistry, University of Bath, Claverton Down, United Kingdom
    PLoS ONE 8:e54833. 2013
    ..Furthermore, we show that the two fzd7 genes function together with fzd10 to regulate epiboly movements and mesoderm differentiation...
  7. pmc An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development
    Emma R Greenhill
    Department of Biology and Biochemistry and Centre for Regenerative Medicine, University of Bath, Bath, United Kingdom
    PLoS Genet 7:e1002265. 2011
    ..More generally, this novel approach to understanding melanocyte differentiation provides a basis for systematic modelling of differentiation in this and other cell-types...
  8. pmc An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10
    James R Dutton
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    BMC Dev Biol 8:105. 2008
    ..As expected, the SOX10 expression pattern is complex and highly dynamic, but little is known of the underlying mechanisms regulating its spatiotemporal pattern. SOX10 expression is highly conserved between all vertebrates characterised...
  9. ncbi Genetic analysis of melanophore development in zebrafish embryos
    R N Kelsh
    Max Planck Institute für Entwicklungsbiologie, Abteilung III, Spemannstrasse 35, Tubingen, D 72076, Germany
    Dev Biol 225:277-93. 2000
    ..Furthermore, their distribution indicates a defect in melanoblast dispersal. These observations permit us to refine our model of the genetic control of melanophore development in zebrafish embryos...
  10. pmc Stripes and belly-spots -- a review of pigment cell morphogenesis in vertebrates
    Robert N Kelsh
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Semin Cell Dev Biol 20:90-104. 2009
    ....
  11. ncbi Genetics and evolution of pigment patterns in fish
    Robert N Kelsh
    Centre for Regenerative Medicine, Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath, UK
    Pigment Cell Res 17:326-36. 2004
    ..Initial 'evo-devo' studies indicate how fish pigment patterns may evolve and will become more complete as the developmental genetics is integrated with theoretical modelling...
  12. ncbi The Tomita collection of medaka pigmentation mutants as a resource for understanding neural crest cell development
    Robert N Kelsh
    Developmental Biology Programme, Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Mech Dev 121:841-59. 2004
    ..These mutants will be a valuable resource for pigment cell and neural crest studies and will strongly complement the mutant collections in other vertebrates...
  13. pmc The origin and evolution of the neural crest
    Philip C J Donoghue
    Department of Earth Sciences, University of Bristol, UK
    Bioessays 30:530-41. 2008
    ..Finally, we provide a brief outline of how the evolutionary emergence of neural crest potentiality may have proceeded, and how it may be investigated...
  14. ncbi dino and mercedes, two genes regulating dorsal development in the zebrafish embryo
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:95-102. 1996
    ..Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo...
  15. ncbi Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
    M C Mullins
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:81-93. 1996
    ..This pathway provides ventral positional information, counteracting the dorsalizing instructions of the organizer, which is localized in the dorsal shield...
  16. ncbi Genes involved in forebrain development in the zebrafish, Danio rerio
    C P Heisenberg
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:191-203. 1996
    ..In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses...
  17. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  18. ncbi Mutations affecting the formation of the notochord in the zebrafish, Danio rerio
    J Odenthal
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:103-15. 1996
    ..In addition to the four mutants with defects in early notochord formation, we have isolated 84 mutants, defining at least 15 genes, with defects in later stages of notochord development. These are listed in an appendix to this study...
  19. ncbi Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva
    M Granato
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:399-413. 1996
    ..Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes...
  20. ncbi Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates
    K A Dutton
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Development 128:4113-25. 2001
    ..This suggests a novel mechanism for the aetiology of Waardenburg-Shah syndrome in which affected neural crest derivatives fail to be generated from the neural crest...
  21. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
    ..As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues...
  22. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
    ..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
  23. ncbi Mutations affecting the cardiovascular system and other internal organs in zebrafish
    J N Chen
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:293-302. 1996
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis...
  24. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
    ....
  25. ncbi Genetic analysis of fin formation in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:255-62. 1996
    ..Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported...
  26. ncbi The zebrafish early arrest mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:57-66. 1996
    ....
  27. ncbi Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:179-90. 1996
    ..Our results confirm and extend a previous report, and show that at least one member of this conserved signalling pathway is required for formation of the boundary between midbrain and hindbrain in the zebrafish...
  28. ncbi Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio
    J Odenthal
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:391-8. 1996
    ..These mutations may affect xanthophore pigment distribution within the cells or xanthophore cell shape. Mutations in seven genes affecting xanthophore pigmentation remain unclassified...
  29. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
    ..The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation...
  30. ncbi Neural degeneration mutants in the zebrafish, Danio rerio
    M Furutani-Seiki
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:229-39. 1996
    ..These results suggest that focal cell death may be a useful clue for the detection of early patterning defects of the vertebrate nervous system in regions devoid of visible landmarks...
  31. ncbi Characterization of zebrafish mutants with defects in embryonic hematopoiesis
    D G Ransom
    Max Planck Institut für Entwickslungbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:311-9. 1996
    ..The analysis of these mutants provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development...
  32. ncbi The zebrafish epiboly mutants
    D A Kane
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:47-55. 1996
    ..Furthermore, the dominant zygotic-maternal effect phenotypes illustrate the maternal and zygotic interplay of genes that orchestrate the early cell movements of the zebrafish...
  33. ncbi Expression of zebrafish fkd6 in neural crest-derived glia
    R N Kelsh
    Department of Biology and Biochemistry, University of Bath, UK
    Mech Dev 93:161-4. 2000
    ..Expression in colourless mutant embryos is consistent with these cells being satellite glia and Schwann cells...
  34. ncbi Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent
    Stone Elworthy
    Centre for Regenerative Medicine, Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Mech Dev 122:659-69. 2005
    ..However, in addition, we trace back the sox10 mutant ENS defect to an even earlier time point, finding that most neural crest cells fail to migrate ventrally to the gut primordium...
  35. ncbi A direct role for Sox10 in specification of neural crest-derived sensory neurons
    Thomas J Carney
    Centre for Regenerative Medicine, Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 133:4619-30. 2006
    ..In conjunction with previous findings, these data establish the generality of our model of Sox10 function in NC fate specification...
  36. ncbi Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development
    Stone Elworthy
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 130:2809-18. 2003
    ..We propose that the dominant melanophore phenotype in Waardenburg syndrome IV individuals with SOX10 mutations is likely to result from failure to activate MITF in the normal number of melanoblasts...
  37. ncbi The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
    P Haffter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:1-36. 1996
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish...
  38. ncbi Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants
    Valentina Svetic
    Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 134:1011-22. 2007
    ..We thus identify Sdf1 as a key molecule in pigment pattern formation, adding to the growing inventory of its roles in embryonic development...
  39. pmc A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle
    Kirsten Dutton
    Department of Biology and Biochemistry, Centre for Regenerative Medicine, Developmental Biology Programme, University of Bath, Bath, UK
    Dis Model Mech 2:68-83. 2009
    ..We discuss the implication that the deafness in WS4 patients with SOX10 mutations might reflect a haploinsufficiency for SOX10 in the otic epithelium, resulting in patterning and functional abnormalities in the inner ear...
  40. ncbi Specification of zebrafish neural crest
    Robert N Kelsh
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Results Probl Cell Differ 40:216-36. 2002
    ..There is still a wealth of zebrafish mutations whose molecular bases remain unknown, and it is likely that the revelation of the underlying genes will both broaden and alter our understanding of specification within the neural crest...
  41. ncbi The proliferating field of neural crest stem cells
    Mariana Delfino-Machin
    Centre for Regenerative Medicine and Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    Dev Dyn 236:3242-54. 2007
    ..Together, analysis of these issues will clarify this expanding, but still young, field and contribute to exploration of the important therapeutic potential of these cells...
  42. ncbi Roles for GFRalpha1 receptors in zebrafish enteric nervous system development
    Iain T Shepherd
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195, USA
    Development 131:241-9. 2004
    ..Phenotypes induced by injection of antisense morpholinos against both Gfra orthologs can be rescued by introduction of mRNA for gfra1a or for gfra2, suggesting that GFRalpha1 and GFRalpha2 are functionally equivalent...
  43. ncbi Pigment pattern formation in the medaka embryo
    M Lynn Lamoreux
    Comparative Medicine Program, Texas A and M University, College Station, TX, USA
    Pigment Cell Res 18:64-73. 2005
    ..These two models will, in combination, be a powerful system for studies of the embryogenesis and evolution of pigmentation...
  44. pmc The emergence of ectomesenchyme
    Aida Blentic
    MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    Dev Dyn 237:592-601. 2008
    ..However, our results further suggest that, although FGF signaling is required for the realization of the ectomesenchymal lineages, other cues from the pharyngeal epithelia are also likely to be involved...
  45. ncbi Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro
    Jorge P Pinto
    CCMAR, University of Algarve, Campus de Gambelas, Faro, Portugal
    J Bone Miner Res 20:1440-53. 2005
    ..The runx2b pebp2alphaA2 isoform induces osteocalcin gene expression by binding to a specific region of the promoter and seems to have been selectively conserved in the teleost lineage...
  46. ncbi In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development
    Brandon B Kirby
    Department of Biological Sciences, Vanderbilt University, 465 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Neurosci 9:1506-11. 2006
    ....
  47. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ....
  48. ncbi Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome
    Anthony Antonellis
    Geome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 15:259-71. 2006
    ..These studies will direct further analyses of Sox10 regulation and provide candidate sequences for mutation detection in WS4 patients lacking a SOX10-coding mutation...
  49. ncbi A golden clue to human skin colour variation
    Jeanette Müller
    Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Bath, UK
    Bioessays 28:578-82. 2006
    ..1 Strikingly this study identifies the human orthologue, SLC24A5, as likely to make a major contribution to the pale skin colouration of Western Europeans...
  50. ncbi Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood
    Paulo J Gavaia
    CCMAR, Universidade do Algarve, 8005 139 Faro, Portugal
    Gene Expr Patterns 6:637-52. 2006
    ..These results suggest different patterns of Mgp accumulation between fish and mammals...