M A Kelly

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Circadian gene variants and susceptibility to type 2 diabetes: a pilot study
    M Ann Kelly
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e32670. 2012
  2. pmc The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population
    Simon D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 10:83. 2009
  3. pmc Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population
    Simon D Rees
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 9:8. 2008
  4. pmc Molecular aspects of type 1 diabetes
    M A Kelly
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Mol Pathol 56:1-10. 2003
  5. ncbi request reprint Long-term expression of an HLA-DQ molecule in the EBV-transformed bare lymphocyte cell line, BLS-1, using a plasmid vector
    M A Kelly
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham, UK
    Scand J Immunol 55:599-605. 2002
  6. ncbi request reprint HLA typing and immunological characterization of young-onset diabetes mellitus in a Hong Kong Chinese population
    M A Kelly
    Department of Medicine, University of Birmingham, UK
    Diabet Med 18:22-8. 2001
  7. ncbi request reprint An investigation of HLA-encoded genetic susceptibility to multiple sclerosis in subjects of Asian Indian and Afro-Caribbean ethnic origin
    M A Kelly
    Department of Medicine, University of Birmingham, United Kingdom
    Tissue Antigens 45:197-202. 1995
  8. ncbi request reprint HLA-DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in Jamaica
    J M Heward
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Immunogenet 29:47-52. 2002
  9. doi request reprint Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes
    A C Britten
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Int J Immunogenet 36:47-57. 2009
  10. pmc An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference
    S D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Diabet Med 28:673-80. 2011

Collaborators

Detail Information

Publications23

  1. pmc Circadian gene variants and susceptibility to type 2 diabetes: a pilot study
    M Ann Kelly
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e32670. 2012
    ..The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants...
  2. pmc The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population
    Simon D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 10:83. 2009
    ..We therefore aimed to investigate the association between common variants of the PCK1 gene and T2D in a UK-resident South Asian population of Punjabi ancestry, originating predominantly from the Mirpur area of Azad Kashmir, Pakistan...
  3. pmc Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population
    Simon D Rees
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    BMC Med Genet 9:8. 2008
    ..The aim of this study was to determine whether variants of this gene are also risk factors for type 2 diabetes development in a UK-resident South Asian cohort of Punjabi ancestry...
  4. pmc Molecular aspects of type 1 diabetes
    M A Kelly
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
    Mol Pathol 56:1-10. 2003
    ..This review will focus on the mechanisms by which these genes might influence the risk of developing type 1 diabetes...
  5. ncbi request reprint Long-term expression of an HLA-DQ molecule in the EBV-transformed bare lymphocyte cell line, BLS-1, using a plasmid vector
    M A Kelly
    Department of Medicine, Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham, UK
    Scand J Immunol 55:599-605. 2002
    ..These clones will be used in functional studies to investigate the antigen binding and T-cell activation properties of the DQ6 molecule...
  6. ncbi request reprint HLA typing and immunological characterization of young-onset diabetes mellitus in a Hong Kong Chinese population
    M A Kelly
    Department of Medicine, University of Birmingham, UK
    Diabet Med 18:22-8. 2001
    ....
  7. ncbi request reprint An investigation of HLA-encoded genetic susceptibility to multiple sclerosis in subjects of Asian Indian and Afro-Caribbean ethnic origin
    M A Kelly
    Department of Medicine, University of Birmingham, United Kingdom
    Tissue Antigens 45:197-202. 1995
    ..Our study also raises the possibility that genetically distinct forms of the disease may be expressed in white Caucasian and non-Caucasian populations...
  8. ncbi request reprint HLA-DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in Jamaica
    J M Heward
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Eur J Immunogenet 29:47-52. 2002
    ..Further support is provided for roles of the DQ genes and the DRB1 gene (or a gene in linkage disequilibrium with it) in determining susceptibility to type 1 diabetes...
  9. doi request reprint Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes
    A C Britten
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Int J Immunogenet 36:47-57. 2009
    ..The functional relevance of our findings and their implications for the pathogenesis of autoimmunity remain to be determined...
  10. pmc An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference
    S D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Diabet Med 28:673-80. 2011
    ....
  11. ncbi request reprint Genetics of type 1 diabetes
    M A Kelly
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, Edgbaston, B15 2TH, UK
    Best Pract Res Clin Endocrinol Metab 15:279-91. 2001
    ..The IDDM2 locus maps to a variable number of tandem repeats in the insulin gene region on chromosome 11. Further research is necessary to determine the precise location and identity of other diabetes susceptibility genes...
  12. ncbi request reprint Sequencing of the second exon of the MHC class II DQ6 alleles in patients with type 1 diabetes
    M L Rayner
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Autoimmunity 35:155-7. 2002
    ..No mutations were found. This suggests that all the subjects possessed the "wild-type" second exons of the DQ6 alleles and, hence, that the protective effect associated with the antigen-binding domain of DQ6 is not absolute...
  13. doi request reprint Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations
    S D Rees
    Diabetes Research Laboratory, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    Diabetologia 54:1368-74. 2011
    ....
  14. ncbi request reprint A missense mutation in the OCTN2 gene associated with residual carnitine transport activity
    Y Wang
    Division of Medical Genetics, Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    Hum Mutat 15:238-45. 2000
    ..These results indicate that primary carnitine deficiency can be caused by mutations encoding for carnitine transporters with residual activity, and that the E452K affects a domain not involved in carnitine recognition...
  15. ncbi request reprint Genetic susceptibility to multiple sclerosis: detection of polymorphic nucleotides and an intron in the 3' untranslated region of the major histocompatibility complex class II transactivator gene
    H B Rasmussen
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Hum Immunol 62:371-7. 2001
    ..So far, the function and significance of the intron in the human and mouse CIITA genes are unknown...
  16. ncbi request reprint CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese
    H B Rasmussen
    Department of Life Sciences, Roskilde University, PO Box 260, DK 4000 Roskilde, Denmark
    J Neurol Sci 184:143-7. 2001
    ..On the other hand, they raise the possibility that the development of MS in other ethnic groups involves interaction between CTLA4 and DR2...
  17. ncbi request reprint Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis
    H B Rasmussen
    Department of Life Sciences and Chemistry, Roskilde University, 1 Universitetsvej, DK 4000 Roskilde, Denmark
    Mult Scler 7:91-3. 2001
    ..Possible implications of our finding to future studies of the genetic background of MS is discussed...
  18. ncbi request reprint HLA alleles and IDDM in children in Hungary: a comparison with Finland
    R Hermann
    Department of Paediatrics, , Hungary
    Hum Immunol 62:391-8. 2001
    ..Other genetic and/or environmental influences must be involved...
  19. ncbi request reprint The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice
    M G Murer
    INSERM U289, Hopital de la Salpetriere, Paris, France
    Neuroscience 99:643-50. 2000
    ....
  20. ncbi request reprint Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice
    G Diaz-Torga
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Endocrinology 143:1270-9. 2002
    ..In accordance, the D2R antagonist sulpiride lowered GH levels in 1-month-old wild-type mice. Our results indicate that lack of D2R alters the GHRH-GH-IGF-I axis, and impairs body growth and the somatotrope population...
  21. ncbi request reprint Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
    M A Whitney
    Department of Molecular and Medical Genetics, Vollum Institute, Oregon Regional Primate Center, Portland, USA
    Blood 88:49-58. 1996
    ..Progenitor cells from fac knock-out mice were hypersensitive to interferon gamma. This previously unrecognized phenotype may form the basis for BM failure in human FA...
  22. ncbi request reprint Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
    L S Robbins
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Cell 72:827-34. 1993
    ..The Eso-3J receptor is constitutively activated, while the Etob receptor remains hormone responsive and produces a greater activation of its effector, adenylyl cyclase, than does the wild-type allele...
  23. ncbi request reprint Host-guest study of left-handed polyproline II helix formation
    M A Kelly
    Department of Molecular and Cellular Biochemistry, University of Kentucky, 800 Rose Street, Lexington, Kentucky 40536, USA
    Biochemistry 40:14376-83. 2001
    ..These data are the first step toward a molecular understanding of the formation of this important, and yet little studied, secondary structure...