Dominic F Kelly

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Anti-polyribosylribitol phosphate antibody concentrations and avidities in children since the start of Haemophilus influenzae type b immunization of infants in the United Kingdom
    Dominic F Kelly
    Oxford Vaccine Group, Oxford University Department of Paediatrics, Oxford, United Kingdom
    Clin Vaccine Immunol 16:246-52. 2009
  2. ncbi request reprint An encephalitis primer
    Dominic Kelly
    Children s Hospital, Oxford, UK
    Adv Exp Med Biol 764:133-40. 2013
  3. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
  4. doi request reprint The burden of vaccine-preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban Nepal
    Dominic F Kelly
    Department of Paediatrics, University of Oxford, Level 2, Room 02 46 03, Children s Hospital, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Int J Infect Dis 15:e17-23. 2011
  5. ncbi request reprint Immunological memory: the role of B cells in long-term protection against invasive bacterial pathogens
    Dominic F Kelly
    University of Oxford Department of Paediatrics, Oxford, England
    JAMA 294:3019-23. 2005
  6. ncbi request reprint CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells
    Dominic F Kelly
    Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Blood 108:2642-7. 2006
  7. ncbi request reprint The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response
    Geraldine Blanchard Rohner
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    J Immunol 180:2165-73. 2008
  8. ncbi request reprint Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization
    Matthew D Snape
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX3 7LJ, United Kingdom
    Clin Infect Dis 43:1387-94. 2006
  9. doi request reprint Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibody
    Yeh Chen Lee
    University Department of Paediatrics, University of Oxford, Oxford, UK
    Clin Infect Dis 46:186-92. 2008
  10. doi request reprint Persistence of serum bactericidal antibody one year after a booster dose of either a glycoconjugate or a plain polysaccharide vaccine against serogroup C Neisseria meningitidis given to adolescents previously immunized with a glycoconjugate vaccine
    Philip C S de Whalley
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    Pediatr Infect Dis J 30:e203-8. 2011

Collaborators

Detail Information

Publications21

  1. pmc Anti-polyribosylribitol phosphate antibody concentrations and avidities in children since the start of Haemophilus influenzae type b immunization of infants in the United Kingdom
    Dominic F Kelly
    Oxford Vaccine Group, Oxford University Department of Paediatrics, Oxford, United Kingdom
    Clin Vaccine Immunol 16:246-52. 2009
    ..This study emphasizes the factors affecting anti-PRP antibody concentration following immunization with conjugate vaccines and the importance of these in long-term protection from invasive disease...
  2. ncbi request reprint An encephalitis primer
    Dominic Kelly
    Children s Hospital, Oxford, UK
    Adv Exp Med Biol 764:133-40. 2013
    ..This review focuses on encephalitis aetiology and investigation; HSV encephalitis; mycoplasma encephalitis; and flavivirus encephalitis as a globally important cause of disease...
  3. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
    ..Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection...
  4. doi request reprint The burden of vaccine-preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban Nepal
    Dominic F Kelly
    Department of Paediatrics, University of Oxford, Level 2, Room 02 46 03, Children s Hospital, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Int J Infect Dis 15:e17-23. 2011
    ..Nepal is one of many resource-poor nations with limited information on the epidemiology of childhood infections caused by these pathogens...
  5. ncbi request reprint Immunological memory: the role of B cells in long-term protection against invasive bacterial pathogens
    Dominic F Kelly
    University of Oxford Department of Paediatrics, Oxford, England
    JAMA 294:3019-23. 2005
    ..An improved understanding of the immunobiology of the B-cell response to these vaccines may direct development of immunization strategies that provide sustained protection...
  6. ncbi request reprint CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells
    Dominic F Kelly
    Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Blood 108:2642-7. 2006
    ..Detection of peripheral blood memory B-cell responses after vaccination may be a useful signature of successful induction of immunologic memory during novel vaccine evaluation...
  7. ncbi request reprint The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response
    Geraldine Blanchard Rohner
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    J Immunol 180:2165-73. 2008
    ..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
  8. ncbi request reprint Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization
    Matthew D Snape
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX3 7LJ, United Kingdom
    Clin Infect Dis 43:1387-94. 2006
    ....
  9. doi request reprint Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibody
    Yeh Chen Lee
    University Department of Paediatrics, University of Oxford, Oxford, UK
    Clin Infect Dis 46:186-92. 2008
    ....
  10. doi request reprint Persistence of serum bactericidal antibody one year after a booster dose of either a glycoconjugate or a plain polysaccharide vaccine against serogroup C Neisseria meningitidis given to adolescents previously immunized with a glycoconjugate vaccine
    Philip C S de Whalley
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    Pediatr Infect Dis J 30:e203-8. 2011
    ..Adolescents are at particular risk from meningococcal disease, therefore they might benefit from a booster dose of vaccine. The duration of serologic response to such a booster in adolescents is unknown...
  11. pmc Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine
    Dominic F Kelly
    Oxford Vaccine Group, Department of Paediatrics, Oxford University, Oxford, UK
    Immunology 127:134-43. 2009
    ..This study provides data on B-cell kinetics following a primary schedule of immunization in young infants upon which to base further studies of the underlying cellular mechanism of humoral immunity...
  12. doi request reprint Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom
    Geraldine Blanchard-Rohner
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    Pediatr Infect Dis J 32:768-76. 2013
    ..We also assessed the impact of maternal antibody present at 2 months of age on the immune response to a primary course of quadrivalent meningococcal conjugate vaccine (MenACWY-CRM197) given at 2 and 4 months of age...
  13. doi request reprint The B-cell response to a primary and booster course of MenACWY-CRM₁₉₇ vaccine administered at 2, 4 and 12 months of age
    Geraldine Blanchard-Rohner
    Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
    Vaccine 31:2441-8. 2013
    ....
  14. doi request reprint Hospital-based surveillance of invasive pneumococcal disease among young children in urban Nepal
    Eleri J Williams
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 48:S114-22. 2009
    ..The aims of this study were to determine the prevalence and serotype distribution of invasive pneumococcal disease among young children hospitalized in urban Nepal...
  15. pmc Haemophilus influenzae type b conjugate vaccines
    Dominic F Kelly
    Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    Immunology 113:163-74. 2004
    ..However, the burden of disease remains highest in resource-poor countries and urgent efforts are needed to provide the benefits of this vaccine for children living in regions where it cannot be used for economic and logistical reasons...
  16. doi request reprint Prevalence and genetic analysis of phenotypically Vi- negative Salmonella typhi isolates in children from Kathmandu, Nepal
    Anoop S Pulickal
    Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, Oxfordshire, OX3 7LE, UK
    J Trop Pediatr 59:317-20. 2013
    ..These data suggest that phenotypically acapsulate S.Typhi may not have a genetic basis for the same. ..
  17. ncbi request reprint Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccine
    Matthew D Snape
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
    Pediatr Infect Dis J 24:128-31. 2005
    ..A serum bactericidal titer of <1/8 correlates with susceptibility to invasive meningococcal disease. We assessed this correlate of protection in a cohort of children approximately 2 years after a single dose of vaccine...
  18. doi request reprint Baseline polysaccharide-specific antibodies may not consistently inhibit booster antibody responses in infants to a serogroup C meningococcal protein-polysaccharide conjugate vaccine
    Geraldine Blanchard-Rohner
    Oxford Vaccine Group and the NIHR Oxford Biomedical Research Centre, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, UK
    Vaccine 30:4153-9. 2012
    ..That an inhibitory effect of baseline antibody cannot be assumed a priori is supported by observations in animal models, which show that baseline antibody can both suppress or enhance the antibody response to a specific antigen...
  19. doi request reprint The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal
    Andrew S J Marshall
    Oxford Vaccine Group, Oxford University, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
    PLoS ONE 9:e85055. 2014
    ..Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease. ..
  20. doi request reprint Evaluation of haemophilus influenzae type b vaccine for routine immunization in Nepali infants
    Jane Astrid Metz
    Department of Pediatrics, Oxford Vaccine Group, University of Oxford, UK
    Pediatr Infect Dis J 31:e66-72. 2012
    ..Hib conjugate vaccines (HibCV) do not have uniform immunogenicity between populations. We determined the immunogenicity of HibCV in Nepali infants, before its introduction into the routine immunization schedule...
  21. ncbi request reprint Reverse vaccinology and vaccines for serogroup B Neisseria meningitidis
    Dominic F Kelly
    Department of Paediatrics, University of Oxford, John Radcliffe Hospital, United Kingdom
    Adv Exp Med Biol 568:217-23. 2005
    ..Despite the advantages of the approach, development in conventional areas of vaccinology remains important to support the process of producing vaccines from genome-derived antigens...