N H Keep

Summary

Affiliation: University of London
Country: UK

Publications

  1. pmc Crystal structures of the human Dysferlin inner DysF domain
    Altin Sula
    Crystallography, Biological Sciences, Institute for Structural and Molecular Biology, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
    BMC Struct Biol 14:3. 2014
  2. ncbi request reprint The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin
    N H Keep
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 285:1257-64. 1999
  3. ncbi request reprint Bacterial resuscitation factors: revival of viable but non-culturable bacteria
    N H Keep
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom
    Cell Mol Life Sci 63:2555-9. 2006
  4. ncbi request reprint Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer
    N H Keep
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Structure 7:1539-46. 1999
  5. ncbi request reprint The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy
    F L Norwood
    Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
    Structure 8:481-91. 2000
  6. ncbi request reprint The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation
    S D Edwards
    BBSRC Bloomsbury Centre for Structural Biology and School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biochemistry 40:7061-8. 2001
  7. doi request reprint Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20
    C Bagneris
    Department of Crystallography, Birkbeck College, Institute of Structural and Molecular Biology, Malet Street, London WC1E 7HX, UK
    J Mol Biol 392:1242-52. 2009
  8. pmc Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove
    A R Clark
    Department of Biological Sciences, Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
    J Mol Biol 408:118-34. 2011
  9. ncbi request reprint A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
    N H Keep
    Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Structure 5:623-33. 1997
  10. ncbi request reprint Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1
    L Y Lian
    Department of Biochemistry and Biological NMR Centre, University of Leicester, Leicester, LE1 7RH, UK
    Structure 8:47-55. 2000

Collaborators

Detail Information

Publications11

  1. pmc Crystal structures of the human Dysferlin inner DysF domain
    Altin Sula
    Crystallography, Biological Sciences, Institute for Structural and Molecular Biology, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
    BMC Struct Biol 14:3. 2014
    ..Dysferlin contains several C2 domains and two DysF domains which are nested one inside the other. Many pathogenic point mutations fall in the DysF domain region...
  2. ncbi request reprint The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin
    N H Keep
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 285:1257-64. 1999
    ..Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin...
  3. ncbi request reprint Bacterial resuscitation factors: revival of viable but non-culturable bacteria
    N H Keep
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom
    Cell Mol Life Sci 63:2555-9. 2006
  4. ncbi request reprint Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer
    N H Keep
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Structure 7:1539-46. 1999
    ..Utrophin is the autosomal homologue of dystrophin, the protein defective in the X-linked Duchenne and Becker muscular dystrophies, and upregulation of utrophin has been suggested as a potential therapy for muscular dystrophy patients...
  5. ncbi request reprint The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy
    F L Norwood
    Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
    Structure 8:481-91. 2000
    ..Pathogenic mutations in dystrophin result in Duchenne or Becker muscular dystrophy...
  6. ncbi request reprint The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation
    S D Edwards
    BBSRC Bloomsbury Centre for Structural Biology and School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biochemistry 40:7061-8. 2001
    ..More interestingly, a negatively charged peptide binds to the inositol site in a crystal contact and causes a greater conformational change in the structure than inositol...
  7. doi request reprint Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20
    C Bagneris
    Department of Crystallography, Birkbeck College, Institute of Structural and Molecular Biology, Malet Street, London WC1E 7HX, UK
    J Mol Biol 392:1242-52. 2009
    ..The empty pockets and groove provide a starting model for designing drugs to inhibit those sHsps that have a negative effect on cancer treatment...
  8. pmc Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove
    A R Clark
    Department of Biological Sciences, Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
    J Mol Biol 408:118-34. 2011
    ..We speculate that the αB R120G mutation disturbs oligomer dynamics, causing the growth of large soluble oligomers that are toxic to cells by blocking essential processes...
  9. ncbi request reprint A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
    N H Keep
    Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Structure 5:623-33. 1997
    ..Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes...
  10. ncbi request reprint Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1
    L Y Lian
    Department of Biochemistry and Biological NMR Centre, University of Leicester, Leicester, LE1 7RH, UK
    Structure 8:47-55. 2000
    ..The cytosolic guanine nucleotide dissociation inhibitors, RhoGDIs, regulate both the GDP/GTP exchange cycle and the membrane association/dissociation cycle...
  11. ncbi request reprint Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP)
    R Harris
    J Biomol NMR 21:185-6. 2001