Genomes and Genes
N H Keep
Affiliation: University of London
- Crystal structures of the human Dysferlin inner DysF domainAltin Sula
Crystallography, Biological Sciences, Institute for Structural and Molecular Biology, Birkbeck University of London, Malet Street, London WC1E 7HX, UK
BMC Struct Biol 14:3. 2014..Dysferlin contains several C2 domains and two DysF domains which are nested one inside the other. Many pathogenic point mutations fall in the DysF domain region...
- The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophinN H Keep
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
J Mol Biol 285:1257-64. 1999..Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin...
- Bacterial resuscitation factors: revival of viable but non-culturable bacteriaN H Keep
School of Crystallography and Institute of Structural Molecular Biology, Birkbeck, University of London, Malet Street, London, WC1E 7HX, United Kingdom
Cell Mol Life Sci 63:2555-9. 2006
- Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimerN H Keep
MRC Laboratory of Molecular Biology, Cambridge, UK
Structure 7:1539-46. 1999..Utrophin is the autosomal homologue of dystrophin, the protein defective in the X-linked Duchenne and Becker muscular dystrophies, and upregulation of utrophin has been suggested as a potential therapy for muscular dystrophy patients...
- The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophyF L Norwood
Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK
Structure 8:481-91. 2000..Pathogenic mutations in dystrophin result in Duchenne or Becker muscular dystrophy...
- The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activationS D Edwards
BBSRC Bloomsbury Centre for Structural Biology and School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
Biochemistry 40:7061-8. 2001..More interestingly, a negatively charged peptide binds to the inositol site in a crystal contact and causes a greater conformational change in the structure than inositol...
- Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20C Bagneris
Department of Crystallography, Birkbeck College, Institute of Structural and Molecular Biology, Malet Street, London WC1E 7HX, UK
J Mol Biol 392:1242-52. 2009..The empty pockets and groove provide a starting model for designing drugs to inhibit those sHsps that have a negative effect on cancer treatment...
- Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a grooveA R Clark
Department of Biological Sciences, Crystallography, Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
J Mol Biol 408:118-34. 2011..We speculate that the αB R120G mutation disturbs oligomer dynamics, causing the growth of large soluble oligomers that are toxic to cells by blocking essential processes...
- A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal armN H Keep
Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
Structure 5:623-33. 1997..Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes...
- Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1L Y Lian
Department of Biochemistry and Biological NMR Centre, University of Leicester, Leicester, LE1 7RH, UK
Structure 8:47-55. 2000..The cytosolic guanine nucleotide dissociation inhibitors, RhoGDIs, regulate both the GDP/GTP exchange cycle and the membrane association/dissociation cycle...
- Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP)R Harris
J Biomol NMR 21:185-6. 2001