Fredrik Karpe

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK
    Diabetes 59:2465-73. 2010
  2. ncbi request reprint Adipose tissue function in the insulin-resistance syndrome
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Biochem Soc Trans 33:1045-8. 2005
  3. doi request reprint Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men
    Kyriakoula Marinou
    Corresponding author Fredrik Karpe
    Diabetes Care 37:821-9. 2014
  4. ncbi request reprint Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
  5. ncbi request reprint The nicotinic acid receptor--a new mechanism for an old drug
    Fredrik Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Lancet 363:1892-4. 2004
  6. doi request reprint PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function
    Fredrik Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Curr Opin Lipidol 20:333-6. 2009
  7. ncbi request reprint Reduced oxidation of dietary fat after a short term high-carbohydrate diet
    Rachel Roberts
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:824-31. 2008
  8. doi request reprint Fatty acid metabolism in patients with PPARgamma mutations
    Garry D Tan
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 93:4462-70. 2008
  9. doi request reprint Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    Toralph Ruge
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:1781-8. 2009
  10. pmc Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Diabetes 60:47-55. 2011

Detail Information

Publications68

  1. pmc Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK
    Diabetes 59:2465-73. 2010
    ..Our objective was to test the hypothesis that this reflects differences in the ability of the two depots to sequester fatty acids, with gluteo-femoral fat acting as a longer-term "sink."..
  2. ncbi request reprint Adipose tissue function in the insulin-resistance syndrome
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Biochem Soc Trans 33:1045-8. 2005
    ..In healthy people adipose tissue blood flow is much enhanced by food intake, whereas in insulin-resistant subjects this response is blunted. This is another facet of unresponsiveness of adipose tissue in the insulin-resistance syndrome...
  3. doi request reprint Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men
    Kyriakoula Marinou
    Corresponding author Fredrik Karpe
    Diabetes Care 37:821-9. 2014
    ..Its expansion is related to increased CVR independent of other adiposity measures, and it has biological properties suggestive of higher metabolic activity contributing to global IR. ..
  4. ncbi request reprint Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
    ..Under circumstances of reduced efficiency in the removal of triacylglycerols from lipoproteins, there is accumulation of remnant lipoproteins, which are potentially atherogenic...
  5. ncbi request reprint The nicotinic acid receptor--a new mechanism for an old drug
    Fredrik Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Lancet 363:1892-4. 2004
    ..Suppression of lipolysis by nicotinic acid gives rise to a prominent rebound and the degree to which this occurs might explain this paradox...
  6. doi request reprint PPARdelta in humans: genetic and pharmacological evidence for a significant metabolic function
    Fredrik Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Curr Opin Lipidol 20:333-6. 2009
    ..Considerably less is known in humans and this review will focus on evidence derived from studies of the PPARD gene and pharmacological use of specific PPARdelta agonists...
  7. ncbi request reprint Reduced oxidation of dietary fat after a short term high-carbohydrate diet
    Rachel Roberts
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:824-31. 2008
    ..The underlying tissue-specific alterations in fatty acid metabolism are not well understood...
  8. doi request reprint Fatty acid metabolism in patients with PPARgamma mutations
    Garry D Tan
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 93:4462-70. 2008
    ..PPARG mutations may cause insulin resistance and dyslipidemia, but little is known about the mechanisms of the abnormalities of lipid metabolism...
  9. doi request reprint Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage
    Toralph Ruge
    Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:1781-8. 2009
    ..Adipose tissue sequesters dietary fat and thus protects other tissues from excess fat exposure, especially after meals...
  10. pmc Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Diabetes 60:47-55. 2011
    ..It is not clear whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery from adipose tissue or from impaired adipose tissue storage of ingested fat...
  11. ncbi request reprint Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period
    Alex S T Bickerton
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Diabetes 56:168-76. 2007
    ..With this integrative physiological approach, we have revealed hidden complexities in pathways of fatty acid uptake in adipose tissue and skeletal muscle...
  12. ncbi request reprint The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetes 56:2433-41. 2007
    ..We aimed to determine differences in the postprandial contributions of different fatty acid sources to VLDL triglycerides (TGs) in healthy men and women with varying degrees of insulin resistance...
  13. ncbi request reprint Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity
    Fredrik Karpe
    Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Diabetes 51:2467-73. 2002
    ..There is a close relationship between insulin sensitivity and the regulation of postprandial ATBF, independent of adiposity. Impaired regulation of ATBF seems to be another facet of the insulin resistance syndrome...
  14. pmc Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Am J Physiol Endocrinol Metab 299:E584-92. 2010
    ..These alterations may represent further pathways for redirection of fatty acids into export from the liver or oxidation to prevent liver fat accumulation...
  15. doi request reprint Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men
    Kyriakoula Marinou
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Br J Nutr 105:857-65. 2011
    ..The ability of young women to partition fatty acids towards ketone body production rather than VLDL-TAG may contribute to their more advantageous metabolic profile compared with young men...
  16. ncbi request reprint Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state
    Richard B Heath
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Am J Physiol Endocrinol Metab 292:E732-9. 2007
    ..We conclude that there is rapid flux of fatty acids from the diet into endogenous pools. Further study of these processes may open up new targets for intervention to reduce VLDL-TG concentrations and postprandial lipemia...
  17. doi request reprint Regulation of subcutaneous adipose tissue blood flow is related to measures of vascular and autonomic function
    Jun ichi Funada
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, UK
    Clin Sci (Lond) 119:313-22. 2010
    ..In conclusion, our results show that the regulation of ATBF has features in common with endothelial function, but also relationships with autonomic cardiovascular control as reflected in HRV...
  18. doi request reprint Ghrelin levels are suppressed and show a blunted response to oral glucose in women with polycystic ovary syndrome
    Thomas M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
    Eur J Endocrinol 158:511-6. 2008
    ..Abnormal ghrelin regulation may influence the development of obesity-associated conditions including polycystic ovary syndrome (PCOS). Our aim was to compare ghrelin regulation between PCOS cases and controls...
  19. ncbi request reprint Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo
    Fredrik Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Diabetes 54:1297-303. 2005
    ..Insulin concentrations were pulsatile with a typical period of 12 min, but this was not significantly cross-correlated with lipolysis. We conclude that release from adipose tissue of the products of lipolysis is pulsatile in humans...
  20. ncbi request reprint Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding
    Mary F F Chong
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:817-23. 2008
    ..High-carbohydrate (HC) diets increase de novo lipogenesis (DNL), but effects on stearoyl-CoA desaturase (SCD) are not so well studied...
  21. pmc Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Am J Physiol Endocrinol Metab 296:E64-71. 2009
    ..The marked rapid incorporation of linoleate from a single meal into blood PL fractions may have functional consequences such as maintenance of membrane fluidity and may explain why linoleate is a useful biomarker of dietary intake...
  22. pmc Metabolic signatures of human adipose tissue hypoxia in obesity
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Diabetes 62:1417-25. 2013
    ..Although delivery of O₂ to the obese AT is reduced, O₂ consumption is low, and metabolic signatures of human AT do not support the notion of a hypoxic state in obesity...
  23. ncbi request reprint Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period
    Richard B Heath
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, United Kingdom
    J Lipid Res 44:2065-72. 2003
    ..In summary, the contribution of dietary fatty acids to early postprandial VLDL TG is substantial. The role of DHA in VLDL TG production will require further investigation...
  24. pmc Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans
    Katherine E Pinnick
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Diabetes 61:1399-403. 2012
    ..Moreover, this appears to be an inherent feature of gluteofemoral AT. We propose that the beneficial metabolic properties of lower-body AT may be partly explained by the intrinsically greater production and release of palmitoleate...
  25. ncbi request reprint Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma
    Ulf Riserus
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetes 54:1379-84. 2005
    ..The restored SCD activity index after rosiglitazone in PPARgamma mutation supports a pivotal role of PPARgamma function in SCD regulation...
  26. doi request reprint Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake
    Meftun Ahmed
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 18:27-34. 2010
    ..Such orchestrated changes in expression of multiple proteins provide insights into the mechanism underlying the increased efficiency in glucose uptake and improvement of insulin sensitivity in response to rosiglitazone treatment...
  27. doi request reprint Transcriptional control of human adipose tissue blood flow
    Patricia Pérez-Matute
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 17:681-8. 2009
    ..Interestingly, these associations were not secondary to changes in BMI. We also found that certain genes involved in the regulation of ATBF are subject to coordinate regulation of expression suggesting physiological autoregulation...
  28. doi request reprint Development of an arterio-venous difference method to study the metabolic physiology of the femoral adipose tissue depot
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 18:1055-8. 2010
    ..These findings suggest that blood so obtained is representative of AT drainage with little apparent contribution of skeletal muscle. We believe this technique will facilitate physiological studies of a lower-body fat depot in humans...
  29. ncbi request reprint Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans
    Garry D Tan
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom
    Obes Res 12:114-8. 2004
    ....
  30. ncbi request reprint Adipose tissue fatty acid metabolism and cardiovascular disease
    Keith N Frayn
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Curr Opin Lipidol 16:409-15. 2005
    ..We review new developments in adipose tissue fatty acid metabolism and how that might relate to cardiovascular disease...
  31. ncbi request reprint Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans
    Jean Luc Ardilouze
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Circulation 109:47-52. 2004
    ..We hypothesized that insulin may act indirectly via sympathetic activation, mainly in the postprandial period, and that nitric oxide may be an overall major regulator of subcutaneous ATBF...
  32. ncbi request reprint Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans
    Carine Beysen
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, United Kingdom
    Am J Physiol Endocrinol Metab 284:E18-24. 2003
    ..01). The method described here successfully increases several types of plasma NEFA concentrations and could be used to investigate differential effects of elevated individual NEFAs on metabolic processes...
  33. pmc Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling
    Junichi Funada
    The Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 4:e7533. 2009
    ..Using direct measurements of metabolic substrate uptake by arterio-venous difference technique, the compensated human failing heart does not appear to have reduced myocardial fatty acid uptake...
  34. ncbi request reprint Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    Ulf Riserus
    Churchill Hospital, Oxford OX3 7LJ, UK
    Diabetes 57:332-9. 2008
    ..We hypothesize a similar mechanism operates in humans...
  35. pmc Effects of insulin on adipose tissue blood flow in man
    Fredrik Karpe
    Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Physiol 540:1087-93. 2002
    ..In the postprandial state, other candidate peptides and hormones are also likely to play important roles...
  36. pmc Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations
    Katharine R Owen
    Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, U K
    Diabetes Care 33:1919-24. 2010
    ..We hypothesized that serum levels of high-sensitivity C-reactive protein (hs-CRP) could represent a clinically useful biomarker for the identification of HNF1A mutations causing maturity-onset diabetes of the young (MODY)...
  37. doi request reprint Is there something special about palmitoleate?
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
    Curr Opin Clin Nutr Metab Care 16:225-31. 2013
    ..The fatty acid, palmitoleate (16:1 n - 7), has received a lot of attention in recent years for being 'lipokine' and for the first time, we review the evidence to determine if there is something special about palmitoleate in humans...
  38. doi request reprint Comprehensive human adipose tissue mRNA and microRNA endogenous control selection for quantitative real-time-PCR normalization
    Matt J Neville
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
    Obesity (Silver Spring) 19:888-92. 2011
    ..This test clearly indicated that spurious results could arise from using less stable control transcripts for mRNA and microRNA qRT-PCR...
  39. ncbi request reprint Absence of relationship between MTTP haplotypes and longevity
    Matt J Neville
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    J Gerontol A Biol Sci Med Sci 62:202-5. 2007
    ..However, the association of MTTP with longevity has been contested in a large German collection of nonagenarians and centenarians...
  40. pmc Assessing association between protein truncating variants and quantitative traits
    Manuel A Rivas
    Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki 00290, Finland, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Oxford OX3 7LJ, UK, NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK and Department of Statistics, University of Oxford, Oxford OX1 3TG, UK
    Bioinformatics 29:2419-26. 2013
    ..We propose a Bayesian modelling framework for the analysis of protein truncating variants and quantitative traits...
  41. doi request reprint The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease
    Aaron J Trachtenberg
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, University of Oxford, Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Neurobiol Aging 33:618.e1-618.e13. 2012
    ..These results question the often assumed link between APOE, the blood oxygenation level dependent (BOLD) response, and AD risk...
  42. ncbi request reprint Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome
    Thomas M Barber
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 93:999-1004. 2008
    ..Obesity-related predisposition to polycystic ovary syndrome (PCOS) could reflect overall adiposity and/or regional accumulation of abdominal visceral fat...
  43. doi request reprint Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man
    Constantinos Christodoulides
    Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 94:3594-601. 2009
    ..FGF21 is also a PPAR gamma target gene in mouse adipose tissue. Little information is available on FGF21 functions in humans...
  44. doi request reprint DNA methylation of genes in adipose tissue
    Katherine E Pinnick
    Oxford Centre for Diabetes, Endocrinology, University of Oxford, Churchill Hospital, Oxford, UK
    Proc Nutr Soc 70:57-63. 2011
    ..In this review, we will discuss the contribution of DNA methylation to the determination of cells of adipogenic fate as well as the role DNA methylation may play during adipocyte terminal differentiation...
  45. doi request reprint Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Hedley Way, OX3 9DU, Oxford, UK
    Circulation 124:1860-70. 2011
    ..We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states...
  46. ncbi request reprint Postprandial lipemia--effect of lipid-lowering drugs
    Fredrik Karpe
    Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Metabolism and Endocrinology, Radcliffe Infirmary, UK
    Atheroscler Suppl 3:41-6. 2002
    ....
  47. ncbi request reprint Effects of atorvastatin on postprandial plasma lipoproteins in postinfarction patients with combined hyperlipidaemia
    Susanna Boquist
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 162:163-70. 2002
    ..In conclusion, atorvastatin 40 mg once daily causes profound reductions of postprandial plasma concentrations of all TRLs in combined hyperlipidaemic patients with premature coronary artery disease...
  48. ncbi request reprint Postprandial plasma ApoB-48 levels are influenced by a polymorphism in the promoter of the microsomal triglyceride transfer protein gene
    Björn Lundahl
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 22:289-93. 2002
    ..005). These data support the notion that elevated transcriptional activity of MTP leads to an increased generation of the smallest triglyceride-rich lipoprotein from the intestine...
  49. ncbi request reprint Postprandial enrichment of remnant lipoproteins with apoC-I in healthy normolipidemic men with early asymptomatic atherosclerosis
    Johan Björkegren
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 22:1470-4. 2002
    ..In this study, the number and composition of chylomicron remnants and very low density lipoproteins (VLDLs) were examined in 30 asymptomatic normolipidemic 50-year-old men with and without early carotid atherosclerotic lesions...
  50. ncbi request reprint The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease
    Helena Ledmyr
    King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Circulation 109:2279-84. 2004
    ..We hypothesize that this polymorphism impacts on coronary heart disease (CHD) risk...
  51. ncbi request reprint Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    David B Savage
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 52:910-7. 2003
    ..Although the condition is rare, the study of humans with dominant-negative mutations in PPAR-gamma can provide important insight into the roles of this nuclear receptor in human metabolism...
  52. ncbi request reprint Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
    Camilla Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 167:311-7. 2003
    ..The observed associations were further modulated by gene-gene and gene-environment interactions...
  53. ncbi request reprint A "futile cycle" induced by thiazolidinediones in human adipose tissue?
    Garry D Tan
    Nat Med 9:811-2; author reply 812. 2003
  54. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  55. ncbi request reprint Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men
    Deborah J Wake
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, United Kingdom
    J Clin Endocrinol Metab 92:1848-56. 2007
    ....
  56. doi request reprint Human adipose tissue blood flow and micromanipulation of human subcutaneous blood flow
    Gijs H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Methods Mol Biol 456:97-107. 2008
    ....
  57. pmc Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    ..Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits...
  58. pmc A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice
    David B Savage
    Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e27. 2008
    ..However, the functional implications of the mutation were not known. The objective of this study was to characterise the molecular and physiological consequences of this genetic variant...
  59. ncbi request reprint Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis
    Vanessa van Harmelen
    Karolinska Institutet, Department of Medicine, M63, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Diabetes 57:378-86. 2008
    ..We investigated whether adipose tissue releases the vascular peptide endothelin-1 (ET-1) and whether ET-1 could account for regional differences in lipolysis...
  60. ncbi request reprint Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia
    Kevin Evans
    Department of Clinical Chemistry, Staffordshire General Hospital, Stafford, UK
    Atherosclerosis 197:164-70. 2008
    ..We used stable isotope techniques combined with tissue-specific measurements in adipose tissue and forearm muscle to investigate fatty acid handling by these tissues in the fasting and postprandial states...
  61. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  62. ncbi request reprint Fire-and-forget in prevention of coronary heart disease
    Fredrik Karpe
    Lancet 360:1984; author reply 1984. 2002
  63. ncbi request reprint European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006
    Marten Hofker
    Department of Molecular Genetics, University of Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Atherosclerosis 193:461-8. 2007
  64. doi request reprint European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007
    Marten Hofker
    Atherosclerosis 197:471-9. 2008
  65. ncbi request reprint Coupling of metabolism and cardiovascular responses
    Keith N Frayn
    Clin Sci (Lond) 106:547-8. 2004
  66. doi request reprint Caution on the interpretation of plasma fatty acid composition as a proxy marker for SCD1 activity: particular implications for using the 16:1/16:0 ratio in QTL studies involving hyperlipidemic patients
    Fredrik Karpe
    Arterioscler Thromb Vasc Biol 28:e152; author reply e153. 2008
  67. ncbi request reprint Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index
    Helena Ledmyr
    King Gustaf V Research Institute, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    J Lipid Res 43:51-8. 2002
    ..This may, in turn, have implications for genetic regulation of cardiovascular risk factors...
  68. ncbi request reprint Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles
    Björn Lundahl
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 290:E739-45. 2006
    ..Reduced direct production of LDL plus IDL appears to be related to lower plasma concentrations of large LDL particles...