F Karpe

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Postprandial lipoprotein metabolism and atherosclerosis
    F Karpe
    King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 246:341-55. 1999
  2. ncbi request reprint Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men
    F Karpe
    King Gustaf V Research Institute, Department of Emergency and Cardiovascular Medicine, Karolinska Hospital, Stockholm, Sweden
    Atherosclerosis 141:307-14. 1998
  3. ncbi request reprint LDL particle size distribution is associated with carotid intima-media thickness in healthy 50-year-old men
    C Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 19:2422-30. 1999
  4. ncbi request reprint Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides
    F Karpe
    King Gustaf V Research Institute, Department of Medicine, 17176 Karolinska Institutet, Stockholm, Sweden
    J Lipid Res 42:17-21. 2001
  5. ncbi request reprint Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation
    A Bröijersen
    Department of Laboratory Medicine, Karolinska Institute and Hospital, Stockholm, Sweden
    Atherosclerosis 137:107-13. 1998
  6. ncbi request reprint A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
    F Karpe
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 18:756-61. 1998
  7. ncbi request reprint In vitro and in vivo lipolysis of plasma triglycerides increases the resistance to oxidative modification of low-density lipoproteins
    C Skoglund-Andersson
    King Gustaf V Research Institute, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Eur J Clin Invest 33:51-7. 2003
  8. ncbi request reprint Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia
    P Eriksson
    King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 18:20-6. 1998
  9. ncbi request reprint In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway
    A Silveira
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 16:1333-9. 1996
  10. ncbi request reprint The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients
    L Juntti-Berggren
    Department of Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Diabetes Care 19:1200-6. 1996

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Postprandial lipoprotein metabolism and atherosclerosis
    F Karpe
    King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 246:341-55. 1999
    ..remnant formation and its relation to atherosclerosis will enable us to test a pertinent clinical question: is there a direct relationship between repeated elevations of postprandial lipoproteins and development of atherosclerosis?..
  2. ncbi request reprint Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men
    F Karpe
    King Gustaf V Research Institute, Department of Emergency and Cardiovascular Medicine, Karolinska Hospital, Stockholm, Sweden
    Atherosclerosis 141:307-14. 1998
    ..Therefore, in healthy middle-aged men, elevated postprandial triglyceride levels might identify a metabolic state related to early atherosclerosis...
  3. ncbi request reprint LDL particle size distribution is associated with carotid intima-media thickness in healthy 50-year-old men
    C Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 19:2422-30. 1999
    ....
  4. ncbi request reprint Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides
    F Karpe
    King Gustaf V Research Institute, Department of Medicine, 17176 Karolinska Institutet, Stockholm, Sweden
    J Lipid Res 42:17-21. 2001
    ..S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;-21...
  5. ncbi request reprint Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation
    A Bröijersen
    Department of Laboratory Medicine, Karolinska Institute and Hospital, Stockholm, Sweden
    Atherosclerosis 137:107-13. 1998
    ..The present finding of enhanced platelet P-selectin expression suggests that platelets are mildly sensitized postprandially. Whether this is of importance for thrombus formation and atherosclerosis needs to be studied further...
  6. ncbi request reprint A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
    F Karpe
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 18:756-61. 1998
    ..This common genetic variation of the MTP promoter is likely to have important implications for cardiovascular disease...
  7. ncbi request reprint In vitro and in vivo lipolysis of plasma triglycerides increases the resistance to oxidative modification of low-density lipoproteins
    C Skoglund-Andersson
    King Gustaf V Research Institute, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Eur J Clin Invest 33:51-7. 2003
    ..The majority of studies on low-density lipoprotein (LDL) particle size and susceptibility to oxidative modification have been either descriptive or interventional, but there are few mechanistic studies...
  8. ncbi request reprint Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia
    P Eriksson
    King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 18:20-6. 1998
    ..These findings may provide a molecular explanation to the link between VLDL and PAI-1 activity elevation in plasma and to the interaction between the 4G/5G polymorphism and plasma triglycerides...
  9. ncbi request reprint In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway
    A Silveira
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 16:1333-9. 1996
    ..Whether activation of factor XI by triglyceride rich lipoproteins initiates these reactions needs to be demonstrated in future studies...
  10. ncbi request reprint The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients
    L Juntti-Berggren
    Department of Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Diabetes Care 19:1200-6. 1996
    ..To investigate the long-term antidiabetogenic effect of glucagon-like peptide 1 (GLP-1) and its influence on diabetic dyslipoproteinemia, patients with NIDDM were treated with GLP-1 subcutaneously for 1 week...
  11. ncbi request reprint A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents
    S K Vasan
    Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Pediatr Obes 8:e45-9. 2013
    ..Associations with obesity traits among Indian adolescents have not been determined...
  12. ncbi request reprint Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    J Skogsberg
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 254:597-604. 2003
    ..Against this background, we investigated the relationships between the PPARD polymorphism and plasma lipoprotein concentrations and the risk for contracting CHD in the West of Scotland Coronary Prevention Study (WOSCOPS)...
  13. ncbi request reprint A functional polymorphism in the promoter region of the microsomal triglyceride transfer protein (MTP -493G/T) influences lipoprotein phenotype in familial hypercholesterolemia
    - Björn Lundahl
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 20:1784-8. 2000
    ..These data suggest that the MTP gene has a role in modulating the clinical phenotype of FH...
  14. ncbi request reprint Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men
    T Skoog
    The Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Eur Heart J 23:376-83. 2002
    ....
  15. ncbi request reprint The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank
    G D Tan
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, UK
    Diabetologia 49:158-68. 2006
    ..We hypothesised that Ala12 allele carriers demonstrate greater adipose tissue metabolic flexibility and insulin sensitivity...
  16. ncbi request reprint Insulin sensitisation affects lipoprotein lipase transport in type 2 diabetes: role of adipose tissue and skeletal muscle in response to rosiglitazone
    G D Tan
    OCDEM, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Diabetologia 49:2412-8. 2006
    ..Insulin resistance is associated with decreased plasma LPL mass. We investigated the effects of insulin sensitisation on tissue-specific LPL expression and transport in patients with type 2 diabetes...
  17. ncbi request reprint Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes
    T Cadoudal
    INSERM UMR S 530 747, Paris, France
    Diabetologia 50:666-75. 2007
    ..Here we investigate the effect of rosiglitazone on the expression of genes involved in fatty acid metabolism and the resulting metabolic consequences...
  18. ncbi request reprint Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis
    F Karpe
    Oxford Lipid Metabolism Group, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Int J Obes Relat Metab Disord 26:1-5. 2002
    ..ATBF can be measured quantitatively by the (133)Xe washout technique, but the microdialysis ethanol escape method has also been employed to detect relative changes in ATBF...
  19. ncbi request reprint Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Biochem Soc Trans 35:472-6. 2007
    ..Under circumstances of reduced efficiency in the removal of triacylglycerols from lipoproteins, there is accumulation of remnant lipoproteins, which are potentially atherogenic...
  20. ncbi request reprint Adipose tissue: a key target for diabetes pathophysiology and treatment?
    K N Frayn
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Horm Metab Res 39:739-42. 2007
    ..Some evidence for this comes from the effects of the thiazolidinediones, which improve adipose tissue function and in parallel reduce inflammatory changes...
  21. doi request reprint Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome
    T M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetologia 51:1153-8. 2008
    ..Given the important role of obesity in the aetiology of both polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, our aim was to establish whether FTO variants are also implicated in PCOS susceptibility...
  22. doi request reprint Adipose tissue fatty acid metabolism in insulin-resistant men
    A S T Bickerton
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetologia 51:1466-74. 2008
    ..Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant overweight men (BMI 25-35 kg/m2)...
  23. ncbi request reprint Adipose tissue function in the insulin-resistance syndrome
    F Karpe
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Biochem Soc Trans 33:1045-8. 2005
    ..In healthy people adipose tissue blood flow is much enhanced by food intake, whereas in insulin-resistant subjects this response is blunted. This is another facet of unresponsiveness of adipose tissue in the insulin-resistance syndrome...
  24. ncbi request reprint Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy
    G D Tan
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Diabetologia 48:1585-9. 2005
    ..We therefore explored the regulation of adipoR1/R2 and adiponectin expression in adipose tissue and skeletal muscle, and of adiponectin plasma concentrations in response to insulin sensitisation by rosiglitazone...
  25. ncbi request reprint Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects
    T J Ulahannan
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Horm Metab Res 34:499-503. 2002
    ..We conclude that alpha1 -adrenoceptor activity may be more important in regulation of human lipid metabolism than previously recognized...
  26. ncbi request reprint Interaction between specific fatty acids, GLP-1 and insulin secretion in humans
    C Beysen
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Diabetologia 45:1533-41. 2002
    ..Our aim was to investigate differential effects of acutely increased plasma monounsaturated, polyunsaturated and saturated fatty acids on glucose-stimulated insulin secretion in healthy humans...
  27. ncbi request reprint Integrative physiology of human adipose tissue
    K N Frayn
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Int J Obes Relat Metab Disord 27:875-88. 2003
    ..This implies the existence of one (or more) signal(s) to the adipose tissue that reflects the body's energy status, and points once again to the need for an integrative view of adipose tissue function...
  28. ncbi request reprint Plasma leptin is influenced by diet composition and exercise
    C Koutsari
    Human Muscle Metabolism Research Group, School of Sport and Exercise Sciences, Loughborough University, Loughborough, UK
    Int J Obes Relat Metab Disord 27:901-6. 2003
    ..The aim of this study was to assess the effect of adding daily exercise to a short-term high-carbohydrate diet on fasting and postprandial leptin levels...
  29. ncbi request reprint Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall
    J L Ardilouze
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK
    Int J Obes Relat Metab Disord 28:228-33. 2004
    ..Therefore, we investigated if any differences in subcutaneous adipose tissue blood flow (ATBF) exist at different locations of the anterior abdominal wall...
  30. ncbi request reprint The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes
    G D Tan
    Oxford Centre for Diabetes Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, OX3 7LJ, UK
    Diabetologia 48:83-95. 2005
    ..We investigated the effects of rosiglitazone on NEFA and triglyceride metabolism in type 2 diabetes...
  31. ncbi request reprint Risk of fatal stroke in patients with treated familial hypercholesterolemia: a prospective registry study
    R R Huxley
    Division Public Health and Primary Health Care, Institute of Health Sciences, University of Oxford, Oxford, UK
    Stroke 34:22-5. 2003
    ..The goal of this study was to determine the risk of fatal stroke in patients with treated familial hypercholesterolemia...
  32. ncbi request reprint Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased
    K N Frayn
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    Diabetologia 51:394-7. 2008
    ..We conclude that prevention or treatment of insulin resistance through alteration of adipocyte fatty acid handling will require more than a simple alteration of the activity of mitochondrial beta-oxidation within normal limits...
  33. doi request reprint Remodeling phenotype of human subcutaneous adipose tissue macrophages
    V Bourlier
    Equipe AVENIR INSERM U858, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    Circulation 117:806-15. 2008
    ..However, the phenotype and functions of human ATMs are still to be defined...
  34. pmc Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans
    G H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    J Physiol 571:451-60. 2006
    ..Locally produced Ang II does not appear to regulate ATBF. Ang II appears to have no major effect on the postprandial enhancement of ATBF...
  35. ncbi request reprint Exercise prevents the accumulation of triglyceride-rich lipoproteins and their remnants seen when changing to a high-carbohydrate diet
    C Koutsari
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough, UK
    Arterioscler Thromb Vasc Biol 21:1520-5. 2001
    ..These carbohydrate-induced increases in the number of circulating triglyceride-rich particles and their remnants were abolished when subjects had exercised daily during the high-carbohydrate diet...