Ragnhildur Karadottir

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Unraveling the secrets of white matter--bridging the gap between cellular, animal and human imaging studies
    K B Walhovd
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, POB 1094 Blindern, 0317 Oslo, Norway Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, 0424 Oslo, Norway Electronic address
    Neuroscience 276:2-13. 2014
  2. pmc Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes
    Iben Lundgaard
    Wellcome Trust Medical Research Council MRC Stem Cell Institute, John van Geest Centre for Brain Repair, and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 11:e1001743. 2013
  3. pmc Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:450-6. 2008
  4. ncbi request reprint Electrical signalling properties of oligodendrocyte precursor cells
    Yamina Bakiri
    Department of Physiology, University College London, Gower St, London, WC1E 6BT, UK
    Neuron Glia Biol 5:3-11. 2009
  5. pmc The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes
    Karolina Kolodziejczyk
    Department of Physiology, University College London, Gower Street, London, UK
    Brain 132:1496-508. 2009
  6. pmc Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter
    Yamina Bakiri
    Department of Physiology, University College London, London, England
    Glia 56:233-40. 2008
  7. ncbi request reprint A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells
    Nicola J Allen
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:848-59. 2005
  8. pmc Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum
    Yamina Bakiri
    Department of Physiology, University College London, London, UK
    J Physiol 589:559-73. 2011
  9. pmc NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 438:1162-6. 2005
  10. pmc Combining patch-clamping of cells in brain slices with immunocytochemical labeling to define cell type and developmental stage
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Protoc 1:1977-86. 2006

Collaborators

  • D Attwell
  • Nicola J Allen
  • Mark Baccei
  • K P Giese
  • Yamina Bakiri
  • K B Walhovd
  • Iben Lundgaard
  • Karolina Kolodziejczyk
  • Nicola B Hamilton
  • Damian Pattinson
  • H Johansen-Berg
  • Aryna Luzhynskaya
  • Kimberley A Evans
  • Robin J M Franklin
  • John H Stockley
  • Katrin Volbracht
  • Hélène O B Gautier
  • Zhen Wang
  • Matthew Swire
  • Lee Cossell
  • Anna Wade
  • Andrew Moss
  • Maria Fitzgerald
  • Jaime McCutcheon
  • Carole Torsney

Detail Information

Publications13

  1. ncbi request reprint Unraveling the secrets of white matter--bridging the gap between cellular, animal and human imaging studies
    K B Walhovd
    Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, POB 1094 Blindern, 0317 Oslo, Norway Department of Physical Medicine and Rehabilitation, Unit of Neuropsychology, Oslo University Hospital, 0424 Oslo, Norway Electronic address
    Neuroscience 276:2-13. 2014
    ..In this review, we try to address this hindrance by introducing the methods and providing a basic background to myelin biology and human imaging as a prelude to the other reviews within this special issue. ..
  2. pmc Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes
    Iben Lundgaard
    Wellcome Trust Medical Research Council MRC Stem Cell Institute, John van Geest Centre for Brain Repair, and Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 11:e1001743. 2013
    ..These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage. ..
  3. pmc Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:450-6. 2008
    ..These data challenge the idea that only neurons generate action potentials in the CNS and imply that the development of therapies for demyelinating disorders will require defining which OPC type can carry out remyelination...
  4. ncbi request reprint Electrical signalling properties of oligodendrocyte precursor cells
    Yamina Bakiri
    Department of Physiology, University College London, Gower St, London, WC1E 6BT, UK
    Neuron Glia Biol 5:3-11. 2009
    ....
  5. pmc The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes
    Karolina Kolodziejczyk
    Department of Physiology, University College London, Gower Street, London, UK
    Brain 132:1496-508. 2009
    ..We conclude that an action of NAAG on oligodendrocyte NMDA receptors is unlikely to be a major contributor to white matter damage in the leucodystrophies...
  6. pmc Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter
    Yamina Bakiri
    Department of Physiology, University College London, London, England
    Glia 56:233-40. 2008
    ..Our results highlight the importance of developing new antagonists selective for oligodendrocyte NMDA receptors based on their difference in subunit structure from most neuronal NMDA receptors...
  7. ncbi request reprint A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells
    Nicola J Allen
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:848-59. 2005
    ..They also define a hierarchy of pool sizes for hippocampal energy stores and suggest that brain ATP production from glial lactate may not be significant in conditions of energy deprivation...
  8. pmc Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum
    Yamina Bakiri
    Department of Physiology, University College London, London, UK
    J Physiol 589:559-73. 2011
    ....
  9. pmc NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 438:1162-6. 2005
    ..These results point to NMDA receptors of unusual subunit composition as a potential therapeutic target for preventing white matter damage in a variety of diseases...
  10. pmc Combining patch-clamping of cells in brain slices with immunocytochemical labeling to define cell type and developmental stage
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Protoc 1:1977-86. 2006
    ..With practice, approximately 80% of patch-clamped cells can be retrieved and have their proteins identified in this way. The entire protocol can be completed in 3-4 d...
  11. ncbi request reprint Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy
    Nicola J Allen
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Pflugers Arch 449:132-42. 2004
    ..This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders...
  12. ncbi request reprint Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIalpha autophosphorylation
    Damian Pattinson
    Department of Anatomy and Developmental Biology, University College London, London, UK
    Mol Cell Neurosci 33:88-95. 2006
    ..These results show that CaMKII autophosphorylation is required for the normal development of spinal sensory circuits...