Research Topics
| N KaliaSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Mast cell stabilization prevents ethanol-induced rat gastric mucosal injury: mechanisms of protectionN Kalia
Department of Surgical and Anaesthetic Sciences, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Gastroenterol Hepatol 15:133-41. 2000..Fluorescent in vivo microscopy was used to assess the effects of ketotifen, a mast cell stabilizer, and pyrilamine, a histamine (H1)-receptor antagonist, on ethanol-induced rat gastric mucosal injury...- Of blood and guts: association between Helicobacter pylori and the gastric microcirculationNeena Kalia
Department of Biomedical Sciences, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK
J Gastroenterol Hepatol 18:1010-7. 2003..pylori infection and coronary heart disease. The present review highlights the major findings from these studies and proposes an important role for the gastric microcirculation in the pathophysiology of H. pylori-induced injury... - Mucosal villus microcirculatory disturbances associated with rat intestinal ischaemia-reperfusion injury are not prevented by tacrolimusNeena Kalia
Department of Biomedical Science, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield, UK
Digestion 67:154-60. 2003..However, its effects on intestinal I/R injury have not been evaluated... - Toxigenic Helicobacter pylori induces changes in the gastric mucosal microcirculation in ratsN Kalia
Section of Surgical and Anaesthetic Sciences, Division of Clinical Sciences S, Royal Hallamshire Hospital, Sheffield, UK
Gut 51:641-7. 2002..This study used fluorescent in vivo microscopy to determine the acute effects of extracts of genotypically different H pylori strains on the GMMC... - FK409 inhibits both local and remote organ damage after intestinal ischaemiaNeena Kalia
Surgical and Anaesthetic Sciences, Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
J Pathol 197:595-602. 2002..FK409 may therefore be of value in reducing both local and remote tissue damage and improving outcome in situations where intestinal I/R injury is obligatory, such as small bowel transplantation... - Effects of hypothermia and rewarming on the mucosal villus microcirculation and survival after rat intestinal ischemia-reperfusion injuryNeena Kalia
Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, UK
Ann Surg 236:67-74. 2002..To determine the effects of hypothermia and rewarming on changes in the villus microcirculation induced by intestinal ischemia-reperfusion (I/R)... - L-Arginine protects and exacerbates ethanol-induced rat gastric mucosal injuryN Kalia
Department of Surgical and Anaesthetic Sciences, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Gastroenterol Hepatol 15:915-24. 2000..This study used fluorescent in vivo microscopy to investigate (i) whether L-arginine (NO precursor) prevented EtOH induced injury and (ii) the mechanisms of protection... - Effects of FK409 on intestinal ischemia-reperfusion injury and ischemia-induced changes in the rat mucosal villus microcirculationN Kalia
Section of Surgical and Anesthetic Sciences, Division of Clinical Sciences (CSUH, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
Transplantation 72:1875-80. 2001.... - Effects of genotypically different strains of Helicobacter pylori on human microvascular endothelial cells in vitroN Kalia
Department of Surgical and Anaesthetic Sciences, Royal Hallamshire Hospital, University of Sheffield, UK
Dig Dis Sci 46:54-61. 2001..This suggests that microcirculatory disturbances observed in vivo may not be the result of direct endothelial cell damage. However, inhibition of angiogenesis may explain why ulcer healing is delayed in H. pylori-infected patients... - Effects of intestinal ischemia-reperfusion injury on rat peripheral blood neutrophil activationN Kalia
Department of Biomedical Science, University of Sheffield, UK
Dig Dis Sci 48:1677-84. 2003..Monitoring the peripheral blood for activated neutrophils is of no value in assessing the severity of direct intestinal I/R injury or predicting remote organ damage after intestinal ischemia... - Effects of aspirin and indomethacin on endothelial cell proliferation in vitroH R Pearce
Academic Unit of Surgery, Division of Clinical Sciences, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK
J Gastroenterol Hepatol 18:1180-7. 2003..Interestingly, PGE2 was also antiproliferative. Inhibition of EC proliferation may prevent angiogenesis at the ulcer site, which may in part explain the delayed ulcer healing associated with NSAID... - Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acidsN Kalia
Department of Biomedical Science, University of Sheffield, Sheffield, UK
Gut 57:41-9. 2008..Changes in the protein expression of apical sodium-dependent bile acid transporter (ASBT) were also measured... - Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injuryNeena Kalia
Academic Unit of Surgical Oncology, Division of Clinical Sciences (South, Royal Hallamshire Hospital, Sheffield, UK
J Gastroenterol Hepatol 20:1032-8. 2005..However, its effects are manifested in the absence of any influence on intestinal I/R-induced vascular leakage... - Rac1 is essential for platelet lamellipodia formation and aggregate stability under flowOwen J T McCarty
Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
J Biol Chem 280:39474-84. 2005.... - Effects of Helicobacter pylori on endothelial cell proliferation and chemotaxisHannah Rose Pearce
Academic Unit of Surgery, Division of Clinical Sciences, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, UK
Digestion 69:201-10. 2004..A similar antiproliferative effect of C. jejuni was observed. Our findings suggest that both H. pylori and C. jejuni have the ability to inhibit one of the key stages of angiogenesis which may have implications in peptic ulcer disease... - Helicobacter pylori prevents proliferative stage of angiogenesis in vitro: role of cytokinesLesley Jenkinson
Division of Clinical Sciences (S, Royal Hallamshire Hospital, Sheffield, UK
Dig Dis Sci 47:1857-62. 2002..In conclusion, H. pylori induces cytokine up-regulation as part of its pathophysiological mechanism, which could prove detrimental to ulcer healing through an inhibitory effect on angiogenesis... - Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivoSarah L Nolan
Renal Immunobiology, Medical School, University of Birmingham, Birmingham, United Kingdom
J Am Soc Nephrol 19:973-84. 2008..In addition, it suggests that neutrophils primed by cytokines in the presence of anti-MPO IgG can have systemic effects and target specific vascular beds...