Raj N Kalaria


Affiliation: University of Newcastle
Country: UK


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    Kalaria R, Kalimo H. Introduction: Non-atherosclerotic cerebrovascular disorders. Brain Pathol. 2002;12:337-42 pubmed
    ..The identification of novel genes associated with the hereditary forms of cerebrovascular disorders has been invaluable to understanding of the pathogenesis and management of sporadic disease. ..
  2. Akinyemi R, Firbank M, Ogbole G, Allan L, Owolabi M, Akinyemi J, et al. Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors. BMC Res Notes. 2015;8:625 pubmed publisher
    ..These observations have implications for a vascular basis of MTA in older stroke survivors among sub-Saharan Africans. ..
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    Kalaria R. Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc Dis. 2002;13 Suppl 2:48-52 pubmed
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    Kalaria R, Viitanen M, Kalimo H, Dichgans M, Tabira T. The pathogenesis of CADASIL: an update. J Neurol Sci. 2004;226:35-9 pubmed
    ..This report summarizes some of the highlights of the satellite symposium on CADASIL at Vas-Cog 2003. ..
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    Kalaria R. Vascular factors in Alzheimer's disease. Int Psychogeriatr. 2003;15 Suppl 1:47-52 pubmed
    ..These factors would modify the cerebral circulation such that a sustained hypoperfusion or oligemia is impacted upon the aging processes to induce the characteristic pathology. ..
  6. Paddick S, Kalaria R, Mukaetova Ladinska E. The prevalence and clinical manifestations of delirium in sub-Saharan Africa: a systematic review with inferences. J Neurol Sci. 2015;348:6-17 pubmed publisher
    ..This knowledge gap should be tackled with some urgency, in order to address questions of screening, diagnosis, prevention and management in this setting. ..
  7. Kalaria R, Maestre G, Arizaga R, Friedland R, Galasko D, Hall K, et al. Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008;7:812-26 pubmed publisher
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions. ..
  8. Kalaria R, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochim Biophys Acta. 2016;1862:915-25 pubmed publisher
    ..This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. ..
  9. Kalaria R. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease. Acta Neuropathol. 2016;131:659-85 pubmed publisher
    ..The investigation of relevant animal models would be valuable in exploring the pathogenesis as well as prevention of the vascular causes of cognitive impairment. ..

More Information


  1. Akinyemi R, Owolabi M, Oyeniyi T, Ovbiagele B, Arnett D, Tiwari H, et al. Neurogenomics in Africa: Perspectives, progress, possibilities and priorities. J Neurol Sci. 2016;366:213-223 pubmed publisher
    ..The translational barriers can be overcome through robust stakeholder engagement and sustainable multilevel, multigenerational and multidisciplinary capacity building and infrastructural development for genomic medicine in Africa. ..
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    Kalaria R, Premkumar D, Lin C, Kroon S, Bae J, Sayre L, et al. Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis. Brain Res Mol Brain Res. 1998;58:178-87 pubmed
    ..Our study suggests that mammalian cerebrovascular and choroidal tissues contain high amounts of the ubiquitous amiloride-sensitive [3H]MIA binding proteins consistent with the expression of NHE type 1 mRNA. ..