Raj N Kalaria

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Similarities between Alzheimer's disease and vascular dementia
    Raj Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Sci 203:29-34. 2002
  2. ncbi request reprint Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias
    Vincent Foster
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Brain 137:2509-21. 2014
  3. ncbi request reprint Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis
    R N Kalaria
    Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Brain Res Mol Brain Res 58:178-87. 1998
  4. ncbi request reprint Comparison between Alzheimer's disease and vascular dementia: implications for treatment
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurol Res 25:661-4. 2003
  5. pmc Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
  6. ncbi request reprint The pathogenesis of CADASIL: an update
    R N Kalaria
    Institute for Ageing and Health, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE4 6 BE, UK
    J Neurol Sci 226:35-9. 2004
  7. ncbi request reprint Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
  8. ncbi request reprint Vascular factors in Alzheimer's disease
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, and Department of Psychiatry, University of Newcastle, Newcastle upon Tyne, UK
    Int Psychogeriatr 15:47-52. 2003
  9. pmc Vascular basis for brain degeneration: faltering controls and risk factors for dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Nutr Rev 68:S74-87. 2010
  10. doi request reprint Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease
    Raj N Kalaria
    Institute for Ageing and Health, Wolfson Research Center Neuropathology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Nat Rev Neurol 5:305-6. 2009

Detail Information

Publications59

  1. ncbi request reprint Similarities between Alzheimer's disease and vascular dementia
    Raj Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Sci 203:29-34. 2002
    ..Regarding effective therapeutic management of dementia patients, further concerted epidemiological study of these related dementia types should aid in clinical decisions on the applicability of cholinergic treatments...
  2. ncbi request reprint Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias
    Vincent Foster
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Brain 137:2509-21. 2014
    ..The changes in dorsolateral prefrontal cortex pyramidal cells were not associated with neurofibrillary pathology suggesting there is a vascular basis for the observed highly selective neuronal atrophy. ..
  3. ncbi request reprint Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis
    R N Kalaria
    Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Brain Res Mol Brain Res 58:178-87. 1998
    ..Our study suggests that mammalian cerebrovascular and choroidal tissues contain high amounts of the ubiquitous amiloride-sensitive [3H]MIA binding proteins consistent with the expression of NHE type 1 mRNA...
  4. ncbi request reprint Comparison between Alzheimer's disease and vascular dementia: implications for treatment
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurol Res 25:661-4. 2003
    ..Cerebrovascular pathology, ischemic brain damage and autonomic dysregulation resulting in cerebral hypoperfusion appears fundamental in the pathogenesis of late-onset dementias...
  5. pmc Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 7:812-26. 2008
    ..Dementia costs in developing countries are estimated to be US$73 billion yearly, but care demands social protection, which seems scarce in these regions...
  6. ncbi request reprint The pathogenesis of CADASIL: an update
    R N Kalaria
    Institute for Ageing and Health, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, NE4 6 BE, UK
    J Neurol Sci 226:35-9. 2004
    ..This report summarizes some of the highlights of the satellite symposium on CADASIL at Vas-Cog 2003...
  7. ncbi request reprint Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
    ..Similar to other common dementias consensus criteria for VaD need unambiguous definition to impact on preventative and treatment strategies and are critical for selective recruitment to clinical trials...
  8. ncbi request reprint Vascular factors in Alzheimer's disease
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, and Department of Psychiatry, University of Newcastle, Newcastle upon Tyne, UK
    Int Psychogeriatr 15:47-52. 2003
    ..These factors would modify the cerebral circulation such that a sustained hypoperfusion or oligemia is impacted upon the aging processes to induce the characteristic pathology...
  9. pmc Vascular basis for brain degeneration: faltering controls and risk factors for dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Nutr Rev 68:S74-87. 2010
    ..Lifestyle measures that maintain or improve cardiovascular health, including consumption of healthy diets, moderate use of alcohol, and implementation of regular physical exercise are important factors for brain protection...
  10. doi request reprint Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease
    Raj N Kalaria
    Institute for Ageing and Health, Wolfson Research Center Neuropathology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Nat Rev Neurol 5:305-6. 2009
    ..A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity...
  11. ncbi request reprint Dementia comes of age in the developing world
    Raj N Kalaria
    Institute for Ageing and Health, Wolfson Unit, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK
    Lancet 361:888-9. 2003
  12. ncbi request reprint Introduction: Non-atherosclerotic cerebrovascular disorders
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health and Department of Psychiatry, Newcastle General Hospital, United Kingdom
    Brain Pathol 12:337-42. 2002
    ..The identification of novel genes associated with the hereditary forms of cerebrovascular disorders has been invaluable to understanding of the pathogenesis and management of sporadic disease...
  13. ncbi request reprint Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia
    R N Kalaria
    Departments of Neurology, Neurosciences, Neurological Surgery and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Brain Res Mol Brain Res 62:101-5. 1998
    ..We suggest the increased VEGF reactivity, also observed in infarcted human brain tissue, implicates compensatory mechanisms to counter insufficient vascularity or reduced perfusion (oligemia) apparent in AD...
  14. ncbi request reprint The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease
    R N Kalaria
    Institute for Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 893:113-25. 1999
    ..These vascular abnormalities are likely to worsen cognitive disability in AD...
  15. ncbi request reprint The role of cerebral ischemia in Alzheimer's disease
    R N Kalaria
    Wolfson Research Centre, Institute for Health of the Elderly, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, United Kingdom
    Neurobiol Aging 21:321-30. 2000
    ..Irrespective of the ultimate pathogenetic mechanism, these approaches implicate that management of peripheral vascular disease is important in the treatment or prevention of Alzheimer's disease or mixed dementia...
  16. ncbi request reprint Stroke and cognition
    R N Kalaria
    CBV Group, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Curr Atheroscler Rep 3:334-9. 2001
    ..Although several neurotransmitter systems may be affected in post-stroke dementia, the amelioration of cholinergic function is a worthy target...
  17. ncbi request reprint Small vessel disease and Alzheimer's dementia: pathological considerations
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, and Department of Psychiatry, University of Newcastle, Newcastle upon Tyne, UK
    Cerebrovasc Dis 13:48-52. 2002
    ....
  18. ncbi request reprint Neuron volumes in hippocampal subfields in delayed poststroke and aging-related dementias
    Elizabeth Gemmell
    From the Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Neuropathol Exp Neurol 73:305-11. 2014
    ..These data suggest that CA4 neurons are vulnerable to disease processes and support our previous finding that a reduction in hippocampal neuron volume predominantly reflects vascular mechanisms as contributing to dementia after stroke. ..
  19. doi request reprint Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias
    Elizabeth Gemmell
    Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Stroke 43:808-14. 2012
    ..We have previously shown delayed poststroke dementia in elderly (≥75 years old) stroke survivors is associated with medial temporal lobe atrophy; however, the basis of the structural and functional changes is unknown...
  20. ncbi request reprint Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors
    Louise M Allan
    Louise M Allan, PhD, MRCP, Elise N Rowan, PhD, Alan J Thomas, PhD, FRCPsych, Tuomo M Polvikoski, MD, John T O Brien, DM, Raj N Kalaria, PhD, FRCPsych, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 203:453-60. 2013
    ..Depression is common and an important consequence of stroke but there is limited information on the longer-term relationship between these conditions...
  21. pmc Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies
    Masafumi Ihara
    Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Acta Neuropathol 119:579-89. 2010
    ....
  22. pmc Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors
    Louise M Allan
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Brain 134:3716-27. 2011
    ..Careful monitoring and treatment of modifiable vascular risk factors may be of benefit in preventing post-stroke dementia in the general population...
  23. pmc Neuroimaging predictors of death and dementia in a cohort of older stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 83:263-7. 2012
    ..Stroke is a risk factor for subsequent death and dementia. Being able to identify subjects at particular risk would be beneficial to inform treatment and patient management...
  24. doi request reprint NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors
    Christopher M Morris
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurobiol Aging 32:554.e1-6. 2011
    ..001). We hypothesize that this may be mediated by reduction of nitric oxide production and cerebral perfusion. Our findings, if replicated widely, have implications for treatments to ameliorate cognitive decline in stroke survivors...
  25. ncbi request reprint Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 28:1664-9. 2007
    ..The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke...
  26. pmc Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL
    Yumi Yamamoto
    Institute for Ageing and Health, WRc, Campus for Ageing and Vitality, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, United Kingdom
    Stroke 40:2004-11. 2009
    ..We assessed pathological changes in postmortem tissue from the temporal pole to reveal the cause of CADASIL-specific WM hyperintensities...
  27. ncbi request reprint Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia
    Rufus O Akinyemi
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, United Kingdom
    Curr Alzheimer Res 10:642-53. 2013
    ....
  28. doi request reprint Increase in platelet immunoglobulin in Alzheimer's disease is normalised following cholinesterase inhibitor treatment: preliminary results
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
    J Alzheimers Dis 32:431-6. 2012
    ....
  29. doi request reprint Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
    Age Ageing 41:408-12. 2012
    ..Since cerebrospinal fluid analysis and molecular neuroimaging are not routinely used in many countries, blood biomarker molecules may be more readily applicable in a routine clinical setting...
  30. ncbi request reprint White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    Lucinda J L Craggs
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 40:591-602. 2014
    ..We examined whether the distribution of axonal abnormalities is related to microvascular pathology in the underlying WM...
  31. ncbi request reprint Post-stroke dementia: the contribution of thalamus and basal ganglia changes
    Marcos Antônio Lopes
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 24:568-76. 2012
    ..This study aimed to investigate the contribution of changes in subcortical gray matter structures to post-stroke dementia (PSD)...
  32. doi request reprint Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL
    Yumi Yamamoto
    Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Neuropathol Exp Neurol 72:416-31. 2013
    ....
  33. doi request reprint Can healthy lifestyle modify risk factors for dementia? Findings from a pilot community-based survey in Chennai (India) and Newcastle (UK)
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neuroepidemiology 39:163-70. 2012
    ..Attention has turned to defining preventive strategies and identifying modifying effects of lifestyle, including physical activity, diet, alcohol intake and smoking, in reducing cognitive decline and overt memory problems in the elderly...
  34. pmc A comparative study to screen dementia and APOE genotypes in an ageing East African population
    Chien Hsiun Chen
    Laboratory of Neurogeriatrics, Department of Neurology and Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Neurobiol Aging 31:732-40. 2010
    ..There was no evidence to suggest years of education or vascular factors were associated with dementia status...
  35. ncbi request reprint Hypoxia of sleep apnoea: cardiopulmonary and cerebral changes after intermittent hypoxia in rats
    Raj N Kalaria
    Wolfson Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Respir Physiol Neurobiol 140:53-62. 2004
    ..This suggests that the signals for angiogenesis were complete or arrested after CH. Our findings have implications for the elderly subjected to hypoxic episodes during sleep apnoea...
  36. doi request reprint Does vascular pathology contribute to Alzheimer changes?
    Raj N Kalaria
    Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom
    J Neurol Sci 322:141-7. 2012
    ....
  37. doi request reprint Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    J Neuropathol Exp Neurol 72:53-60. 2013
    ..These findings draw attention to molecular changes within the primary visual cortex in DLB and correlate with the neuroimaging findings within the occipital lobe in patients with this disorder...
  38. ncbi request reprint Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementia
    Sally Stephens
    University of Newcastle, UK
    J Am Geriatr Soc 53:103-7. 2005
    ..To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia...
  39. ncbi request reprint Neuropsychological deficits in older stroke patients
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle NE4 6BE, United Kingdom
    Ann N Y Acad Sci 977:179-82. 2002
    ....
  40. ncbi request reprint Prospective follow-up study between 3 and 15 months after stroke: improvements and decline in cognitive function among dementia-free stroke survivors >75 years of age
    Clive Ballard
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Rd, Newcastle NE4 6BE UK
    Stroke 34:2440-4. 2003
    ..Poststroke cognitive impairment is frequent. There are, however, few longitudinal studies examining delayed changes in poststroke cognition...
  41. ncbi request reprint Profile of neuropsychological deficits in older stroke survivors without dementia
    Clive Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Dement Geriatr Cogn Disord 16:52-6. 2003
    ..Few studies have examined the profile of cognitive impairments in older stroke patients without dementia...
  42. ncbi request reprint Homocysteine and post-stroke cognitive decline
    Elise N Rowan
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Age Ageing 36:339-43. 2007
  43. ncbi request reprint Neurocardiovascular instability in cognitive impairment and dementia
    Rose Anne M Kenny
    MRC Development Centre for Clinical Brain Ageing, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 977:183-95. 2002
    ..NCVI is common in patients with dementia and may be a reversible cause of falls and syncope. Repeated hypotensive episodes may exaggerate cognitive decline in these patients...
  44. ncbi request reprint Cholinergic neuronal deficits in CADASIL
    Jessica S Keverne
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, United Kingdom
    Stroke 38:188-91. 2007
    ..Previous evidence from MRI and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)...
  45. ncbi request reprint White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients
    Emma J Burton
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Stroke 35:1270-5. 2004
    ..We hypothesized that processing speed and executive dysfunction will be associated with frontal WMH whereas impaired memory will be associated with temporal WMH...
  46. ncbi request reprint Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia
    Alan Thomas
    Institute for Ageing and Health, Newcastle, UK
    Dement Geriatr Cogn Disord 19:57-60. 2005
    ..To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia...
  47. ncbi request reprint Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke
    Emma Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 16:113-8. 2003
    ..The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits...
  48. ncbi request reprint Pathologies and pathological mechanisms for white matter hyperintensities in depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, United Kingdom
    Ann N Y Acad Sci 977:333-9. 2002
    ..However, since large vessel and small vessel disease were not associated with WMH, our findings suggest hypotensive disease might be an important and unrecognized mechanism underlying WMH in late-life depression...
  49. pmc Microangiopathy in the cerebellum of patients with mitochondrial DNA disease
    Nichola Z Lax
    The Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Brain 135:1736-50. 2012
    ..Since therapeutic strategies targeting the central nervous system are limited, modulating vascular function presents an exciting opportunity to lessen the burden of disease in these patients...
  50. doi request reprint Revisiting dietary antioxidants, neurodegeneration and dementia
    Lucinda Craggs
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neuroreport 22:1-3. 2011
    ..Alzheimer's disease is a complex disorder. A single target through use of antioxidants may be effective in some but multiple approaches for its control seem to be necessary...
  51. ncbi request reprint CADASIL-causing mutations do not alter Notch3 receptor processing and activation
    Wee Chuang Low
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Neuroreport 17:945-9. 2006
    ..Our results suggest that the arteriopathy in CADASIL is caused by other mechanisms not necessarily involving Notch3 processing and activation...
  52. ncbi request reprint Rounding up the usual suspects: lacunar infarction and impairment in CADASIL
    Raj N Kalaria
    Neurology 69:131-2. 2007
  53. ncbi request reprint CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia
    Hannu Kalimo
    Department of Pathology, Turku University Hospital, Finland
    Brain Pathol 12:371-84. 2002
    ..It is as yet unclear which disturbance in the Notch signaling pathway leads to the characteristic vascular pathology of CADASIL...
  54. ncbi request reprint White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury
    Malee S Fernando
    Division of Genomic Medicine, University of Sheffield, United Kingdom
    Stroke 37:1391-8. 2006
    ..Direct evidence of ischemia associated with incidental WM lesions (WMLs) has been lacking, and their pathogenesis is unresolved...
  55. ncbi request reprint Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia
    Gustavo C Roman
    University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neurobiol Aging 27:1769-85. 2006
    ..We postulate that vascular pathology likely plays a common role in initiating cholinergic neuronal abnormalities in VaD and AD...
  56. ncbi request reprint Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease
    Jeannine M Heckmann
    Division of Neurology, Groote Schur Hospital and University of Cape Town, South Africa
    Brain 127:133-42. 2004
    ..Although sporadic cases of AD do exist in African populations, our study confirms the existence of early-onset familial AD among indigenous Southern Africans...
  57. ncbi request reprint National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  58. ncbi request reprint Amyloid-beta and synaptic activity in mice and men
    Masafumi Ihara
    Neuroreport 18:1205-6. 2007
  59. ncbi request reprint Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD
    Huw D Lewis
    Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Neurobiol Aging 25:1175-85. 2004
    ..Application of the same extraction and quantitation procedures to samples of temporal cortex from AD sufferers indicates however that A beta(40) is only a minor component of beta-amyloid in humans...

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