Aras Kadioglu

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Nat Rev Microbiol 6:288-301. 2008
  2. doi Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis
    A Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, UK
    Mol Oral Microbiol 25:50-60. 2010
  3. doi The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease
    Luke Richards
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE19HN, United Kingdom
    Immunobiology 215:251-63. 2010
  4. pmc Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin
    Rania Jounblat
    Department of Microbiology and Immunology, University of Leicester, University Road, Leicester, LE1 9HN, UK
    Infect Immun 71:1813-9. 2003
  5. doi A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection
    Melissa E K Carter
    Department of Infection, Immunity, and Infection, University of Leicester, Leicester, United Kingdom
    J Infect Dis 202:935-42. 2010
  6. pmc Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis
    Sonia Manco
    Department of Infection, Immunity and Inflammation, University of Leicester, P O Box 138, University Rd, Leicester LE1 9HN, United Kingdom
    Infect Immun 74:4014-20. 2006
  7. pmc Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type
    Aras Kadioglu
    Department of Microbiology and Immunology, University of Leicester, Leicester, LE1 United Kingdom
    Infect Immun 70:2886-90. 2002
  8. doi The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Immunol 186:5907-15. 2011
  9. doi Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 184:7108-15. 2010
  10. doi Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice
    Aras Kadioglu
    Department of Infection, Immunity, and Inflammation, University of Leicester, United Kingdom
    J Infect Dis 204:1971-9. 2011

Collaborators

Detail Information

Publications25

  1. doi The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Nat Rev Microbiol 6:288-301. 2008
    ..In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease...
  2. doi Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis
    A Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, UK
    Mol Oral Microbiol 25:50-60. 2010
    ..Pneumococcal sepsis is a major cause of mortality worldwide so identification of factors such as PavA that are necessary for carriage and for translocation from tissue to blood is of clinical and therapeutic importance...
  3. doi The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease
    Luke Richards
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE19HN, United Kingdom
    Immunobiology 215:251-63. 2010
    ..Our results suggest that both mucosal and systemic antibody as well as cellular host factors have a role in long-term protection against both colonisation and invasive pneumococcal challenge...
  4. pmc Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin
    Rania Jounblat
    Department of Microbiology and Immunology, University of Leicester, University Road, Leicester, LE1 9HN, UK
    Infect Immun 71:1813-9. 2003
    ..The complement-activating activity of pneumolysin affected the accumulation of T cells, whereas the toxin's cytolytic activity influenced neutrophil recruitment into lung tissue...
  5. doi A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection
    Melissa E K Carter
    Department of Infection, Immunity, and Infection, University of Leicester, Leicester, United Kingdom
    J Infect Dis 202:935-42. 2010
    ....
  6. pmc Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis
    Sonia Manco
    Department of Infection, Immunity and Inflammation, University of Leicester, P O Box 138, University Rd, Leicester LE1 9HN, United Kingdom
    Infect Immun 74:4014-20. 2006
    ..The work presented here demonstrates the importance of pneumococcal neuraminidase A and for the first time neuraminidase B in the development of upper and lower respiratory tract infection and sepsis...
  7. pmc Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type
    Aras Kadioglu
    Department of Microbiology and Immunology, University of Leicester, Leicester, LE1 United Kingdom
    Infect Immun 70:2886-90. 2002
    ..The combination of capsule type and genetic background also determined virulence. Thus, the wild-type serotype 3 strain was virulent, whereas the capsule-switched mutant was avirulent...
  8. doi The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Immunol 186:5907-15. 2011
    ....
  9. doi Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin
    Glenn Cruse
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
    J Immunol 184:7108-15. 2010
    ..This suggests that mast cells provide an early warning system and potentially limit pneumococcal dissemination early in the course of invasive pulmonary pneumococcal disease...
  10. doi Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice
    Aras Kadioglu
    Department of Infection, Immunity, and Inflammation, University of Leicester, United Kingdom
    J Infect Dis 204:1971-9. 2011
    ..The data presented here describe surprising differences in survival rates, neutrophil recruitment, and proinflammatory cytokine levels, indicating a sex-based difference in susceptibility to respiratory and systemic pneumococcal disease...
  11. pmc T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice
    Daniel R Neill
    Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom
    PLoS Pathog 8:e1002660. 2012
    ..This study provides exciting new evidence for the importance of immunomodulation during pulmonary pneumococcal infection and suggests that TGF-β signalling is a potential target for immunotherapy or drug design...
  12. doi Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections
    Hany Ibrahim Kenawy
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Immunobiology 217:272-80. 2012
    ..aeruginosa infection. We conclude that the lectin pathway does not play an essential role in fighting P. aeruginosa infection in mice...
  13. pmc CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Infect Immun 72:2689-97. 2004
    ..There is evidence that the activation of IL-4 expression occurs during migration...
  14. ncbi The innate immune response to pneumococcal lung infection: the untold story
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U K
    Trends Immunol 25:143-9. 2004
  15. pmc Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils
    Rania Jounblat
    Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, LE1 9HN, United Kingdom
    Infect Immun 72:709-16. 2004
    ..Therefore, although the capsule serotype is not the only determinant of aggregation by SP-D, the data presented here indicate that it does have a role to play...
  16. pmc The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
    Youssif M Ali
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS Pathog 8:e1002793. 2012
    ..This study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of MBL-independent lectin pathway activation in the host defense against pneumococci...
  17. ncbi Susceptibility and resistance to pneumococcal disease in mice
    Aras Kadioglu
    Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester, LE1 9HN, UK
    Brief Funct Genomic Proteomic 4:241-7. 2005
    ..This review summarises the current knowledge of mouse susceptibility and resistance to pneumococcal infection...
  18. pmc Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14
    Ewan M Harrison
    Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
    Infect Immun 78:1437-46. 2010
    ....
  19. pmc The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae
    Aras Kadioglu
    Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Infect Immun 71:6676-9. 2003
    ..It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection...
  20. doi Increased TNF expression in CD43++ murine blood monocytes
    Bernard Burke
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Immunol Lett 118:142-7. 2008
    ..These data indicate that the murine CD43++ monocyte subset exhibits features of pro-inflammatory monocytes and is functionally homologeous to the human CD14+CD16+ monocytes...
  21. ncbi The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo
    Clare P Lawrence
    Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom
    J Immunol 177:3827-36. 2006
    ..Because host response to bronchopneumonia in mice is T cell dependent, our collective results demonstrated that z-FA-FMK is immunosuppressive in vitro and in vivo...
  22. pmc Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis
    Marco R Oggioni
    Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita di Siena, Siena, Italy
    Mol Microbiol 61:1196-210. 2006
    ..During bacteraemic sepsis pneumococci resemble planktonic growth, while during tissue infection, such as pneumonia or meningitis, pneumococci are in a biofilm-like state...
  23. ncbi Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts
    Alison R Kerr
    Division of Infection and Immunity, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Microbes Infect 7:845-52. 2005
    ..Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome...
  24. pmc Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae
    Jose Echenique
    Laboratoire d Interactions et Signalisation Cellulaire Relation Hôte Pathogène, Institut Louis Bugnard, Centre Hospitalo Universitaire de Rangueil, Universite Paul Sabatier, 31403 Toulouse Cedex, France
    Infect Immun 72:2434-7. 2004
    ..This is the first description of positive regulation of comCDE transcription in balance with its repression by CiaRH...
  25. ncbi The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae
    Hasan Yesilkaya
    FEMS Microbiol Lett 278:231-5. 2008
    ..Growth in mucin resulted in an increase in nanA transcription and a DeltananA-deficient strain of pneumococcus could not grow when mucin was used as the sole carbon source...