Research Topics
Genomes and Genes | Aras KadiogluSummaryAffiliation: University of Leicester Country: UK Publications
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Publications
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and diseaseAras Kadioglu
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
Nat Rev Microbiol 6:288-301. 2008..In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease...- Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsisA Kadioglu
Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, UK
Mol Oral Microbiol 25:50-60. 2010..Pneumococcal sepsis is a major cause of mortality worldwide so identification of factors such as PavA that are necessary for carriage and for translocation from tissue to blood is of clinical and therapeutic importance... - The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive diseaseLuke Richards
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE19HN, United Kingdom
Immunobiology 215:251-63. 2010..Our results suggest that both mucosal and systemic antibody as well as cellular host factors have a role in long-term protection against both colonisation and invasive pneumococcal challenge... 
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysinRania Jounblat
Department of Microbiology and Immunology, University of Leicester, University Road, Leicester, LE1 9HN, UK
Infect Immun 71:1813-9. 2003..The complement-activating activity of pneumolysin affected the accumulation of T cells, whereas the toxin's cytolytic activity influenced neutrophil recruitment into lung tissue...- Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsisSonia Manco
Department of Infection, Immunity and Inflammation, University of Leicester, P.O. Box 138, University Rd, Leicester LE1 9HN, United Kingdom
Infect Immun 74:4014-20. 2006..The work presented here demonstrates the importance of pneumococcal neuraminidase A and for the first time neuraminidase B in the development of upper and lower respiratory tract infection and sepsis... - A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infectionMelissa E K Carter
Department of Infection, Immunity, and Infection, University of Leicester, Leicester, United Kingdom
J Infect Dis 202:935-42. 2010.... - Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule typeAras Kadioglu
Department of Microbiology and Immunology, University of Leicester, Leicester, LE1 United Kingdom
Infect Immun 70:2886-90. 2002..The combination of capsule type and genetic background also determined virulence. Thus, the wild-type serotype 3 strain was virulent, whereas the capsule-switched mutant was avirulent... - Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysinGlenn Cruse
Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester Medical School, Leicester, United Kingdom
J Immunol 184:7108-15. 2010..This suggests that mast cells provide an early warning system and potentially limit pneumococcal dissemination early in the course of invasive pulmonary pneumococcal disease... - The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infectionAras Kadioglu
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
J Immunol 186:5907-15. 2011.... - Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in miceAras Kadioglu
Department of Infection, Immunity, and Inflammation, University of Leicester, United Kingdom
J Infect Dis 204:1971-9. 2011..The data presented here describe surprising differences in survival rates, neutrophil recruitment, and proinflammatory cytokine levels, indicating a sex-based difference in susceptibility to respiratory and systemic pneumococcal disease... - T regulatory cells control susceptibility to invasive pneumococcal pneumonia in miceDaniel R Neill
Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom
PLoS Pathog 8:e1002660. 2012..This study provides exciting new evidence for the importance of immunomodulation during pulmonary pneumococcal infection and suggests that TGF-β signalling is a potential target for immunotherapy or drug design... - Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infectionsHany Ibrahim Kenawy
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
Immunobiology 217:272-80. 2012..aeruginosa infection. We conclude that the lectin pathway does not play an essential role in fighting P. aeruginosa infection in mice... - CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infectionAras Kadioglu
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
Infect Immun 72:2689-97. 2004..There is evidence that the activation of IL-4 expression occurs during migration... - Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophilsRania Jounblat
Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, LE1 9HN, United Kingdom
Infect Immun 72:709-16. 2004..Therefore, although the capsule serotype is not the only determinant of aggregation by SP-D, the data presented here indicate that it does have a role to play... 
The innate immune response to pneumococcal lung infection: the untold storyAras Kadioglu
Department of Infection, Immunity and Inflammation, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K
Trends Immunol 25:143-9. 2004- Susceptibility and resistance to pneumococcal disease in miceAras Kadioglu
Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester, LE1 9HN, UK
Brief Funct Genomic Proteomic 4:241-7. 2005..This review summarises the current knowledge of mouse susceptibility and resistance to pneumococcal infection... - The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniaeAras Kadioglu
Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN, United Kingdom
Infect Immun 71:6676-9. 2003..It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection... - Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14Ewan M Harrison
Department of Infection, University of Leicester, Leicester LE1 9HN, United Kingdom
Infect Immun 78:1437-46. 2010.... - The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivoClare P Lawrence
Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom
J Immunol 177:3827-36. 2006..Because host response to bronchopneumonia in mice is T cell dependent, our collective results demonstrated that z-FA-FMK is immunosuppressive in vitro and in vivo... - Increased TNF expression in CD43++ murine blood monocytesBernard Burke
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
Immunol Lett 118:142-7. 2008..These data indicate that the murine CD43++ monocyte subset exhibits features of pro-inflammatory monocytes and is functionally homologeous to the human CD14+CD16+ monocytes... - Switch from planktonic to sessile life: a major event in pneumococcal pathogenesisMarco R Oggioni
Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita di Siena, Siena, Italy
Mol Microbiol 61:1196-210. 2006..During bacteraemic sepsis pneumococci resemble planktonic growth, while during tissue infection, such as pneumonia or meningitis, pneumococci are in a biofilm-like state... - Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniaeJose Echenique
, Institut Louis Bugnard, Centre Hospitalo Universitaire de Rangueil, , 31403 Toulouse Cedex, France
Infect Immun 72:2434-7. 2004..This is the first description of positive regulation of comCDE transcription in balance with its repression by CiaRH... - Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hostsAlison R Kerr
Division of Infection and Immunity, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
Microbes Infect 7:845-52. 2005..Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome... - The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniaeHasan Yesilkaya
FEMS Microbiol Lett 278:231-5. 2008..Growth in mucin resulted in an increase in nanA transcription and a DeltananA-deficient strain of pneumococcus could not grow when mucin was used as the sole carbon source...