Gabriella Juhasz

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint [Application of pharmaco functional magnetic resonance imaging (phMRI) in the research of affective disorders]
    Andrea Edit Edes
    Semmelweis Egyetem, Gyógyszerhatástani Intézet, Budapest, Hungary
    Neuropsychopharmacol Hung 16:59-66. 2014
  2. doi request reprint The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, United Kingdom
    Biol Psychiatry 69:762-71. 2011
  3. pmc Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Neuropsychopharmacology 35:1109-19. 2010
  4. doi request reprint Variations in the cannabinoid receptor 1 gene predispose to migraine
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK
    Neurosci Lett 461:116-20. 2009
  5. doi request reprint CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Neuropsychopharmacology 34:2019-27. 2009
  6. doi request reprint The HTR1A and HTR1B receptor genes influence stress-related information processing
    Krisztina Mekli
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, UK
    Eur Neuropsychopharmacol 21:129-39. 2011
  7. ncbi request reprint Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102T/C polymorphism and migraine
    Gabriella Juhasz
    Laboratory of Neurochemistry and Experimental Medicine, and Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Budapest, Hungary
    J Neurogenet 17:231-40. 2003
  8. doi request reprint Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression
    Dorottya Pap
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 159:928-40. 2012
  9. doi request reprint Star-crossed? The association of the 5-HTTLPR s allele with season of birth in a healthy female population, and possible consequences for temperament, depression and suicide
    Xenia Gonda
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
    J Affect Disord 143:75-83. 2012
  10. doi request reprint Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene
    Eszter Molnar
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Eur Neuropsychopharmacol 20:655-62. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint [Application of pharmaco functional magnetic resonance imaging (phMRI) in the research of affective disorders]
    Andrea Edit Edes
    Semmelweis Egyetem, Gyógyszerhatástani Intézet, Budapest, Hungary
    Neuropsychopharmacol Hung 16:59-66. 2014
    ..Thus, the application of phMRI methods may help deepen our understanding of serotonergic function in the living human brain as well as of diseases related to serotonergic neurotransmitter system dysfunction. ..
  2. doi request reprint The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, United Kingdom
    Biol Psychiatry 69:762-71. 2011
    ....
  3. pmc Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Neuropsychopharmacology 35:1109-19. 2010
    ..In conclusion, our study demonstrates the role of the TPH2 gene and the serotonin system in risk taking and suggests that TPH2 gene may contribute to the expression of psychiatric phenotypes through altered decision making...
  4. doi request reprint Variations in the cannabinoid receptor 1 gene predispose to migraine
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK
    Neurosci Lett 461:116-20. 2009
    ..However, further studies are needed to elucidate the role of CNR1 and the cannabinoid system in migraine...
  5. doi request reprint CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Neuropsychopharmacology 34:2019-27. 2009
    ..This study also suggests that the CNR1 gene influences vulnerability to recent psychosocial adversity to produce current symptoms of depression...
  6. doi request reprint The HTR1A and HTR1B receptor genes influence stress-related information processing
    Krisztina Mekli
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, The University of Manchester, UK
    Eur Neuropsychopharmacol 21:129-39. 2011
    ....
  7. ncbi request reprint Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102T/C polymorphism and migraine
    Gabriella Juhasz
    Laboratory of Neurochemistry and Experimental Medicine, and Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Budapest, Hungary
    J Neurogenet 17:231-40. 2003
    ..In conclusion, our results support that the genetic susceptibility of migraine may be associated with a locus at or near the 5-HT transporter gene...
  8. doi request reprint Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression
    Dorottya Pap
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 159:928-40. 2012
    ..These findings emphasise that modeling of disease pathways at phenotypic level are valuable for identifying genetic risk factors...
  9. doi request reprint Star-crossed? The association of the 5-HTTLPR s allele with season of birth in a healthy female population, and possible consequences for temperament, depression and suicide
    Xenia Gonda
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
    J Affect Disord 143:75-83. 2012
    ..Our aim was to investigate the association of 5-HTTLPR genotype and birth season in a healthy female population...
  10. doi request reprint Seasonality and winter-type seasonal depression are associated with the rs731779 polymorphism of the serotonin-2A receptor gene
    Eszter Molnar
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Eur Neuropsychopharmacol 20:655-62. 2010
    ..The fact that the above polymorphism showed association not only with clinical SAD but also seasonality symptoms in a general population provides evidence for the spectrum nature of this connection...
  11. doi request reprint Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype
    Judit Lazary
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 150:1118-27. 2009
    ..In conclusion, genetically determined serotonergic and endocannabinoid dysfunctions could lead to a vulnerability causing anxiety disorders and possibly depression...
  12. doi request reprint State-dependent alteration in face emotion recognition in depression
    Ian M Anderson
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Br J Psychiatry 198:302-8. 2011
    ..Negative biases in emotional processing are well recognised in people who are currently depressed but are less well described in those with a history of depression, where such biases may contribute to vulnerability to relapse...
  13. doi request reprint Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment
    Danilo Arnone
    Neuroscience and Psychiatry Unit and Department of Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom
    Am J Psychiatry 169:841-50. 2012
    ....
  14. doi request reprint Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population
    Xenia Gonda
    Dept of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Centre, Semmelweis University, Kutvolgyi ut 4, 1125, Budapest, Hungary
    Eur Arch Psychiatry Clin Neurosci 259:106-13. 2009
    ..The aim of our study was to investigate the association of the 5-HTTLPR polymorphism with several smaller, distinct and better characterisable phenomena related to the neuroticism trait...
  15. doi request reprint Significant association between the C(-1019)G functional polymorphism of the HTR1A gene and impulsivity
    Anita Benko
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 153:592-9. 2010
    ..002), and for the BIS total score (P = 0.008) but not for the Nonplanning Impulsiveness (P = 0.520) subscale of the BIS-11. Our results suggest the involvement of the HTR(1A) in the continuum phenotype of impulsivity...
  16. doi request reprint Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality
    Judit Lazary
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Eur Neuropsychopharmacol 21:63-70. 2011
    ..Our results suggest that genetic epistasis in post-receptor signaling pathways in memory systems may have relevance for depression and its treatment...
  17. doi request reprint The effect of acute citalopram on face emotion processing in remitted depression: a pharmacoMRI study
    Ian M Anderson
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, M13 9PT, UK
    Eur Neuropsychopharmacol 21:140-8. 2011
    ....
  18. ncbi request reprint TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder
    Martyn McFarquhar
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Neuropsychopharmacology 39:1743-53. 2014
    ....
  19. ncbi request reprint The relationship between the big five personality dimensions and acute psychopathology: mediating and moderating effects of coping strategies
    Zsuzsanna Mirnics
    Institute of Psychology, Károli Gáspár University of the Reformed Church, 1037 Bp Bécsi út 324, Budapest, Hungary
    Psychiatr Danub 25:379-88. 2013
    ..The aim of the present study was to investigate direct and indirect associations between the Big Five personality traits, coping styles, and psychopathological variables...
  20. ncbi request reprint New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype
    Judit Lazary
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Biol Psychiatry 64:498-504. 2008
    ..To clarify this question, we analyzed the interaction between the serotonin transporter gene (SLC6A4) and threatening life events (TLE) on Zung Self-Rating Depression Score (ZSDS)...
  21. pmc Reversed frontotemporal connectivity during emotional face processing in remitted depression
    Nia Goulden
    Neuroscience and Psychiatry Unit, University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United Kingdom
    Biol Psychiatry 72:604-11. 2012
    ..This suggests the problem might lie in the integrated functioning of emotion processing circuits...
  22. ncbi request reprint Brain galanin system genes interact with life stresses in depression-related phenotypes
    Gabriella Juhasz
    Department of Pharmacodynamics, Semmelweis University, 1089, Budapest, Hungary
    Proc Natl Acad Sci U S A 111:E1666-73. 2014
    ..Correcting abnormal galanin function in depression could prove to be a novel target for drug development. The findings further emphasize the importance of modeling environmental interaction in finding new genes for depression. ..
  23. ncbi request reprint NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release
    Gabriella Juhasz
    Laboratory of Neurochemistry and Experimental Medicine, Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Huvosvolgyi ut 116, Budapest, H 1021, Hungary
    Pain 106:461-70. 2003
    ..In contrast, serotonin release from platelets does not provoke migraine, it may even counteract the headache and the concomitant CGRP release in this model...
  24. ncbi request reprint Cultural differences in the development and characteristics of depression
    Gabriella Juhasz
    Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
    Neuropsychopharmacol Hung 14:259-65. 2012
    ..In the present paper we describe the most consistently replicated findings concerning the most important cross-national differences in the rates and characteristics of depression with a short comment on possible background factors...
  25. doi request reprint Reduced medial prefrontal responses to social interaction images in remitted depression
    Rebecca Elliott
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, England
    Arch Gen Psychiatry 69:37-45. 2012
    ..Stimuli with social context represent a distinct class of emotional stimuli, which in healthy volunteers are associated with specific neural substrates but have not previously been studied relative to vulnerability to depression...
  26. doi request reprint Hopelessness, a potential endophenotpye for suicidal behavior, is influenced by TPH2 gene variants
    Judit Lazary
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
    Prog Neuropsychopharmacol Biol Psychiatry 36:155-60. 2012
    ..We hypothesized that hopelessness could be a mediating phenotype between TPH2 gene, depression and suicidal behavior...
  27. ncbi request reprint Effects of autogenic training on nitroglycerin-induced headaches
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK
    Headache 47:371-83. 2007
    ..To investigate the prophylactic and acute effects of autogenic training (AT) during a nitroglycerin-induced migraine attack...
  28. ncbi request reprint Despite the general correlation of the serotonin transporter gene regulatory region polymorphism (5-HTTLPR) and platelet serotonin concentration, lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants
    Gabriella Juhasz
    Laboratory of Neurochemistry and Experimental Medicine, and Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Budapest, Huvosvolgyi ut 116, H 1021, Hungary
    Neurosci Lett 350:56-60. 2003
    ..In conclusion, 5-HTTLPR variants may have an effect on the platelet 5-HT concentrations, but the lower 5-HT concentrations in migraine patients seem to be determined by other factors...
  29. doi request reprint Personalized medicine can pave the way for the safe use of CB₁ receptor antagonists
    Judit Lazary
    Kutvolgyi Clinical Centre, Semmelweis University, Budapest, Hungary
    Trends Pharmacol Sci 32:270-80. 2011
    ....
  30. ncbi request reprint 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy
    Rita Jakus
    Laboratory of Neurochemistry and Experimental Medicine, Department of Vascular Neurology, Semmelweis University, Budapest, Hungary
    Exp Neurol 184:964-72. 2003
    ..In conclusion, these results indicate that the increase in endogenous 5-HT produces a dual effect on SWD; the inhibition of epileptiform activity is mediated by 5-HT(2C), the activation by 5-HT(1A) receptors...