Sarah J Judge

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system
    Sarah J Judge
    Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK Electronic address
    Chem Biol Interact 245:82-9. 2016
  2. ncbi request reprint GABA receptor modulation of 5-HT neuronal firing: characterization and effect of moderate in vivo variations in glucocorticoid levels
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Neurochem Int 45:1057-65. 2004
  3. ncbi request reprint Moderate differences in circulating corticosterone alter receptor-mediated regulation of 5-hydroxytryptamine neuronal activity
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne NE2 4HH, UK
    J Psychopharmacol 18:475-83. 2004
  4. ncbi request reprint Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Neurochem Int 48:100-7. 2006
  5. ncbi request reprint GABA(A) receptor modulation of 5-HT neuronal firing in the median raphe nucleus: implications for the action of anxiolytics
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Eur Neuropsychopharmacol 16:612-9. 2006
  6. ncbi request reprint The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity
    Vikas Kaura
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Eur Neuropsychopharmacol 17:108-15. 2007
  7. doi request reprint Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour
    Claire Y Savy
    Medical Toxicology Centre, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UK Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Neurotoxicology 50:149-56. 2015
  8. doi request reprint Sex differences in effects of low level domoic acid exposure
    Andrew W Baron
    Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne NE2 4AA, UK
    Neurotoxicology 34:1-8. 2013

Collaborators

Detail Information

Publications8

  1. doi request reprint Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system
    Sarah J Judge
    Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, NE2 4AA, UK Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK Electronic address
    Chem Biol Interact 245:82-9. 2016
    ..This mechanism may be involved in the reported increase in risk of developing anxiety and depression following occupational OP exposure. ..
  2. ncbi request reprint GABA receptor modulation of 5-HT neuronal firing: characterization and effect of moderate in vivo variations in glucocorticoid levels
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Neurochem Int 45:1057-65. 2004
    ..The data indicate that the control of 5-HT neuronal activity by GABA is mediated by both GABA(A) and GABA(B) receptors and that this control is insensitive to moderate changes in circulating glucocorticoid levels...
  3. ncbi request reprint Moderate differences in circulating corticosterone alter receptor-mediated regulation of 5-hydroxytryptamine neuronal activity
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne NE2 4HH, UK
    J Psychopharmacol 18:475-83. 2004
    ..This shift would have a major impact on control of 5-HT neuronal activity...
  4. ncbi request reprint Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Neurochem Int 48:100-7. 2006
    ..The lower sensitivity of median raphe neurones to alpha(1)-adrenoceptor excitation and 5-HT(1A) receptor inhibition will have consequences for 5-HT neurotransmission in forebrain regions innervated by the two nuclei...
  5. ncbi request reprint GABA(A) receptor modulation of 5-HT neuronal firing in the median raphe nucleus: implications for the action of anxiolytics
    Sarah J Judge
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Eur Neuropsychopharmacol 16:612-9. 2006
    ..The anxiolytic effects of GABA(A) receptor modulators are reportedly mediated by alpha(3)-containing receptors. Hence the MRN 5-HT system may be a target for anxiolytic drugs...
  6. ncbi request reprint The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity
    Vikas Kaura
    Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, UK
    Eur Neuropsychopharmacol 17:108-15. 2007
    ..This effect on 5-HT neurotransmission may have relevance for mood disorders commonly associated with reproductive hormone events, such as premenstrual dysphoric disorder and postpartum depression...
  7. doi request reprint Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour
    Claire Y Savy
    Medical Toxicology Centre, Newcastle University, Claremont Place, Newcastle upon Tyne NE2 4AA, UK Institute of Neuroscience, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Neurotoxicology 50:149-56. 2015
    ..These data indicate exposure to occupational and domestic OPs, below the threshold to inhibit acetylcholinesterase, can subtly alter behaviour and neurochemistry. ..
  8. doi request reprint Sex differences in effects of low level domoic acid exposure
    Andrew W Baron
    Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne NE2 4AA, UK
    Neurotoxicology 34:1-8. 2013
    ..Understanding sex differences in DOM-induced neurotoxicity may contribute to future protective strategies and treatments...