Roy W Jones

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. doi Rates of cognitive change in Alzheimer disease: observations across a decade of placebo-controlled clinical trials with donepezil
    Roy W Jones
    Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
    Alzheimer Dis Assoc Disord 23:357-64. 2009
  2. pmc Dimebon disappointment
    Roy W Jones
    Research Institute for the Care of Older People, Royal United Hospital, Bath BA1 3NG, UK
    Alzheimers Res Ther 2:25. 2010
  3. ncbi Dementia, postcode prescribing and NICE
    Roy W Jones
    Age Ageing 33:331-2. 2004
  4. pmc Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
    Linda Clare
    School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
    Trials 14:152. 2013
  5. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
  6. ncbi The dementias
    Roy W Jones
    The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath
    Clin Med 3:404-8. 2003
  7. ncbi Safety and tolerability of once-daily versus twice-daily memantine: a randomised, double-blind study in moderate to severe Alzheimer's disease
    Roy W Jones
    Research Institute for the Care of the Elderly RICE, Bath, UK
    Int J Geriatr Psychiatry 22:258-62. 2007
  8. ncbi Assessing attitudes and behaviours surrounding Alzheimer's disease in Europe: key findings of the Important Perspectives on Alzheimer's Care and Treatment (IMPACT) survey
    R W Jones
    RICE Centre, Royal United Hospital, Combe Park, Bath, UK
    J Nutr Health Aging 14:525-30. 2010
  9. ncbi Have cholinergic therapies reached their clinical boundary in Alzheimer's disease?
    Roy W Jones
    The Research Institute for the Care of the Elderly, St Martins Hospital, Bath, UK
    Int J Geriatr Psychiatry 18:S7-S13. 2003
  10. doi A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors
    R W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
    Int J Geriatr Psychiatry 25:547-53. 2010

Detail Information

Publications32

  1. doi Rates of cognitive change in Alzheimer disease: observations across a decade of placebo-controlled clinical trials with donepezil
    Roy W Jones
    Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
    Alzheimer Dis Assoc Disord 23:357-64. 2009
    ..This finding may have important potential implications for future clinical trial design...
  2. pmc Dimebon disappointment
    Roy W Jones
    Research Institute for the Care of Older People, Royal United Hospital, Bath BA1 3NG, UK
    Alzheimers Res Ther 2:25. 2010
    ..The potential reasons for these disappointing results are discussed, as well as the implication for dimebon and drug treatment in Alzheimer's disease...
  3. ncbi Dementia, postcode prescribing and NICE
    Roy W Jones
    Age Ageing 33:331-2. 2004
  4. pmc Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
    Linda Clare
    School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
    Trials 14:152. 2013
    ..This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers...
  5. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
    ..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
  6. ncbi The dementias
    Roy W Jones
    The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath
    Clin Med 3:404-8. 2003
  7. ncbi Safety and tolerability of once-daily versus twice-daily memantine: a randomised, double-blind study in moderate to severe Alzheimer's disease
    Roy W Jones
    Research Institute for the Care of the Elderly RICE, Bath, UK
    Int J Geriatr Psychiatry 22:258-62. 2007
    ..To assess the safety and tolerability of three different dosing schedules of memantine in patients with moderate to severe Alzheimer's disease (AD)...
  8. ncbi Assessing attitudes and behaviours surrounding Alzheimer's disease in Europe: key findings of the Important Perspectives on Alzheimer's Care and Treatment (IMPACT) survey
    R W Jones
    RICE Centre, Royal United Hospital, Combe Park, Bath, UK
    J Nutr Health Aging 14:525-30. 2010
    ..Despite the prevalence of AD in the ageing population of Europe, the perception within each of the 5 countries surveyed is that AD is not viewed as a health care priority...
  9. ncbi Have cholinergic therapies reached their clinical boundary in Alzheimer's disease?
    Roy W Jones
    The Research Institute for the Care of the Elderly, St Martins Hospital, Bath, UK
    Int J Geriatr Psychiatry 18:S7-S13. 2003
    ..Trials are also being conducted in Mild Cognitive Impairment, other dementias and other conditions where cognitive impairment is a problem...
  10. doi A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors
    R W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
    Int J Geriatr Psychiatry 25:547-53. 2010
    ..This paper reviews the most recent safety data for memantine in comparison with the AChEIs...
  11. doi The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics
    Roy W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
    Alzheimers Dement 4:145-53. 2008
    ....
  12. pmc Collaborative research between academia and industry using a large clinical trial database: a case study in Alzheimer's disease
    Roy Jones
    Research Institute for the Care of Older People, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
    Trials 12:233. 2011
    ..We present here a successful example of this type of collaboration in the field of dementia...
  13. ncbi A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease
    Roy W Jones
    Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
    Int J Geriatr Psychiatry 19:58-67. 2004
    ....
  14. ncbi Physicians and caregivers: ready and waiting for increased participation in clinical research
    R W Jones
    Rice, Royal United Hospital, Combe Park, Bath, UK
    J Nutr Health Aging 14:563-8. 2010
    ....
  15. doi Making errorless learning more active: self-generation in an error free learning context is superior to standard errorless learning of face-name associations in people with Alzheimer's disease
    Amanda J Laffan
    Research Institute for the Care of Older People, Hillview Lodge, Royal United Hospital, Combe Park, Bath, Somerset, UK
    Neuropsychol Rehabil 20:197-211. 2010
    ..The implications of this research for individualised memory rehabilitation programmes are discussed...
  16. doi A direct comparison of errorless and errorful therapy for object name relearning in Alzheimer's disease
    Krist A Noonan
    Research Institute for Care of Older People, Royal United Hospital, Bath, UK
    Neuropsychol Rehabil 22:215-34. 2012
    ..These results suggest that either EL or EF therapy can be used to alleviate word-finding problems in AD...
  17. ncbi Disordered memory awareness: recollective confabulation in two cases of persistent déjà vecu
    Christopher J A Moulin
    The Research Institute for the Care of the Elderly, St Martin s Hospital, UK
    Neuropsychologia 43:1362-78. 2005
    ....
  18. ncbi Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes
    Ian W Jones
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    J Mol Neurosci 30:83-4. 2006
    ..We have undertaken a semiquantitative histological evaluation of alpha7 nAChR expression in a mouse model of AD pathology, as well as a comparison of alpha7 nAChR levels in lymphocytes from AD patients and control subjects...
  19. ncbi Music enhances category fluency in healthy older adults and Alzheimer's disease patients
    R G Thompson
    The Research Institute for the Care of the Elderly, Bath, UK
    Exp Aging Res 31:91-9. 2005
    ..In keeping with previous reports, the authors conclude that music enhances attentional processes, and that this can be demonstrated in Alzheimer's disease...
  20. ncbi The significance of dyslexia screening for the assessment of dementia in older people
    Claudia Metzler-Baddeley
    The Research Institute for the Care of Older People RICE, Bath, UK
    Int J Geriatr Psychiatry 23:766-8. 2008
    ..These results highlight the importance of dyslexia screening for the assessment of dementia, not least because the choice of treatment is guided by the outcome of the assessment of the severity and the type of dementia...
  21. ncbi Cost effectiveness of memantine in Alzheimer's disease: an analysis based on a probabilistic Markov model from a UK perspective
    Roy W Jones
    The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
    Drugs Aging 21:607-20. 2004
    ..While these findings suggest that, compared with placebo, memantine provides cost savings, further analyses may help to quantify potential economic gains over a longer treatment period...
  22. doi Visual impairments in dementia with Lewy bodies and posterior cortical atrophy
    Claudia Metzler-Baddeley
    Research Institute for the Care of Older People RICE, The RICE Centre, Royal United Hospital, Bath, BA1 3NG, United Kingdom
    Neuropsychology 24:35-48. 2010
    ..The latter suggests that both lower and higher level visual impairments contribute to the complex visual symptoms associated with PCA...
  23. ncbi Deficient acquisition and consolidation: intertrial free recall performance in Alzheimer's disease and mild cognitive impairment
    Christopher J A Moulin
    Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK and School of Psychology, University of Leeds, Leeds, UK
    J Clin Exp Neuropsychol 26:1-10. 2004
    ..Finally, we showed strong correlations between our measure and dementia severity, suggesting that acquisition and consolidation both get worse as the dementia progresses...
  24. ncbi Recall of 9.11 in Alzheimer's disease: further evidence for intact flashbulb memory
    R G Thompson
    The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath BA2 5RP, UK
    Int J Geriatr Psychiatry 19:495-6. 2004
  25. ncbi Donepezil for the treatment of agitation in Alzheimer's disease
    Robert J Howard
    Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    N Engl J Med 357:1382-92. 2007
    ..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear...
  26. ncbi Deficits for semantics and the irregular past tense: a causal relationship?
    Lorraine K Tyler
    Department of Experimental Psychology, University of Cambridge, Cambridge CB3 ODX, UK
    J Cogn Neurosci 16:1159-72. 2004
    ....
  27. doi Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
    Clive Holmes
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
    Lancet 372:216-23. 2008
    ..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
  28. ncbi How can we best assess the quality of life of people with dementia? the Bath Assessment of Subjective Quality of Life in Dementia (BASQID)
    Richard Trigg
    Department of Psychology, World Health Organization Centre for the Study of Quality of Life, University of Bath, England
    Gerontologist 47:789-97. 2007
    ..The study aim was to develop a measure of self-reported quality of life (QoL) for people with mild to moderate dementia based on their views-the Bath Assessment of Subjective Quality of Life in Dementia (BASQID)...
  29. ncbi Can people with mild to moderate dementia provide reliable answers about their quality of life?
    Richard Trigg
    Department of Psychology, WHO Centre for the Study of Quality of Life, University of Bath, UK
    Age Ageing 36:663-9. 2007
    ..However growing evidence suggests that people with mild to moderate dementia may be able to complete standardised questionnaire items and articulate feelings, providing reliable evaluations of their health and QoL...
  30. ncbi Memantine in moderate to severe Alzheimer's disease: a meta-analysis of randomised clinical trials
    Bengt Winblad
    Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 24:20-7. 2007
    ..Memantine was well tolerated, and the overall incidence rates of adverse events were comparable to placebo. This meta-analysis supports memantine's clinically relevant efficacy in patients with moderate to severe AD...
  31. ncbi A category-specific advantage for numbers in verbal short-term memory: evidence from semantic dementia
    Elizabeth Jefferies
    University of Bristol, Bristol, UK
    Neuropsychologia 42:639-60. 2004
    ....
  32. ncbi Retrieval-induced forgetting in Alzheimer's disease
    Chris J A Moulin
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Neuropsychologia 40:862-7. 2002
    ..This suggests that a deficit in inhibitory processes during retrieval is not behind the high levels of intrusion errors made in recall in AD...