Research Topics
Species | Peter B JonesSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Adult mental health disorders and their age at onsetP B Jones
Department of Psychiatry, University of Cambridge, Cameo Early Intervention Services, Cambridgeshire and Peterborough Foundation National Health Service Trust, Herchel Smith Building for Brain and Mind Science, Cambridge CB2 0SX, UK
Br J Psychiatry Suppl 54:s5-10. 2013..The paper then discusses whether this fits what is known about the developmental neurobiology of the brain and introduces the implications for mental health services...
Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)Peter B Jones
Department of Psychiatry, University of Cambridge and Cambridgeshire and Peterborough Mental Health NHS Trust, Cambridge, England
Arch Gen Psychiatry 63:1079-87. 2006..Most evidence comes from short-term efficacy trials of symptoms...- Neuregulin-1 genotype is associated with structural differences in the normal human brainAnna Barnes
Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Neuroimage 59:2057-61. 2012..These results suggest that this genetic variant may mediate risk for schizophrenia, in part, through its effect on brain structure in these regions... 
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of childrenJennifer H Barnett
Department of Psychiatryand the Centre for Family Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Am J Psychiatry 166:909-16. 2009..The authors tested the hypothesis that a more informative COMT haplotype predicts normal cognitive development in a large population-based cohort of children enrolled in the Avon Longitudinal Study of Parents and Children...- No association of COMT (Val158Met) genotype with brain structure differences between men and womenAnna Barnes
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
PLoS ONE 7:e33964. 2012.... - Neurological abnormalities and cognitive ability in first-episode psychosisPaola Dazzan
Department of Psychiatry, Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 193:197-202. 2008.... - Neighbourhood variation in the incidence of psychotic disorders in Southeast LondonJames B Kirkbride
Dept of Psychiatry, University of Cambridge, Box 189, Cambridge CB2 2QQ, UK
Soc Psychiatry Psychiatr Epidemiol 42:438-45. 2007..Urbanicity is a risk factor for schizophrenia, but it is unclear whether this risk is homogenous across urban areas... - Effects of modafinil on cognitive functions in first episode psychosisLinda Scoriels
Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK
Psychopharmacology (Berl) 220:249-58. 2012..Modafinil is a wake-promoting drug that has been shown to improve attention, memory and executive function in the healthy population and in patients with schizophrenia... - Neighbourhood-level effects on psychoses: re-examining the role of contextJames B Kirkbride
Department of Psychiatry, University of Cambridge, Cambridge, UK
Psychol Med 37:1413-25. 2007..Cross-level interactions are poorly understood. We investigated these issues using data from the Aetiology and Ethnicity in Schizophrenia and Other Psychoses (AESOP) study... - Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brainLinda Scoriels
Department of Psychiatry, University of Cambridge, UK
Neuropharmacology 64:168-84. 2013..These reviews seek to delineate the neuronal mechanisms by which modafinil affects cognitive and emotional function. This article is part of a Special Issue entitled 'Cognitive Enhancers'... - Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of maniaEugenia Kravariti
Department of Psychiatry, NIHR Biomedical Research Centre, Maudsley NHS Foundation Trust Institute of Psychiatry, King s College London, Box 58, De Crespigny Park, London SE5 8AF, UK
Bipolar Disord 11:323-9. 2009..We investigated neuropsychological performance in an epidemiologically derived sample of patients with a first affective episode with psychotic symptoms and a positive history of mania, compared to community controls... - Effects of modafinil on emotional processing in first episode psychosisLinda Scoriels
Department of Psychiatry, University of Cambridge, Robinson Way, Cambridge, UK
Biol Psychiatry 69:457-64. 2011..We aimed to establish whether modafinil might have a role in the adjuvant treatment of emotional impairments in the first episode of psychosis, when therapeutic endeavor is arguably most vital... - Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPRJennifer H Barnett
Department of Psychiatry, University of Cambridge, Cambridge, UK
Am J Med Genet B Neuropsychiatr Genet 156:158-67. 2011..These results suggest that assessment of multiple genes within functionally related systems may improve our understanding of the genetic basis of cognition... - Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analysesJames B Kirkbride
Department of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 7:e31660. 2012.... - Depressive symptoms during adolescence: comparison between epidemiological and high risk samplingMichelle C St Clair
Department of Psychiatry, Developmental and Lifecourse Research Group, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK
Soc Psychiatry Psychiatr Epidemiol 47:1333-41. 2012..This study compared depressive symptoms across the two sampling methods to test this possibility... - Childhood cognitive function and adult psychopathology: associations with psychotic and non-psychotic symptoms in the general populationJennifer H Barnett
Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK
Br J Psychiatry 201:124-30. 2012..Lower cognitive ability in childhood is associated with increased risk of future schizophrenia, but its relationship with adult psychotic-like experiences and other psychopathology is less understood... - The prevention of schizophrenia--what can we learn from eco-epidemiology?James B Kirkbride
Department of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK
Schizophr Bull 37:262-71. 2011..We conclude by speculating on the forms effective strategies might take... - A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophreniaGolam M Khandaker
Department of Psychiatry, University of Cambridge, Cambridge, UK
Schizophr Res 132:220-7. 2011.... - A longitudinal typology of symptoms of depression and anxiety over the life courseIan Colman
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Biol Psychiatry 62:1265-71. 2007..The objective of this study was to identify a novel typology of symptoms of depression and anxiety over the life course and examine its neurodevelopmental antecedents in an epidemiological sample... - 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescenceMatthew Owens
Development and Lifecourse Research Group, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 7:e48482. 2012..Whether these two factors interact to influence cognitive and emotional processing is not known... - Incentive motivation in first-episode psychosis: a behavioural studyGraham K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 8:34. 2008..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue... - Substance use in a population-based clinic sample of people with first-episode psychosisJennifer H Barnett
Department of Psychiatry, Box 189, University of Cambridge, UK
Br J Psychiatry 190:515-20. 2007..Substance use is implicated in the cause and course of psychosis... - Infant developmental milestones and subsequent cognitive functionGraham K Murray
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Ann Neurol 62:128-36. 2007..We hypothesized that earlier attainment of developmental milestones would be associated with better subsequent intellectual performance throughout the range of abilities, rather than confined to extremes... - Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modellingJennifer H Barnett
University of Cambridge Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK
BMC Psychiatry 7:16. 2007..Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function... - Childhood infection and adult schizophrenia: a meta-analysis of population-based studiesGolam M Khandaker
Department of Psychiatry, University of Cambridge, Cambridge, UK
Schizophr Res 139:161-8. 2012..To determine whether exposures to infectious illness during childhood involving the CNS or elsewhere is associated with adult schizophrenia or other psychoses... - Use of the theory of planned behaviour to assess factors influencing the identification of individuals at ultra-high risk for psychosis in primary careDebra A Russo
Cameo Early Intervention Services, Cambridgeshire and Peterborough NHS Foundation Trust, UK
Early Interv Psychiatry 6:265-75. 2012..It will inform the subsequent design of educational interventions to help general practitioners (GPs; primary care physicians) detect these individuals... - Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in childrenJennifer H Barnett
University of Cambridge, Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Am J Psychiatry 164:142-9. 2007..This polymorphism affects cognitive function in healthy adults and may contribute to risk for schizophrenia... - Mokken scale analysis of mental health and well-being questionnaire item responses: a non-parametric IRT method in empirical research for applied health researchersJan Stochl
Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Med Res Methodol 12:74. 2012..abstract:.. - Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental healthValerie J Dunn
Developmental and Life course Research Group, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 11:109. 2011..Adverse family experiences in early life are associated with subsequent psychopathology. This study adds to the growing body of work exploring the nature and associations between adverse experiences over the childhood years... - Psychotic symptoms in young people without psychotic illness: mechanisms and meaningGraham K Murray
Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Br J Psychiatry 201:4-6. 2012..Clinicians should be aware that psychotic symptoms in young people are more often associated with common mental disorders such as depression and anxiety than with severe psychotic illness... - The brain structural disposition to social interactionMaël Lebreton
Brain Mapping Unit, University of Cambridge, Cambridge, UK
Eur J Neurosci 29:2247-52. 2009..These findings provide evidence for a brain structural disposition to social interaction, and that sensitivity to social reward shares a common neural basis with systems for processing primary reward information... - Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?Lisa Ronan
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
Int J Neural Syst 21:351-66. 2011..Thus, the degree of cortical intrinsic curvature may have implications for short-range connectivity... - Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP studyJames B Kirkbride
Department of Psychiatry, University of Cambridge, Cambridge, England
Arch Gen Psychiatry 63:250-8. 2006..Convention suggests uniformity of incidence of schizophrenia and other psychoses; variation would have implications for their causes and biological characteristics...