Nick S Jones

..Headaches are rarely due to sinusitis...

..Reference textbooks on the intracranial complications of rhinosinusitis imply that many of the intracranial complications of rhinosinusitis can be prevented. We sought to examine whether or not this is true...

..Nasal endoscopy and CT scans are typically normal. Most patients with this condition respond to low-dose amitriptyline, but noticeable improvement might require up to 6 weeks...

..We therefore sought to run a comparative study of the proteomes and functional properties of these cells...

..The fact that computed tomography is poor at diagnosing sinusitis in children is also a recurring theme...

..Although endonasal laser dacryocystorhinostomy (ELDCR) offers many advantages compared with conventional techniques, postoperative scarring leading to occlusion of the rhinostomy is more common with ELDCR...

..Staining with a Mib-1 antibody that detects cells in cycle showed positive staining in a small fraction of proliferated perichondrial cells where new cartilage had been produced...

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..Patients with facial pain who have no objective evidence of sinus disease are unlikely to be helped by surgery. Most patients with pain caused by sinusitis respond to medical therapy...

..Furthermore we can gain a better understanding of the disease mechanisms from the histological and molecular tissue studies that relate to allergic rhinitis...

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..To examine the causes of facial pain that persists after endoscopic and other sinonasal surgery...

..Chronic infective rhinosinusitis usually responds to medical therapy, and the remainder resolve with surgery...

..To assess the results of reconstruction of composite defects involving the nose which extend to involve the cheeks, eyelids or upper lip...

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..Misconceptions about the causation of facial pain have led to wrong conclusions about the prevalence of chronic rhinosinusitis...

..These patients should receive a trial of medical therapy, such as low-dose amitriptyline for 6 weeks in the first instance, before any surgical intervention is considered...

..We report serious complications that result from a disregard to these basic principles in two patients following the insertion of giant titanium nasal implants along with their management...

..In contrast, allergic rhinitis has a Th2 type inflammatory pathology mediated by IgE and mast cells...

..Furthermore, successful therapeutic regimens used in the treatment of non-allergic rhinitis will be examined as these could provide an insight into the underlying pathophysiology of this common but poorly understood disease...

..This review is intended to provide an improved understanding of the mechanisms and causes of local mucosal hypersensitivity...

..CONCLUSION: The use of autogenous cartilage is a good option for nasal augmentation immediately after the removal of an alloplastic implant...

..This review discusses the management of aspergillosis of the paranasal sinuses, and in particular the role of itraconazole antifungal therapy...

..Postnasal secretions do not appear to be an adequate cause for cough and the term 'PNDS' should be replaced by rhinosinusitis when nasal disease is the cause of chronic cough...

..A diagnosis of idiopathic rhinitis can only be used when all other causes have been excluded and this review tries to clarify whom this term should be applied to, and the reasons why...

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..These guidelines have been approved across disciplines in our unit and trialled successfully for 2 years...

..001). Although patients with idiopathic rhinitis may exhibit clinical and pathological features of allergy, they do not show raised levels of anti-IgE in their serum...

..It is possible that DCs from atopic individuals are inherently programmed to support allergic disease, or it is the exposure of dendritic cells to allergens that is key to the development of allergic sensitisation...

..These cases illustrate the characteristics and management of facial pain after sinonasal surgery and highlight the importance of medical neurological treatment in the absence of any objective evidence of sinus disease...

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..It can augment the learning curve and enhance teaching and training in endoscopic sinus surgery but it is not a substitute for a thorough knowledge of paranasal sinus anatomy...

..Five-year survival currently appears to be optimized by surgery followed by postoperative radiotherapy and is approximately 65%...

..Visual and ocular motor function did not recover, but ptosis and proptosis improved. We believe this to be the first documented case of successful treatment of such a lesion with oral itraconazole monotherapy...

..Substance P caused variable nasal itching and sneezing. None of the stimuli caused referred pain to the face. The results question the role of mucosal contact points in facial pain...

..The new hypotheses that have been proposed appear to be of clinical relevance...

..Of particular interest were the 6% of patients with facial pain who had migraine confined to the second division of the trigeminal nerve. This entity is not widely recognized and has rarely been described in the literature...

..Surgery undertaken to remove mucosal contact points for facial pain is usually unnecessary as the aetiology of this facial pain appears to be a more central processes...

..8 months. These results suggest that this is a suitable technique for closing nasal septal perforation...

..It was further shown that the reproducibility of olfactory delivery of a polymer formulation was significantly better intra-subject than inter-subject...

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..We illustrate our experience with 78 patients who were referred with a diagnosis of CSF rhinorrhoea...

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..One patient needed no surgery. The mean follow-up period was 6 years 3 months. There was the lowest number of recurrences in the endoscopic surgical group. We emphasize the importance of long-term follow-up...

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..Presenting features, diagnosis, adverse effects of treatment and mortality rate, were also studied...

..Trainee surgeons feel that the operation of septoplasty is poorly taught. Some common problems encountered during septal surgery are described and a variety of surgical solutions are offered...

..We report a rare case of iatrogenic pseudoaneurysm of the internal carotid artery secondary to endoscopic sphenoid surgery...

..Extramedullary plasmacytoma carries a better prognosis than a solitary plasmacytoma of the bone. We report four cases of solitary plasmacytoma of the bone and an extramedullary plasmacytoma of the paranasal sinuses and soft palate...

..5 : 1 (SEM +/- 0.5). It can be concluded that the nasal cycle has a marked effect on the mucociliary clearance patterns of the nose. This may have both theoretical and practical implications for the nasal delivery of drugs...

..The ICSR guidelines are not always sufficient to allow reproducible measurement and specially designed protocols may be necessary to produce reliable results...

..Normal results from a simple panel of blood tests will exclude the commonest immune deficiencies. An abnormal result from these tests, or a strong suspicion despite normal initial testing, should prompt discussion with an immunologist...

..An attractive mechanism for a component of Der p 1 allergenicity lies in its ability to cleave key regulatory molecules from leucocyte surfaces, subverting cellular function and driving abnormal immunoglobulin E (IgE) responses...

..This effect was not found in subjects with perennial rhinitis. This study adds weight to the 'hygiene hypothesis'...

..Subsequent to this she had a further episode of CSF rhinorrhoea that originated from a middle-ear meningocele that was then repaired...

..This observation, along with the fact that retained secretions are not seen within the sinuses in this condition, raises doubt about the theory that a one-way valve is responsible...

..There must be: (1) Meticulous removal of all visible mucosa and the inner bony cortex of the sinus wall. (2) Permanent occlusion of the nasofrontal duct. (3) The correct choice of material for the obliteration...

..Nasal disease is more likely to result in cough from the co-existing involvement of the lower airways through an as yet undefined pathway, and eosinophil and mast cell mediation appear a likely mechanism...

..Although endoscopic closure is now the treatment of choice in the majority of patients with sinonasal cerebrospinal fluid (CSF) leaks, there is a recurrence rate of up to 10% in most series...

..We discuss the classification and presentation of encephaloceles, and present our experience in the repair of six cases. We believe transnasal endoscopic repair is the method of choice in dealing with selected basal encephaloceles...

..The most severely and most frequently affected patients had the greatest benefit. We conclude that the suggested regime can be effective in breaking the vicious cycle of persistent throat-clearing...

..In contrast a slowly progressive lesion often does not warrant extensive surgical excision. Understanding the nature of fibro-osseous lesions facilitates appropriate clinical management...

..Not only does it avoid any disruption to their anticoagulant therapy, but it also can be performed as an outpatient procedure...

..With an endoscopic approach, removal of the crista ethmoidalis helps visualize these branches...