I Jones

..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:850-853, 2000...

..0077). Despite relatively small numbers, this study provides evidence to support the hypothesis that puerperal episodes identify a more familial subtype of bipolar disorder...

..Psychiatrists, who will have to administer such tests, appear significantly more cautious...

..It is likely that the controversy surrounding anticipation and the existence of triplet repeats will only finally be resolved with the demonstration of such a mutation in the aetiology of bipolar disorder...

..Elucidating the pathophysiological basis of this disorder will lead to better prevention and treatment and, it is anticipated, inform research on affective disorders more generally...

..The single large study that used direct interview of relatives suggested that familial factors play a role in vulnerability to puerperal triggering itself. The authors' goal was to test this hypothesis further...

..To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis...

..However, variation at other polymorphisms within TNFalpha or in other oestrogen-regulated genes involved in immune function remain interesting candidates for study in post-partum mood disorders...

..54). Overall the highest MLS was 1.70 on chromosome 2 at marker D2S125, under the broadest diagnostic model...

..It remains possible, however, that other sequence variations within the DRD3 gene could play a role...

..58). The family provides strong evidence against the Darier-causing mutation itself playing a major role in affective disorder but strongly supports the existence of a bipolar disorder susceptibility gene in the Darier region...

..As susceptibility genes are found and knowledge of aetiology advanced it is likely that many more candidate genes in novel biological systems will attract attention...

..To examine the nature of the earliest reported symptoms in women who develop a bipolar affective puerperal psychosis (PP)...

..We find no evidence of a latent period. Over 50% of symptom onsets occur on days 1-3, with over 22% occurring on the first postpartum day...

..Recent advances in molecular genetics have made it possible to identify these susceptibility genes...

..Mania scales developed in bipolar disorder populations must be specifically validated for postpartum use...

..We conclude that elevated self-reported schizotypy as measured by the KSQ is not specific to schizophrenia, and may be associated with functional psychosis in general...

..The authors conducted a search by systematic whole genome linkage scan for loci influencing vulnerability to bipolar affective puerperal psychosis...

..Follow-up of this region should use samples enriched for cases of schizoaffective disorder. Our findings have similar implications for the search for genetic variation on chromosome 22q11 that influences susceptibility to psychosis...

..Abnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance...

..We previously reported that variation at a specific 3-locus haplotype influences susceptibility to schizophrenia in a large United Kingdom (UK) Caucasian case-control sample...

..Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association...

..They suggest that a postnatal onset definition of within 6-8 weeks of delivery may be optimal in studies of the triggering of depressive illness by childbirth...

..We have undertaken within- and between-individual comparisons of the clinical presentation of postnatal (PN) and non-postnatal (NPN) depressive episodes in women with recurrent depression...

..We are undertaking association studies in women with postpartum psychosis at a number of candidate genes of interest in BP disorder with an emphasis on those for which the expression is influenced by steroid hormones...

..Such features should alert a clinician to a possible bipolar course. This is important because optimal management is not the same for bipolar and unipolar depression...

..The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects...

..Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder...

..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America...

..Further molecular genetic analysis of this region is required to identify the gene(s)...

..A history of bipolar episodes prior to the puerperal psychosis did not predict risk following subsequent pregnancies, but positive family history of mental illness predicted shorter time to non-puerperal relapse...

..We conclude that variation in the coding sequence and flanking splice junctions of the ERalpha gene does not play an important pathogenic role in the majority of cases of Bipolar Disorder or Bipolar Affective Puerperal Psychosis...

..Few studies have examined the rates of physical disorders in those with recurrent depression...

..We will identify the areas of uncertainty that remain for clinicians and consider the practical questions that future research should address...

..Coronary care units have transformed the treatment of many patients whose lives are at risk. But many others who should be in these wards are still treated elsewhere...

..Here we compare the clinical profile of major depression for men and women from a sample of almost 600 well-characterized individuals with recurrent major depressive disorder (MDD)...

..No pathogenic triplet repeat has yet been unambiguously implicated...

..These three conditions share a very similar pathology, although treatments differ. This paper examines the pathophysiology, identification, classification and management of these conditions...

..Applying information technology may overcome some barriers and facilitate an ED-based vaccination initiative...

..The current study investigated associations among eating disorders, depressive symptoms during pregnancy and postpartum, and perfectionism in a population-based sample of women...

..68, P=0.022). CONCLUSIONS: This study provides further evidence of the association between primiparity and puerperal psychosis and suggests that complications during delivery may be associated with a severe post-partum episode...

..This latter limitation is particularly pertinent in the context of the increasing evidence for the existence of a broader bipolar spectrum than has been acknowledged within existing classifications...

..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...

..This paper critically reviews the literature on milder forms of high mood occurring in the puerperium and discusses the potential clinical and research significance of 'the highs'...

..Locally administered gentamicin resulted in high local concentrations, potentially effective against agents normally considered resistant...

..Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN)...