E Yvonne Jones

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
    Elena Seiradake
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 20:958-64. 2013
  2. pmc Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1
    Yuguang Zhao
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Structure 22:612-20. 2014
  3. pmc Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors
    Stephan D Gadola
    Department of Rheumathology and Clinical Immunology, University of Bern, Inselspital, Berne CH 3010, Switzerland
    J Exp Med 203:699-710. 2006
  4. ncbi request reprint MHC class II proteins and disease: a structural perspective
    E Yvonne Jones
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Rev Immunol 6:271-82. 2006
  5. ncbi request reprint Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells
    Jonathan D Silk
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    J Immunol 180:6452-6. 2008
  6. doi request reprint Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
    Maria Harkiolaki
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX37BN, UK
    Structure 17:809-22. 2009
  7. pmc Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth
    Dellel Rezgui
    Cancer Research UK Tumour Growth Control Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Mol Endocrinol 42:341-56. 2009
  8. ncbi request reprint The crystal structure of human CD1d with and without alpha-galactosylceramide
    Michael Koch
    Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Nat Immunol 6:819-26. 2005
  9. pmc A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus
    Max Crispin
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 284:21684-95. 2009
  10. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004

Detail Information

Publications71

  1. pmc Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
    Elena Seiradake
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 20:958-64. 2013
    ..Mutant Ephs link these characteristics to interactions observed in the crystal lattices, suggesting a mechanism by which distinctive ectodomain surfaces determine clustering, and thereby signaling, properties. ..
  2. pmc Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1
    Yuguang Zhao
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Structure 22:612-20. 2014
    ..These results provide a structural basis for the development of 5T4/WAIF1-targeted therapies that preserve or block 5T4/WAIF1-mediated inhibition of Wnt/β-catenin signaling. ..
  3. pmc Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors
    Stephan D Gadola
    Department of Rheumathology and Clinical Immunology, University of Bern, Inselspital, Berne CH 3010, Switzerland
    J Exp Med 203:699-710. 2006
    ..This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer...
  4. ncbi request reprint MHC class II proteins and disease: a structural perspective
    E Yvonne Jones
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Rev Immunol 6:271-82. 2006
    ..Here, we discuss the insights that the crystal structures of MHC class II molecules provide into the molecular mechanisms by which sequence polymorphisms might contribute to disease susceptibility...
  5. ncbi request reprint Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells
    Jonathan D Silk
    Tumour Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    J Immunol 180:6452-6. 2008
    ..The ability of these compounds to assist the priming of Ag-specific immune responses while minimizing iNKT cell-dependent DC lysis makes them attractive adjuvants for vaccination strategies...
  6. doi request reprint Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
    Maria Harkiolaki
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX37BN, UK
    Structure 17:809-22. 2009
    ..In summary, our study reveals interaction types of SH3 domains, highlighting their great versatility...
  7. pmc Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth
    Dellel Rezgui
    Cancer Research UK Tumour Growth Control Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Mol Endocrinol 42:341-56. 2009
    ..Other potential IGF2R polymorphisms may account for the correlation with childhood growth, warranting further functional evaluation...
  8. ncbi request reprint The crystal structure of human CD1d with and without alpha-galactosylceramide
    Michael Koch
    Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Nat Immunol 6:819-26. 2005
    ..These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents...
  9. pmc A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus
    Max Crispin
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 284:21684-95. 2009
    ..The Lec36 cell line will be useful for expressing therapeutic glycoproteins with hybrid-type glycans and as a sensitive host for detecting mutations in human MAN2A1 causing type II congenital dyserythropoietic anemia...
  10. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
  11. pmc Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor
    Ji Li Chen
    Weatherall Institute of Molecular Medicine, Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Immunol 184:1829-39. 2010
    ..This, in turn, modulates Ca(2+) influx from the extracellular environment, ultimately controlling T cell activation...
  12. pmc Structure and functional analysis of the IGF-II/IGF2R interaction
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
    EMBO J 27:265-76. 2008
    ..Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site...
  13. pmc Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design
    Thomas A Bowden
    Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Virol 82:11628-36. 2008
    ..These results suggest possible pathways of virus-host interaction and strategies for the optimization of recombinant vaccines...
  14. pmc Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
    Benjamin Bishop
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 16:698-703. 2009
    ..This interplay of several metal binding sites suggests a tuneable mechanism for regulation of Hh signaling...
  15. pmc Structural basis of semaphorin-plexin signalling
    Bert J C Janssen
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nature 467:1118-22. 2010
    ....
  16. pmc Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function
    James Brown
    CR UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Protein Sci 16:1042-52. 2007
    ..These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens...
  17. ncbi request reprint Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation
    Max Crispin
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    FEBS Lett 581:1963-8. 2007
    ....
  18. ncbi request reprint Structure determination of human semaphorin 4D as an example of the use of MAD in non-optimal cases
    Robert M Esnouf
    Division of Structural Biology, University of Oxford, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, England
    Acta Crystallogr D Biol Crystallogr 62:108-15. 2006
    ....
  19. ncbi request reprint Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression
    Guillaume B E Stewart-Jones
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Immunol 175:2459-68. 2005
    ....
  20. ncbi request reprint Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin
    Nathan R Zaccai
    CR UK Receptor Structure Research Group, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Mol Biol 365:1469-79. 2007
    ....
  21. ncbi request reprint T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides
    Maria Harkiolaki
    Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Immunity 30:348-57. 2009
    ..Thus, these data suggest a possible explanation for the difficulty in incriminating individual infections in the development of MS...
  22. ncbi request reprint Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
    Manuel A Friese
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK
    Nat Med 14:1227-35. 2008
    ....
  23. ncbi request reprint Computational model for the IGF-II/IGF2r complex that is predictive of mutational and surface plasmon resonance data
    Philippe Roche
    Division of Structural Biology, University of Oxford, Henry Wellcome Building for Genomic Medicine, Oxford, United Kingdom
    Proteins 64:758-68. 2006
    ..One model was strongly supported by these analyses and is discussed here in detail. Furthermore, we demonstrate in vitro experimental support for this model by studying the binding of chimeras of IGF-I and IGF-II to IGF2R fragments...
  24. ncbi request reprint The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain
    Jeffrey Ishizuka
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Immunity 28:171-82. 2008
    ..The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype...
  25. ncbi request reprint Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions
    Max Crispin
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Mol Biol 387:1061-6. 2009
    ....
  26. pmc The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
    Corinna McCarthy
    Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Exp Med 204:1131-44. 2007
    ..This indirect effect provides a general mechanism by which lipid-specific lymphocytes are capable of recognizing both the group head and the length of lipid antigens, ensuring greater specificity of antigen recognition...
  27. ncbi request reprint The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D
    Christopher A Love
    Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Struct Biol 10:843-8. 2003
    ..This face of the propeller also mediates ligand binding in integrins, and functional data for semaphorin-receptor interactions map to the equivalent surface...
  28. pmc Dimeric architecture of the Hendra virus attachment glycoprotein: evidence for a conserved mode of assembly
    Thomas A Bowden
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Virol 84:6208-17. 2010
    ....
  29. pmc Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling
    Thomas A Bowden
    Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford, UK
    Structure 17:1386-97. 2009
    ..This interactive plasticity reveals EphA4 as a structural chameleon, able to adopt both A and B class Eph receptor conformations, and thus provides a molecular basis for EphA-type cross-class reactivity...
  30. ncbi request reprint Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors
    Gijs I van Boxel
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Immunol Methods 350:14-21. 2009
    ....
  31. pmc Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis
    Thomas A Bowden
    Division of Structural Biology, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Am Chem Soc 134:17554-63. 2012
    ..Our crystal structure of this intermediate reveals a molecular basis for antibody biogenesis and provides a template for the structure-guided engineering of the protein-glycan interface of therapeutic antibodies...
  32. ncbi request reprint Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism
    A Radu Aricescu
    Cancer Research UK Receptor Structure Research Group, University of Oxford, Henry Wellcome Building of Genomic Medicine, Division of Structural Biology, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 317:1217-20. 2007
    ..These data suggest that the RPTPmu ectodomain acts as a distance gauge and plays a key regulatory function, locking the phosphatase to its appropriate functional location...
  33. pmc Cells under siege: viral glycoprotein interactions at the cell surface
    Thomas A Bowden
    Division of Structural Biology, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX37BN, United Kingdom
    J Struct Biol 175:120-6. 2011
    ..The structures also support molecular level rationales for how viruses can be transmitted to unrelated organisms and thus pose severe health risks...
  34. ncbi request reprint The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome p450 peptide: steric hindrance influences TCR allo-recognition
    Christopher S Hourigan
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 36:3288-93. 2006
    ..These findings are relevant to understanding the basis of T cell cross-reactivity in allo-recognition, optimal transplant donor-recipient matching and developing specific molecular inhibitors of allo-recognition...
  35. pmc Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension
    Charlotte H Coles
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Science 332:484-8. 2011
    ..These results lead to a model where proteoglycans can exert opposing effects on neuronal extension by competing to control the oligomerization of a common receptor...
  36. ncbi request reprint Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Trends Biochem Sci 34:612-9. 2009
    ..The recently elucidated crystal structure of IGF-II-IGF2R complex provides new insight into IGF-II regulation, and reveals a common binding surface on IGF-II for the regulatory proteins, IGF2R and the IGFBPs...
  37. pmc High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule
    Christian Siebold
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, University of Oxford, UK
    Proc Natl Acad Sci U S A 102:16836-41. 2005
    ....
  38. ncbi request reprint Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors
    Amber Clayton
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    J Mol Biol 392:1125-32. 2009
    ..Lattice contacts in a 4.1-A resolution crystal form reveal a tetrameric (dimer-dimer) arrangement consistent with previous cellular and cryo-electron microscopic data for full-length AMPA receptors...
  39. ncbi request reprint A closer look at CD1d molecules: new horizons in studying NKT cells
    Victoria S Stronge
    Cancer Research UK, Tumour Immunology Group, The Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DS, UK
    Trends Immunol 28:455-62. 2007
    ..Here we review new reagents and novel protocols that are facilitating a closer look at lipid presentation by CD1d molecules and their recognition by iNKT cells...
  40. pmc Structural and kinetic basis for heightened immunogenicity of T cell vaccines
    Ji Li Chen
    Tumour Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Exp Med 201:1243-55. 2005
    ....
  41. ncbi request reprint Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
    Wai Ching Hon
    Division of Structural Biology, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 417:975-8. 2002
    ..This mechanism provides a new focus for development of therapeutic agents to modulate cellular responses to hypoxia...
  42. pmc Automation of large scale transient protein expression in mammalian cells
    Yuguang Zhao
    Division of Structural Biology STRUBI, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    J Struct Biol 175:209-15. 2011
    ..This automated method for large scale transient transfection is now offered as a Europe-wide service via the P-cube initiative...
  43. pmc A dual binding mode for RhoGTPases in plexin signalling
    Christian H Bell
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 9:e1001134. 2011
    ..Our findings are consistent with a model in which extracellular and intracellular plexin clustering events combine into a single signalling output...
  44. pmc Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies
    Thomas A Bowden
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem Soc Trans 38:1349-55. 2010
    ..This structural information highlights the adaptability of the paramyxovirus attachment glycoprotein surface and the potential for the emergence of new and potentially harmful viruses in human hosts...
  45. ncbi request reprint A time- and cost-efficient system for high-level protein production in mammalian cells
    A Radu Aricescu
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England
    Acta Crystallogr D Biol Crystallogr 62:1243-50. 2006
    ..The system is suitable for use in conventional laboratories or can be implemented in a medium- or high-throughput pipeline...
  46. pmc An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
    Elena Seiradake
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 17:398-402. 2010
    ..Our results suggest a 'nucleation' mechanism whereby a limited number of ligand-receptor interactions 'seed' an arrangement of receptors which can propagate into extended signaling arrays...
  47. ncbi request reprint Dissection of the multiple sclerosis associated DR2 haplotype
    Ruth Etzensperger
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DS, UK
    J Autoimmun 31:201-7. 2008
    ..Here we discuss the emerging role of the constituent alleles of the DR2 haplotype and our ongoing efforts to uncover the mechanisms by which they influence MS pathogenesis...
  48. pmc Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
    Bert J C Janssen
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 19:1293-9. 2012
    ....
  49. ncbi request reprint Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
    Thomas A Bowden
    Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Struct Mol Biol 15:567-72. 2008
    ..By analogy with the development of antivirals against sialic acid binding viruses, these results provide a structural template to target antiviral inhibition of protein-protein interactions...
  50. pmc An alternative conformation of the T-cell receptor alpha constant region
    Gijs I van Boxel
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, The University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Mol Biol 400:828-37. 2010
    ..This substantial conformational change may represent a signaling intermediate. Our structure is the first example for the Ig fold of the increasingly recognized concept of "metamorphic proteins."..
  51. pmc Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76
    Maria Harkiolaki
    Cancer Research UK Cell Signalling Group and Weatherall Institute of Molecular Medicine, Oxford, UK
    EMBO J 22:2571-82. 2003
    ..Interestingly, the SH3C displays ion-dependent dimerization in the crystal and in solution, suggesting a novel mechanism for the regulation of SH3 domain functions...
  52. pmc Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
    Tomas Malinauskas
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 18:886-93. 2011
    ..This combination of HSPG- and Wnt-binding properties suggests a modular model for the localization of WIF-1 and for signal inhibition within morphogen gradients...
  53. pmc Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin
    Matthias Zebisch
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Commun 4:2787. 2013
    ....
  54. pmc Rational development of high-affinity T-cell receptor-like antibodies
    Guillaume Stewart-Jones
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 106:5784-8. 2009
    ....
  55. pmc Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells
    Stephan D Gadola
    Tumour Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 358:875-7. 2003
    ..The analysis of these crystal structures clarified how CD1b molecules can bind lipid ligands of different size, and revealed a broader spectrum of potential CD1b ligands than previously predicted...
  56. ncbi request reprint A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization
    Thomas S Walter
    Oxford Protein Production Facility, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, England
    Acta Crystallogr D Biol Crystallogr 61:651-7. 2005
    ..Experience based on 592 crystallization projects is reported...
  57. ncbi request reprint Receptor protein tyrosine phosphatase micro: measuring where to stick
    A Radu Aricescu
    Cancer Research UK Receptor Structure Research Group, University of Oxford, Henry Wellcome Building of Genomic Medicine, Division of Structural Biology, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem Soc Trans 36:167-72. 2008
    ..The physical characteristics and dimensions of the adhesion dimer suggest a mechanism by which the location of this phosphatase can be influenced by cell-cell spacings...
  58. ncbi request reprint Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding
    Michael Koch
    Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Immunity 27:885-99. 2007
    ..This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease...
  59. ncbi request reprint Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705
    Guillame B E Stewart-Jones
    The Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Oxford, UK
    Eur J Immunol 35:341-51. 2005
    ..Substitution of EBV P8 glutamate to threonine allowed recognition by KIR3DL1. In the HLA-B*2705-EBV structure the P8 glutamate side chain is solvent-exposed and may inhibit KIR3DL1 binding through electrostatic forces...
  60. ncbi request reprint Immunoglobulin superfamily cell adhesion molecules: zippers and signals
    A Radu Aricescu
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Curr Opin Cell Biol 19:543-50. 2007
    ....
  61. ncbi request reprint Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin
    Nathan R Zaccai
    CR UK Receptor Structure Research Group, Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    Structure 11:557-67. 2003
    ..Crystal structures of these sialosides in complex with SnD1 suggest explanations for the differences in specificity and affinity, providing further ideas for compound design of physiological and potentially therapeutic relevance...
  62. ncbi request reprint MHC II molecules in inflammatory diseases: interplay of qualities and quantities
    Manuel A Friese
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Trends Immunol 26:559-61. 2005
    ..This predisposes to rheumatoid arthritis, multiple sclerosis and myocardial infarction...
  63. ncbi request reprint Structural insights into semaphorins and their receptors
    Christian Siebold
    Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Semin Cell Dev Biol 24:139-45. 2013
    ..These structural analyses, in combination with biochemical, biophysical and cellular studies, have progressed our understanding of this signalling system into the realm of molecular mechanism...
  64. ncbi request reprint Benefits of automated crystallization plate tracking, imaging, and analysis
    Christopher J Mayo
    The Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom
    Structure 13:175-82. 2005
    ..Features of this system address requirements common to many crystallographic laboratories that are currently setting up (semi-)automated crystallization imaging systems...
  65. ncbi request reprint Multiple sclerosis: MHC associations and therapeutic implications
    Samantha Holmes
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Expert Rev Mol Med 7:1-17. 2005
    ..Many of these therapies work at the antigen-specific level, disrupting the interaction between T-cell receptors and MHC molecules that leads to disease...
  66. pmc Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling
    Shuo Chen
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Dev Cell 21:848-61. 2011
    ....
  67. pmc The dynamics of signal triggering in a gp130-receptor complex
    Rishi Matadeen
    Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    Structure 15:441-8. 2007
    ..This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade...
  68. ncbi request reprint Structure of the snake-venom toxin convulxin
    Thil Batuwangala
    Cancer Research UK Receptor Structure Group, Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, England
    Acta Crystallogr D Biol Crystallogr 60:46-53. 2004
    ..The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly...
  69. pmc PCNA directs type 2 RNase H activity on DNA replication and repair substrates
    Doryen Bubeck
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nucleic Acids Res 39:3652-66. 2011
    ..Our findings provide insights into how type 2 RNase H activity is directed during genome replication and repair, and suggest a mechanism by which RNase H2 may suppress generation of immunostimulatory nucleic acids...
  70. pmc Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    EMBO J 21:1054-62. 2002
    ..The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3)...
  71. ncbi request reprint A structural basis for immunodominant human T cell receptor recognition
    Guillaume B E Stewart-Jones
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Immunol 4:657-63. 2003
    ..This previously unknown binding mode underlies the immunodominant T cell response...