A K Jones

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
  2. ncbi Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency
    Andrew K Jones
    Medical Research Council, Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 29:4287-92. 2009
  3. ncbi Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
    Trends Pharmacol Sci 31:455-62. 2010
  4. ncbi Diversity of insect nicotinic acetylcholine receptor subunits
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
    Adv Exp Med Biol 683:25-43. 2010
  5. doi The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis
    A K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Heredity (Edinb) 104:247-59. 2010
  6. ncbi Alternative splicing of the Anopheles gambiae nicotinic acetylcholine receptor, Agamalphabeta9, generates both alpha and beta subunits
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Invert Neurosci 9:77-84. 2009
  7. pmc The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans
    Andrew K Jones
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 8:41-7. 2008
  8. pmc The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, The Sherrington Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    BMC Genomics 8:327. 2007
  9. pmc The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature
    Andrew K Jones
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    Invert Neurosci 7:129-31. 2007
  10. ncbi Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial species
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 7:67-73. 2007

Detail Information

Publications31

  1. doi The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
    ..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...
  2. ncbi Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency
    Andrew K Jones
    Medical Research Council, Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 29:4287-92. 2009
    ..These results provide insights into how the rich diversity of signaling necessary for complex brain function can be achieved by relatively few genes...
  3. ncbi Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
    Trends Pharmacol Sci 31:455-62. 2010
    ..Mutations giving rise to disease states highlight the importance of these interacting proteins. Here, we consider their potential as future therapeutic targets for treating diseases associated with altered nAChR function...
  4. ncbi Diversity of insect nicotinic acetylcholine receptor subunits
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
    Adv Exp Med Biol 683:25-43. 2010
    ..Species-specific subunit diversification may offer promising targets for future rational design of insecticides that target specific pest insects while sparing beneficial species...
  5. doi The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis
    A K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Heredity (Edinb) 104:247-59. 2010
    ....
  6. ncbi Alternative splicing of the Anopheles gambiae nicotinic acetylcholine receptor, Agamalphabeta9, generates both alpha and beta subunits
    Andrew K Jones
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Invert Neurosci 9:77-84. 2009
    ..Our findings further characterise a potential target to control the malaria mosquito as well as provide insights into the diversification of nAChRs...
  7. pmc The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans
    Andrew K Jones
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 8:41-7. 2008
    ..Phylogenetic analysis shows that several of these lgc subunits form distinct groups which may represent novel cys-loop LGIC subtypes...
  8. pmc The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, The Sherrington Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    BMC Genomics 8:327. 2007
    ..The red flour beetle, Tribolium castaneum, is a major pest of stored agricultural products and is also an important model organism for studying development...
  9. pmc The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature
    Andrew K Jones
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    Invert Neurosci 7:129-31. 2007
    ..We present here the resulting updated version of the C. elegans nAChR gene family and related ligand-gated ion channel genes...
  10. ncbi Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial species
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 7:67-73. 2007
    ..Unitary conductance measurements on native nAChRs indicate that more frequent openings of the largest conductance state may offer an explanation for the superagonist actions of clothianidin...
  11. pmc The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Genome Res 16:1422-30. 2006
    ..These findings on Apis mellifera enhance our understanding of nAChR functional genomics and provide a useful basis for the development of improved insecticides that spare a major beneficial insect species...
  12. ncbi Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster
    D B Sattelle
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Bioessays 27:366-76. 2005
    ..We present here three-dimensional models constructed for insect nAChRs, which show that many variations introduced by alternative splicing and RNA editing may influence receptor function...
  13. ncbi The nicotinic acetylcholine receptor gene family of the malaria mosquito, Anopheles gambiae
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    Genomics 85:176-87. 2005
    ..These findings shed further light on the diversity of nAChR subunits and may present a useful basis for the development of improved malaria control agents by enhancing our understanding of a validated mosquito insecticide target...
  14. ncbi Sgbeta1, a novel locust (Schistocerca gregaria) non-alpha nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dbeta1 subunit
    A K Jones
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1, 3QX, UK
    Invert Neurosci 5:147-55. 2005
    ..We conclude that either Sgbeta1 does not co-assemble with Sgalpha1, or that it is unable to contribute to the functional properties of the receptor, in the Xenopus oocyte expression system...
  15. ncbi The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit
    Emmanuel Culetto
    Medical Research Council Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    J Biol Chem 279:42476-83. 2004
    ..Thus, at least four subunits, two alpha types (UNC-38 and UNC-63) and two non-alpha types (UNC-29 and LEV-1), can contribute to levamisole-sensitive muscle nAChRs in nematodes...
  16. ncbi Contributions from Caenorhabditis elegans functional genetics to antiparasitic drug target identification and validation: nicotinic acetylcholine receptors, a case study
    L A Brown
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Int J Parasitol 36:617-24. 2006
    ..Physiology and molecular biology studies on nAChRs of parasitic nematodes have also identified levamisole-sensitive and insensitive subtypes and further subdivisions are under investigation...
  17. ncbi The nicotinic acetylcholine receptor gene family of the pufferfish, Fugu rubripes
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Genomics 82:441-51. 2003
    ..We show, using RT-PCR, that the Fugu nAChR subunits are expressed in a variety of tissues...
  18. ncbi Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX
    Bioessays 26:39-49. 2004
    ..Future studies using C. elegans offer the prospect of increasing our understanding of the functional diversity of a complex nAChR gene family as well as addressing the role of nAChRs and associated proteins in human disorders...
  19. pmc Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans
    Nigel P Mongan
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Protein Sci 11:1162-71. 2002
    ..elegans to date, suggest that at least some of these subunits may contribute to heteromers in vivo...
  20. doi Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors
    David B Sattelle
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Biochem Pharmacol 78:836-43. 2009
    ..The new pharmacological findings and computational approaches being developed may inform the design of novel PAM drugs targeting major neurological disorders...
  21. pmc A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor
    Steven D Buckingham
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    BMC Neurosci 6:2. 2005
    ..The growing amount of structural, pharmacological and physiological data for these receptors indicates the need for a dedicated and accurate database to provide a means to access this information in a coherent manner...
  22. ncbi The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 6:123-32. 2006
    ..These findings on Apis mellifera enhance our understanding of cys-loop LGIC functional genomics and provide a useful basis for the development of improved insecticides that spare a major beneficial insect species...
  23. doi Edited GluR2, a gatekeeper for motor neurone survival?
    S D Buckingham
    MRC Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Bioessays 30:1185-92. 2008
    ..Here we suggest that edited AMPA glutamate (GluR2) receptor subunits serve as gatekeepers for motor neurone survival...
  24. doi A role for Leu118 of loop E in agonist binding to the alpha 7 nicotinic acetylcholine receptor
    Shiva Amiri
    Structural Bioinformatics and Computational Biochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Mol Pharmacol 73:1659-67. 2008
    ..Together, the results indicate a role for Leu118 in influencing agonist actions on alpha7 nAChRs...
  25. ncbi Nicotinic acetylcholine receptors as drug/chemical targets, contributions from comparative genomics, forward and reverse genetics
    David B Sattelle
    University of Oxford, UK
    SEB Exp Biol Ser 58:93-113. 2007
  26. ncbi Chemistry-to-gene screens in Caenorhabditis elegans
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Nat Rev Drug Discov 4:321-30. 2005
    ..Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases...
  27. pmc Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection
    Steven D Buckingham
    Medical Research Council Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX
    Pharmacol Rev 61:39-61. 2009
    ..We propose that understanding the differential activation of these pathways by nicotine and/or Abeta(1-42) may offer the prospect of new routes to therapy for AD...
  28. ncbi Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke Schistosoma
    Geoffrey N Bentley
    The School of Biology, University of Leeds, West Yorkshire, LS2 9JT, Leeds, UK
    Gene 314:103-12. 2003
    ..We discuss our findings in the context of the molecular phylogeny of the AChE genes and the potential application to the control of schistosomiasis...
  29. ncbi ShAR1alpha and ShAR1beta: novel putative nicotinic acetylcholine receptor subunits from the platyhelminth blood fluke Schistosoma
    Geoffrey N Bentley
    The School of Biology, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK
    Gene 329:27-38. 2004
    ..We discuss our findings in the context of the proposed role for surface nAChRs in the regulation of glucose uptake in the parasite, and the potential exploitation of these receptors as targets for cholinergic schistosomicides...
  30. ncbi Insect genomes: challenges and opportunities for neuroscience
    David B Sattelle
    Invert Neurosci 7:133-6. 2007
  31. ncbi Molecular characterization of an acetylcholinesterase implicated in the regulation of glucose scavenging by the parasite Schistosoma
    Andrew K Jones
    The School of Biology, University of Leeds, Leeds, West Yorkshire, UK, LS2 9JT
    FASEB J 16:441-3. 2002
    ..Distinctions between host and parasite AChEs will allow the rational design of schistosome-specific drugs and vaccines...