Research Topics
Genomes and Genes | A K JonesSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators
|
Detail Information
Publications
The genome of the model beetle and pest Tribolium castaneumStephen Richards
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 452:949-55. 2008..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...- Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potencyAndrew K Jones
Medical Research Council, Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, United Kingdom
J Neurosci 29:4287-92. 2009..These results provide insights into how the rich diversity of signaling necessary for complex brain function can be achieved by relatively few genes... - Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizonsAndrew K Jones
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
Trends Pharmacol Sci 31:455-62. 2010..Mutations giving rise to disease states highlight the importance of these interacting proteins. Here, we consider their potential as future therapeutic targets for treating diseases associated with altered nAChR function... 
Diversity of insect nicotinic acetylcholine receptor subunitsAndrew K Jones
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK
Adv Exp Med Biol 683:25-43. 2010..Species-specific subunit diversification may offer promising targets for future rational design of insecticides that target specific pest insects while sparing beneficial species...- The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennisA K Jones
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Heredity (Edinb) 104:247-59. 2010.... - Alternative splicing of the Anopheles gambiae nicotinic acetylcholine receptor, Agamalphabeta9, generates both alpha and beta subunitsAndrew K Jones
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Invert Neurosci 9:77-84. 2009..Our findings further characterise a potential target to control the malaria mosquito as well as provide insights into the diversification of nAChRs... 
The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegansAndrew K Jones
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
Invert Neurosci 8:41-7. 2008..Phylogenetic analysis shows that several of these lgc subunits form distinct groups which may represent novel cys-loop LGIC subtypes...- The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneumAndrew K Jones
MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, The Sherrington Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
BMC Genomics 8:327. 2007..The red flour beetle, Tribolium castaneum, is a major pest of stored agricultural products and is also an important model organism for studying development... - The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclatureAndrew K Jones
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
Invert Neurosci 7:129-31. 2007..We present here the resulting updated version of the C. elegans nAChR gene family and related ligand-gated ion channel genes... - Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial speciesAndrew K Jones
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK
Invert Neurosci 7:67-73. 2007..Unitary conductance measurements on native nAChRs indicate that more frequent openings of the largest conductance state may offer an explanation for the superagonist actions of clothianidin... - The nicotinic acetylcholine receptor gene family of the honey bee, Apis melliferaAndrew K Jones
MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 16:1422-30. 2006..These findings on Apis mellifera enhance our understanding of nAChR functional genomics and provide a useful basis for the development of improved insecticides that spare a major beneficial insect species... - Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogasterD B Sattelle
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Bioessays 27:366-76. 2005..We present here three-dimensional models constructed for insect nAChRs, which show that many variations introduced by alternative splicing and RNA editing may influence receptor function... - The nicotinic acetylcholine receptor gene family of the malaria mosquito, Anopheles gambiaeAndrew K Jones
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
Genomics 85:176-87. 2005..These findings shed further light on the diversity of nAChR subunits and may present a useful basis for the development of improved malaria control agents by enhancing our understanding of a validated mosquito insecticide target... - Sgbeta1, a novel locust (Schistocerca gregaria) non-alpha nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dbeta1 subunitA K Jones
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1, 3QX, UK
Invert Neurosci 5:147-55. 2005..We conclude that either Sgbeta1 does not co-assemble with Sgalpha1, or that it is unable to contribute to the functional properties of the receptor, in the Xenopus oocyte expression system... - The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunitEmmanuel Culetto
Medical Research Council Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
J Biol Chem 279:42476-83. 2004..Thus, at least four subunits, two alpha types (UNC-38 and UNC-63) and two non-alpha types (UNC-29 and LEV-1), can contribute to levamisole-sensitive muscle nAChRs in nematodes... - Contributions from Caenorhabditis elegans functional genetics to antiparasitic drug target identification and validation: nicotinic acetylcholine receptors, a case studyL A Brown
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Int J Parasitol 36:617-24. 2006..Physiology and molecular biology studies on nAChRs of parasitic nematodes have also identified levamisole-sensitive and insensitive subtypes and further subdivisions are under investigation... - The nicotinic acetylcholine receptor gene family of the pufferfish, Fugu rubripesAndrew K Jones
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Genomics 82:441-51. 2003..We show, using RT-PCR, that the Fugu nAChR subunits are expressed in a variety of tissues... - Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegansAndrew K Jones
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX
Bioessays 26:39-49. 2004..Future studies using C. elegans offer the prospect of increasing our understanding of the functional diversity of a complex nAChR gene family as well as addressing the role of nAChRs and associated proteins in human disorders... - Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegansNigel P Mongan
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Protein Sci 11:1162-71. 2002..elegans to date, suggest that at least some of these subunits may contribute to heteromers in vivo... - Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptorsDavid B Sattelle
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Biochem Pharmacol 78:836-43. 2009..The new pharmacological findings and computational approaches being developed may inform the design of novel PAM drugs targeting major neurological disorders... - A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptorSteven D Buckingham
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
BMC Neurosci 6:2. 2005..The growing amount of structural, pharmacological and physiological data for these receptors indicates the need for a dedicated and accurate database to provide a means to access this information in a coherent manner... - The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis melliferaAndrew K Jones
MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
Invert Neurosci 6:123-32. 2006..These findings on Apis mellifera enhance our understanding of cys-loop LGIC functional genomics and provide a useful basis for the development of improved insecticides that spare a major beneficial insect species... - Edited GluR2, a gatekeeper for motor neurone survival?S D Buckingham
MRC Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Bioessays 30:1185-92. 2008..Here we suggest that edited AMPA glutamate (GluR2) receptor subunits serve as gatekeepers for motor neurone survival... - A role for Leu118 of loop E in agonist binding to the alpha 7 nicotinic acetylcholine receptorShiva Amiri
Structural Bioinformatics and Computational Biochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Mol Pharmacol 73:1659-67. 2008..Together, the results indicate a role for Leu118 in influencing agonist actions on alpha7 nAChRs... - Nicotinic acetylcholine receptors as drug/chemical targets, contributions from comparative genomics, forward and reverse geneticsDavid B Sattelle
University of Oxford, UK
SEB Exp Biol Ser 58:93-113. 2007 - Chemistry-to-gene screens in Caenorhabditis elegansAndrew K Jones
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Nat Rev Drug Discov 4:321-30. 2005..Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases... - Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotectionSteven D Buckingham
Medical Research Council Functional Genomics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX
Pharmacol Rev 61:39-61. 2009..We propose that understanding the differential activation of these pathways by nicotine and/or Abeta(1-42) may offer the prospect of new routes to therapy for AD... - Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke SchistosomaGeoffrey N Bentley
The School of Biology, University of Leeds, West Yorkshire, LS2 9JT, Leeds, UK
Gene 314:103-12. 2003..We discuss our findings in the context of the molecular phylogeny of the AChE genes and the potential application to the control of schistosomiasis... - ShAR1alpha and ShAR1beta: novel putative nicotinic acetylcholine receptor subunits from the platyhelminth blood fluke SchistosomaGeoffrey N Bentley
The School of Biology, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK
Gene 329:27-38. 2004..We discuss our findings in the context of the proposed role for surface nAChRs in the regulation of glucose uptake in the parasite, and the potential exploitation of these receptors as targets for cholinergic schistosomicides... - Insect genomes: challenges and opportunities for neuroscienceDavid B Sattelle
Invert Neurosci 7:133-6. 2007 - Molecular characterization of an acetylcholinesterase implicated in the regulation of glucose scavenging by the parasite SchistosomaAndrew K Jones
The School of Biology, University of Leeds, Leeds, West Yorkshire, UK, LS2 9JT
FASEB J 16:441-3. 2002..Distinctions between host and parasite AChEs will allow the rational design of schistosome-specific drugs and vaccines...