Research Topics
Genomes and GenesSpecies | Elaine JohnstoneSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Trial Protocol: Using genotype to tailor prescribing of nicotine replacement therapy: a randomised controlled trial assessing impact of communication upon adherenceTheresa M Marteau
Psychology Department at Guy s, Health Psychology Section, King s College London, 5th floor Bermondsey Wing, Guy s Campus, London SE1 9RT, UK
BMC Public Health 10:680. 2010..II Amongst smokers who fail to quit at six months, motivation to make another quit attempt is lower when informed that their oral dose of NRT was tailored to genotype rather than phenotype...
Determinants of the rate of nicotine metabolism and effects on smoking behaviorElaine Johnstone
Department of Clinical Pharmacology, Cancer Research UK Medical Statistics Group, Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Clin Pharmacol Ther 80:319-30. 2006....- Zyban for smoking cessation in a general practice setting: the response to an invitation to make a quit attemptElaine Johnstone
Cancer Research UK General Practice Research Group, Clinical Pharmacology, Oxford University, UK
Addict Biol 9:227-32. 2004..05). In conclusion, a real-world smoking cessation programme using Zyban with moderate support within a general practice setting may achieve satisfactory quit rates without widening existing disparities in cessation... - The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK populationE C Johnstone
Cancer Research UK, General Practice Research Group, University of Oxford Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK
Addict Biol 9:221-6. 2004..003) and age (p=0.002) but not with alcohol consumption (p=0.25) or DRD2 genotype (p=0.76)... - Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patchElaine C Johnstone
Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
Pharmacogenetics 14:83-90. 2004..Our results support the need for further investigation into personalized therapies for smoking cessation based on individual genotype... 
Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancerJeremie H Lefevre
Department of Clinical Pharmacology, Cancer and Immunogenetics Laboratory, University of Oxford, Oxford, UK
J Hum Genet 57:709-16. 2012..2; 95% confidence interval=1.1-9.5; P=0.04). Rare variants are important risk factors in CRC and, as such, should be systematically assayed alongside common variation in the search for the genetic basis of complex diseases...- Weekly versus basic smoking cessation support in primary care: a randomised controlled trialPaul Aveyard
Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
Thorax 62:898-903. 2007.... - The genetic basis for smoking behavior: a systematic review and meta-analysisMarcus Munafo
Department of Clinical Pharmacology, University of Oxford, UK
Nicotine Tob Res 6:583-97. 2004..Implications for the design of future studies are discussed, such as the need for the development of more specific phenotypes to increase the genetic signal in candidate gene studies... - Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trialPatricia Yudkin
Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
BMJ 328:989-90. 2004 - Use of multivariate analysis to suggest a new molecular classification of colorectal cancerEnric Domingo
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, UK
J Pathol 229:441-8. 2013..Our classification also showed potentially improved prognostic capabilities, with group 3, and possibly group 1, independently predicting disease-free survival... - A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21Ian Tomlinson
Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK
Nat Genet 39:984-8. 2007..21, 95% c.i.: 1.10-1.34; P = 6.89 x 10(-5)). These data show that common, low-penetrance susceptibility alleles predispose to colorectal neoplasia... - Cyclin D1 rare variants in UK multiple adenoma and early-onset colorectal cancer patientsCarolina Bonilla
Department of Clinical Pharmacology, University of Oxford, Headington, Oxford, UK
J Hum Genet 56:58-63. 2011..We conclude that rare variants of CCND1 are risk factors for colorectal cancer, with considerably larger effects than common polymorphisms, and as such should be systematically evaluated in susceptibility studies... - Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CINAndrew D Beggs
University of Oxford, Oxford, UK
Oncotarget 3:1348-55. 2012..015). For Ku70, further studies are required to investigate the potential relationship of non-homologous end joining with chromosomal instability. Loss of ATM expression might serve as a biomarker of poor prognosis in colorectal cancer... - A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessationNicky J Welton
Primary Care, Department, Community Based Medicine, University of Bristol, Bristol, UK
Nicotine Tob Res 10:231-40. 2008..In addition, single-gene tests are unlikely to be cost-effective, partly because the predictive value of these tests is likely to be modest... - Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trialElaine C Johnstone
Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1065-9. 2007.... - Genes and cigarette smokingMarcus R Munafo
Department of Experimental Psychology, University of Bristol, Bristol, UK
Addiction 103:893-904. 2008..We also review future research horizons and the direction which studies of this kind are likely to take in the near future... - The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trialSean P David
Center for Primary Care and Prevention, Brown Medical School Memorial Hospital of Rhode Island, Pawtucket, RI 02960, USA
Nicotine Tob Res 9:225-31. 2007.... - Smoking cessation, weight gain, and DRD4 -521 genotypeMarcus R Munafo
Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 141:398-402. 2006..Smoking cessation programmes should therefore consider incorporating follow-up support to promote weight loss among those who successfully stop smoking... - Polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers: seeking confirmation of the association in a follow-up studyElaine C Johnstone
Cancer Research UK General Practice Research Group, Institute of Health Sciences, Oxford, UK
Pharmacogenetics 12:585-7. 2002 - Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1Matt J Neville
Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
Hum Mutat 23:540-5. 2004..If this is the case, then changes in ANKK1 activity may provide an alternative explanation for previously described associations between the DRD2 Taq1A RFLP and neuropsychiatric disorders such as addiction... - Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotypingRobyn M Jacob
Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
Clin Chem 50:1372-7. 2004..The aim of the present study was to develop a reliable and robust assay for determining genotypic variants... - Association between the serotonin transporter gene and alcohol consumption in social drinkersMarcus R Munafo
Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 135:10-4. 2005..Age at time of data collection and cigarette consumption were entered as covariates. These results replicate recent previous findings and suggest a possibility that this association may differ in men and women... - Genetic testing: the future of smoking cessation therapy?Elaine C Johnstone
ICRF General Practice Research Group, Institute of Health Sciences, Old Road, Oxford, OX3 7LF, UK
Expert Rev Mol Diagn 2:60-8. 2002.... - A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humansSean P David
Department of Clinical Pharmacology, Cancer Research United Kingdom General Practice Research Group, University of Oxford, Oxford OX2 6HE, United Kingdom
J Neurosci 25:2586-90. 2005..The results may offer a plausible physiological mechanism underlying the association between 5-HTTLPR genotype, behavioral traits, and mood states... - Association of serotonin transporter genotype with selective processing of smoking-related stimuli in current smokers and ex-smokersMarcus R Munafo
Department of Experimental Psychology, University of Bristol, United Kingdom
Nicotine Tob Res 7:773-8. 2005..086). Our data provide tentative support for a moderating influence of 5HTT genotype on attentional bias for smoking-related stimuli in ex-smokers. This finding may account for inconsistent reports of attentional bias among ex-smokers... - Lack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trialMarcus R Munafo
Department of Experimental Psychology, University of Bristol, 8 Woodland Road, Bristol BS8 1TN, United Kingdom
Cancer Epidemiol Biomarkers Prev 15:398-400. 2006 - Neuroticism mediates the association of the serotonin transporter gene with lifetime major depressionMarcus R Munafo
Department of Experimental Psychology, University of Bristol, Bristol, UK
Neuropsychobiology 53:1-8. 2006..We sought to address the question of whether trait neuroticism mediates the putative association between this polymorphism and lifetime major depression in adults drawn from the general population... - Association of COMT Val108/158Met genotype with smoking cessationMarcus R Munafo
Department of Experimental Psychology, University of Bristol, UK
Pharmacogenet Genomics 18:121-8. 2008..We also investigated the association of the COMT genotype with withdrawal and mood symptoms, to identify possible mediating mechanisms by which the COMT genotype might influence response to NRT...