Affiliation: University of Edinburgh
- Beneficial mutations, hitchhiking and the evolution of mutation rates in sexual populationsT Johnson
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
Genetics 151:1621-31. 1999..However, the role of beneficial mutations in determining the evolutionarily stable mutation rate may still be significant if the function describing the cost of high-fidelity replication has a shallow gradient...
- Bayesian method for gene detection and mapping, using a case and control design and DNA poolingToby Johnson
School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JT, UK
Biostatistics 8:546-65. 2007..The method is illustrated on data consisting of 27 markers in an 880-kb region around the CYP2D6 gene...
- Theoretical models of selection and mutation on quantitative traitsToby Johnson
Rothamsted Research, Harpenden, Hertfordshire AL5 2FQ, UK
Philos Trans R Soc Lond B Biol Sci 360:1411-25. 2005..We discuss some of the thorny issues that arise when formulating models that describe many traits simultaneously...
- Multipoint linkage disequilibrium mapping using multilocus allele frequency dataT Johnson
Rothamsted Research, Harpenden, and School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
Ann Hum Genet 69:474-97. 2005..Depending on how we choose to measure information, allele frequency data at an additional approximately 18 or approximately 33 markers is needed to compensate for this loss of information...
- The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation ratesT Johnson
Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
Proc Biol Sci 266:2389-97. 1999..This flux raises the mean fitness of the mutator subpopulation, and when this factor is taken into account, the frequency of the mutator may be more than an order of magnitude greater than recent theoretical work has suggested...
- MCALIGN2: faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolutionJun Wang
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
BMC Bioinformatics 7:292. 2006..Unraveling the functional significance of non-coding DNA depends on how well we are able to align non-coding DNA sequences. However, the alignment of non-coding DNA sequences is more difficult than aligning protein-coding sequences...
- Performance of marker-based relatedness estimators in natural populations of outbred vertebratesKatalin Csilléry
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, UK
Genetics 173:2091-101. 2006..Our five examples of vertebrate breeding systems suggest that due to the remarkably low variance in relatedness across the population, marker-based estimates may often have low power to address research questions of interest...
- MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolutionPeter D Keightley
University of Edinburgh, School of Biological Sciences, Ashworth Laboratories, Edinburgh EH9 3JT, UK. Peter.Keightley_at_ed.ac.uk
Genome Res 14:442-50. 2004..We show that there is excellent agreement between true and estimated alignments over a wide range of sequence divergences, and that the method outperforms other available alignment methods...
- The effect of deleterious alleles on adaptation in asexual populationsToby Johnson
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Genetics 162:395-411. 2002..Again, this analysis relaxes the assumption made previously that selection against deleterious alleles is stronger than on beneficial alleles...
- General models of multilocus evolutionMark Kirkpatrick
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
Genetics 161:1727-50. 2002..We illustrate the methods by finding the effect of natural selection, sexual selection, mutation, and migration on the genetic composition of a population...
- Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008....
- Genome-wide association analysis identifies 20 loci that influence adult heightMichael N Weedon
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
Nat Genet 40:575-83. 2008..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
- LDL-cholesterol concentrations: a genome-wide association studyManjinder S Sandhu
Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
Lancet 371:483-91. 2008..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
- The fixation probability of a beneficial allele in a population dividing by binary fissionToby Johnson
Department of Zoology, University of British Columbia, Vancouver, Canada
Genetica 115:283-7. 2002..We find that P approximately = 2s for mutations occurring during chromosome replication and P approximately = 2.8s for mutations occurring at random times between replication events...
- Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesXin Yuan
Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
Am J Hum Genet 83:520-8. 2008..The specific associations with ALP levels may point to genes for bone or intestinal diseases...