Tim S Johnson
Affiliation: University of Sheffield
- Matrix metalloproteinases and their inhibitions in experimental renal scarringTimothy S Johnson
Sheffield Kidney Institute, Northern General Hospital Trust, Sheffield, UK
Exp Nephrol 10:182-95. 2002..01), respectively. This data suggests that reduced MMP activity may contribute towards renal scarring, however this is not a result of reduced MMP transcription or activation, but likely to be due to the inhibition by TIMPs...
- Development of a chronic kidney disease model in C57BL/6 mice with relevance to human pathologyLinghong Huang
Academic Nephrology Unit, Sheffield Kidney Institute, University of Sheffield, Sheffield, UK
Nephron Extra 3:12-29. 2013..Therefore, we aimed to develop a standardised protocol to develop tubulointerstitial fibrosis using pure aristolochic acid I (AAI) in C57BL/6 mice...
- Urinary matrix metalloproteinase activity in diabetic kidney disease: a potential marker of disease progressionNagi Altemtam
Sheffield Kidney Institute Academic Nephrology Unit, School of Medicine and Biomedical Sciences, Sheffield, UK
Nephron Extra 2:219-32. 2012..We tested the hypothesis that MMP activity can be measured in human urine and can be used as a potential biomarker of the progression of diabetic kidney disease (DKD)...
- Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney diseaseTim S Johnson
Melvyn Round Kidney Research Laboratories, Sheffield Kidney Institute, Northern General Hospital, University of Sheffield, Sheffield, UK
J Am Soc Nephrol 18:3078-88. 2007
- The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosisT S Johnson
Sheffield Kidney Institute, Northern General Hospital NHS Trust, Sheffield S5 7AU, United Kingdom
J Clin Invest 99:2950-60. 1997....
- Tissue transglutaminase: a mediator and predictor of chronic allograft nephropathy?Timothy S Johnson
Sheffield Kidney Institute, Sheffield, UK
Transplantation 77:1667-75. 2004..Sequential biopsies were investigated using immunohistochemical, immunofluorescence, and in situ enzyme activity techniques...
- Tissue transglutaminase and the progression of human renal scarringTimothy S Johnson
Sheffield Kidney Institute, Sheffield, United Kingdom
J Am Soc Nephrol 14:2052-62. 2003..tTg may therefore play a role in the pathogenesis of renal scarring and fibrosis in patients with CRD and can therefore be considered a potential therapeutic target...
- Modulation of tissue transglutaminase in tubular epithelial cells alters extracellular matrix levels: a potential mechanism of tissue scarringMarie Fisher
Academic Nephrology Unit, University of Sheffield, United Kingdom
Matrix Biol 28:20-31. 2009..These findings support a role for TG2 in the expansion of the ECM associated with kidney scarring...
- Transglutaminase inhibition ameliorates experimental diabetic nephropathyLinghong Huang
Academic Nephrology Unit, Sheffield Kidney Institute, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
Kidney Int 76:383-94. 2009..Our study suggests that transglutaminase inhibition ameliorates the progression of experimental diabetic nephropathy and can be considered for clinical application...
- A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritisBin Yang
Sheffield Kidney Institute, Division of Clinical Sciences, Department of Histopathology, Northern General Hospital Trust, Sheffield University, Herries Road, Sheffield, England S5 7AU, UK
Kidney Int 62:1301-13. 2002..However, its importance in controlling apoptosis in glomerulonephritis is unclear. Here, using the nephrotoxic nephritis (NTN) model, we evaluated Bax/Bcl-2 in relation to changes in the apoptosis co-ordination enzyme, caspase-3...
- Effects of caspase inhibition on the progression of experimental glomerulonephritisBin Yang
Sheffield Kidney Institute, Department of Histopathology and Division of Clinical Sciences, Sheffield Teaching Hospitals, Sheffield University, United Kingdom
Kidney Int 63:2050-64. 2003..In a nephrotoxic nephritis (NTN) model, we previously demonstrated an up-regulation of caspase-3 that was associated with inappropriate renal apoptosis, inflammation, tubular atrophy, and renal scarring...
- An IGF-I antagonist does not inhibit renal fibrosis in the rat following subtotal nephrectomySimon D Oldroyd
School of Allied Health Sciences, De Montfort University, Leicester, UK
Am J Physiol Renal Physiol 290:F695-702. 2006..Thus an interventional study with an IGF-I receptor antagonist does not support a role for IGF-I in the development of renal fibrosis in the SNx rat, although IGF-I does make an important contribution to compensatory kidney growth...
- Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cellsNicholas J Skill
School of Science, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS United Kingdom
J Biol Chem 279:47754-62. 2004....
- Tissue engineering cartilage with aged articular chondrocytes in vivoJohn M Mesa
Plastic Surgery Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
Plast Reconstr Surg 118:41-9; discussion 50-3. 2006..The authors hypothesized that articular chondrocytes isolated from old animals could produce neocartilage in vivo as well as articular chondrocytes from young donors...
- Heterotopic limb allotransplantation model to study skin rejection in the ratJamal A Nazzal
Division of Plastic Surgery, Harvard Medical School, Massachusetts General Hospital, 25 Fruit Street, Boston, MA 02114, USA
Microsurgery 24:448-53. 2004..6 days (without). Our heterotopic limb transplantation model takes less time and is less stressful to the animals, while allowing for early observation of graft skin rejection, when compared to orthotopic whole-limb transplantation...