Randall S Johnson
Affiliation: University of Cambridge
Evans C, Palazon A, Sim J, Tyrakis P, Prodger A, Lu X, et al
. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biol Open. 2017;6:688-697 pubmed publisher
..The model system described here demonstrates the importance of thrombotic insult in metastatic success and can be used to improve understanding of thrombosis-associated tumorigenesis and its treatment. ..
Sim J, Johnson R. Through a Clear Cell, Darkly: HIF2Î±/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress. Cancer Discov. 2015;5:584-5 pubmed publisher
..This adaptation is indispensable in tumor cells-where growth demands and a fluctuating blood supply place unnatural stresses on ER function-and is therefore an attractive therapeutic target. ..
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, MacÃas D, et al
. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018;27:898-913.e7 pubmed publisher
..We find that FIH, through its regulation of oxidation, acts in concert with the PHD/vHL pathway to accelerate HIF-mediated metabolic responses to hypoxia. ..
Cowburn A, Alexander L, Southwood M, Nizet V, Chilvers E, Johnson R. Epidermal deletion of HIF-2Î± stimulates wound closure. J Invest Dermatol. 2014;134:801-808 pubmed publisher
..This indicates that manipulating or reducing the HIF-2Î± response in keratinocytes could be a useful means to accelerate wound healing and tissue repair. ..
Lee Y, Kim J, Osborne O, Oh D, Sasik R, Schenk S, et al
. Increased adipocyte O2 consumption triggers HIF-1Î±, causing inflammation and insulin resistance in obesity. Cell. 2014;157:1339-52 pubmed publisher
..These results reveal the sequential series of events in obesity-induced inflammation and insulin resistance. ..
O Reilly V, Lopes Floro K, Shi H, Chapman B, Preis J, James A, et al
. Gene-environment interaction demonstrates the vulnerability of the embryonic heart. Dev Biol. 2014;391:99-110 pubmed publisher
..Importantly, these findings extend our understanding of the roles of Hif1Î± in cardiovascular development. ..
Palazon A, Goldrath A, Nizet V, Johnson R. HIF transcription factors, inflammation, and immunity. Immunity. 2014;41:518-28 pubmed publisher
..Here we discuss how oxygen sensing in the immune microenvironment shapes immunological response and examine how HIF and the hypoxia pathway control innate and adaptive immunity. ..
Branco C, Johnson R. To PFKFB3 or Not to PFKFB3, That Is the Question. Cancer Cell. 2016;30:831 pubmed publisher
..describe how reduction of PFKFB3 enzyme activity can promote vascular normalization. The authors show in turn how this affects vascular permeability and can ultimately improve the efficacy of chemotherapeutic agents. ..
Palazon A, Tyrakis P, Macías D, Veliça P, Rundqvist H, Fitzpatrick S, et al
. An HIF-1?/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017;32:669-683.e5 pubmed publisher
..These data demonstrate that the HIF-1?/VEGF-A axis is an essential aspect of tumor immunity. ..