Research Topics
| Colin JohnsonSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitisC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Dig Surg 16:93-101. 1999..Confirmation of clinical findings with lexipafant will indicate an effective new therapy for the treatment of severe acute pancreatitis...
Development of the European Organisation for Research and Treatment of Cancer quality of life questionnaire module for older people with cancer: The EORTC QLQ-ELD15Colin Johnson
University Surgical Unit, University of Southampton School of Medicine, Tremona Road, Southampton, UK
Eur J Cancer 46:2242-52. 2010..The aim of this study was to develop a HRQOL questionnaire module to supplement the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire, the EORTC QLQ-C30 for older (>70years) patients with cancer...
Arris & Gale lecture. Regulation and responses of gallbladder muscle activity in health and diseaseC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Ann R Coll Surg Engl 85:297-305. 2003..The work reported here gives an overview of the symptoms and mechanisms of disease associated with the presence of stones in the gallbladder...- Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitisC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Pancreatology 4:1-6. 2004..The aim of this study was to evaluate a combination of the APACHE-II score with an obesity score in patients with acute pancreatitis, to predict severity using information available during the first 24 h of hospital admission... - Urinary trypsinogen activation peptide as a marker of severe acute pancreatitisC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Br J Surg 91:1027-33. 2004.... - Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitisC D Johnson
University Surgical Unit, F Level, Centre Block 816, Southampton General Hospital, Southampton SO16 6YD, UK
Gut 53:1340-4. 2004..It has been suggested that half of patients with progressive early organ failure may die, but there are no data to relate death or local complications to duration of early (week 1) organ failure... - Antioxidants in acute pancreatitisC D Johnson
University Surgical Unit, Mail Point 816, Southampton General Hospital, Southampton SO16 6YD, UK
Gut 56:1344-5. 2007 - An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy for pain management in patients with pancreatic and other abdominal malignanciesColin D Johnson
University Surgical Unit 816, Southampton General Hospital, Southampton, UK
Pancreatology 9:755-63. 2009..Nerve block procedures may improve symptom control. Our aim was to assess celiac plexus block (CPB) and thoracoscopic splanchnicectomy (TS) in patients receiving appropriate medical management (MM)... - Detection of gallstones in acute pancreatitis: when and how?Colin Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Pancreatology 10:27-32. 2010..This review analyses the evidence that defines current best practice in this area. and IAP... - Early severity indexes in acute pancreatitisC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, S016 6YD, UK
Acta Gastroenterol Belg 66:174-6. 2003 - Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitisC D Johnson
University Surgical Unit, F Level, Centre Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Gut 48:62-9. 2001..We tested the hypothesis that a potent PAF antagonist, lexipafant, could dampen SIRS and reduce organ failure in severe acute pancreatitis... - Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinomaC D Johnson
University Surgical Unit, Southampton General Hospital, Southampton, UK
Br J Surg 88:662-8. 2001..Chemotherapy for pancreatic cancer offers small survival benefits and considerable side-effects. Unsaturated fatty acids have an antitumour effect in experimental studies; in phase II studies few side-effects were seen... - Preoperative biliary drainage before resection in obstructive jaundiceE A Aly
Pancreas and Biliary Research Group, University Surgical Unit, Southampton General Hospital, Southampton, UK c d
Dig Surg 18:84-9. 2001..Surgery for patients with malignant obstructive jaundice carries high morbidity and mortality rates. Preoperative biliary drainage (PBD) has been used in an attempt to improve the outcome in these patients... - Body composition, physiological function and psychological changes in patients with predicted severe acute pancreatitisR Gupta
University Department of Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Pancreatology 1:58-62. 2001..Improvement in these variables is apparent over 7 days of effective treatment. Further research is indicated to examine the effect of nutritional support on these variables... - A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or =6)R Gupta
University Department of Surgery, Southampton General Hospital, UK
Pancreatology 3:406-13. 2003..CONCLUSION: Immediate institution of nutritional support in the form of TEN is safe in predicted severe acute pancreatitis. It is as safe and as efficacious as TPN and may be beneficial in the clinical course of this disease... - Non-compliance with national guidelines in the management of acute pancreatitis in the United kingdomEmad A H Aly
Pancreas and Biliary Research Group, University Surgical Unit, Southampton General Hospital, UK
Dig Surg 19:192-8. 2002..This has implications for the rationale of creating guidelines, and for the strategies associated with their introduction... - Pancreas divisumS Varshney
University Surgical Unit, Southampton General Hospital, UK
Int J Pancreatol 25:135-41. 1999..It seems unlikely that PD alone could cause obstructive pancreatitis and the presence of another factor, such as minor papilla insufficiency, is probably required for this relatively common anomaly to develop complications... - Neuroendocrine tumors of the pancreasS Varshney
University Surgical Unit, Southampton General Hospital, UK
Indian J Gastroenterol 19:181-3. 2000..During follow up from 1 to 7 years, one patient with malignant carcinoid tumor died at two and half years, of local recurrence. The other 8 patients are disease-free with good quality of life... - CT arterial portography in the staging of pancreatic malignancyS Varshney
University Surgical Unit, and Southampton General Hospital, UK
Int J Pancreatol 28:59-65. 2000..We have assessed CTAP in patients with pancreatic cancer considered suitable for resection after standard ultrasonography (US) and computed tomography (CT) examination... - Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficienciesT Armstrong
University Department of Surgery, Southampton General Hospital, Southampton, UK
Pancreatology 7:37-44. 2007..After pancreaticoduodenectomy (PD) patients may be deficient in essential micronutrients. This study was designed to determine if this is a consequence of surgery... - A meta-analysis comparing suprapubic and transurethral catheterization for bladder drainage after abdominal surgeryM J W McPhail
University Surgical Unit, Mail Point 816, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Br J Surg 93:1038-44. 2006..97, P=0.213, 95 percent c.i. 0.68 to 5.74) with heterogeneity between studies. CONCLUSION: The suprapubic route for bladder drainage in general surgery is more acceptable to patients and reduces microbiological morbidity... - Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitisW M Howell
The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
J Clin Pathol 58:595-9. 2005.... - Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell linesP A Whitehouse
Department of Surgery, Southampton General Hospital, Southampton, UK
Pancreatology 3:367-73; discussion 373-4. 2003..GLA with 5-FU is synergistic only at a tight range of high concentrations of 5-FU. GLA lacks toxic side effects and may be useful in combination with gemcitabine... - An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell linesA Agombar
University Surgical Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Anticancer Drugs 15:157-60. 2004.... - Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet functionA C Bateman
The Pancreatic and Liver Fibrosis Research Groups, Division of Infection, University of Southampton, Southampton General Hospital, UK
Gut 50:542-8. 2002..This is mirrored pathologically by extensive acinar cell destruction and islet preservation. The mechanisms underlying this differential rate of cellular destruction are unknown... - Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysisJ Martinez
Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain
Pancreatology 6:206-9. 2006..We have performed a new meta-analysis to confirm the relationship between obesity and the outcome of acute pancreatitis... - Quality of life after surgery for chronic pancreatitisC D Johnson
Pancreatology 6:497-8; author reply 498. 2006 - Genomic profiles and predictive biological networks in oxidant-induced atherogenesisC D Johnson
Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843, USA
Physiol Genomics 13:263-75. 2003..Redox-dependent patterns of gene deregulation indicate that oxidative stress plays a prominent role during the early stages of BaP-induced atherogenesis... - A phase II trial of marimastat in advanced pancreatic cancerJ D Evans
Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK
Br J Cancer 85:1865-70. 2001..Of 90 patients, 46 (51%) had stabilization or reduction in pain, mobility and analgesia scores. Further development and clinical evaluation of matrix metalloproteinase inhibitors for the treatment of pancreatic cancer is warranted...