Colin Johnson

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Dig Surg 16:93-101. 1999
  2. pmc Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: a pilot trial demonstrating safety
    Marie K Gurka
    Department of Radiation Oncology, Georgetown University Hospital, Washington, DC 20007, USA
    Radiat Oncol 8:44. 2013
  3. pmc Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: the EORTC QLQ-TC26
    Bernhard Holzner
    Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
    Qual Life Res 22:369-78. 2013
  4. pmc Arris & Gale lecture. Regulation and responses of gallbladder muscle activity in health and disease
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Ann R Coll Surg Engl 85:297-305. 2003
  5. ncbi request reprint Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Pancreatology 4:1-6. 2004
  6. ncbi request reprint Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Br J Surg 91:1027-33. 2004
  7. pmc Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis
    C D Johnson
    University Surgical Unit, F Level, Centre Block 816, Southampton General Hospital, Southampton SO16 6YD, UK
    Gut 53:1340-4. 2004
  8. pmc Antioxidants in acute pancreatitis
    C D Johnson
    University Surgical Unit, Mail Point 816, Southampton General Hospital, Southampton SO16 6YD, UK
    Gut 56:1344-5. 2007
  9. doi request reprint An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy for pain management in patients with pancreatic and other abdominal malignancies
    Colin D Johnson
    University Surgical Unit 816, Southampton General Hospital, Southampton, UK
    Pancreatology 9:755-63. 2009
  10. doi request reprint Detection of gallstones in acute pancreatitis: when and how?
    Colin Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Pancreatology 10:27-32. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Dig Surg 16:93-101. 1999
    ..PAF has also been implicated as a key mediator in the progression of severe acute pancreatitis, which can lead to complications and unacceptably high mortality rates...
  2. pmc Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: a pilot trial demonstrating safety
    Marie K Gurka
    Department of Radiation Oncology, Georgetown University Hospital, Washington, DC 20007, USA
    Radiat Oncol 8:44. 2013
    ..This Pilot study assessed the safety of concurrent full-dose gemcitabine with SBRT for LAPC...
  3. pmc Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: the EORTC QLQ-TC26
    Bernhard Holzner
    Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
    Qual Life Res 22:369-78. 2013
    ..The low mortality rate makes quality of life (QOL) an important issue in this patient group. This study aimed to develop a supplementary module of the EORTC QLQ-C30 questionnaire to assess TC-specific aspects of QOL...
  4. pmc Arris & Gale lecture. Regulation and responses of gallbladder muscle activity in health and disease
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Ann R Coll Surg Engl 85:297-305. 2003
    ..The work reported here gives an overview of the symptoms and mechanisms of disease associated with the presence of stones in the gallbladder...
  5. ncbi request reprint Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Pancreatology 4:1-6. 2004
    ..The aim of this study was to evaluate a combination of the APACHE-II score with an obesity score in patients with acute pancreatitis, to predict severity using information available during the first 24 h of hospital admission...
  6. ncbi request reprint Urinary trypsinogen activation peptide as a marker of severe acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Br J Surg 91:1027-33. 2004
    ....
  7. pmc Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis
    C D Johnson
    University Surgical Unit, F Level, Centre Block 816, Southampton General Hospital, Southampton SO16 6YD, UK
    Gut 53:1340-4. 2004
    ..It has been suggested that half of patients with progressive early organ failure may die, but there are no data to relate death or local complications to duration of early (week 1) organ failure...
  8. pmc Antioxidants in acute pancreatitis
    C D Johnson
    University Surgical Unit, Mail Point 816, Southampton General Hospital, Southampton SO16 6YD, UK
    Gut 56:1344-5. 2007
  9. doi request reprint An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy for pain management in patients with pancreatic and other abdominal malignancies
    Colin D Johnson
    University Surgical Unit 816, Southampton General Hospital, Southampton, UK
    Pancreatology 9:755-63. 2009
    ..Nerve block procedures may improve symptom control. Our aim was to assess celiac plexus block (CPB) and thoracoscopic splanchnicectomy (TS) in patients receiving appropriate medical management (MM)...
  10. doi request reprint Detection of gallstones in acute pancreatitis: when and how?
    Colin Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Pancreatology 10:27-32. 2010
    ..This review analyses the evidence that defines current best practice in this area. and IAP...
  11. doi request reprint Development of the European Organisation for Research and Treatment of Cancer quality of life questionnaire module for older people with cancer: The EORTC QLQ-ELD15
    Colin Johnson
    University Surgical Unit, University of Southampton School of Medicine, Tremona Road, Southampton, UK
    Eur J Cancer 46:2242-52. 2010
    ..The aim of this study was to develop a HRQOL questionnaire module to supplement the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire, the EORTC QLQ-C30 for older (>70years) patients with cancer...
  12. ncbi request reprint Early severity indexes in acute pancreatitis
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, S016 6YD, UK
    Acta Gastroenterol Belg 66:174-6. 2003
  13. ncbi request reprint Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma
    C D Johnson
    University Surgical Unit, Southampton General Hospital, Southampton, UK
    Br J Surg 88:662-8. 2001
    ..Chemotherapy for pancreatic cancer offers small survival benefits and considerable side-effects. Unsaturated fatty acids have an antitumour effect in experimental studies; in phase II studies few side-effects were seen...
  14. pmc Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis
    C D Johnson
    University Surgical Unit, F Level, Centre Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Gut 48:62-9. 2001
    ..We tested the hypothesis that a potent PAF antagonist, lexipafant, could dampen SIRS and reduce organ failure in severe acute pancreatitis...
  15. ncbi request reprint Preoperative biliary drainage before resection in obstructive jaundice
    E A Aly
    Pancreas and Biliary Research Group, University Surgical Unit, Southampton General Hospital, Southampton, UK c d
    Dig Surg 18:84-9. 2001
    ..Surgery for patients with malignant obstructive jaundice carries high morbidity and mortality rates. Preoperative biliary drainage (PBD) has been used in an attempt to improve the outcome in these patients...
  16. ncbi request reprint Body composition, physiological function and psychological changes in patients with predicted severe acute pancreatitis
    R Gupta
    University Department of Surgery, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Pancreatology 1:58-62. 2001
    ..Improvement in these variables is apparent over 7 days of effective treatment. Further research is indicated to examine the effect of nutritional support on these variables...
  17. ncbi request reprint A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II > or =6)
    R Gupta
    University Department of Surgery, Southampton General Hospital, UK
    Pancreatology 3:406-13. 2003
    ..Our aim was to ascertain the safety of immediate TEN in these patients and the effect of TEN on systemic inflammation, psychological state, oxidative stress, plasma glutamine levels and endotoxaemia...
  18. ncbi request reprint Non-compliance with national guidelines in the management of acute pancreatitis in the United kingdom
    Emad A H Aly
    Pancreas and Biliary Research Group, University Surgical Unit, Southampton General Hospital, UK
    Dig Surg 19:192-8. 2002
    ..However, implementation of national guidelines in other areas has been patchy, suggesting that evaluation of the uptake of the pancreatitis guidelines would be appropriate...
  19. ncbi request reprint Neuroendocrine tumors of the pancreas
    S Varshney
    University Surgical Unit, Southampton General Hospital, UK
    Indian J Gastroenterol 19:181-3. 2000
    ..During follow up from 1 to 7 years, one patient with malignant carcinoid tumor died at two and half years, of local recurrence. The other 8 patients are disease-free with good quality of life...
  20. ncbi request reprint Pancreas divisum
    S Varshney
    University Surgical Unit, Southampton General Hospital, UK
    Int J Pancreatol 25:135-41. 1999
    ..It seems unlikely that PD alone could cause obstructive pancreatitis and the presence of another factor, such as minor papilla insufficiency, is probably required for this relatively common anomaly to develop complications...
  21. pmc Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
    W M Howell
    The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
    J Clin Pathol 58:595-9. 2005
    ....
  22. ncbi request reprint An aqueous formulation of gamma-linolenic acid with anti-proliferative action on human pancreatic cancer cell lines
    A Agombar
    University Surgical Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Anticancer Drugs 15:157-60. 2004
    ....
  23. ncbi request reprint A meta-analysis comparing suprapubic and transurethral catheterization for bladder drainage after abdominal surgery
    M J W McPhail
    University Surgical Unit, Mail Point 816, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Surg 93:1038-44. 2006
    ..Although bladder drainage is widely used for general surgical patients undergoing laparotomy, there is little consensus on whether suprapubic or transurethral catheterization is better...
  24. ncbi request reprint Synergistic activity of gamma-linolenic acid and cytotoxic drugs against pancreatic adenocarcinoma cell lines
    P A Whitehouse
    Department of Surgery, Southampton General Hospital, Southampton, UK
    Pancreatology 3:367-73; discussion 373-4. 2003
    ..Chemotherapeutic agents have limited activity in pancreatic cancer. Interactions between GLA and cytotoxic drugs have not previously been investigated; any synergy might improve the therapeutic effect of these agents...
  25. ncbi request reprint Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficiencies
    T Armstrong
    University Department of Surgery, Southampton General Hospital, Southampton, UK
    Pancreatology 7:37-44. 2007
    ..After pancreaticoduodenectomy (PD) patients may be deficient in essential micronutrients. This study was designed to determine if this is a consequence of surgery...
  26. pmc Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function
    A C Bateman
    The Pancreatic and Liver Fibrosis Research Groups, Division of Infection, University of Southampton, Southampton General Hospital, UK
    Gut 50:542-8. 2002
    ..This is mirrored pathologically by extensive acinar cell destruction and islet preservation. The mechanisms underlying this differential rate of cellular destruction are unknown...
  27. ncbi request reprint CT arterial portography in the staging of pancreatic malignancy
    S Varshney
    University Surgical Unit, and Southampton General Hospital, UK
    Int J Pancreatol 28:59-65. 2000
    ..We have assessed CTAP in patients with pancreatic cancer considered suitable for resection after standard ultrasonography (US) and computed tomography (CT) examination...
  28. ncbi request reprint Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis
    J Martinez
    Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain
    Pancreatology 6:206-9. 2006
    ..We have performed a new meta-analysis to confirm the relationship between obesity and the outcome of acute pancreatitis...
  29. ncbi request reprint Quality of life after surgery for chronic pancreatitis
    C D Johnson
    Pancreatology 6:497-8; author reply 498. 2006
  30. pmc A phase II trial of marimastat in advanced pancreatic cancer
    J D Evans
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Br J Cancer 85:1865-70. 2001
    ..Of 90 patients, 46 (51%) had stabilization or reduction in pain, mobility and analgesia scores. Further development and clinical evaluation of matrix metalloproteinase inhibitors for the treatment of pancreatic cancer is warranted...
  31. ncbi request reprint Genomic profiles and predictive biological networks in oxidant-induced atherogenesis
    C D Johnson
    Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843, USA
    Physiol Genomics 13:263-75. 2003
    ..Redox-dependent patterns of gene deregulation indicate that oxidative stress plays a prominent role during the early stages of BaP-induced atherogenesis...