Andrew D Johnson

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Evolution of predetermined germ cells in vertebrate embryos: implications for macroevolution
    Andrew D Johnson
    Division of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Evol Dev 5:414-31. 2003
  2. pmc Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
  3. pmc Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage
    Andrew D Johnson
    Department of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Philos Trans R Soc Lond B Biol Sci 358:1371-9. 2003
  4. doi request reprint Evolution of the germ line-soma relationship in vertebrate embryos
    Andrew D Johnson
    School of Biology, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Reproduction 141:291-300. 2011
  5. doi request reprint 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development
    Rimple D Almeida
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, University of Nottingham, Nottingham, UK
    Epigenetics 7:383-9. 2012
  6. pmc Epigenetic reprogramming of breast cancer cells with oocyte extracts
    Cinzia Allegrucci
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Cancer 10:7. 2011
  7. pmc Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals
    Rimple D Almeida
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Epigenetics 7:137-40. 2012
  8. ncbi request reprint A conserved mechanism for vertebrate mesoderm specification in urodele amphibians and mammals
    Gemma Swiers
    Institute of Genetics, Queens Medical Centre, University of Nottingham, NG7 2UH, UK
    Dev Biol 343:138-52. 2010
  9. ncbi request reprint Acquisition of germ plasm accelerates vertebrate evolution
    Teri Evans
    School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Science 344:200-3. 2014
  10. pmc Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos
    Jodie Chatfield
    School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Development 141:2429-40. 2014

Collaborators

  • Virginie Sottile
  • R Alberio
  • Alexey Ruzov
  • Rosemary F Bachvarova
  • Cinzia Allegrucci
  • Roger Patient
  • Brian I Crother
  • Chris Denning
  • Elena Matsa
  • Matthew Loose
  • Rimple D Almeida
  • Lee M Wheldon
  • Zoltan Ferjentsik
  • Jodie Chatfield
  • James E Dixon
  • Yuhong Bian
  • Farhat Habib
  • Teri Evans
  • Abdulkadir Abakir
  • Anthony Alioui
  • Catherine Redwood
  • Yi Hsien Chen
  • Gemma Swiers
  • Tahsin Kurc
  • Ivan R Correa
  • Nan Dai
  • Shengxi Guan
  • Tatiana Dudnakova
  • Stephanie Strohbuecker
  • Jeremy M Foster
  • Denise Christie
  • Frank A Chapman
  • Marie Anne O'Reilly
  • Mathew Loose
  • Maggie Walmsley
  • Christopher M Wade
  • Paul A De Sousa
  • Martin Gering
  • Lorraine Young
  • S Randal Voss
  • Kevin Kump
  • Keith H Campbell
  • Daniel Janies
  • Ralf Bundschuh
  • Stephen Langella
  • Umit V Catalyurek
  • David Ervin
  • Daniel A Janies
  • Joel H Saltz
  • Scott Oster
  • Terry Camerlengo
  • Shannon Hastings

Detail Information

Publications21

  1. ncbi request reprint Evolution of predetermined germ cells in vertebrate embryos: implications for macroevolution
    Andrew D Johnson
    Division of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Evol Dev 5:414-31. 2003
    ..Moreover, our analysis suggests that germ plasm has evolved independently in several lineages of vertebrate embryos...
  2. pmc Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
    ..We have used AEI to discover and characterize regulatory polymorphisms in OPRM1, TPH2, MDR1, DRD2, and VKORC1. The objective of this study was to use AEI to determine the extent of cis-regulatory factors in pharmacogenetic genes...
  3. pmc Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage
    Andrew D Johnson
    Department of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Philos Trans R Soc Lond B Biol Sci 358:1371-9. 2003
    ..Our results imply that germ plasm, as found in species such as frogs and teleosts, is the result of convergent evolution. We discuss the evolutionary implications of our findings...
  4. doi request reprint Evolution of the germ line-soma relationship in vertebrate embryos
    Andrew D Johnson
    School of Biology, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Reproduction 141:291-300. 2011
    ..We also present the correlation of preformation with enhanced species radiations, and we discuss the mutually exclusive trajectories influenced by germ plasm or pluripotency, which shaped chordate evolution...
  5. doi request reprint 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development
    Rimple D Almeida
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, University of Nottingham, Nottingham, UK
    Epigenetics 7:383-9. 2012
    ..Our findings show that 5-hmC enrichment of non-committed cells is not a universal feature of vertebrate development and give insights both into evolution of embryonic pluripotency and the potential role of 5-hmC in its regulation...
  6. pmc Epigenetic reprogramming of breast cancer cells with oocyte extracts
    Cinzia Allegrucci
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Cancer 10:7. 2011
    ..In this study we apply the reprogramming capacity of oocytes to cancer cells in order to study breast oncogenesis...
  7. pmc Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals
    Rimple D Almeida
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
    Epigenetics 7:137-40. 2012
    ....
  8. ncbi request reprint A conserved mechanism for vertebrate mesoderm specification in urodele amphibians and mammals
    Gemma Swiers
    Institute of Genetics, Queens Medical Centre, University of Nottingham, NG7 2UH, UK
    Dev Biol 343:138-52. 2010
    ....
  9. ncbi request reprint Acquisition of germ plasm accelerates vertebrate evolution
    Teri Evans
    School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Science 344:200-3. 2014
    ..Our results support the hypothesis that germ plasm liberates constraints on somatic development and that enhanced evolvability drives the evolution of germ plasm. ..
  10. pmc Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos
    Jodie Chatfield
    School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
    Development 141:2429-40. 2014
    ..Before this, germline potential was maintained by MAP kinase signalling. We propose that this stochastic mechanism of PGC specification, from mesodermal precursors, is conserved in vertebrates. ..
  11. pmc 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary
    Anthony Alioui
    School of Biology, University of Nottingham, Nottingham, UK
    Nucleus 3:565-9. 2012
    ..Our results suggest that 5-carboxylcytosine may play a distinct functional role in certain biological contexts...
  12. ncbi request reprint Reprogramming somatic cells into stem cells
    Ramiro Alberio
    School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
    Reproduction 132:709-20. 2006
    ..We also overview reprogramming events after somatic cell nuclear transfer (SCNT), as they may further instruct ex ovo strategies for cellular manipulation...
  13. pmc Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammals
    James E Dixon
    Institute of Genetics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham NG2 2UH, UK
    Development 137:2973-80. 2010
    ..Our results show that protein interactions mediated by Nanog dimerization promote proliferation. More importantly, they demonstrate that the mechanisms governing pluripotency are conserved from urodele amphibians to mammals...
  14. ncbi request reprint Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells
    Lee M Wheldon
    Medical Molecular Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Cell Rep 7:1353-61. 2014
    ..Our data suggest that active demethylation contributes to epigenetic reprogramming determining lineage specification in embryonic brain. ..
  15. ncbi request reprint Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts
    Yuhong Bian
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Epigenetics 4:194-202. 2009
    ..The results demonstrate that axolotl oocyte extracts are a useful tool for studying epigenetic remodelling of somatic cells to a stem cell configuration, and for elucidating oocyte specific mechanisms of nuclear reprogramming...
  16. ncbi request reprint Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm
    Ramiro Alberio
    Animal Development and Biotechnology Group, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
    Exp Cell Res 307:131-41. 2005
    ....
  17. ncbi request reprint Gene expression in the axolotl germ line: Axdazl, Axvh, Axoct-4, and Axkit
    Rosemary F Bachvarova
    Department of Cell Biology and Development, Weill Medical College of Cornell University, New York, New York, USA
    Dev Dyn 231:871-80. 2004
    ..We conclude that PGCs are restricted to the germ line later in urodeles than in mice or lack migration and proliferation programs...
  18. ncbi request reprint Inferring developmental constraint and constraint release: primordial germ cell determination mechanisms as examples
    Brian I Crother
    Southeastern Louisiana University, Hammond, LA 70402, USA
    J Theor Biol 248:322-30. 2007
    ..Our results corroborate previous conclusions that the induced mode is the constraint and the predetermined mode is the release and we speculate on the importance of these two processes in terms of robustness and evolvability...
  19. pmc An XML-based system for synthesis of data from disparate databases
    Tahsin Kurc
    Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Am Med Inform Assoc 13:289-301. 2006
    ..The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets...
  20. ncbi request reprint Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics
    Andrew D Johnson
    Integrated Biomedical Sciences Graduate Program, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5072 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
    Pharmacol Ther 106:19-38. 2005
    ..Current methods and challenges associated with the identification and characterization of functional polymorphisms are also discussed...
  21. ncbi request reprint Large scale genotype-phenotype correlation analysis based on phylogenetic trees
    Farhat Habib
    Department of Physics, The Ohio State University, Columbus, OH 43210, USA
    Bioinformatics 23:785-8. 2007
    ..We use these methods to find SNPs correlated with resistance to Bacillus anthracis in inbred mouse strains. Our findings are consistent with the current biological literature, and also suggest potential novel candidate genes...