A C Joerger

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The tumor suppressor p53: from structures to drug discovery
    Andreas C Joerger
    MRC Centre for Protein Engineering, Hills Road, Cambridge, United Kingdom
    Cold Spring Harb Perspect Biol 2:a000919. 2010
  2. ncbi request reprint Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations
    Andreas C Joerger
    Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 2QH, UK
    J Biol Chem 279:1291-6. 2004
  3. ncbi request reprint Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro
    Sebastian Mayer
    Cambridge University Chemical Laboratory and Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 372:268-76. 2007
  4. pmc Halogen-enriched fragment libraries as leads for drug rescue of mutant p53
    Rainer Wilcken
    Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
    J Am Chem Soc 134:6810-8. 2012
  5. pmc Structure and kinetic stability of the p63 tetramerization domain
    Eviatar Natan
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 415:503-13. 2012
  6. pmc Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer
    Eviatar Natan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Mol Biol 409:358-68. 2011
  7. pmc Conservation of DNA-binding specificity and oligomerisation properties within the p53 family
    Tobias Brandt
    MRC Laboratory of Molecular Biology, Cambridge CB20QH, UK
    BMC Genomics 10:628. 2009
  8. doi request reprint Structural biology of the tumor suppressor p53
    Andreas C Joerger
    Medical Research Council Centre for Protein Engineering, Cambridge, United Kingdom
    Annu Rev Biochem 77:557-82. 2008
  9. ncbi request reprint Structure-function-rescue: the diverse nature of common p53 cancer mutants
    A C Joerger
    Centre for Protein Engineering, Medical Research Council Centre, Cambridge, UK
    Oncogene 26:2226-42. 2007
  10. doi request reprint Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73
    J van Dieck
    MRC Centre for Protein Engineering, Hills Road, Cambridge, UK
    Oncogene 29:2024-35. 2010

Collaborators

  • Alan R Fersht
  • Eviatar Natan
  • Frank M Boeckler
  • Sebastian Mayer
  • Hwee Ching Ang
  • Rainer Wilcken
  • Trevor J Rutherford
  • J van Dieck
  • Tobias Brandt
  • Dmitry B Veprintsev
  • Xiangrui Liu
  • Markus O Zimmermann
  • Stefan M V Freund
  • Nina Morgner
  • Kevin Pagel
  • Carol V Robinson
  • Cetin Baloglu
  • T Brandt
  • D B Veprintsev
  • D P Teufel
  • Miriana Petrovich
  • Gaurav Jaggi
  • Stefan Rudiger

Detail Information

Publications15

  1. pmc The tumor suppressor p53: from structures to drug discovery
    Andreas C Joerger
    MRC Centre for Protein Engineering, Hills Road, Cambridge, United Kingdom
    Cold Spring Harb Perspect Biol 2:a000919. 2010
    ..These emerging anticancer strategies include targeting mutant-specific lesions on the surface of destabilized cancer mutants with small molecules and selective inhibition of p53's degradative pathways...
  2. ncbi request reprint Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations
    Andreas C Joerger
    Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 2QH, UK
    J Biol Chem 279:1291-6. 2004
    ..This increase in rigidity provides the structural basis for the increase in thermostability and an understanding how N268D and N239Y rescue some of the common cancer mutants...
  3. ncbi request reprint Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro
    Sebastian Mayer
    Cambridge University Chemical Laboratory and Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 372:268-76. 2007
    ..coli, and provide insights into the correlation between protein instability and disease at the cellular level...
  4. pmc Halogen-enriched fragment libraries as leads for drug rescue of mutant p53
    Rainer Wilcken
    Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
    J Am Chem Soc 134:6810-8. 2012
    ..The best binders showed induction of apoptosis in a human cancer cell line with homozygous Y220C mutation. Our structural and biophysical data suggest a more widespread applicability of HEFLibs in drug discovery...
  5. pmc Structure and kinetic stability of the p63 tetramerization domain
    Eviatar Natan
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 415:503-13. 2012
    ..Differential stability of the tetramers may play an important role in the cross talk between different isoforms and regulation of p53, p63 and p73 function in the cell cycle...
  6. pmc Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer
    Eviatar Natan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Mol Biol 409:358-68. 2011
    ..These data have important implications for studies of multidomain proteins in general, highlighting the fact that weak ordered-disordered domain interactions can modulate the properties of proteins of complex structure...
  7. pmc Conservation of DNA-binding specificity and oligomerisation properties within the p53 family
    Tobias Brandt
    MRC Laboratory of Molecular Biology, Cambridge CB20QH, UK
    BMC Genomics 10:628. 2009
    ..In this study, the molecular basis of the functional divergence of related transcription factors was investigated...
  8. doi request reprint Structural biology of the tumor suppressor p53
    Andreas C Joerger
    Medical Research Council Centre for Protein Engineering, Cambridge, United Kingdom
    Annu Rev Biochem 77:557-82. 2008
    ..p53 emerges as a paradigm for a more general understanding of the structural organization of modular proteins and the effects of disease-causing mutations...
  9. ncbi request reprint Structure-function-rescue: the diverse nature of common p53 cancer mutants
    A C Joerger
    Centre for Protein Engineering, Medical Research Council Centre, Cambridge, UK
    Oncogene 26:2226-42. 2007
    ..In combination with studies on second-site suppressor mutations, it appears that some mutants are ideal rescue candidates, whereas for others simple pharmacological rescue by small molecule drugs may not be successful...
  10. doi request reprint Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73
    J van Dieck
    MRC Centre for Protein Engineering, Hills Road, Cambridge, UK
    Oncogene 29:2024-35. 2010
    ..Our results outlining the complexity of the interaction should be considered when studying the functional effects of S100 proteins in their biological context...
  11. pmc Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
    Frank M Boeckler
    Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 105:10360-5. 2008
    ..We point out some general principles in relationships between binding constants, raising of melting temperatures, and increase of protein half-lives by stabilizing ligands...
  12. ncbi request reprint Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains
    Hwee Ching Ang
    Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 281:21934-41. 2006
    ..Many mutants that have lowered melting temperatures should be good drug targets, although the common R273H mutant binds response elements too weakly for simple rescue...
  13. pmc Structural basis for understanding oncogenic p53 mutations and designing rescue drugs
    Andreas C Joerger
    Cambridge University Chemical Laboratory and Cambridge Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 103:15056-61. 2006
    ..g., temperature sensitivity). Some mutants have the potential of being rescued by a generic stabilizing drug. In addition, a mutation-induced crevice is a potential target site for a mutant-selective stabilizing drug...
  14. ncbi request reprint Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations
    Andreas C Joerger
    Centre for Protein Engineering, Medical Research Council, Cambridge, CB2 2QH, United Kingdom
    J Biol Chem 280:16030-7. 2005
    ..Our structural and biophysical data provide compelling evidence for the mechanism of rescue of mutant p53 by intragenic suppressor mutations and reveal features by which proteins can adapt to deleterious mutations...
  15. pmc Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity
    Andreas C Joerger
    Cambridge University Chemical Laboratory and Cambridge Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 100:5694-9. 2003
    ..The high flexibility of R142 may favor its role in assisting in catalysis. Perhaps, nature has exploited the catalytic promiscuity of many enzymes to evolve novel enzymes or biological pathways during the course of evolution...