Research Topics
Species | M A JoblingSummaryAffiliation: University of Leicester Country: UK Publications
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Publications
The impact of recent events on human genetic diversityMark A Jobling
Department of Genetics, University of Leicester, Leicester, UK
Philos Trans R Soc Lond B Biol Sci 367:793-9. 2012..The field would benefit from more consensus on appropriate methods, and better communication between geneticists and experts in other disciplines, such as history, archaeology and linguistics...
The human Y chromosome: an evolutionary marker comes of ageMark A Jobling
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Nat Rev Genet 4:598-612. 2003..Y-chromosome research is growing up...- Encoded evidence: DNA in forensic analysisMark A Jobling
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
Nat Rev Genet 5:739-51. 2004.... - Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin YMark A Jobling
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Hum Mol Genet 16:307-16. 2007..The persistence and expansion of deletion lineages, together with direct phenotypic evidence, suggests that absence of these genes has no major deleterious effects... - New uses for new haplotypes the human Y chromosome, disease and selectionM A Jobling
Department of Genetics, University of Leicester, UK
Trends Genet 16:356-62. 2000..However, the peculiar genetics of this bizarre chromosome means that we should interpret such studies particularly cautiously... - The Y chromosome in forensic analysis and paternity testingM A Jobling
Department of Genetics, University of Leicester, UK
Int J Legal Med 110:118-24. 1997..Y haplotyping is most likely to find application in special instances, such as deficiency cases in paternity testing and in the analysis of mixtures of male and female DNA, or in combination with autosomal markers... - A selective difference between human Y-chromosomal DNA haplotypesM A Jobling
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Curr Biol 8:1391-4. 1998..Here, we show that one class of infertile males, PRKX/PRKY translocation XX males, arises predominantly on a particular Y haplotypic background. Selection is, therefore, acting on Y haplotype distributions in the population... - In the name of the father: surnames and geneticsM A Jobling
Dept of Genetics, University of Leicester, University Road, Leicester, UK LE1 7RH
Trends Genet 17:353-7. 2001..Recent studies involving Y-chromosomal haplotyping and surname analysis are promising and indicate that genealogists of the future could be turning to records written in DNA, as well as in paper archives, to solve their problems... - Haploid chromosomes in molecular ecology: lessons from the human YM E Hurles
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Mol Ecol 10:1599-613. 2001..We present some methodologies for extracting information from these uniquely informative yet under-utilized loci... - Founders, drift, and infidelity: the relationship between Y chromosome diversity and patrilineal surnamesTuri E King
Department of Genetics, University of Leicester, Leicester, United Kingdom
Mol Biol Evol 26:1093-102. 2009.... - Dynamic nature of the proximal AZFc region of the human Y chromosome: multiple independent deletion and duplication events revealed by microsatellite analysisPatricia Balaresque
Department of Genetics, University of Leicester, Leicester, United Kingdom
Hum Mutat 29:1171-80. 2008..The nonrandom phylogenetic distribution of duplication and deletion events suggests possible structural predisposition to such mutations in hgs C and G... 
What's in a name? Y chromosomes, surnames and the genetic genealogy revolutionTuri E King
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Trends Genet 25:351-60. 2009....- Dynamics of a human interparalog gene conversion hotspotElena Bosch
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
Genome Res 14:835-44. 2004..Analysis of great ape homologs shows that conversion in this hotspot has a deep evolutionary history... - Y-chromosomal SNP haplotype diversity in forensic analysisM A Jobling
Department of Genetics, University of Leicester, University Road, LE1 7RH, Leicester, UK
Forensic Sci Int 118:158-62. 2001..If this potential is to be exploited in forensic analysis, high-throughput, parallel methods are required for Y-SNP typing... - Hypervariable digital DNA codes for human paternal lineages: MVR-PCR at the Y-specific minisatellite, MSY1 (DYF155S1)M A Jobling
Department of Genetics, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Hum Mol Genet 7:643-53. 1998.... - Copy number variation on the human Y chromosomeM A Jobling
Department of Genetics, University of Leicester, Leicester, UK
Cytogenet Genome Res 123:253-62. 2008.... - Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying duplicationsPatricia Balaresque
Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
Int J Legal Med 123:15-23. 2009..Understanding the basis and population distribution of these DYS19 alleles will aid in the utilisation and interpretation of profiles that contain them... - Diversity of 26-locus Y-STR haplotypes in a Nepalese population sample: isolation and drift in the HimalayasEmma J Parkin
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Forensic Sci Int 166:176-81. 2007..Extended (11-locus) haplotypes for the Nepalese samples have been submitted to the Y-STR Haplotype Reference Database (YHRD)... - Genetic signatures of coancestry within surnamesTuri E King
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
Curr Biol 16:384-8. 2006..This approach would be applicable to any society that uses patrilineal surnames of reasonable time-depth... - The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian PeninsulaSusan M Adams
Department of Genetics, University of Leicester, Leicester, UK
Am J Hum Genet 83:725-36. 2008.... - Thomas Jefferson's Y chromosome belongs to a rare European lineageTuri E King
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Am J Phys Anthropol 132:584-9. 2007..Our findings represent a cautionary tale in showing the difficulty of assigning individual ancestry based on a Y-chromosome haplotype, particularly for rare lineages where population data are scarce... - The case of the unreliable SNP: recurrent back-mutation of Y-chromosomal marker P25 through gene conversionSusan M Adams
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Forensic Sci Int 159:14-20. 2006..Because of its inherent instability, we suggest that P25 be used with caution in forensic studies, and perhaps replaced with the more reliable binary marker M269... - High level of male-biased Scandinavian admixture in Greenlandic Inuit shown by Y-chromosomal analysisElena Bosch
Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
Hum Genet 112:353-63. 2003..However, the extreme sex bias in the admixture makes the later event more likely as the source... - Molecular evidence for absence of Y-linkage of the Hairy Ears traitAndrew C Lee
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Eur J Hum Genet 12:1077-9. 2004..The trait cannot, therefore, be Y-linked in southern Indians, and by extension, is unlikely to be so in any population... - Excavating past population structures by surname-based sampling: the genetic legacy of the Vikings in northwest EnglandGeorgina R Bowden
Department of Genetics, University of Leicester, Leicester, United Kingdom
Mol Biol Evol 25:301-9. 2008.... - A predominantly neolithic origin for European paternal lineagesPatricia Balaresque
Department of Genetics, University of Leicester, Leicester, United Kingdom
PLoS Biol 8:e1000285. 2010.... - Y-chromosomal STR haplotypes in Inuit and Danish population samplesElena Bosch
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Forensic Sci Int 132:228-32. 2003.... - Africans in Yorkshire? The deepest-rooting clade of the Y phylogeny within an English genealogyTuri E King
Department of Genetics, University of Leicester, Leicester, UK
Eur J Hum Genet 15:288-93. 2007..Our findings represent the first genetic evidence of Africans among 'indigenous' British, and emphasize the complexity of human migration history as well as the pitfalls of assigning geographical origin from Y-chromosomal haplotypes... - Genetic variation of 15 autosomal STR loci in Upper (Southern) EgyptiansGhada A Omran
East Midlands Forensic Pathology Unit, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Forensic Sci Int Genet 3:e39-44. 2009..The combined power of exclusion was 0.99999868 and the combined match probability was 1.93x10(-18). The genetic diversity of the Upper Egyptians was compared with those of other populations at the local, regional and global levels... - Gene conversion between the X chromosome and the male-specific region of the Y chromosome at a translocation hotspotZoë H Rosser
Department of Genetics, University of Leicester, University Road, Leicester, UK
Am J Hum Genet 85:130-4. 2009..Sequence exchange outside the pseudoautosomal regions could play a role in protecting the Y-linked copies of gametologous genes from degeneration... - Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertilityElena Bosch
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Hum Mol Genet 12:341-7. 2003.... - High resolution Y chromosome typing: 19 STRs amplified in three multiplex reactionsElena Bosch
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Forensic Sci Int 125:42-51. 2002..24%) were found in single individuals. The overall haplotype diversity was 0.9988 and that obtained by each multiplex system was 0.9812 for EBF, 0.9292 for MS1 and 0.9089 for CTS... - 26-Locus Y-STR typing in a Bhutanese population sampleEmma J Parkin
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK
Forensic Sci Int 161:1-7. 2006..We identify novel alleles at five loci and microvariants at a further three, which were characterised by sequencing. Extended (11-locus) haplotypes for these samples have been submitted to the Y-STR Haplotype Reference Database (YHRD)... - Challenges in human genetic diversity: demographic history and adaptationPatricia L Balaresque
Department of Genetics, University of Leicester, University Road, Leicester, UK
Hum Mol Genet 16:R134-9. 2007..Some past adaptations are now maladaptive, and can lead to disease. However, the history of adaptation is complex, and adaptive explanations are often unsupported by hard evidence... - Y chromosomal evidence for the origins of oceanic-speaking peoplesMatthew E Hurles
McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, United Kingdom
Genetics 160:289-303. 2002..Furthermore, it is demonstrated that a geographical rather than linguistic classification of Oceanic populations best accounts for their extant Y chromosomal diversity... - A comprehensive survey of human Y-chromosomal microsatellitesManfred Kayser
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Am J Hum Genet 74:1183-97. 2004..As a result of this work, a large number of new, highly polymorphic Y-chromosomal microsatellites are now available for population-genetic, evolutionary, genealogical, and forensic investigations... - Y chromosome haplogroups of elite Ethiopian endurance runnersColin N Moran
International Centre for East African Running Science (ICEARS, Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow, G12 8QQ, UK
Hum Genet 115:492-7. 2004.... 
Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspectiveAlexandra Rosa
Department of Evolutionary Biology, Estonian Biocentre, Riia 23, Tartu, Estonia
BMC Evol Biol 7:124. 2007..To address this, we have analysed the variation of 31 binary and 11 microsatellite markers on the non-recombining portion of the Y chromosome in Guinea-Bissau samples of diverse ethnic affiliations, some not studied before...- Signature of recent historical events in the European Y-chromosomal STR haplotype distributionLutz Roewer
Institute of Legal Medicine, Humboldt-University, Berlin, Germany
Hum Genet 116:279-91. 2005..We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history... - Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus studyLaure Segurel
Museum national d histoire naturelle, Centre National de la Recherche Scientifique UMR 5145, Universite Paris 7, Eco anthropologie et Ethnobiologie, Musée de l Homme, Paris, France
PLoS Genet 4:e1000200. 2008..This study suggests that differences in sex-specific migration rates may not be the only cause of contrasting male and female differentiation in humans, and that differences in effective numbers do matter... - Y-chromosomal STR haplotypes in Kalmyk population samplesLutz Roewer
Institute of Legal Medicine, Charite, University Medicine Berlin, Hannoversche Str 6, 10115 Berlin, Germany
Forensic Sci Int 173:204-9. 2007..AMOVA analysis reveals a close vicinity to Mongolian and Kazakh populations and large genetic distance to geographical neighbours from Russia, Ukraine and the Caucasus... - Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysisRafal Ploski
Human Molecular Genetics Lab, Department of Forensic Medicine, Warsaw Medical Academy, Poland
Hum Genet 110:592-600. 2002..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00439-002-0728-0... - Native American Y chromosomes in Polynesia: the genetic impact of the Polynesian slave tradeMatthew E Hurles
McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, United Kingdom
Am J Hum Genet 72:1282-7. 2003.... - The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineagesMatthew E Hurles
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Am J Hum Genet 76:894-901. 2005..As a result of their equally balanced admixed ancestry, the Malagasy may represent an ideal population in which to identify loci underlying complex traits of both anthropological and medical interest...