Dominic E Job

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
  2. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
  3. ncbi request reprint Grey matter changes over time in high risk subjects developing schizophrenia
    Dominic E Job
    Division of Psychiatry, University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 25:1023-30. 2005
  4. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
  5. doi request reprint Impact of cannabis use on thalamic volume in people at familial high risk of schizophrenia
    Killian A Welch
    Robert Ferguson Unit, Astley Ainslee Hospital, Edinburgh and Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 199:386-90. 2011
  6. doi request reprint Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:428-33. 2008
  7. doi request reprint Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1474-82. 2010
  8. doi request reprint Overactivation of fear systems to neutral faces in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:70-3. 2008
  9. ncbi request reprint Brain-behaviour relationships in people at high genetic risk of schizophrenia
    G Katherine S Lymer
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 33:275-85. 2006
  10. ncbi request reprint Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Res 64:1-13. 2003

Detail Information

Publications27

  1. doi request reprint Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
    Benjamin J Baig
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, United Kingdom
    Psychiatry Res 183:195-201. 2010
    ....
  2. pmc Grey matter changes can improve the prediction of schizophrenia in subjects at high risk
    Dominic E Job
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, EH10 5HF, UK
    BMC Med 4:29. 2006
    ....
  3. ncbi request reprint Grey matter changes over time in high risk subjects developing schizophrenia
    Dominic E Job
    Division of Psychiatry, University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 25:1023-30. 2005
    ..These particular reductions may therefore be able to predict the later onset of schizophrenia...
  4. pmc Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Psychiatry 7:61. 2007
    ....
  5. doi request reprint Impact of cannabis use on thalamic volume in people at familial high risk of schizophrenia
    Killian A Welch
    Robert Ferguson Unit, Astley Ainslee Hospital, Edinburgh and Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Br J Psychiatry 199:386-90. 2011
    ..No longitudinal study has yet examined the association between substance use and brain volume changes in a population at high risk of schizophrenia...
  6. doi request reprint Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:428-33. 2008
    ..Preliminary evidence in healthy control subjects has implicated genetic variation in the DAOA gene in the modulation of hippocampal complex and prefrontal cortex activation...
  7. doi request reprint Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
    Heather C Whalley
    Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1474-82. 2010
    ..BDNF may therefore be one of the heritable factors involved in the development of abnormal prefrontal function in schizophrenia. © 2010 Wiley-Liss, Inc...
  8. doi request reprint Overactivation of fear systems to neutral faces in schizophrenia
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, United Kingdom
    Biol Psychiatry 64:70-3. 2008
    ..We investigated whether the apparent decrease in amygdala activation in schizophrenia could actually derive from increased amygdala activation to the neutral comparator stimuli...
  9. ncbi request reprint Brain-behaviour relationships in people at high genetic risk of schizophrenia
    G Katherine S Lymer
    Division of Psychiatry, School of Molecular and Clinical Medicine, The University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 33:275-85. 2006
    ..These results suggest complex and changing patterns of structural-functional relationships in those subjects at high-risk of schizophrenia...
  10. ncbi request reprint Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Schizophr Res 64:1-13. 2003
    ..control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis...
  11. doi request reprint Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder
    Andrew C Stanfield
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:135-44. 2009
    ..We examined the presence and location of ventral prefrontal abnormalities in a large sample of individuals with bipolar disorder and their relationship to gender, psychotic symptoms, and age...
  12. ncbi request reprint White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, Scotland, UK
    Biol Psychiatry 58:254-7. 2005
    ..This study sought to assess white matter density in patients and relatives with histories of bipolar disorder and/or schizophrenia...
  13. doi request reprint Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
    Viktoria Eleni Gountouna
    Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuroimage 49:552-60. 2010
    ....
  14. ncbi request reprint A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
    Jeremy Hall
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK
    Nat Neurosci 9:1477-8. 2006
    ..We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ...
  15. ncbi request reprint Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods
    T William J Moorhead
    Image Analysis Laboratory, Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 22:188-202. 2004
    ..VBM has the facility to compare grey matter distributions in this structurally diverse cohort...
  16. pmc Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: procedure development using CaliBrain structural MRI data
    T William J Moorhead
    The Division of Psychiatry, Centre for Clinical Brain Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK
    BMC Med Imaging 9:8. 2009
    ..The CaliBrain project was designed to provide for an assessment of scanner differences at three centres in Scotland, and to assess the practicality of pooling scans from multiple-centres...
  17. ncbi request reprint Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH 10 5HF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:76-83. 2006
    ..Genes for bipolar illness might have subtle effects on brain structure, which may need particularly large samples to detect...
  18. ncbi request reprint Empirical comparison of maximal voxel and non-isotropic adjusted cluster extent results in a voxel-based morphometry study of comorbid learning disability with schizophrenia
    T William J Moorhead
    Division of Psychiatry, Image Analysis Laboratory, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland UK
    Neuroimage 28:544-52. 2005
    ....
  19. ncbi request reprint Structural correlates of intellectual impairment and autistic features in adolescents
    Michael D Spencer
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
    Neuroimage 33:1136-44. 2006
    ....
  20. ncbi request reprint Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives
    Andrew M McIntosh
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom
    Biol Psychiatry 56:544-52. 2004
    ..This study sought to examine these issues and clarify the associations of phenotypic expression and genetic liability...
  21. pmc The impact of substance use on brain structure in people at high risk of developing schizophrenia
    Killian A Welch
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Schizophr Bull 37:1066-76. 2011
    ..A family history of schizophrenia may render the brain particularly sensitive to the risk-modifying effects of these substances...
  22. ncbi request reprint Automated computation of the Gyrification Index in prefrontal lobes: methods and comparison with manual implementation
    T William J Moorhead
    Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Neuroimage 31:1560-6. 2006
    ..A-GI is therefore a reliable measure of cortical folding that could be usefully applied to a number of MRI data sets of the brain in health and disease...
  23. ncbi request reprint Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry
    Dominic E Job
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, United Kingdom
    Neuroimage 17:880-9. 2002
    ..These results are compatible with and extend the relevant findings of the previous volumetric ROI analysis, when allowing for the differences between the methods and interpretation of their results...
  24. ncbi request reprint A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia
    Dominic Marjoram
    University of Edinburgh, Division of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK
    Neuroimage 31:1850-8. 2006
    ..This study is the first time relatives of individuals with schizophrenia have been imaged using a ToM paradigm, and the results provide evidence of both a state and state-mediated trait effect...
  25. ncbi request reprint Structural and functional abnormalities of the amygdala in schizophrenia
    Stephen M Lawrie
    Edinburgh University, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, Scotland, UK
    Ann N Y Acad Sci 985:445-60. 2003
    ....
  26. pmc Variance in brain volume with advancing age: implications for defining the limits of normality
    David Alexander Dickie
    Brain Research Imaging Centre BRIC, The University of Edinburgh, Neuroimaging Sciences, Western General Hospital, Edinburgh, United Kingdom Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, United Kingdom
    PLoS ONE 8:e84093. 2013
    ..e. whether regression models derived from mean values accurately represented the distributions and boundaries of brain tissue volume at older ages...
  27. doi request reprint Do brain image databanks support understanding of normal ageing brain structure? A systematic review
    David Alexander Dickie
    Division of Clinical Neurosciences, Western General Hospital, Brain Research Imaging Centre BRIC, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK
    Eur Radiol 22:1385-94. 2012
    ..To document accessible magnetic resonance (MR) brain images, metadata and statistical results from normal older subjects that may be used to improve diagnoses of dementia...