Lars J C Jeuken


Affiliation: University of Leeds
Country: UK


  1. Hwang E, Sheikh K, Orchard K, Hojo D, Radu V, Lee C, et al. A Decaheme Cytochrome as a Molecular Electron Conduit in Dye-Sensitized Photoanodes. Adv Funct Mater. 2015;25:2308-2315 pubmed
  2. Stikane A, Hwang E, Ainsworth E, Piper S, Critchley K, Butt J, et al. Towards compartmentalized photocatalysis: multihaem proteins as transmembrane molecular electron conduits. Faraday Discuss. 2019;: pubmed publisher
    ..Future work is focused on incorporation of fuel generating redox catalysts in the MtrCAB proteoliposome lumen. ..
  3. Lee C, Reuillard B, Sokol K, Laftsoglou T, Lockwood C, Rowe S, et al. A decahaem cytochrome as an electron conduit in protein-enzyme redox processes. Chem Commun (Camb). 2016;52:7390-3 pubmed publisher
    ..Using a hydrogenase and a fumarate reductase, MtrC was shown as a suitable and efficient diode to shuttle electrons to and from the electrode with the MtrC redox activity regulating the direction of the enzymatic reactions. ..
  4. Laftsoglou T, Jeuken L. Supramolecular electrode assemblies for bioelectrochemistry. Chem Commun (Camb). 2017;53:3801-3809 pubmed publisher
    ..Two approaches are particularly highlighted: the use of layer-by-layer assembly, and the modification of electrodes with planar lipid membranes. ..
  5. Mazurenko I, Hatzakis N, Jeuken L. Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy. J Vis Exp. 2019;: pubmed publisher
    ..The respective single enzyme analysis can reveal patterns in the enzyme functional dynamics that might be otherwise hidden by the behavior of the whole population. We include a description of a script for automated image analysis. ..
  6. Oram J, Jeuken L. Tactic Response of Shewanella oneidensis MR-1 toward Insoluble Electron Acceptors. MBio. 2019;10: pubmed publisher
    ..Based on these experiments, taxis toward electrodes is observed to switch at about -0.2 V versus standard hydrogen electrode (SHE), coinciding with the reduction potential of flavins. ..
  7. Radu V, Frielingsdorf S, Lenz O, Jeuken L. Reactivation from the Ni-B state in [NiFe] hydrogenase of Ralstonia eutropha is controlled by reduction of the superoxidised proximal cluster. Chem Commun (Camb). 2016;52:2632-5 pubmed publisher
    ..We propose that the [4Fe-3S] cluster plays a major role in protecting MBH by blocking the reversal of electron transfer to the [NiFe] active site, which would produce damaging radical oxygen species. ..
  8. Jeuken L. Structure and Modification of Electrode Materials for Protein Electrochemistry. Adv Biochem Eng Biotechnol. 2016;158:43-73 pubmed publisher
    ..Drawbacks and benefits of each material and its modifications are discussed. Where examples exist of applications in photobioelectrochemistry, these are highlighted. ..
  9. Vasilca V, Sadeghpour A, Rawson S, Hawke L, Baldwin S, Wilkinson T, et al. Spherical-supported membranes as platforms for screening against membrane protein targets. Anal Biochem. 2018;549:58-65 pubmed publisher
    ..We conclude that SSBLMs are a promising new means of presenting membrane protein targets for (biomimetic) antibody screening in a native-like lipid environment. ..

More Information


  1. Jeuken L, Connell S, Henderson P, Gennis R, Evans S, Bushby R. Redox enzymes in tethered membranes. J Am Chem Soc. 2006;128:1711-6 pubmed
    ..Enzyme coverages observed with TM-AFM and CV coincide (2-8.5, indicating that most-if not all-cbo(3) on the surface is catalytically active and thus retains its integrity during immobilization. ..
  2. Li M, Khan S, Rong H, Tuma R, Hatzakis N, Jeuken L. Effects of membrane curvature and pH on proton pumping activity of single cytochrome bo3 enzymes. Biochim Biophys Acta Bioenerg. 2017;1858:763-770 pubmed publisher
    ..These single-enzyme results confirm our model in which HCO exhibit heterogeneous pumping rates and can adopt rare leak states in which protons are able to rapidly flow back. ..