Eric Jauniaux

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease
    E Jauniaux
    UCL Institute for Women s Health, University College London UCL, London, UK
    Placenta 33:244-51. 2012
  2. pmc Hepcidin and iron species distribution inside the first-trimester human gestational sac
    Patricia Evans
    Department of Haematology, UCL Cancer Institute Evans and Porter, London, UK
    Mol Hum Reprod 17:227-32. 2011
  3. doi request reprint Do assisted-reproduction twin pregnancies require additional antenatal care?
    E Jauniaux
    Institute for Women s Health, Royal Free and University College London Medical School, London, United Kingdom
    Reprod Biomed Online 26:107-19. 2013
  4. pmc Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study
    Joanne Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Reprod Biol Endocrinol 2:58. 2004
  5. ncbi request reprint Pathophysiology of histological changes in early pregnancy loss
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School UCL Campus, 86 96 Chenies Mews, London WC1E 6HX, United Kingdom
    Placenta 26:114-23. 2005
  6. ncbi request reprint Short and long term outcomes of smoking during pregnancy
    Eric Jauniaux
    EGA Institute for Women s Health, Royal Free and University College London, Academic Department of Obstetrics and Gynaecology UCL Campus, 86 96 Chenies Mews, WC1E 6HX, London, UK
    Early Hum Dev 83:697-8. 2007
  7. ncbi request reprint Rapid and radical amniodrainage in the treatment of severe twin-twin transfusion syndrome
    E Jauniaux
    Academic Department of Obstetrics, Royal Free and University College London Medical School, London, UK
    Prenat Diagn 21:471-6. 2001
  8. ncbi request reprint Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Hum Reprod 21:2216-22. 2006
  9. ncbi request reprint Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Early Hum Dev 83:699-706. 2007
  10. doi request reprint Obstetric outcome after early placental complications
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, UCL Institute for Women s Health, University College London, London, UK
    Curr Opin Obstet Gynecol 22:452-7. 2010

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Placenta accreta: pathogenesis of a 20th century iatrogenic uterine disease
    E Jauniaux
    UCL Institute for Women s Health, University College London UCL, London, UK
    Placenta 33:244-51. 2012
    ..Overall these data support the concept that abnormal decidualization and trophoblastic changes of the placental bed in placenta accreta are secondary to the uterine scar and thus entirely iatrogenic...
  2. pmc Hepcidin and iron species distribution inside the first-trimester human gestational sac
    Patricia Evans
    Department of Haematology, UCL Cancer Institute Evans and Porter, London, UK
    Mol Hum Reprod 17:227-32. 2011
    ..The low transferrin concentrations and the presence of NTBI in CF and AF suggest that transferrin-independent iron transfer is important in early gestation...
  3. doi request reprint Do assisted-reproduction twin pregnancies require additional antenatal care?
    E Jauniaux
    Institute for Women s Health, Royal Free and University College London Medical School, London, United Kingdom
    Reprod Biomed Online 26:107-19. 2013
    ..The increased obstetrical risks in this population must be considered prior to attempts at assisted conception, and the transfer of more than one embryo should be avoided in women with a pre-existing maternal medical condition...
  4. pmc Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study
    Joanne Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Reprod Biol Endocrinol 2:58. 2004
    ..The aim was to determine the activity of the glands throughout the first trimester, and to identify components of the secretions...
  5. ncbi request reprint Pathophysiology of histological changes in early pregnancy loss
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School UCL Campus, 86 96 Chenies Mews, London WC1E 6HX, United Kingdom
    Placenta 26:114-23. 2005
    ..Prospective studies are needed to evaluate the impact of these findings on routine histopathologic examination in first-trimester miscarriages...
  6. ncbi request reprint Short and long term outcomes of smoking during pregnancy
    Eric Jauniaux
    EGA Institute for Women s Health, Royal Free and University College London, Academic Department of Obstetrics and Gynaecology UCL Campus, 86 96 Chenies Mews, WC1E 6HX, London, UK
    Early Hum Dev 83:697-8. 2007
  7. ncbi request reprint Rapid and radical amniodrainage in the treatment of severe twin-twin transfusion syndrome
    E Jauniaux
    Academic Department of Obstetrics, Royal Free and University College London Medical School, London, UK
    Prenat Diagn 21:471-6. 2001
    ..Compared to the standard amniodrainage technique it also appears to reduce the need for multiple procedures...
  8. ncbi request reprint Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Hum Reprod 21:2216-22. 2006
    ..Tender loving care and health advice are the only interventions that do not require more RCTs. All other proposed therapies, which require more investigations, are of no proven benefit or are associated with more harm than good...
  9. ncbi request reprint Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Early Hum Dev 83:699-706. 2007
    ..In particular, smoking interferes strongly with the fetal brain and pancreas biological parameters and induces chromosomal instability, which is associated with an increase in the risk of cancer, especially childhood malignancies...
  10. doi request reprint Obstetric outcome after early placental complications
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, UCL Institute for Women s Health, University College London, London, UK
    Curr Opin Obstet Gynecol 22:452-7. 2010
    ..To evaluate the impact of early pregnancy complications involving placentation and early placental development on adverse obstetric outcome in ongoing and subsequent pregnancies...
  11. ncbi request reprint Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 89:1452-8. 2004
    ..This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established...
  12. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction...
  13. ncbi request reprint Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation
    E Jauniaux
    Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, United Kingdom
    Am J Obstet Gynecol 184:998-1003. 2001
    ..Our purpose was to evaluate the changes in intrauterine gases and acid-base gradients inside the human fetoplacental unit at 7 to 16 weeks' gestation...
  14. ncbi request reprint Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, United Kingdom
    Am J Obstet Gynecol 197:58.e1-6. 2007
    ..The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking...
  15. ncbi request reprint Chronic maternal smoking and cord blood amino acid and enzyme levels at term
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, London, United Kingdom
    Obstet Gynecol 97:57-61. 2001
    ..To assess the influence of chronic active maternal smoking on cord blood amino acid and enzyme levels at term...
  16. ncbi request reprint Maternal tobacco exposure and cotinine levels in fetal fluids in the first half of pregnancy
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, United Kingdom
    Obstet Gynecol 93:25-9. 1999
    ..To evaluate the distribution of cotinine in fetal fluids and serum during the first half of pregnancy, and compare the fetal and maternal cotinine levels in passive and active smokers...
  17. ncbi request reprint Partial moles: from postnatal to prenatal diagnosis
    E Jauniaux
    Academic Departments of Obstetrics and Gynaecology, University College London UCH, London, UK
    Placenta 20:379-88. 1999
    ..Women with this pregnancy complication should be offered immediate termination and a specific follow-up...
  18. ncbi request reprint Diminished expression of placental isoferritin p43 component in first trimester abnormal pregnancies
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College, UCL Campus, London, UK
    Placenta 21:408-11. 2000
    ..This suggests that PLF may be involved in the pathogenesis of early pregnancy disorders related to an abnormal placentation...
  19. ncbi request reprint Fluid compartments of the embryonic environment
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UK
    Hum Reprod Update 6:268-78. 2000
    ..Further investigation should include a comparison between the coelomic fluid values of a molecule and its quantifiable presence in decidual, placental and fetal tissues...
  20. ncbi request reprint Fetal amino acid and enzyme levels with maternal smoking
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, United Kingdom
    Obstet Gynecol 93:680-3. 1999
    ..To assess the influence of active maternal smoking on fetal amino acid and enzyme levels in early pregnancy...
  21. ncbi request reprint Comparison of ultrasonographic and Doppler mapping of the intervillous circulation in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology Royal Free and University College London Medical School, London, United Kingdom
    Fertil Steril 79:100-6. 2003
    ..To assess the value of ultrasonography and Doppler imaging in characterizing the intervillous circulation in normal and abnormal early pregnancy...
  22. ncbi request reprint In vivo investigation of placental transfer early in human pregnancy
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College, London Medical School, 86 96 Chenies Mews, WC1E 6HX, London, UK
    Eur J Obstet Gynecol Reprod Biol 92:45-9. 2000
    ..This prolonged fetal exposure to tobacco carcinogens has important teratogenic implications and should be further explored...
  23. ncbi request reprint Villous histomorphometry and placental bed biopsy investigation in Type I diabetic pregnancies
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College Hospital, 86 96 Chenies Mews, London WC1E 6HX, United Kingdom
    Placenta 27:468-74. 2006
    ..The reduction in the specific diffusing capacity of the villous membrane may contribute to the fetal hypoxia and increased fetal and neonatal morbidity associated with diabetes...
  24. ncbi request reprint Physiological implications of the materno-fetal oxygen gradient in human early pregnancy
    Eric Jauniaux
    Academic Department of Obstetrics, Royal Free and University College London Medical School, UCL Campus, London, UK
    Reprod Biomed Online 7:250-3. 2003
    ....
  25. ncbi request reprint The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus--a review
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UK
    Placenta 24:S86-93. 2003
    ....
  26. ncbi request reprint Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure
    Natalie Greenwold
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UCL Campus, London, United Kingdom
    Fertil Steril 79:1373-9. 2003
    ..To evaluate the relationship among maternal serum endocrinology, placental karyotype, and intervillous blood flow in missed miscarriage...
  27. ncbi request reprint Threatened miscarriage as a predictor of obstetric outcome
    Jemma Johns
    Early Pregnancy Unit, Elizabeth Garrett Anderson Hospital, Academic Department of Obstetrics and Gynaecology, University College London Hospital, London, United Kingdom
    Obstet Gynecol 107:845-50. 2006
    ..To investigate prospectively the risk of adverse pregnancy outcome in women presenting with first-trimester threatened miscarriage...
  28. ncbi request reprint Evaluation of the relationship between follicular fluid oxidative stress, ovarian hormones, and response to gonadotropin stimulation
    Malathy Appasamy
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London, University College London Campus, London, United Kingdom
    Fertil Steril 89:912-21. 2008
    ..To investigate the relationship between oxidative stress and the underlying causes of infertility, preovulatory ovarian hormones, and ovarian response to gonadotropin stimulation in patients undergoing assisted reproductive techniques...
  29. doi request reprint Placental production and maternal serum and urine levels of inhibin A and activin A are modified by antihypertensive therapy in hypertensive disorders of pregnancy
    Asma Khalil
    Academic Department of Obstetrics and Gynaecology, EGA Institute for Women s Health, University College, London, UK
    Clin Endocrinol (Oxf) 70:924-31. 2009
    ..Our aim was to investigate the effect of the antihypertensive drug alpha-methyldopa on serum, urine and placental concentrations of inhibin A and activin A in women presenting with hypertensive disorders of pregnancy...
  30. pmc Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Am J Pathol 162:115-25. 2003
    ..High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve...
  31. ncbi request reprint Drug intervention in early pregnancy after assisted reproductive technology
    Ozkan Ozturk
    Academic Department of Obstetrics and Gynaecology, University College London Hospitals, 86 96 Chenies Mews, London, WC1E 6HX, UK
    Reprod Biomed Online 9:452-65. 2004
    ..There is an urgent need for more epidemiological studies and randomized controlled trials to explore the use, efficacy and side-effects of both old and new drugs in early pregnancy after assisted reproduction treatment...
  32. ncbi request reprint Hypothesis: the placental 'steal' phenomenon - a possible hazard of amnioreduction
    Charles H Rodeck
    Department of Obstetrics and Gynaecology, University College London, UK
    Fetal Diagn Ther 21:302-6. 2006
    ..This could explain some of the severe neurological outcomes, such as hypoxic ischemic brain damage, seen in these cases...
  33. ncbi request reprint The contribution of maternal serum markers in the early prenatal diagnosis of molar pregnancies
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London UCH, UK
    Hum Reprod 14:842-6. 1999
    ....
  34. ncbi request reprint Impact on delivery outcome of ultrasonographic fetal head position prior to induction of labor
    Elisabeth Peregrine
    Department of Obstetrics and Gynaecology, University College London Hospitals, London, United Kingdom
    Obstet Gynecol 109:618-25. 2007
    ..To assess clinical and sonographic fetal head position before induction of labor, position at delivery, and whether occiput posterior (OP) position is associated with adverse delivery outcome...
  35. ncbi request reprint Obstetric outcome after threatened miscarriage with and without a hematoma on ultrasound
    Jemma Johns
    The Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London, United Kingdom
    Obstet Gynecol 102:483-7. 2003
    ....
  36. ncbi request reprint Updated and revised nomenclature for description of early pregnancy events
    Roy G Farquharson
    Department of Obstetrics and Gynaecology, Liverpool Women s Hospital, Liverpool, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 20:3008-11. 2005
    ..We hope that this paper will facilitate the introduction of a revised terminology in an attempt to provide clarity and to enhance uptake and use in the literature as well as clinical assessment and documentation...
  37. ncbi request reprint Placental haematomas in early pregnancy
    Jemma Johns
    Royal Free and University College London Medical School, University College London, London WC1E 6HX
    Br J Hosp Med (Lond) 68:32-5. 2007
  38. ncbi request reprint Prenatal diagnosis and management of twin pregnancies complicated by a co-existing molar pregnancy
    Ling Wee
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London, London, UK
    Prenat Diagn 25:772-6. 2005
    ..Maternal serum human chorionic gonadotrophin (MShCG) could be useful in predicting outcome in twin pregnancy combining normal pregnancy and CHM, but this needs to be investigated prospectively...
  39. ncbi request reprint The secretion and effect of inhibin A, activin A and follistatin on first-trimester trophoblasts in vitro
    C Bearfield
    Department of Obstetrics and Gynaecology, RFUC Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Eur J Endocrinol 152:909-16. 2005
    ..The objectives of this study were to investigate the effect of activin A and follistatin on first-trimester cytotrophoblast invasion in culture and to study the secretion of inhibin A, activin A and follistatin by these cells in vitro...
  40. ncbi request reprint Scanning for chorionicity: comparison between sonographers and perinatologists
    Boaz Weisz
    Department of Obstetrics and Gynaecology, University College London, London, UK
    Prenat Diagn 25:835-8. 2005
    ..In order to assess this screening strategy, we have compared the diagnosis of chorionicity made by the sonographers in the ultrasound department with the diagnosis done in the fetal medicine unit...
  41. ncbi request reprint Collection of villous tissue under ultrasound guidance to improve the cytogenetic study of early pregnancy failure
    Natalie Greenwold
    Early Pregnancy Unit, Department of Obstetrics and Gynaecology, Obstetric Hospital, University College Hospital, London, UK
    Hum Reprod 17:452-6. 2002
    ..The aim of this study was to assess the effect of improving the method of collection of villous tissues at the time of surgery on the karyotype success rate of cell culture...
  42. doi request reprint Pro- and antiinflammatory cytokines in threatened miscarriages
    Jean Calleja-Agius
    Academic Department of Obstetrics and Gynecology, UCL Institute for Women s Health, University College London, Chenies Mews, London, United Kingdom
    Am J Obstet Gynecol 205:83.e8-16. 2011
    ..The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome...
  43. ncbi request reprint Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment
    Eric Jauniaux
    Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 90:1171-5. 2005
    ..Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac...
  44. pmc Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, London, United Kingdom
    Am J Pathol 157:2111-22. 2000
    ..We speculate that this may serve a physiological role in stimulating normal placental differentiation, but may also be a factor in the pathogenesis of pre-eclampsia and early pregnancy failure if antioxidant defenses are depleted...
  45. doi request reprint Placental villous expression of TNFα and IL-10 and effect of oxygen tension in euploid early pregnancy failure
    Jean Calleja-Agius
    UCL Elizabeth Garrett Anderson Institute for Women s Health, University College London, UK
    Am J Reprod Immunol 67:515-25. 2012
    ..The objective was to investigate placental inflammation in chromosomally normal miscarriages in vivo and in vitro...
  46. ncbi request reprint First-trimester diagnosis of conjoined twins
    Eva Pajkrt
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Prenat Diagn 25:820-6. 2005
    ..Overall, very early prenatal diagnosis and first-trimester 3D imaging provide very little additional practical medical information compared to the 11-14 weeks' ultrasound examination...
  47. ncbi request reprint Perinatal outcome in fetuses with megacystis in the first half of pregnancy
    Jean Marie Jouannic
    Academic Department of Obstetrics and Gynaecology, University College London, London, UK
    Prenat Diagn 23:340-4. 2003
    ..To present the outcome of a consecutive series of 19 fetuses referred to our center for megacystis in the first half of the pregnancy...
  48. pmc Inflammatory cytokines in maternal circulation and placenta of chromosomally abnormal first trimester miscarriages
    Jean Calleja-Agius
    UCL EGA Institute for Women s Health, University College London, 86 96, Chenies Mews, London, WCIE 6HX, UK
    Clin Dev Immunol 2012:175041. 2012
    ..In miscarriage with abnormal karyotype, there is an exacerbated placental inflammatory response, in contrast to miscarriage of normal karyotype where maternal systemic response is increased...
  49. ncbi request reprint Prenatal diagnosis of congenital rubella infection in the second trimester of pregnancy
    Julian W Tang
    Department of Virology, Royal Free and University College Medical School, London, UK
    Prenat Diagn 23:509-12. 2003
    ..This case report describes the clinical presentation, diagnosis and management of a case of acute rubella infection in the second trimester. The complex issues of prenatal diagnosis of a congenital rubella infection are discussed...
  50. ncbi request reprint Ontogeny of beta 2 glycoprotein I and annexin V in villous placenta of normal and antiphospholipid syndrome pregnancies
    S Donohoe
    Department of Haematology, University College London, UK
    Thromb Haemost 84:32-8. 2000
    ..93, 0.64-1.26 microg/mg, term; 3.67, 2.58-4.48 microg/mg) in normal pregnancy. Term APS placentas had a reduced beta2GPI content (2.31, 1.87-2.49 microg/mg), p <0.05. The placental role of these proteins remains to be identified...
  51. ncbi request reprint A prospective study of ultrasound screening for molar pregnancies in missed miscarriages
    J Johns
    Elizabeth Garrett Anderson Hospital, Academic Department of Obstetrics and Gynaecology, University College London Hospital, London, UK
    Ultrasound Obstet Gynecol 25:493-7. 2005
    ..To examine the relationship between ultrasound and histological features in the screening for molar changes in missed miscarriage...
  52. ncbi request reprint The role of ultrasound imaging in diagnosing and investigating early pregnancy failure
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Ultrasound Obstet Gynecol 25:613-24. 2005
    ..Expectant management of miscarriage, using ultrasound parameters to determine eligibility, could significantly reduce the number of unnecessary evacuations of the retained products of conception, depending on the criteria used...
  53. ncbi request reprint Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the villous tissue of miscarriage patients
    S Muttukrishna
    Department of Obstetrics and Gynaecology, Royal Free University College Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Mol Hum Reprod 10:793-8. 2004
    ..This finding also confirms that the trophoblast is the major source of inhibin A after the luteo-placental shift in early pregnancy...
  54. ncbi request reprint In-vivo concentrations of inhibins, activin A and follistatin in human early pregnancy
    S Muttukrishna
    Department of Obstetrics and Gynaecology, RFUC Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Reprod Biomed Online 8:712-9. 2004
    ..In the second trimester, high concentrations of inhibin B with testosterone in the fetal circulation indicate that these hormones may interact in the development of the male fetal gonads...
  55. ncbi request reprint Maternal serum hormone concentrations for prediction of adverse outcome in threatened miscarriage
    J Johns
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London, UCL Campus London, 86 96 Chenies Mews, London WC1E 6HX, UK
    Reprod Biomed Online 15:413-21. 2007
    ..Inhibin A was best at predicting the likelihood of subsequent miscarriage in this group...
  56. ncbi request reprint Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages
    S Muttukrishna
    Department of Obstetrics and Gynaecology, Royal Free UCL Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Hum Reprod 17:3072-8. 2002
    ..The aim of this study was to investigate the changes in circulating levels and the clinical use of inhibin A, activin A and follistatin as endocrine markers of early pregnancy loss...
  57. ncbi request reprint Clinical and ultrasound estimation of birth weight prior to induction of labor at term
    E Peregrine
    Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK
    Ultrasound Obstet Gynecol 29:304-9. 2007
    ..To assess and compare the accuracy of clinical and sonographic fetal weight estimation in predicting birth weight prior to induction of labor...
  58. ncbi request reprint Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-0.5 gestation in acute experiments
    T Kiserud
    Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, UK
    BJOG 108:359-64. 2001
    ....
  59. ncbi request reprint Early detection of fetal structural abnormalities
    Boaz Weisz
    Department of Obstetrics and Gynaecology, University College London, WC1E 6HX, London, UK
    Reprod Biomed Online 10:541-53. 2005
    ..The early prenatal diagnosis of these anomalies may be improved by screening at 13-14 weeks rather than during the first trimester...
  60. ncbi request reprint Very early prenatal diagnosis on coelomic cells using quantitative fluorescent polymerase chain reaction
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, 86 96 Chenies Mews, London WC1E 6HX, UK
    Reprod Biomed Online 6:494-8. 2003
    ..One fetus showed trisomy 13. QF-PCR requires very small volumes of sample compared with cell culture, suggesting that coelocentesis may prove useful for very early prenatal diagnosis...
  61. doi request reprint Dichorionic triamniotic triplet pregnancy complicated by acardius acormus
    Khalil Abi-Nader
    Elizabeth Garrett Anderson Institute for Women s Health, University College London, London, UK
    Fetal Diagn Ther 26:45-9. 2009
    ..The report also summarizes the perinatal outcomes of triplet pregnancies complicated by an acardiac fetus, where the median gestational age at delivery is 26-27 weeks, and discusses the possible therapeutic interventions...
  62. pmc Pulse wave analysis in normal pregnancy: a prospective longitudinal study
    Asma Khalil
    The Homerton University Hospital NHS Trust, Queen Mary and Westfield College, University of London, London, UK
    PLoS ONE 4:e6134. 2009
    ..We aimed to establish normal ranges for parameters of pulse wave analysis in normal pregnancy and to compare different ethnic groups...
  63. pmc Relationships between TGFbeta proteins and oxygen concentrations inside the first trimester human gestational sac
    Shanthi Muttukrishna
    UCL EGA Institute for Women s Health, University College London, London, United Kingdom
    PLoS ONE 3:e2302. 2008
    ..Our results indicate a direct relationship in the early intrauterine PaO(2) in vivo and inhibin A and sFLT-1 concentrations confirming our hypothesis that specific placental proteins are regulated by intrauterine O(2) tension...
  64. ncbi request reprint Prospective study of parental choice for aneuploidy screening in assisted conception versus spontaneously conceived twins
    Anna Holmes
    Department of Obstetrics and Gynaecology, Obstetric Hospital, University College London Hospitals, London, UK
    Reprod Biomed Online 8:243-5. 2004
    ..When needed, an amniocentesis was preferred to CVS. These data also indicate that the antenatal counselling needs to be adapted to couples presenting with an assisted conception twin pregnancy...
  65. pmc Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders
    Asma Khalil
    The Homerton University Hospital NHS Trust, Queen Mary and Westfield College, University of London, London, United Kingdom
    PLoS ONE 3:e2766. 2008
    ....
  66. ncbi request reprint Role of utero-ovarian vascular impedance: predictor of ongoing pregnancy in an IVF-embryo transfer programme
    Ozkan Ozturk
    Academic Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK
    Reprod Biomed Online 9:299-305. 2004
    ..Measures to decrease vascular impedance in such women might enhance pregnancy rates by improving embryo quality and uterine receptivity for implantation...
  67. doi request reprint Fetal and placental malignancies: prenatal diagnosis and management
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 33:235-44. 2009
    ..Placental malignancy is most commonly in the form of gestatational trophoblastic disease, which requires assessment and management in specialist centers...
  68. ncbi request reprint Clinical and ultrasound parameters to predict the risk of cesarean delivery after induction of labor
    Elisabeth Peregrine
    Department of Obstetrics and Gynaecology, University College London Hospitals, UK
    Obstet Gynecol 107:227-33. 2006
    ..To evaluate whether factors in the maternal history and/or ultrasound parameters are useful in predicting the risk of cesarean delivery after induction of labor...
  69. ncbi request reprint Fetal haemopoietic cells display enhanced migration across endothelium
    Kwee L Yong
    Department of Haematology, University College London, UK
    Br J Haematol 116:392-400. 2002
    ..The superior migratory activity of fetal haemopoietic cells may underlie a more efficient homing ability, in keeping with their physiological role...
  70. ncbi request reprint Successful early in utero management of fetal hydrothorax in a twin pregnancy
    H Lam
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Prenat Diagn 23:221-4. 2003
    ..Treatment at this stage of gestation would also minimize the risk of lung hypoplasia, which is the main clinical issue when shunts are inserted after 24 weeks...
  71. ncbi request reprint Ultrasound detection of nuchal cord prior to labor induction and the risk of Cesarean section
    E Peregrine
    Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK
    Ultrasound Obstet Gynecol 25:160-4. 2005
    ..To investigate the ability of ultrasound to detect the presence of a nuchal cord immediately prior to induction of labor and the association of its presence with delivery by Cesarean section...
  72. doi request reprint Twin pregnancy presenting as a praevia complete hydatidiform mole and coexisting fetus complicated by a placental abscess
    S Suri
    Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK
    Fetal Diagn Ther 26:181-4. 2009
    ..A twin pregnancy consisting of a complete hydatidiform mole and a coexisting normal fetus (CMCF) is a rare and challenging condition when diagnosed prenatally and is associated with major obstetric complications...
  73. doi request reprint Effect of antihypertensive therapy with alpha-methyldopa on uterine artery Doppler in pregnancies with hypertensive disorders
    A Khalil
    Academic Department of Obstetrics and Gynaecology, UCL Institute for Women s Health, University College London, London, UK
    Ultrasound Obstet Gynecol 35:688-94. 2010
    ..This study aimed to evaluate the impact of antihypertensive therapy with alpha-methyldopa on maternal uterine artery Doppler pulsatility index (PI) and resistance index (RI) in women presenting with hypertensive disorders of pregnancy...
  74. ncbi request reprint Placental nitric oxide production and umbilical artery vascular impedance in early pregnancy
    C Lees
    Academic Department of Obstetrics and Gynaecology, St George s Hospital Medical School, University College London, United Kingdom
    Obstet Gynecol 91:761-5. 1998
    ....
  75. ncbi request reprint Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility
    M Appasamy
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London, UCL Campus, 86 96 Chenies Mews, London, WC1E6HX, United Kingdom
    Reprod Biomed Online 14:159-65. 2007
    ..However, there was no significant relationship between hormone concentrations, sperm DNA damage and total antioxidant capacity, suggesting other mechanisms for sperm dysfunction...
  76. doi request reprint Implementing an obstetric ultrasound training program in rural Africa
    Natalie Greenwold
    Academic Department of Maternal and Fetal Medicine, UCL Elizabeth Garrett Anderson Institute for Women s Health, London, UK Medical Aid Films, London, UK
    Int J Gynaecol Obstet 124:274-7. 2014
    ..To evaluate the feasibility and sustainability of basic obstetric ultrasound training in rural Africa...
  77. ncbi request reprint The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro
    Samina S Riaz
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, South Kensington, London, SW7 2AY, UK
    Brain Res Dev Brain Res 136:27-34. 2002
    ....
  78. ncbi request reprint Increased nuchal translucency as a prenatal manifestation of congenital adrenal hyperplasia
    B Masturzo
    Academic Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK
    Prenat Diagn 21:314-6. 2001
    ..These findings in four affected fetuses suggest that congenital adrenal hyperplasia should be added to the list of genetic anomalies associated with an increase in nuchal translucency...
  79. doi request reprint In utero treatment of severe fetal anaemia due to parvovirus B19 in one fetus in a twin pregnancy--a case report and literature review
    M T Bekhit
    Department of Obstetrics and Gynaecology, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK
    Fetal Diagn Ther 25:153-7. 2009
    ..Parvovirus B19 (PVB19) is a well-established cause of nonimmune hydrops fetalis and fetal anaemia in pregnancy. However, discordant viral infection of only 1 fetus in a twin pregnancy is a rare occurrence...
  80. ncbi request reprint Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy
    M T M Raijmakers
    MFRU, Division of Reproductive Health, Endocrinology and Development, GKT School of Medicine, St Thomas Hospital, London, UK
    Placenta 27:158-63. 2006
    ..05) when compared to corresponding term placental values. NAD(P)H oxidase mediated superoxide generation could be an important modulator of the antioxidant defence response in early pregnancy...
  81. ncbi request reprint Monopolar thermocoagulation in acardiac twinning
    A Holmes
    Department of Obstetrics and Gynaecology, University College London, UK
    BJOG 108:1000-2. 2001
    ..The technique and outcomes of a series of 12 pregnancies which have presented for treatment at the Fetal Medicine Unit of University College London are presented...
  82. ncbi request reprint Evaluation of the impact of current antismoking advice in the UK on women with planned pregnancies
    G Acharya
    Department of Obstetrics and Gynaecology, Whittington Hospital, London, UK
    J Obstet Gynaecol 22:498-500. 2002
    ..Health-care professionals should spend more time to inform women adequately about the dangers of smoking and help them to quit before pregnancy...
  83. ncbi request reprint Evidence that insulin is imprinted in the human yolk sac
    G E Moore
    Division of Paediatrics, Obstetrics and Gynaecology, Queen Charlotte s and Chelsea Hospital, Imperial College of Science, Technology and Medicine, London, UK
    Diabetes 50:199-203. 2001
    ....
  84. ncbi request reprint Procedure-related complications of rapid amniodrainage in the treatment of polyhydramnios
    W C Leung
    Fetal Medicine Unit, Elizabeth Garrett Anderson and Obstetric Hospital, The University College London Hospitals, London, UK
    Ultrasound Obstet Gynecol 23:154-8. 2004
    ..To investigate the procedure-related complications of rapid amniodrainage in the treatment of polyhydramnios...
  85. ncbi request reprint The origin of alpha-fetoprotein in first-trimester anembryonic pregnancies
    E Jauniaux
    Department of Obstetrics and Gynaecology, King s College School of Medicine and Dentistry, University of London, United Kingdom
    Am J Obstet Gynecol 173:1749-53. 1995
    ....
  86. ncbi request reprint Cultured human foetal cerebral cortex, transfected with tyrosine hydroxylase cDNA, as a source of neural transplant material
    M J Hurley
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Neural Transm 108:781-92. 2001
    ..TH transfected foetal cerebral cortex cells may therefore be a useful alternative supply of tissue for use in neural transplants to treat Parkinson's disease...
  87. ncbi request reprint Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor
    S Theofilopoulos
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, SW7 2AY, London, UK
    Brain Res Dev Brain Res 127:111-22. 2001
    ..This study indicates a new source of dopaminergic brain tissue for use as transplants to neurosurgically treat Parkinson's disease patients...
  88. ncbi request reprint Working with oxygen and oxidative stress in vitro
    Graham J Burton
    Department of Anatomy, University of Cambridge, United Kingdom
    Methods Mol Med 122:413-25. 2006
    ..This chapter describes techniques by which the effects of oxygen and oxidative stress on placental tissues can be systematically investigated in vitro...
  89. ncbi request reprint Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development
    Rosa M Calvo
    Unidad de Endocrinologia Molecular, Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas and Facultad de Medicina, Universidad Autonoma de Madrid, Spain
    J Clin Endocrinol Metab 87:1768-77. 2002
    ..These findings ought to influence our present approach to maternal hypothyroxinemia in early pregnancy regardless of whether TSH is increased or whether overt or subclinical hypothyroidism is detected...
  90. ncbi request reprint The contribution of placental oxidative stress to early pregnancy failure
    Joanne Hempstock
    Department of Anatomy, Cambridge University, UK
    Hum Pathol 34:1265-75. 2003
    ....
  91. ncbi request reprint Recurrent early pregnancy loss and consanguinity
    Fawaz Amin Saad
    Department of Obstetrics and Gynaecology, Recurrent Pregnancy Loss Clinic, Women s Hospital, Hamad Medical Corporation, Doha, Qatar
    Reprod Biomed Online 5:167-70. 2002
    ....
  92. ncbi request reprint Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    ..Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic...
  93. ncbi request reprint Vaginal sonography of the cervix for the prediction of "time to delivery" in ART twins gestations
    Adrian Shulman
    Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Twin Res 5:255-9. 2002
    ..A simple equation using the cervical length (mm) divided by 3 can predict mid gestation scan-to-delivery interval in twin gestation...
  94. ncbi request reprint Placental oxidative stress: from miscarriage to preeclampsia
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge, United Kingdom
    J Soc Gynecol Investig 11:342-52. 2004
    ..To review the role of oxidative stress in two common placental-related disorders of pregnancy, miscarriage and preeclampsia...
  95. ncbi request reprint Down's syndrome screening in pregnancies after assisted reproductive techniques: an update
    Ron Maymon
    Department of Obstetrics and Gynecology, Assaf Harofe Medical Centre and Tel Aviv University, Israel
    Reprod Biomed Online 4:285-93. 2002
    ..Therefore, it should be systematically performed before any fetal reduction in high-order multiple pregnancies is planned...
  96. pmc Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam
    Tereza Cindrova-Davies
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Am J Pathol 170:1511-20. 2007
    ..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro...
  97. ncbi request reprint Oxygen, early embryonic metabolism and free radical-mediated embryopathies
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
    Reprod Biomed Online 6:84-96. 2003
    ..Administration of free radical scavengers, including vitamins C and E, can mitigate many of these effects, indicating the importance of a balanced maternal diet to successful reproduction...
  98. ncbi request reprint The differentiation potential of human foetal neuronal progenitor cells in vitro
    Samina S Riaz
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, Biochemistry Building, South Kensington Campus, Imperial College Road, London SW7 2AZ, UK
    Brain Res Dev Brain Res 153:39-51. 2004
    ....
  99. ncbi request reprint Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors
    Siddharthan Chandran
    Department of Clinical Neurosciences, University of Cambridge, United Kingdom
    Glia 47:314-24. 2004
    ..These results provide further evidence for inter-species difference in the capacity of neural precursors to generate oligodendrocytes...
  100. pmc Oxidative stress, gene expression, and protein changes induced in the human placenta during labor
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
    Am J Pathol 171:1168-79. 2007
    ..Our findings are consistent with intermittent perfusion being the initiating cause. Placentas subjected to labor do not reflect the normal in vivo state at the molecular level...
  101. ncbi request reprint Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    Sabine Bahn
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK
    Lancet 359:310-5. 2002
    ..We did a study to investigate abnormalities in gene expression in human neuronal stem cells and progenitor cells from Down's syndrome and control post-mortem human fetal tissue...