Research Topics
Genomes and GenesSpecies | A P JarmanSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
Epithelial polarity in the Drosophila compound eye: eyes left or right?A P Jarman
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Trends Genet 12:121-3. 1996- Studies of mechanosensation using the flyAndrew P Jarman
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Hum Mol Genet 11:1215-8. 2002..For human geneticists, it is expected that Drosophila studies will provide a source of candidate genes whose human homologues can be examined for roles in mechanosensory development, function and disease... 
Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migrationIvan B N Clark
Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh, UK
BMC Dev Biol 7:52. 2007..These appear to move in organised groups like, for example, lateral line cells in zebra fish or Drosophila ovarian border cells...
The function and regulation of the bHLH gene, cato, in Drosophila neurogenesisPetra I zur Lage
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
BMC Dev Biol 10:34. 2010..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...- Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amosEimear E Holohan
Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
BMC Dev Biol 6:53. 2006..The control of these phases and the transition between them appear to be central to the mechanism of neurogenesis. We present the first investigation of the regulation of the proneural gene, amos... - Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mappingGiuseppe Gallone
Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
BMC Bioinformatics 12:289. 2011.... - Merged consensus clustering to assess and improve class discovery with microarray dataT Ian Simpson
Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
BMC Bioinformatics 11:590. 2010..There are a large number of methods available to perform clustering, but it is often unclear which method is best suited to the data and how to quantify the quality of the classifications produced... - Developmental genetics: vertebrates and insects see eye to eyeA P Jarman
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, UK
Curr Biol 10:R857-9. 2000..The results support the possibility that insect and vertebrate eyes evolved from a complex ancestral organ... - The specificity of proneural genes in determining Drosophila sense organ identityA P Jarman
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Mech Dev 76:117-25. 1998.... - cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organsS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
Dev Biol 221:120-31. 2000..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS... - Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signallingN M White
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
Development 127:1681-9. 2000..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors... - Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursorsP zur Lage
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
Development 126:3149-57. 1999..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs... - amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozengeS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
Neuron 25:69-78. 2000..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS... - Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clustersP Lage
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Curr Biol 7:166-75. 1997..We present evidence that a similar mechanism is required for the clustering of embryonic chordotonal organs... - Context dependence of proneural bHLH proteinsLynn M Powell
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
Curr Opin Genet Dev 18:411-7. 2008..Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes... 
A general mathematical model of transduction events in mechano-sensory stretch receptorsT J Suslak
Doctoral Training Centre in Neuroinformatics and Neural Computation, University of Edinburgh, 10 Crichton St, Edinburgh, UK
Network 22:133-42. 2011..This preliminary model has potential for extension to describe fully the behaviour of non-ciliated mechano-sensors across species and predict the molecular mediators of mechano-transduction...- Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groupsEmma L Rawlins
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, Scotland, UK
Development 130:3715-24. 2003..We suggest that echinoid acts to prevent a similar inductive outcome of Egfr signalling during R8 selection... - The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formationPetra I zur Lage
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Development 130:4683-93. 2003..This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes... - D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesodermIvan B N Clark
Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
Dev Biol 294:220-31. 2006..At stage 9, however, D-six4 and tin are both expressed pan-mesodermally. At this stage, tin function is required for full D-six4 expression. This may explain the known requirement for tin in some non-dorsal cell types... - Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of SenselessLynn M Powell
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
Genes Cells 13:915-29. 2008..Moreover, the proneural cofactor, Senseless, can augment the function of Sc and Ato on their cognate E boxes and therefore may contribute to proneural specificity... - Functional distinctness of closely related transcription factors: a comparison of the Atonal and Amos proneural factorsSam M T W Maung
Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
Mech Dev 124:647-56. 2007..This has implications for structural and functional comparisons of other closely related transcription factors, and for understanding the molecular basis of specificity... - Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with DeltaEmma L Rawlins
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Development 130:6475-84. 2003..In vivo and cell culture studies suggest that homophilic interaction of Echinoid on adjacent cells is necessary for its function... - The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sitesLynn M Powell
Division of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, United Kingdom
Mol Cell Biol 24:9517-26. 2004..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity... - EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulationPetra I zur Lage
Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
Dev Cell 7:687-96. 2004..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene... - Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiationFrancoise Chanut
Department of Anatomy, University of California, San Francisco, California 94143, USA
Genetics 160:623-35. 2002..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...