A P Jarman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Epithelial polarity in the Drosophila compound eye: eyes left or right?
    A P Jarman
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Trends Genet 12:121-3. 1996
  2. ncbi request reprint Studies of mechanosensation using the fly
    Andrew P Jarman
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Hum Mol Genet 11:1215-8. 2002
  3. pmc Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration
    Ivan B N Clark
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh, UK
    BMC Dev Biol 7:52. 2007
  4. pmc Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization
    Fay G Newton
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Cell 22:1221-33. 2012
  5. pmc The role of Atonal transcription factors in the development of mechanosensitive cells
    Andrew P Jarman
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Semin Cell Dev Biol 24:438-47. 2013
  6. pmc The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis
    Petra I zur Lage
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 10:34. 2010
  7. pmc Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos
    Eimear E Holohan
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:53. 2006
  8. pmc Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping
    Giuseppe Gallone
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    BMC Bioinformatics 12:289. 2011
  9. pmc Merged consensus clustering to assess and improve class discovery with microarray data
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Bioinformatics 11:590. 2010
  10. ncbi request reprint The specificity of proneural genes in determining Drosophila sense organ identity
    A P Jarman
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Mech Dev 76:117-25. 1998

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Epithelial polarity in the Drosophila compound eye: eyes left or right?
    A P Jarman
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Trends Genet 12:121-3. 1996
  2. ncbi request reprint Studies of mechanosensation using the fly
    Andrew P Jarman
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Hum Mol Genet 11:1215-8. 2002
    ..For human geneticists, it is expected that Drosophila studies will provide a source of candidate genes whose human homologues can be examined for roles in mechanosensory development, function and disease...
  3. pmc Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration
    Ivan B N Clark
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh, UK
    BMC Dev Biol 7:52. 2007
    ..These appear to move in organised groups like, for example, lateral line cells in zebra fish or Drosophila ovarian border cells...
  4. pmc Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization
    Fay G Newton
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Cell 22:1221-33. 2012
    ..Fd3F cooperates with the pan-ciliary transcription factor, Rfx, to regulate its targets directly. This illuminates pathways involved in ciliary specialization and the molecular mechanism of transcription factors that regulate them...
  5. pmc The role of Atonal transcription factors in the development of mechanosensitive cells
    Andrew P Jarman
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Semin Cell Dev Biol 24:438-47. 2013
    ....
  6. pmc The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis
    Petra I zur Lage
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 10:34. 2010
    ..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...
  7. pmc Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos
    Eimear E Holohan
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:53. 2006
    ..The control of these phases and the transition between them appear to be central to the mechanism of neurogenesis. We present the first investigation of the regulation of the proneural gene, amos...
  8. pmc Bio::Homology::InterologWalk--a Perl module to build putative protein-protein interaction networks through interolog mapping
    Giuseppe Gallone
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    BMC Bioinformatics 12:289. 2011
    ....
  9. pmc Merged consensus clustering to assess and improve class discovery with microarray data
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Bioinformatics 11:590. 2010
    ..There are a large number of methods available to perform clustering, but it is often unclear which method is best suited to the data and how to quantify the quality of the classifications produced...
  10. ncbi request reprint The specificity of proneural genes in determining Drosophila sense organ identity
    A P Jarman
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Mech Dev 76:117-25. 1998
    ....
  11. ncbi request reprint Developmental genetics: vertebrates and insects see eye to eye
    A P Jarman
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Curr Biol 10:R857-9. 2000
    ..The results support the possibility that insect and vertebrate eyes evolved from a complex ancestral organ...
  12. ncbi request reprint cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
    Dev Biol 221:120-31. 2000
    ..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
  13. ncbi request reprint Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
    ..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors...
  14. ncbi request reprint Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors
    P zur Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 126:3149-57. 1999
    ..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs...
  15. ncbi request reprint amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Neuron 25:69-78. 2000
    ..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
  16. ncbi request reprint Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters
    P Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Curr Biol 7:166-75. 1997
    ..We present evidence that a similar mechanism is required for the clustering of embryonic chordotonal organs...
  17. ncbi request reprint Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development
    R J Kirby
    Institute of Cell and Molecular Biology, EH9 3JR, Edinburgh, United Kingdom
    Curr Biol 11:1044-9. 2001
    ....
  18. pmc Context dependence of proneural bHLH proteins
    Lynn M Powell
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    Curr Opin Genet Dev 18:411-7. 2008
    ..Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes...
  19. doi request reprint A general mathematical model of transduction events in mechano-sensory stretch receptors
    T J Suslak
    Doctoral Training Centre in Neuroinformatics and Neural Computation, University of Edinburgh, 10 Crichton St, Edinburgh, UK
    Network 22:133-42. 2011
    ..This preliminary model has potential for extension to describe fully the behaviour of non-ciliated mechano-sensors across species and predict the molecular mediators of mechano-transduction...
  20. ncbi request reprint Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups
    Emma L Rawlins
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, Scotland, UK
    Development 130:3715-24. 2003
    ..We suggest that echinoid acts to prevent a similar inductive outcome of Egfr signalling during R8 selection...
  21. ncbi request reprint The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
    Petra I zur Lage
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Development 130:4683-93. 2003
    ..This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes...
  22. pmc Functional distinctness of closely related transcription factors: a comparison of the Atonal and Amos proneural factors
    Sam M T W Maung
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Mech Dev 124:647-56. 2007
    ..This has implications for structural and functional comparisons of other closely related transcription factors, and for understanding the molecular basis of specificity...
  23. pmc Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless
    Lynn M Powell
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Genes Cells 13:915-29. 2008
    ..Moreover, the proneural cofactor, Senseless, can augment the function of Sc and Ato on their cognate E boxes and therefore may contribute to proneural specificity...
  24. ncbi request reprint D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm
    Ivan B N Clark
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 294:220-31. 2006
    ..At stage 9, however, D-six4 and tin are both expressed pan-mesodermally. At this stage, tin function is required for full D-six4 expression. This may explain the known requirement for tin in some non-dorsal cell types...
  25. ncbi request reprint Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta
    Emma L Rawlins
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Development 130:6475-84. 2003
    ..In vivo and cell culture studies suggest that homophilic interaction of Echinoid on adjacent cells is necessary for its function...
  26. pmc Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation
    Francoise Chanut
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    Genetics 160:623-35. 2002
    ..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...
  27. ncbi request reprint EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation
    Petra I zur Lage
    Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Dev Cell 7:687-96. 2004
    ..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
  28. pmc The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites
    Lynn M Powell
    Division of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, United Kingdom
    Mol Cell Biol 24:9517-26. 2004
    ..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity...