Andrew M James
Affiliation: University of Cambridge
Chouchani E, James A, Methner C, Pell V, Prime T, Erickson B, et al
. Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia. J Biol Chem. 2017;292:14486-14495 pubmed publisher
James A, Smith A, Smith C, Robinson A, Murphy M. Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species. Cell Rep. 2018;24:1445-1455 pubmed publisher
..As acetyl-CoA levels are linked to nutrient supply, these findings suggest how dietary restriction could extend lifespan and how pathologies resulting from dietary excess may occur. ..
James A, Smith C, Smith A, Robinson A, Hoogewijs K, Murphy M. The Causes and Consequences of Nonenzymatic Protein Acylation. Trends Biochem Sci. 2018;43:921-932 pubmed publisher
..Finally, we propose a hypothesis for why low-stoichiometry protein acylation is selected against by evolution and how it might contribute to degenerative processes such as aging. ..
James A, Cocheme H, Murai M, Miyoshi H, Murphy M. Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain. FEBS J. 2010;277:2067-82 pubmed publisher
..Here we suggest that CoQ or its redox state may be a signal for growth during the shift to respiration. ..
James A, Hoogewijs K, Logan A, Hall A, Ding S, Fearnley I, et al
. Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II. Cell Rep. 2017;18:2105-2112 pubmed publisher
..This suggests that the hitherto obscure role of Glo2 in mitochondria is to act upstream of Sirt3 in minimizing protein N-acetylation, thus limiting protein dysfunction when AcCoA accumulates. ..