Marjan Jahanshahi

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Does the pre-frontal cortex contribute to movement-related potentials? Recordings from subdural electrodes
    M Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurocase 7:495-501. 2001
  2. doi request reprint A preliminary investigation of the running digit span as a test of working memory
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Behav Neurol 20:17-25. 2008
  3. ncbi request reprint Striatal contribution to cognition: working memory and executive function in Parkinson's disease before and after unilateral posteroventral pallidotomy
    M Jahanshahi
    Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Cogn Neurosci 14:298-310. 2002
  4. ncbi request reprint Random number generation as an index of controlled processing
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, England
    Neuropsychology 20:391-9. 2006
  5. ncbi request reprint Impairment of movement initiation and execution but not preparation in idiopathic dystonia
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 140:460-8. 2001
  6. ncbi request reprint Cognitive executive function in dystonia
    Marjan Jahanshahi
    Sobell Research Department of Motor, Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 18:1470-81. 2003
  7. doi request reprint Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Behav Neurol 20:1-9. 2008
  8. doi request reprint Medication impairs probabilistic classification learning in Parkinson's disease
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3 BG, United Kingdom
    Neuropsychologia 48:1096-103. 2010
  9. ncbi request reprint The substantia nigra pars compacta and temporal processing
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 26:12266-73. 2006
  10. ncbi request reprint The impact of deep brain stimulation on executive function in Parkinson's disease
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neruology, The National Hospital for Neurology and Neurosurgery, London, UK
    Brain 123:1142-54. 2000

Research Grants

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Does the pre-frontal cortex contribute to movement-related potentials? Recordings from subdural electrodes
    M Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurocase 7:495-501. 2001
    ..These preliminary results require replication in a larger series of patients...
  2. doi request reprint A preliminary investigation of the running digit span as a test of working memory
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Behav Neurol 20:17-25. 2008
    ....
  3. ncbi request reprint Striatal contribution to cognition: working memory and executive function in Parkinson's disease before and after unilateral posteroventral pallidotomy
    M Jahanshahi
    Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Cogn Neurosci 14:298-310. 2002
    ..The results suggest that striatal outflow to the frontal cortex may be essential for those aspects of executive function that showed deterioration after PVP...
  4. ncbi request reprint Random number generation as an index of controlled processing
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, England
    Neuropsychology 20:391-9. 2006
    ..These features render the easily administered RNG task an ideal and robust index of executive function that is highly suitable for repeated clinical use...
  5. ncbi request reprint Impairment of movement initiation and execution but not preparation in idiopathic dystonia
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 140:460-8. 2001
    ..The results are discussed in relation to previous imaging, behavioural and electrophysiological studies and models of fronto-striatal dysfunction in ITD...
  6. ncbi request reprint Cognitive executive function in dystonia
    Marjan Jahanshahi
    Sobell Research Department of Motor, Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 18:1470-81. 2003
    ..A more detailed investigation of cognitive function in a larger sample of patients is required...
  7. doi request reprint Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Behav Neurol 20:1-9. 2008
    ..To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition...
  8. doi request reprint Medication impairs probabilistic classification learning in Parkinson's disease
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3 BG, United Kingdom
    Neuropsychologia 48:1096-103. 2010
    ..These results highlight the need for careful 'titration' of dopaminergic medication to produce the desired improvement of the motor symptoms without the associated detrimental effects on cognition and learning...
  9. ncbi request reprint The substantia nigra pars compacta and temporal processing
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 26:12266-73. 2006
    ..The fundamental role of the substantia nigra in temporal processing is discussed in relation to previous animal lesion studies and evidence for the modulating influence of dopamine on temporal processing...
  10. ncbi request reprint The impact of deep brain stimulation on executive function in Parkinson's disease
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neruology, The National Hospital for Neurology and Neurosurgery, London, UK
    Brain 123:1142-54. 2000
    ..Conversely, disruption of basal ganglia outflow during DBS impaired performance on tests requiring changing behaviour in novel contexts as predicted by Marsden and Obeso in 1994...
  11. doi request reprint Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
    Brain 133:727-45. 2010
    ..In contrast, our results establish for the first time that administration of dopaminergic medication increases striatal-frontal connectivity between the caudate nucleus and prefrontal cortex during motor timing...
  12. ncbi request reprint The effects of transcranial magnetic stimulation over the dorsolateral prefrontal cortex on suppression of habitual counting during random number generation
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Brain 121:1533-44. 1998
    ..To allow emergence of appropriate random responses, the left DLPFC inhibits the superior temporal cortex to prevent spreading activation and habitual counting in ones...
  13. ncbi request reprint The left dorsolateral prefrontal cortex and random generation of responses: studies with transcranial magnetic stimulation
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology and Medical Research Council, The National Hospital for Neurology and Neurosurgery, London, UK
    Neuropsychologia 37:181-90. 1999
    ..The results suggest the generality of network modulation model of random response generation...
  14. doi request reprint Neuropsychological, neuropsychiatric, and quality of life issues in DBS for dystonia
    Marjan Jahanshahi
    UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 26:S63-78. 2011
    ..Quality of life in dystonia patients quantified by generic measures such as the SF36 showed improvement in both mental and physical categories following DBS surgery...
  15. pmc Factors that ameliorate or aggravate spasmodic torticollis
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 68:227-9. 2000
    ....
  16. ncbi request reprint Transcranial magnetic stimulation studies of cognition: an emerging field
    M Jahanshahi
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Exp Brain Res 131:1-9. 2000
    ..Finally, we highlight pertinent design and procedural issues and consider other types of questions that can be addressed by future TMS studies of cognitive function...
  17. doi request reprint Probabilistic classification learning with corrective feedback is selectively impaired in early Huntington's disease--evidence for the role of the striatum in learning with feedback
    Anna K Holl
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square, London, WC1N3BG, United Kingdom
    Neuropsychologia 50:2176-86. 2012
    ..Our findings are consistent with imaging evidence showing recruitment of the caudate during FB based WPT learning, while the MTL is associated with PA based learning...
  18. doi request reprint Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's disease
    Catherine R G Jones
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
    Brain Cogn 68:30-41. 2008
    ..The dissociation of the effects of dopaminergic medication and nature of task on performance in PD raises interesting questions about the pharmacological mediation and task-specificity of deficits in temporal processing...
  19. ncbi request reprint Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disability
    Anette Schrag
    Royal Free and University College Medical School, University College London NW3 2PF, London, UK
    Parkinsonism Relat Disord 12:35-41. 2006
    ....
  20. ncbi request reprint The subthalamic nucleus and inhibitory control: impact of subthalamotomy in Parkinson's disease
    Ignacio Obeso
    1 Cognitive Motor Neuroscience Group and the Functional Neurosurgery Unit, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, WC1N 3BG, UK
    Brain 137:1470-80. 2014
    ..Accordingly, the subthalamic nucleus can be considered a key component of the cerebral inhibitory network. ..
  21. doi request reprint Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
    Neuroimage 64:284-9. 2013
    ..These results are consistent with a frequency-specific role of the STN in executive processes such as suppression of habitual responses and 'switching-on' of more controlled processing strategies...
  22. ncbi request reprint Pallidal stimulation modifies after-effects of paired associative stimulation on motor cortex excitability in primary generalised dystonia
    Stephen Tisch
    Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Box 146 8 11 Queen Square, London WC1N 3BG, UK
    Exp Neurol 206:80-5. 2007
    ..To determine the effect of globus pallidus internus (GPi) deep brain stimulation (DBS) on motor cortex plasticity in patients with primary generalised dystonia...
  23. doi request reprint Patients with Parkinson's disease learn to control complex systems via procedural as well as non-procedural learning
    Magda Osman
    Department of Psychology, University College London, 26 Bedford Way, London WC1E 6BT, United Kingdom
    Neuropsychologia 46:2355-63. 2008
    ..It is possible that the learning and performance on CDC tasks are mediated by perceptual priming mechanisms in the neocortex...
  24. doi request reprint Differential effect of linguistic and non-linguistic pen-holding tasks on motor cortex excitability
    Sasa R Filipovic
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 191:237-46. 2008
    ..They also provide further evidence that the task specific modulation of the excitability of the motor cortex goes beyond motor complexity of the task and is also dependant on associated cognitive components...
  25. pmc Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatment
    Diane Ruge
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 26:1913-21. 2011
    ..Clinical benefit is delayed because engrams of abnormal movement persist and take time to normalize. Our observations suggest that plasticity may be a driver of long-term therapeutic effects of deep brain stimulation in dystonia...
  26. ncbi request reprint Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)
    Anette Schrag
    Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 10:399-405. 2004
    ..Its psychometric properties should be tested further in larger samples, including children of patients with other chronic disorders such as multiple sclerosis or chronic heart disease...
  27. doi request reprint Selective executive dysfunction but intact risky decision-making in early Huntington's disease
    Anna K Holl
    Sobell Department of Motor Neuroscience and Movement Disorders, University College London, Institute of Neurology, London, United Kingdom
    Mov Disord 28:1104-9. 2013
    ..The current results demonstrate that the deterioration of executive functioning in HD is variable and that some types of executive processing might already be impaired in early HD, whereas others remain intact...
  28. ncbi request reprint Attention and cognition in bradykinetic-rigid syndromes: an event-related potential study
    Z Pirtosek
    The National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, UK
    Ann Neurol 50:567-73. 2001
    ..The results of the study support the view that bradykinetic-rigid syndromes involve some attentional deficits, but also have distinct reaction time and ERP characteristics, which may be helpful in differential diagnosis...
  29. doi request reprint Bilateral stimulation of the subthalamic nucleus has differential effects on reactive and proactive inhibition and conflict-induced slowing in Parkinson's disease
    Ignacio Obeso
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 226:451-62. 2013
    ....
  30. pmc Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson's disease
    Louise M McDonald
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Mov Disord 27:372-8. 2012
    ..The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed...
  31. doi request reprint The effect of feedback on non-motor probabilistic classification learning in Parkinson's disease
    Leonora Wilkinson
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, London, United Kingdom
    Neuropsychologia 46:2683-95. 2008
    ..Our results do not support the proposal that the striatum plays a specific role in probabilistic classification learning with feedback...
  32. ncbi request reprint Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
    Ignacio Obeso
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Behav Neurol 25:111-8. 2012
    ....
  33. doi request reprint Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease
    Tessel Boertien
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1835-43. 2011
    ..In this review we discuss the published evidence from functional imaging studies of patients with subthalamic nucleus-deep brain stimulation to date, together with how these data inform the mechanism of action of deep brain stimulation...
  34. doi request reprint Action reprogramming in Parkinson's disease: response to prediction error is modulated by levels of dopamine
    Joseph M Galea
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurosci 32:542-50. 2012
    ..Consequently, when these internal predictions are incorrect, PD patients take longer to respond appropriately to unexpected sensory information...
  35. ncbi request reprint STN stimulation alters pallidal-frontal coupling during response selection under competition
    Stephane Thobois
    Functional Neurosurgery Unit, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Cereb Blood Flow Metab 27:1173-84. 2007
    ..This is the first direct evidence that STN stimulation significantly alters pallidal coupling with prefrontal, cingulate, and temporal cortices during performance of a task that requires response selection under competition...
  36. ncbi request reprint Executive function in dystonia
    Marjan Jahanshahi
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Adv Neurol 94:203-9. 2004
  37. ncbi request reprint The right dorsolateral prefrontal cortex is essential in time reproduction: an investigation with repetitive transcranial magnetic stimulation
    Catherine R G Jones
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 158:366-72. 2004
    ..In addition, we suggest that the selectivity of the rTMS effect for the Reproduction Phase indicates that the right DLPFC plays a particular role in memory processes...
  38. doi request reprint A gamma band specific role of the subthalamic nucleus in switching during verbal fluency tasks in Parkinson's disease
    Anam Anzak
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, WC1N 3BG, UK
    Exp Neurol 232:136-42. 2011
    ..The mechanisms of this deficit are unclear. We aimed to identify and characterise verbal fluency related processing within the subthalamic nucleus through analysis of local field potentials...
  39. doi request reprint The role of the basal ganglia and its cortical connections in sequence learning: evidence from implicit and explicit sequence learning in Parkinson's disease
    Leonora Wilkinson
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom
    Neuropsychologia 47:2564-73. 2009
    ..The results indicate that, in addition to playing a role in implicit sequence learning, the BG and its frontal projections are also involved in explicit sequence learning...
  40. doi request reprint Response selection in dual task paradigms: observations from random generation tasks
    Georg Dirnberger
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, UK
    Exp Brain Res 201:535-48. 2010
    ..Resources of the central executive are not re-allocated or 'switched' from one to the other task. Dual task costs may result from mechanisms effective within each trial such as the demands of response selection...
  41. ncbi request reprint The basal ganglia: anatomy, physiology, and pharmacology
    Stephen Tisch
    Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Psychiatr Clin North Am 27:757-99. 2004
    ..Further work will elucidate this to a greater extent, but for now, it is clear that the basal ganglia form an important nexus in the binding of cognitive, limbic, and motor information into thought and action...
  42. doi request reprint Deep brain stimulation of the subthalamic nucleus selectively improves learning of weakly associated cue combinations during probabilistic classification learning in Parkinson's disease
    Leonora Wilkinson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, England
    Neuropsychology 25:286-94. 2011
    ....
  43. pmc Therapeutic subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinson's disease
    Josh Kahan
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 7:e50270. 2012
    ..Furthermore, we confirm that fMRI is both feasible and is tolerated well by these patients provided strict safety measures are adhered to...
  44. doi request reprint Levodopa medication does not influence motor inhibition or conflict resolution in a conditional stop-signal task in Parkinson's disease
    Ignacio Obeso
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, 33 Queen Square, London, UK
    Exp Brain Res 213:435-45. 2011
    ..This conclusion is consistent with evidence from animal studies and clinical pharmacological investigations suggesting a role for noradrenaline in motor inhibition and impulsivity...
  45. doi request reprint Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011
    ....
  46. doi request reprint Quality of life in Parkinson's disease: the relative importance of the symptoms
    Shibley Rahman
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
    Mov Disord 23:1428-34. 2008
    ..The implications of these results for the medical management of PD are discussed...
  47. ncbi request reprint A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
    Anette Schrag
    Institute of Neurology, University College London, London, UK
    Mov Disord 25:1077-81. 2010
    ..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP...
  48. ncbi request reprint The striatum and probabilistic implicit sequence learning
    Leonora Wilkinson
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
    Brain Res 1137:117-30. 2007
    ..The results support the view that (i) the basal ganglia contribute to probabilistic implicit sequence learning (ii) that such learning can occur implicitly without explicit knowledge in PD patients...
  49. ncbi request reprint Health-related quality of life in patients with progressive supranuclear palsy
    Anette Schrag
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 18:1464-9. 2003
    ..The item pool created in these interviews provides the basis for the development of disease-specific QoL instruments for patients with PSP...
  50. ncbi request reprint Changes in blink reflex excitability after globus pallidus internus stimulation for dystonia
    Stephen Tisch
    Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:1650-5. 2006
    ..We conclude that GPi DBS for PTD results in functional reorganization of the nervous system, which includes a long-term increase in brainstem inhibition...
  51. pmc Genotype and phenotype in Parkinson's disease: lessons in heterogeneity from deep brain stimulation
    Aikaterina Angeli
    Sobell Department of Motor Neuroscience, University College London UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 28:1370-5. 2013
    ..DBS cohorts include large numbers of gene positive PD patients and can be clinically instructive in the exploration of genotype-phenotype relationships. ..
  52. pmc Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    J Neurol 261:164-73. 2014
    ..The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients' QoL, warrants further investigation...
  53. ncbi request reprint Executive dysfunction in Parkinson's disease is associated with altered pallidal-frontal processing
    Georg Dirnberger
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neuroimage 25:588-99. 2005
    ....
  54. pmc Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 25:1343-9. 2010
    ..Explicit sequence learning may be a useful cognitive biomarker for HD progression...
  55. doi request reprint Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson's disease
    Ignacio Obeso
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 212:371-84. 2011
    ....
  56. ncbi request reprint Impact of Parkinson's disease on patients' adolescent and adult children
    Anette Schrag
    Royal Free and University College Medical School, University College London, London NW3 2PF, UK
    Parkinsonism Relat Disord 10:391-7. 2004
    ..PD has a marked effect on the well-being of the adult and adolescent children of patients. The difficulties of children of parents with PD should receive greater attention...
  57. doi request reprint The contribution of primary motor cortex is essential for probabilistic implicit sequence learning: evidence from theta burst magnetic stimulation
    Leonora Wilkinson
    University College London, London, UK
    J Cogn Neurosci 22:427-36. 2010
    ..Sequence learning was not significantly affected by inhibitory TBS over the SMA, DLPFC or excitatory TBS over M1. These results demonstrate that the M1 mediates implicit sequence learning...
  58. ncbi request reprint Deep brain stimulation of the subthalamic nucleus improves set shifting but does not affect dual task performance in Parkinson's disease
    Donna Page
    Institute of Neurology, London WUN 3BG, UK
    IEEE Trans Neural Syst Rehabil Eng 15:198-206. 2007
    ..The improved set shifting with DBS of the STN in PD supports the critical role of the striato-frontal circuits in this cognitive function...
  59. pmc Motivational modulation of bradykinesia in Parkinson's disease off and on dopaminergic medication
    Maja Kojovic
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, London, WC1N 3BG, UK
    J Neurol 261:1080-9. 2014
    ..Thus, medication status should be an important consideration in movement rehabilitation programmes for patients with Parkinson's disease. ..
  60. doi request reprint The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?
    James Gratwicke
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurosci Biobehav Rev 37:2676-88. 2013
    ..Controlled trials of deep brain stimulation of the nucleus basalis of Meynert for Parkinson's disease dementia and Alzheimer's disease are required to evaluate potential efficacy and the mechanisms of possible cognitive changes. ..
  61. doi request reprint Motivation and movement: the effect of monetary incentive on performance speed
    Pablo Mir
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 209:551-9. 2011
    ..These "RT and reward" tasks provide a useful paradigm for investigation into the effects of monetary incentive on reaction times in man and to study motivational modulation of movement speed in health and disease...
  62. ncbi request reprint [Brain imaging and mobility in Parkinson's disease]
    Richard S Frackowiak
    Institute of Neurology, University College London, Queen Square, WC1N3BG, London, UK
    Bull Acad Natl Med 187:295-304. 2003
    ..An excess of activation has been demonstrated in other areas and is probably compensatory...
  63. ncbi request reprint Young- versus older-onset Parkinson's disease: impact of disease and psychosocial consequences
    Anette Schrag
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, London, United Kingdom
    Mov Disord 18:1250-6. 2003
    ..In addition to more severe treatment-related motor complications, social and psychosocial factors may contribute to greater impairment of quality of life in young patients with PD...
  64. ncbi request reprint Pallidotomy and incidental sequence learning in Parkinson's disease
    Richard G Brown
    Department of Psychology, PO77, Institute of Psychiatry, King s College, De Crespigny Park, London, UK
    Neuroreport 14:21-4. 2003
    ..Research on Parkinson's disease patients undergoing functional basal ganglia surgery may shed further light on the mechanisms and neuronal substrate of serial order learning in humans...
  65. ncbi request reprint Changes in corticospinal motor excitability induced by non-motor linguistic tasks
    I Papathanasiou
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, UK
    Exp Brain Res 154:218-25. 2004
    ....
  66. ncbi request reprint Quality of life in focal, segmental, and generalized dystonia
    Donna Page
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Mov Disord 22:341-7. 2007
    ....
  67. ncbi request reprint Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
    Mov Disord 21:989-96. 2006
    ..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...
  68. doi request reprint An approach to deep brain stimulation for severe treatment-refractory Tourette syndrome: the UK perspective
    Andrea E Cavanna
    Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, UK
    Br J Neurosurg 25:38-44. 2011
    ..The present article illustrates the UK perspective on DBS in TS and proposes consensus-based recommendations for double-blind controlled trials...
  69. ncbi request reprint Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
    Dominic C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
    Brain 129:1040-9. 2006
    ..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
  70. ncbi request reprint Timing variability of repetitive saccadic eye movements
    C J Collins
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    Exp Brain Res 120:325-34. 1998
    ....
  71. doi request reprint MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety
    T Foltynie
    Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, Box 146, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 82:358-63. 2011
    ....
  72. ncbi request reprint Executive processes in Parkinson's disease--random number generation and response suppression
    R G Brown
    Department of Clinical Neurology, Institute of Neurology, University College, London, UK
    Neuropsychologia 36:1355-62. 1998
    ..This suppression may be disrupted by the pathophysiology of PD and by concurrent tasks. Convergent evidence from various sources is discussed which supports a role of the dorsolateral prefrontal cortex (DLPFC) in this process...
  73. pmc The EQ-5D--a generic quality of life measure-is a useful instrument to measure quality of life in patients with Parkinson's disease
    A Schrag
    Department of Neurology, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 69:67-73. 2000
    ....
  74. ncbi request reprint Perceived stigma in Spasmodic Torticollis
    I Papathanasiou
    Therapy Services, National Hospital for Neurology and Neurosurgery, United Kingdom
    Mov Disord 16:280-5. 2001
    ..Stigma was found to affect the patients' social, private, and working lives. It is suggested that stigma in Spasmodic Torticollis needs to be considered as a parameter relevant to the clinical management of these patients...
  75. ncbi request reprint The mode of movement selection. Movement-related cortical potentials prior to freely selected and repetitive movements
    G Dirnberger
    General Hospital Vienna, Department of Neurology Neurological University Clinic, Austria
    Exp Brain Res 120:263-72. 1998
    ..These findings are discussed in relation to previous RP and positron emission tomography studies...
  76. ncbi request reprint PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences
    S Thobois
    Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, London, UK
    Neuroimage 23:1-16. 2004
    ..Interestingly, dopaminergic medications or surgical therapy reverse such abnormalities of brain activation...
  77. ncbi request reprint Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testing
    D C Paviour
    The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
    Neurocase 11:274-82. 2005
    ..These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes...
  78. pmc Adolescent and adult children of parents with Parkinson's disease: incorporating their needs in clinical guidelines
    David Morley
    Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Parkinsons Dis 2011:951874. 2011
    ..There is a need to similarly acknowledge the potential impact of parental Parkinson's in UK guidelines for PD...
  79. ncbi request reprint Plasticity of motor cortex excitability induced by rehabilitation therapy for writing
    Ilias Papathanasiou
    National Hospital for Neurology and Neurosurgery, and Institute of Neurology, University College London, UK
    Neurology 61:977-80. 2003
    ..Rehabilitation aimed to increase the use of the paretic hand may induce recruitment of previously silent ipsilateral corticospinal pathways even in poorly recovered poststroke patients...
  80. ncbi request reprint Holmes tremor: Application of modern neuroimaging techniques
    Dominic C Paviour
    The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom
    Mov Disord 21:2260-2. 2006
    ..Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur...
  81. ncbi request reprint Behavioral and psychiatric manifestations in dystonia
    Marjan Jahanshahi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Adv Neurol 96:291-319. 2005
  82. ncbi request reprint Changes in forearm reciprocal inhibition following pallidal stimulation for dystonia
    S Tisch
    obell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square London, United Kingdom
    Neurology 66:1091-3. 2006
    ..The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition...
  83. ncbi request reprint Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow
    I H Jenkins
    MRC Cyclotron Unit, Hammersmith Hospital, London, UK
    Brain 123:1216-28. 2000
    ..In this experiment and in our earlier study, DLPFC was activated only during the self-initiated task, in which decisions were required about the timing of movements...
  84. ncbi request reprint Uncoupling of contingent negative variation and alpha band event-related desynchronization in a go/no-go task
    S R Filipovic
    Medical Research Council Human Movement and Balance Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 112:1307-15. 2001
    ....
  85. ncbi request reprint What contributes to depression in Parkinson's disease?
    A Schrag
    Department of Clinical Neurology, Institute of Neurology, London
    Psychol Med 31:65-73. 2001
    ..Using a community-based sample of patients with Parkinson's disease, we investigated the contributions of impairment, disability and handicap to depression in Parkinson's disease...
  86. ncbi request reprint Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystonia
    A Munchau
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Brain 124:769-83. 2001
    ..Reinnervation is not infrequent and can compromise outcome. Postoperative morbidity is low, but there is a risk of dysphagia...
  87. doi request reprint Depression in focal, segmental and generalized dystonia
    L Lewis
    Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol 255:1750-5. 2008
    ..However, longitudinal followup is required to firmly establish the direction of causality between depression and these psychosocial variables in dystonia...
  88. ncbi request reprint Screening for depression among neuro-otology patients with and without identifiable vestibular lesions
    E A Grunfeld
    Psychology Unit, Guy s, King s and St Thomas Medical School, Guy s Hospital, London, UK
    Int J Audiol 42:161-5. 2003
    ..In particular, the findings highlight the importance of screening for emotional distress in this patient group, regardless of clinical test results or severity of self-reported symptoms...
  89. ncbi request reprint The factors that induce or overcome freezing of gait in Parkinson's disease
    S Rahman
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, WC1N 3BG, UK
    Behav Neurol 19:127-36. 2008
    ..The concept of paradoxical kinesis, the potential neural substrates of such external cueing effects, and their importance for rehabilitation in PD are discussed...
  90. ncbi request reprint The validity of the hospital anxiety and depression scale and the geriatric depression scale in Parkinson's disease
    Federica Mondolo
    Institute of Physical Medicine and Rehabilitation, Gervasutta Hospital, Via Gervasutta, 48, 33100 Udine, Italy
    Behav Neurol 17:109-15. 2006
    ..The results indicate the validity of using the HADS and the GDS to screen for depressive symptoms and to diagnose depressive illness in PD...
  91. ncbi request reprint Learning of ambiguous versus hybrid sequences by patients with Parkinson's disease
    Steve W Kelly
    Department of Psychology, University of Keele, Staffordshire ST5 5BG, UK
    Neuropsychologia 42:1350-7. 2004
    ..This may be interpreted as providing evidence for a non-attentional learning mechanism which is relatively intact in Parkinson's disease...
  92. ncbi request reprint Clinical features of the geste antagoniste in cervical dystonia
    Sasa R Filipovic
    Burden Neurological Institute, Departments of Neurology and Neuropsychiatry, Frenchay Hospital, Bristol, United Kingdom
    Adv Neurol 94:191-201. 2004

Research Grants6

  1. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2001
    ....
  2. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2001
    ....
  3. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2002
    ....
  4. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2003
    ....
  5. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2004
    ....
  6. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    ....