Research Topics
| Marjan JahanshahiSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Factors that ameliorate or aggravate spasmodic torticollisM Jahanshahi
Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 68:227-9. 2000....
Impairment of movement initiation and execution but not preparation in idiopathic dystoniaM Jahanshahi
Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Exp Brain Res 140:460-8. 2001..The results are discussed in relation to previous imaging, behavioural and electrophysiological studies and models of fronto-striatal dysfunction in ITD...- Does the pre-frontal cortex contribute to movement-related potentials? Recordings from subdural electrodesM Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neurocase 7:495-501. 2001..These preliminary results require replication in a larger series of patients... - Striatal contribution to cognition: working memory and executive function in Parkinson's disease before and after unilateral posteroventral pallidotomyM Jahanshahi
Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
J Cogn Neurosci 14:298-310. 2002..The results suggest that striatal outflow to the frontal cortex may be essential for those aspects of executive function that showed deterioration after PVP... 
Neuropsychological, neuropsychiatric, and quality of life issues in DBS for dystoniaMarjan Jahanshahi
UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Mov Disord 26:S63-78. 2011..Quality of life in dystonia patients quantified by generic measures such as the SF36 showed improvement in both mental and physical categories following DBS surgery...- Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's diseaseMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
Brain 133:727-45. 2010..In contrast, our results establish for the first time that administration of dopaminergic medication increases striatal-frontal connectivity between the caudate nucleus and prefrontal cortex during motor timing... - Medication impairs probabilistic classification learning in Parkinson's diseaseMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3 BG, United Kingdom
Neuropsychologia 48:1096-103. 2010..These results highlight the need for careful 'titration' of dopaminergic medication to produce the desired improvement of the motor symptoms without the associated detrimental effects on cognition and learning... - A preliminary investigation of the running digit span as a test of working memoryMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Behav Neurol 20:17-25. 2008.... - Effects on cognition of stereotactic lesional surgery for the treatment of tremor in multiple sclerosisMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Behav Neurol 20:1-9. 2008..To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition... - Cognitive executive function in dystoniaMarjan Jahanshahi
Sobell Research Department of Motor, Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 18:1470-81. 2003..A more detailed investigation of cognitive function in a larger sample of patients is required... - The substantia nigra pars compacta and temporal processingMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 26:12266-73. 2006..The fundamental role of the substantia nigra in temporal processing is discussed in relation to previous animal lesion studies and evidence for the modulating influence of dopamine on temporal processing... - The effects of transcranial magnetic stimulation over the dorsolateral prefrontal cortex on suppression of habitual counting during random number generationM Jahanshahi
Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Brain 121:1533-44. 1998..To allow emergence of appropriate random responses, the left DLPFC inhibits the superior temporal cortex to prevent spreading activation and habitual counting in ones... - The left dorsolateral prefrontal cortex and random generation of responses: studies with transcranial magnetic stimulationM Jahanshahi
Department of Clinical Neurology, Institute of Neurology and Medical Research Council, The National Hospital for Neurology and Neurosurgery, London, UK
Neuropsychologia 37:181-90. 1999..The results suggest the generality of network modulation model of random response generation... - Random number generation as an index of controlled processingMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, England
Neuropsychology 20:391-9. 2006..These features render the easily administered RNG task an ideal and robust index of executive function that is highly suitable for repeated clinical use... - Transcranial magnetic stimulation studies of cognition: an emerging fieldM Jahanshahi
Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Exp Brain Res 131:1-9. 2000..Finally, we highlight pertinent design and procedural issues and consider other types of questions that can be addressed by future TMS studies of cognitive function... - The impact of deep brain stimulation on executive function in Parkinson's diseaseM Jahanshahi
Department of Clinical Neurology, Institute of Neruology, The National Hospital for Neurology and Neurosurgery, London, UK
Brain 123:1142-54. 2000..Conversely, disruption of basal ganglia outflow during DBS impaired performance on tests requiring changing behaviour in novel contexts as predicted by Marsden and Obeso in 1994... - Probabilistic classification learning with corrective feedback is selectively impaired in early Huntington's disease--evidence for the role of the striatum in learning with feedbackAnna K Holl
Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square, London, WC1N3BG, United Kingdom
Neuropsychologia 50:2176-86. 2012..Our findings are consistent with imaging evidence showing recruitment of the caudate during FB based WPT learning, while the MTL is associated with PA based learning... - Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's diseaseCatherine R G Jones
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
Brain Cogn 68:30-41. 2008..The dissociation of the effects of dopaminergic medication and nature of task on performance in PD raises interesting questions about the pharmacological mediation and task-specificity of deficits in temporal processing... - Caregiver-burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disabilityAnette Schrag
Royal Free and University College Medical School, University College London NW3 2PF, London, UK
Parkinsonism Relat Disord 12:35-41. 2006.... - Pallidal stimulation modifies after-effects of paired associative stimulation on motor cortex excitability in primary generalised dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Box 146 8 11 Queen Square, London WC1N 3BG, UK
Exp Neurol 206:80-5. 2007..To determine the effect of globus pallidus internus (GPi) deep brain stimulation (DBS) on motor cortex plasticity in patients with primary generalised dystonia... - Patients with Parkinson's disease learn to control complex systems via procedural as well as non-procedural learningMagda Osman
Department of Psychology, University College London, 26 Bedford Way, London WC1E 6BT, United Kingdom
Neuropsychologia 46:2355-63. 2008..It is possible that the learning and performance on CDC tasks are mediated by perceptual priming mechanisms in the neocortex... - Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatmentDiane Ruge
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
Mov Disord 26:1913-21. 2011..Clinical benefit is delayed because engrams of abnormal movement persist and take time to normalize. Our observations suggest that plasticity may be a driver of long-term therapeutic effects of deep brain stimulation in dystonia... - Development of a measure of the impact of chronic parental illness on adolescent and adult children. The parental illness impact scale (Parkinson's disease)Anette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:399-405. 2004..Its psychometric properties should be tested further in larger samples, including children of patients with other chronic disorders such as multiple sclerosis or chronic heart disease... - Differential effect of linguistic and non-linguistic pen-holding tasks on motor cortex excitabilitySasa R Filipovic
Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Exp Brain Res 191:237-46. 2008..They also provide further evidence that the task specific modulation of the excitability of the motor cortex goes beyond motor complexity of the task and is also dependant on associated cognitive components... - Attention and cognition in bradykinetic-rigid syndromes: an event-related potential studyZ Pirtosek
The National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, UK
Ann Neurol 50:567-73. 2001..The results of the study support the view that bradykinetic-rigid syndromes involve some attentional deficits, but also have distinct reaction time and ERP characteristics, which may be helpful in differential diagnosis... - Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson's diseaseLouise M McDonald
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
Mov Disord 27:372-8. 2012..The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed... - The effect of feedback on non-motor probabilistic classification learning in Parkinson's diseaseLeonora Wilkinson
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, University College London, London, United Kingdom
Neuropsychologia 46:2683-95. 2008..Our results do not support the proposal that the striatum plays a specific role in probabilistic classification learning with feedback... - Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variablesIgnacio Obeso
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
Behav Neurol 25:111-8. 2012.... - Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's diseaseTessel Boertien
Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 26:1835-43. 2011..In this review we discuss the published evidence from functional imaging studies of patients with subthalamic nucleus-deep brain stimulation to date, together with how these data inform the mechanism of action of deep brain stimulation... - Action reprogramming in Parkinson's disease: response to prediction error is modulated by levels of dopamineJoseph M Galea
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, WC1N 3BG, UK
J Neurosci 32:542-50. 2012..Consequently, when these internal predictions are incorrect, PD patients take longer to respond appropriately to unexpected sensory information... - STN stimulation alters pallidal-frontal coupling during response selection under competitionStephane Thobois
Functional Neurosurgery Unit, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
J Cereb Blood Flow Metab 27:1173-84. 2007..This is the first direct evidence that STN stimulation significantly alters pallidal coupling with prefrontal, cingulate, and temporal cortices during performance of a task that requires response selection under competition... - The basal ganglia: anatomy, physiology, and pharmacologyStephen Tisch
Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
Psychiatr Clin North Am 27:757-99. 2004..Further work will elucidate this to a greater extent, but for now, it is clear that the basal ganglia form an important nexus in the binding of cognitive, limbic, and motor information into thought and action... - The right dorsolateral prefrontal cortex is essential in time reproduction: an investigation with repetitive transcranial magnetic stimulationCatherine R G Jones
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
Exp Brain Res 158:366-72. 2004..In addition, we suggest that the selectivity of the rTMS effect for the Reproduction Phase indicates that the right DLPFC plays a particular role in memory processes... - The role of the basal ganglia and its cortical connections in sequence learning: evidence from implicit and explicit sequence learning in Parkinson's diseaseLeonora Wilkinson
Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom
Neuropsychologia 47:2564-73. 2009..The results indicate that, in addition to playing a role in implicit sequence learning, the BG and its frontal projections are also involved in explicit sequence learning... - Response selection in dual task paradigms: observations from random generation tasksGeorg Dirnberger
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, UK
Exp Brain Res 201:535-48. 2010..Resources of the central executive are not re-allocated or 'switched' from one to the other task. Dual task costs may result from mechanisms effective within each trial such as the demands of response selection... - Executive function in dystoniaMarjan Jahanshahi
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Adv Neurol 94:203-9. 2004 - Deep brain stimulation of the subthalamic nucleus selectively improves learning of weakly associated cue combinations during probabilistic classification learning in Parkinson's diseaseLeonora Wilkinson
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, England
Neuropsychology 25:286-94. 2011.... - A gamma band specific role of the subthalamic nucleus in switching during verbal fluency tasks in Parkinson's diseaseAnam Anzak
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, WC1N 3BG, UK
Exp Neurol 232:136-42. 2011..The mechanisms of this deficit are unclear. We aimed to identify and characterise verbal fluency related processing within the subthalamic nucleus through analysis of local field potentials... - Levodopa medication does not influence motor inhibition or conflict resolution in a conditional stop-signal task in Parkinson's diseaseIgnacio Obeso
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, 33 Queen Square, London, UK
Exp Brain Res 213:435-45. 2011..This conclusion is consistent with evidence from animal studies and clinical pharmacological investigations suggesting a role for noradrenaline in motor inhibition and impulsivity... - Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internusRaul Martínez-Fernández
Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 26:1922-30. 2011.... - Changes in blink reflex excitability after globus pallidus internus stimulation for dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 21:1650-5. 2006..We conclude that GPi DBS for PTD results in functional reorganization of the nervous system, which includes a long-term increase in brainstem inhibition... - The striatum and probabilistic implicit sequence learningLeonora Wilkinson
Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
Brain Res 1137:117-30. 2007..The results support the view that (i) the basal ganglia contribute to probabilistic implicit sequence learning (ii) that such learning can occur implicitly without explicit knowledge in PD patients... - Quality of life in Parkinson's disease: the relative importance of the symptomsShibley Rahman
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, United Kingdom
Mov Disord 23:1428-34. 2008..The implications of these results for the medical management of PD are discussed... - A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophyAnette Schrag
Institute of Neurology, University College London, London, UK
Mov Disord 25:1077-81. 2010..Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP... - Health-related quality of life in patients with progressive supranuclear palsyAnette Schrag
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 18:1464-9. 2003..The item pool created in these interviews provides the basis for the development of disease-specific QoL instruments for patients with PSP... - Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's diseaseAnam Anzak
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK
Neuroimage 64:284-9. 2013..These results are consistent with a frequency-specific role of the STN in executive processes such as suppression of habitual responses and 'switching-on' of more controlled processing strategies... - The contribution of primary motor cortex is essential for probabilistic implicit sequence learning: evidence from theta burst magnetic stimulationLeonora Wilkinson
University College London, London, UK
J Cogn Neurosci 22:427-36. 2010..Sequence learning was not significantly affected by inhibitory TBS over the SMA, DLPFC or excitatory TBS over M1. These results demonstrate that the M1 mediates implicit sequence learning... - Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson's diseaseIgnacio Obeso
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, London, WC1N 3BG, UK
Exp Brain Res 212:371-84. 2011.... - Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's diseaseSusanne A Schneider
Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 25:1343-9. 2010..Explicit sequence learning may be a useful cognitive biomarker for HD progression... - Impact of Parkinson's disease on patients' adolescent and adult childrenAnette Schrag
Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Parkinsonism Relat Disord 10:391-7. 2004..PD has a marked effect on the well-being of the adult and adolescent children of patients. The difficulties of children of parents with PD should receive greater attention... - Executive dysfunction in Parkinson's disease is associated with altered pallidal-frontal processingGeorg Dirnberger
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Neuroimage 25:588-99. 2005.... - Deep brain stimulation of the subthalamic nucleus improves set shifting but does not affect dual task performance in Parkinson's diseaseDonna Page
Institute of Neurology, London WUN 3BG, UK
IEEE Trans Neural Syst Rehabil Eng 15:198-206. 2007..The improved set shifting with DBS of the STN in PD supports the critical role of the striato-frontal circuits in this cognitive function... - Pallidotomy and incidental sequence learning in Parkinson's diseaseRichard G Brown
Department of Psychology, PO77, Institute of Psychiatry, King's College, De Crespigny Park, London, UK
Neuroreport 14:21-4. 2003..Research on Parkinson's disease patients undergoing functional basal ganglia surgery may shed further light on the mechanisms and neuronal substrate of serial order learning in humans... - [Brain imaging and mobility in Parkinson's disease]Richard S Frackowiak
Institute of Neurology, University College London, Queen Square, WC1N3BG, London, UK
Bull Acad Natl Med 187:295-304. 2003..An excess of activation has been demonstrated in other areas and is probably compensatory... - Motivation and movement: the effect of monetary incentive on performance speedPablo Mir
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Exp Brain Res 209:551-9. 2011..These "RT and reward" tasks provide a useful paradigm for investigation into the effects of monetary incentive on reaction times in man and to study motivational modulation of movement speed in health and disease... - Young- versus older-onset Parkinson's disease: impact of disease and psychosocial consequencesAnette Schrag
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, London, United Kingdom
Mov Disord 18:1250-6. 2003..In addition to more severe treatment-related motor complications, social and psychosocial factors may contribute to greater impairment of quality of life in young patients with PD... - Changes in corticospinal motor excitability induced by non-motor linguistic tasksI Papathanasiou
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, UK
Exp Brain Res 154:218-25. 2004.... - Bilateral stimulation of the subthalamic nucleus has differential effects on reactive and proactive inhibition and conflict-induced slowing in Parkinson's diseaseIgnacio Obeso
Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, London, WC1N 3BG, UK
Exp Brain Res 226:451-62. 2013.... - Therapeutic subthalamic nucleus deep brain stimulation reverses cortico-thalamic coupling during voluntary movements in Parkinson's diseaseJosh Kahan
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
PLoS ONE 7:e50270. 2012..Furthermore, we confirm that fMRI is both feasible and is tolerated well by these patients provided strict safety measures are adhered to... - Quality of life in focal, segmental, and generalized dystoniaDonna Page
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, The National Hospital for Neurology and Neurosurgery, London, United Kingdom
Mov Disord 22:341-7. 2007.... - Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophyDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
Brain 129:1040-9. 2006..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies... - An approach to deep brain stimulation for severe treatment-refractory Tourette syndrome: the UK perspectiveAndrea E Cavanna
Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, UK
Br J Neurosurg 25:38-44. 2011..The present article illustrates the UK perspective on DBS in TS and proposes consensus-based recommendations for double-blind controlled trials... - Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlationsDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
Mov Disord 21:989-96. 2006..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls... - Perceived stigma in Spasmodic TorticollisI Papathanasiou
Therapy Services, National Hospital for Neurology and Neurosurgery, United Kingdom
Mov Disord 16:280-5. 2001..Stigma was found to affect the patients' social, private, and working lives. It is suggested that stigma in Spasmodic Torticollis needs to be considered as a parameter relevant to the clinical management of these patients... - The EQ-5D--a generic quality of life measure-is a useful instrument to measure quality of life in patients with Parkinson's diseaseA Schrag
Department of Neurology, Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 69:67-73. 2000.... - The mode of movement selection. Movement-related cortical potentials prior to freely selected and repetitive movementsG Dirnberger
General Hospital Vienna, Department of Neurology Neurological University Clinic, Austria
Exp Brain Res 120:263-72. 1998..These findings are discussed in relation to previous RP and positron emission tomography studies... - Timing variability of repetitive saccadic eye movementsC J Collins
MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
Exp Brain Res 120:325-34. 1998.... - MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safetyT Foltynie
Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, Box 146, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 82:358-63. 2011.... - Executive processes in Parkinson's disease--random number generation and response suppressionR G Brown
Department of Clinical Neurology, Institute of Neurology, University College, London, UK
Neuropsychologia 36:1355-62. 1998..This suppression may be disrupted by the pathophysiology of PD and by concurrent tasks. Convergent evidence from various sources is discussed which supports a role of the dorsolateral prefrontal cortex (DLPFC) in this process... - PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequencesS Thobois
Sobell Department of Motor Neurosciences and Movement Disorders, Institute of Neurology, London, UK
Neuroimage 23:1-16. 2004..Interestingly, dopaminergic medications or surgical therapy reverse such abnormalities of brain activation... - Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testingD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
Neurocase 11:274-82. 2005..These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes... - Holmes tremor: Application of modern neuroimaging techniquesDominic C Paviour
The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom
Mov Disord 21:2260-2. 2006..Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur... - Plasticity of motor cortex excitability induced by rehabilitation therapy for writingIlias Papathanasiou
National Hospital for Neurology and Neurosurgery, and Institute of Neurology, University College London, UK
Neurology 61:977-80. 2003..Rehabilitation aimed to increase the use of the paretic hand may induce recruitment of previously silent ipsilateral corticospinal pathways even in poorly recovered poststroke patients... - Behavioral and psychiatric manifestations in dystoniaMarjan Jahanshahi
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Adv Neurol 96:291-319. 2005 - Adolescent and adult children of parents with Parkinson's disease: incorporating their needs in clinical guidelinesDavid Morley
Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Parkinsons Dis 2011:951874. 2011..There is a need to similarly acknowledge the potential impact of parental Parkinson's in UK guidelines for PD... - What contributes to depression in Parkinson's disease?A Schrag
Department of Clinical Neurology, Institute of Neurology, London
Psychol Med 31:65-73. 2001..Using a community-based sample of patients with Parkinson's disease, we investigated the contributions of impairment, disability and handicap to depression in Parkinson's disease... - Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flowI H Jenkins
MRC Cyclotron Unit, Hammersmith Hospital, London, UK
Brain 123:1216-28. 2000..In this experiment and in our earlier study, DLPFC was activated only during the self-initiated task, in which decisions were required about the timing of movements... - Changes in forearm reciprocal inhibition following pallidal stimulation for dystoniaS Tisch
obell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square London, United Kingdom
Neurology 66:1091-3. 2006..The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition... - Uncoupling of contingent negative variation and alpha band event-related desynchronization in a go/no-go taskS R Filipovic
Medical Research Council Human Movement and Balance Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Clin Neurophysiol 112:1307-15. 2001.... - Prospective study of selective peripheral denervation for botulinum-toxin resistant patients with cervical dystoniaA Munchau
University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
Brain 124:769-83. 2001..Reinnervation is not infrequent and can compromise outcome. Postoperative morbidity is low, but there is a risk of dysphagia... - Screening for depression among neuro-otology patients with and without identifiable vestibular lesionsE A Grunfeld
Psychology Unit, Guy s, King s and St Thomas Medical School, Guy s Hospital, London, UK
Int J Audiol 42:161-5. 2003..In particular, the findings highlight the importance of screening for emotional distress in this patient group, regardless of clinical test results or severity of self-reported symptoms... - Depression in focal, segmental and generalized dystoniaL Lewis
Cognitive Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Neurol 255:1750-5. 2008..However, longitudinal followup is required to firmly establish the direction of causality between depression and these psychosocial variables in dystonia... - The factors that induce or overcome freezing of gait in Parkinson's diseaseS Rahman
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London, Queen Square, London, WC1N 3BG, UK
Behav Neurol 19:127-36. 2008..The concept of paradoxical kinesis, the potential neural substrates of such external cueing effects, and their importance for rehabilitation in PD are discussed... - The validity of the hospital anxiety and depression scale and the geriatric depression scale in Parkinson's diseaseFederica Mondolo
Institute of Physical Medicine and Rehabilitation, Gervasutta Hospital, Via Gervasutta, 48, 33100 Udine, Italy
Behav Neurol 17:109-15. 2006..The results indicate the validity of using the HADS and the GDS to screen for depressive symptoms and to diagnose depressive illness in PD... - Learning of ambiguous versus hybrid sequences by patients with Parkinson's diseaseSteve W Kelly
Department of Psychology, University of Keele, Staffordshire ST5 5BG, UK
Neuropsychologia 42:1350-7. 2004..This may be interpreted as providing evidence for a non-attentional learning mechanism which is relatively intact in Parkinson's disease... - Clinical features of the geste antagoniste in cervical dystoniaSasa R Filipovic
Burden Neurological Institute, Departments of Neurology and Neuropsychiatry, Frenchay Hospital, Bristol, United Kingdom
Adv Neurol 94:191-201. 2004
Research Grants
- DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PDMarjan Jahanshahi; Fiscal Year: 2005....