J B Jackson

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Interdomain hydride transfer in proton-translocating transhydrogenase
    J B Jackson
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1365:79-86. 1998
  2. ncbi request reprint The alternating site, binding change mechanism for proton translocation by transhydrogenase
    J Baz Jackson
    School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochemistry 41:4173-85. 2002
  3. ncbi request reprint Proton translocation by transhydrogenase
    J Baz Jackson
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FEBS Lett 545:18-24. 2003
  4. doi request reprint A review of the binding-change mechanism for proton-translocating transhydrogenase
    J Baz Jackson
    University of Birmingham, Birmingham, UK
    Biochim Biophys Acta 1817:1839-46. 2012
  5. ncbi request reprint The crystal structure of an asymmetric complex of the two nucleotide binding components of proton-translocating transhydrogenase
    N P Cotton
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, United Kingdom
    Structure 9:165-76. 2001
  6. ncbi request reprint Catalytic properties of hybrid complexes of the NAD(H)-binding and NADP(H)-binding domains of the proton-translocating transhydrogenases from Escherichia coli and Rhodospirillum rubrum
    O Fjellström
    School of Biochemistry, University of Birmingham, UK
    Biochemistry 38:415-22. 1999
  7. ncbi request reprint A change in ionization of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase regulates both hydride transfer and nucleotide release
    D J Rodrigues
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Biochem 268:1430-8. 2001
  8. ncbi request reprint Kinetic resolution of the reaction catalysed by proton-translocating transhydrogenase from Escherichia coli as revealed by experiments with analogues of the nucleotide substrates
    M Hutton
    School of Biochemistry, University of Birmingham, England
    Eur J Biochem 219:1041-51. 1994
  9. ncbi request reprint Conformational dynamics of a mobile loop in the NAD(H)-binding subunit of proton-translocating transhydrogenases from Rhodospirillum rubrum and Escherichia coli
    C Diggle
    School of Biochemistry, University of Birmingham, UK
    Eur J Biochem 232:315-26. 1995
  10. ncbi request reprint The NADP(H)-binding component (dIII) of human heart transhydrogenase: crystallization and preliminary crystallographic analysis
    S J Peake
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England, UK
    Acta Crystallogr D Biol Crystallogr 56:489-91. 2000

Collaborators

  • P G Quirk
  • S A White
  • C M Thomas
  • M Hutton
  • K J Smith
  • S Gupta
  • P R Rich
  • Giovanni B Strambini
  • John S Snaith
  • Gijs I van Boxel
  • N P Cotton
  • U Mirian Obiozo
  • T Harma C Brondijk
  • Tina Bhakta
  • Simon J Whitehead
  • Jaap Broos
  • Owen C Mather
  • Nick P J Cotton
  • J D Venning
  • Avtar Singh
  • T Bizouarn
  • Daniel J Rodrigues
  • Karina Tveen Jensen
  • Tim R Dafforn
  • D J Rodrigues
  • Rosalind Wilson
  • Masayo Iwaki
  • S J Peake
  • Tania Bizouarn
  • Jamie D Venning
  • Chris J Weston
  • M Jeeves
  • S N Stilwell
  • Margherita Gonnelli
  • O Fjellström
  • Andrew J White
  • Sundaresan Rajesh
  • Gijs van Boxel
  • John Wilkie
  • Gurdyal Singh Besra
  • C Diggle
  • Karen E Rossington
  • Abdul Hafiz
  • Edi Gabellieri
  • S McSweeney
  • N Errington
  • S Finet
  • C J Weston
  • R L Grimley
  • J W Zhang
  • J Rydstrom
  • R Williams

Detail Information

Publications35

  1. ncbi request reprint Interdomain hydride transfer in proton-translocating transhydrogenase
    J B Jackson
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1365:79-86. 1998
    ..An important role for the loop region in the process of hydride transfer is revealed...
  2. ncbi request reprint The alternating site, binding change mechanism for proton translocation by transhydrogenase
    J Baz Jackson
    School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochemistry 41:4173-85. 2002
  3. ncbi request reprint Proton translocation by transhydrogenase
    J Baz Jackson
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FEBS Lett 545:18-24. 2003
    ..In the two monomers of transhydrogenase, there is a reciprocating, out-of-phase alternation of these conformations during turnover...
  4. doi request reprint A review of the binding-change mechanism for proton-translocating transhydrogenase
    J Baz Jackson
    University of Birmingham, Birmingham, UK
    Biochim Biophys Acta 1817:1839-46. 2012
    ..This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012)...
  5. ncbi request reprint The crystal structure of an asymmetric complex of the two nucleotide binding components of proton-translocating transhydrogenase
    N P Cotton
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, United Kingdom
    Structure 9:165-76. 2001
    ..A third component, dII, provides a proton channel through the membrane. Intact membrane-located transhydrogenase is probably a dimer (two copies each of dI, dII, and dIII)...
  6. ncbi request reprint Catalytic properties of hybrid complexes of the NAD(H)-binding and NADP(H)-binding domains of the proton-translocating transhydrogenases from Escherichia coli and Rhodospirillum rubrum
    O Fjellström
    School of Biochemistry, University of Birmingham, UK
    Biochemistry 38:415-22. 1999
    ..rubrum and possibly in the E. coli enzyme. Higher reverse activities for rrI+ecbeta than for rrI+ecIII confirmed the regulatory role of dII for the association and dissociation rates of NADP(H)...
  7. ncbi request reprint A change in ionization of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase regulates both hydride transfer and nucleotide release
    D J Rodrigues
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Biochem 268:1430-8. 2001
    ..The ionisable group might be a component of the proton-translocation pathway in the complete enzyme...
  8. ncbi request reprint Kinetic resolution of the reaction catalysed by proton-translocating transhydrogenase from Escherichia coli as revealed by experiments with analogues of the nucleotide substrates
    M Hutton
    School of Biochemistry, University of Birmingham, England
    Eur J Biochem 219:1041-51. 1994
    ..It is considered that the binding and release of H+, which accompany the binding and release of NADP+/NADPH, might be central to the mechanism of proton translocation by the enzyme in its membrane-bound state...
  9. ncbi request reprint Conformational dynamics of a mobile loop in the NAD(H)-binding subunit of proton-translocating transhydrogenases from Rhodospirillum rubrum and Escherichia coli
    C Diggle
    School of Biochemistry, University of Birmingham, UK
    Eur J Biochem 232:315-26. 1995
    ..rubrum...
  10. ncbi request reprint The NADP(H)-binding component (dIII) of human heart transhydrogenase: crystallization and preliminary crystallographic analysis
    S J Peake
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England, UK
    Acta Crystallogr D Biol Crystallogr 56:489-91. 2000
    ..The crystals belong to the tetragonal space group P4(1)22 or P4(3)22, with unit-cell parameters a = b = 58.1, c = 251.0 A. A 2.1 A resolution native data set has been collected with an R(merge) of 6. 8%...
  11. ncbi request reprint The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria
    S A White
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK
    Structure 8:1-12. 2000
    ..Proton pumping is probably coupled to changes in the binding affinities of dIII for NADP(+) and NADPH...
  12. ncbi request reprint The involvement of NADP(H) binding and release in energy transduction by proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli
    T Bizouarn
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1229:49-58. 1995
    ..It adequately accounts for the pH dependence of the enzyme, for the features described above and for kinetic characteristics of E. coli transhydrogenase described in the literature...
  13. ncbi request reprint The binding of nucleotides to domain I proteins of the proton-translocating transhydrogenases from Rhodospirillum rubrum and Escherichia coli as measured by equilibrium dialysis
    T Bizouarn
    School of Biochemistry, University of Birmingham, England
    Eur J Biochem 239:737-41. 1996
    ..Reasons for the discrepancies between the work on bacterial and mitochondrial transhydrogenases are discussed...
  14. ncbi request reprint Structure and mechanism of proton-translocating transhydrogenase
    J B Jackson
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    FEBS Lett 464:1-8. 1999
    ....
  15. ncbi request reprint Cloning and sequencing of the genes for the proton-translocating nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and the implications for the domain structure of the enzyme
    R Williams
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Microbiology 140:1595-604. 1994
    ..It is suggested that this protease-sensitive region separates two subdomains and that, after trypsinolysis, at least one retains structural integrity and can dock with domains II and/or III...
  16. ncbi request reprint The proton-translocating nicotinamide adenine dinucleotide transhydrogenase
    J B Jackson
    School of Biochemistry, University of Birmingham, U K
    J Bioenerg Biomembr 23:715-41. 1991
    ..The available data are consistent with either direct or indirect mechanisms of energy coupling...
  17. ncbi request reprint The heterotrimer of the membrane-peripheral components of transhydrogenase and the alternating-site mechanism of proton translocation
    J D Venning
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    J Biol Chem 276:30678-85. 2001
    ..These observations lend strong support to the alternating-site mechanism...
  18. ncbi request reprint The reduction of acetylpyridine adenine dinucleotide by NADH: is it a significant reaction of proton-translocating transhydrogenase, or an artefact?
    S N Stilwell
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1320:83-94. 1997
    ..rubrum membranes it can be shown with some certainty that the bound nucleotides are NADP+ or NADPH. The data are thus adequately explained without recourse to suggestions of multiple nucleotide-binding sites on transhydrogenase...
  19. ncbi request reprint Solution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from Rhodospirillum rubrum
    M Jeeves
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK
    Biochim Biophys Acta 1459:248-57. 2000
    ..The results are compared with the recently determined, high-resolution crystal structures of human and bovine dIII which also show the reversed nucleotide orientation...
  20. ncbi request reprint The mobile loop region of the NAD(H) binding component (dI) of proton-translocating nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum: complete NMR assignment and effects of bound nucleotides
    P G Quirk
    School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochim Biophys Acta 1412:139-48. 1999
    ..The role of the mobile loop region in catalysis is discussed with particular reference to a newly-developed model of the dI protein, based on its homology with alanine dehydrogenase...
  21. ncbi request reprint Substitution of tyrosine 146 in the dI component of proton-translocating transhydrogenase leads to reversible dissociation of the active dimer into inactive monomers
    U Mirian Obiozo
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 282:36434-43. 2007
    ..Two peaks in the 1H NMR spectrum of wild-type dI are broadened in dI.Y146A and are tentatively assigned to S-methyl groups of Met resonances in the beta-hairpin, consistent with the segmental mobility of this feature in the structure...
  22. ncbi request reprint Structures of the dI2dIII1 complex of proton-translocating transhydrogenase with bound, inactive analogues of NADH and NADPH reveal active site geometries
    Tina Bhakta
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Biochemistry 46:3304-18. 2007
    ..Molecular dynamics simulations of the enzyme indicate that the (dihydro)nicotinamide rings remain close to a ground state for hydride transfer throughout a 1.4 ns trajectory...
  23. ncbi request reprint A hybrid of the transhydrogenases from Rhodospirillum rubrum and Mycobacterium tuberculosis catalyses rapid hydride transfer but not the complete, proton-translocating reaction
    Rosalind Wilson
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Biochim Biophys Acta 1757:215-23. 2006
    ..It is concluded that sequence mismatch in the hybrid prevents a conformational change between dI and dIII which is essential for the step accompanying proton translocation...
  24. ncbi request reprint The role of invariant amino acid residues at the hydride transfer site of proton-translocating transhydrogenase
    T Harma C Brondijk
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 281:13345-54. 2006
    ....
  25. ncbi request reprint Molecular recognition between protein and nicotinamide dinucleotide in intact, proton-translocating transhydrogenase studied by ATR-FTIR Spectroscopy
    Masayo Iwaki
    School of Biosciences, University of Birmingham, UK
    J Am Chem Soc 128:2621-9. 2006
    ..The data suggest that NADP(H) binding leads to perturbation of a deeply buried part of the polypeptide backbone and to protonation of a carboxylic acid residue...
  26. ncbi request reprint Nucleotide binding affinities of the intact proton-translocating transhydrogenase from Escherichia coli
    Tania Bizouarn
    Laboratoire de Chimie Physique, Bat 350, Université Paris XI Orsay, 91405 Orsay, France
    Biochim Biophys Acta 1708:404-10. 2005
    ..There is negative co-operativity between the binding sites of the intact, detergent-dispersed transhydrogenase when both nucleotides are reduced or both are oxidized...
  27. ncbi request reprint Zinc ions selectively inhibit steps associated with binding and release of NADP(H) during turnover of proton-translocating transhydrogenase
    Simon J Whitehead
    School of Biosciences, University of Birmingham, Edgbaston, UK
    FEBS Lett 579:2863-7. 2005
    ..It is suggested that Zn(2+) and Cd(2+) bind in the proton-transfer pathway and block inter-conversion of states responsible for changing NADP(+)/NADPH binding energy...
  28. ncbi request reprint Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase
    Owen C Mather
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochemistry 43:10952-64. 2004
    ....
  29. ncbi request reprint Proton translocation by transhydrogenase
    J Baz Jackson
    FEBS Lett 555:176-7. 2003
  30. ncbi request reprint Tryptophan phosphorescence spectroscopy reveals that a domain in the NAD(H)-binding component (dI) of transhydrogenase from Rhodospirillum rubrum has an extremely rigid and conformationally homogeneous protein core
    Jaap Broos
    Department of Biochemistry and Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands
    J Biol Chem 278:47578-84. 2003
    ..1 affects the width of a cleft which, in turn, regulates the positioning of bound nucleotides ready for hydride transfer. The unique protein core in dI may be a paradigm for the design of compact and stable de novo proteins...
  31. ncbi request reprint Interactions between transhydrogenase and thio-nicotinamide Analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation
    Avtar Singh
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 278:33208-16. 2003
    ..This might be a consequence of restricted rotation of the 3-carbothiamide group during the conformational change...
  32. ncbi request reprint Glutamine 132 in the NAD(H)-binding component of proton-translocating transhydrogenase tethers the nucleotides before hydride transfer
    Gijs I van Boxel
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochemistry 42:1217-26. 2003
    ..This ensures that hydride transfer is properly gated and does not take place in the absence of proton translocation...
  33. ncbi request reprint The membrane-peripheral subunits of transhydrogenase from Entamoeba histolytica are functional only when dimerized
    Chris J Weston
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 277:26163-70. 2002
    ..The results provide evidence for the alternating site, binding change model for proton translocation by intact transhydrogenase...
  34. ncbi request reprint A conformational change in the isolated NADP(H)-binding component (dIII) of transhydrogenase induced by low pH: a reflection of events during proton translocation by the complete enzyme?
    Daniel J Rodrigues
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1555:8-13. 2002
    ..This is consistent with the view that the lid is retracted to permit NADPH release during turnover of the complete enzyme...
  35. pmc Mutations in transhydrogenase change the fluorescence emission state of TRP72 from 1La to 1Lb
    Karina Tveen Jensen
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Biophys J 95:3419-28. 2008
    ..The phosphorescence spectra of Met(97) mutants are also blue-shifted, indicating that the sulfur atom decreases the transition energy between the (3)L(a) state of the Trp and the ground state...