Research Topics
Genomes and Genes | David G JacksonSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesisDavid G Jackson
MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
APMIS 112:526-38. 2004....- Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1Louise A Johnson
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Biol Chem 282:33671-80. 2007..These findings suggest that LYVE-1 can function independently of hyaluronan and have implications for the use of LYVE-1 as a histological marker for lymphangiogenesis in human pathology... 
A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endotheliumThomas D Nightingale
Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Biol Chem 284:3935-45. 2009..These results reveal unexpected complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo...
Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor functionSuneale Banerji
Medical Research Council Human Immunology Unit, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Biol Chem 285:10724-35. 2010..These results reveal that elements additional to the extended Link module are required to stabilize HA binding in Lyve-1 and indicate important structural and functional differences with CD44...- Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interactionSuneale Banerji
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Nat Struct Mol Biol 14:234-9. 2007..Measurements by NMR indicate that the conformational transition can be induced by hyaluronan binding, providing further insight into possible mechanisms for regulation of Cd44... - A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasisSteven Clasper
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Cancer Res 68:7293-303. 2008..These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis... - Cell traffic and the lymphatic endotheliumLouise A Johnson
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Ann N Y Acad Sci 1131:119-33. 2008..Here we review the current knowledge of leukocyte trans-lymphatic endothelial migration and its role in the development of an immune response... - Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigrationLouise A Johnson
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Int Immunol 22:839-49. 2010..These results imply a direct role for CCL21 in lymphatic transmigration that involves the selective use of integrin activation in inflammation... - Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1Nicholas W Gale
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Mol Cell Biol 27:595-604. 2007..These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged... - Immunological functions of hyaluronan and its receptors in the lymphaticsDavid G Jackson
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK David
Immunol Rev 230:216-31. 2009.... - Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1)Remko Prevo
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Biol Chem 279:52580-92. 2004..These properties support a role for stabilin-1 as a rapidly recycling scavenger receptor and argue against a role in cell adhesion or lymphocyte homing... - Mechanisms of lymphatic metastasis in human colorectal adenocarcinomaDaniel Royston
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Pathol 217:608-19. 2009..These findings raise the exciting prospect of future biomarkers of lymphatic metastasis and identify potential targets for new generation anti-tumour therapies... - An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endotheliumLouise A Johnson
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
J Exp Med 203:2763-77. 2006..These results reveal a CAM-mediated mechanism for recruiting leukocytes to the lymph nodes in inflammation and highlight the process of lymphatic transmigration as a potential new target for antiinflammatory therapy... - Blocking development of a CD8+ T cell response by targeting lymphatic recruitment of APCDenise Teoh
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
J Immunol 182:2425-31. 2009..These results reveal lymphatic entry as an important step that may be rate limiting in the development of immunity and reconfirm its potential as a target for localized immunotherapy in inflammation and tissue rejection... - The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1David G Jackson
MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Trends Cardiovasc Med 13:1-7. 2003..This article considers the biology of LYVE-1 and outlines how recent research into this molecule is providing new insights into the nature of lymphatics and their role in tumor metastasis... - Lymphatic markers, tumour lymphangiogenesis and lymph node metastasisDavid G Jackson
MRC Human Immunology Unit and University of Oxford, Oxford, UK
Cancer Treat Res 135:39-53. 2007 - Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44Peter Teriete
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Mol Cell 13:483-96. 2004..Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies... - Immunohistochemical methods for measuring tissue lymphangiogenesisSteven Clasper
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
Methods Mol Biol 467:79-91. 2009..This chapter focuses on the use of these markers for the immunohistochemical analysis of lymphangiogenesis in both frozen and paraffin-embedded tissue sections and discusses current protocols and their associated problems... - Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancerCory S M Williams
Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Pathol 200:195-206. 2003.... - Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1)Lutz Trojan
Department of Urology, University Hospital Mannheim, Mannheim, Germany
J Urol 172:103-7. 2004..Normal blood vessels were additionally quantified in BPH and PCa... - Time course of angiogenesis and lymphangiogenesis after brief corneal inflammationClaus Cursiefen
Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Cornea 25:443-7. 2006..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes... - An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotypeJeffrey T Wigle
Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 21:1505-13. 2002..On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype... - Structure function relationships in the lymphatic system and implications for cancer biologyMarlys H Witte
Department of Surgery, University of Arizona, Tucson, AZ, USA
Cancer Metastasis Rev 25:159-84. 2006..Therefore, in cancer biology, attention to the multifaceted structure-function relationships within this vast, relatively unexplored system is long overdue... - High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancerPetri Bono
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Clin Cancer Res 10:7144-9. 2004..LYVE-1, a lymphatic endothelium-specific hyaluronan receptor, is a novel lymphatic vessel marker that is expressed on lymph vessel endothelial cells of both normal and neoplastic tissues... - Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesisPhilippe O Van Trappen
Department of Gynaecological Oncology, Cancer Research UK Translational Oncology Laboratory, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
J Pathol 201:544-54. 2003..These results suggest that in cervical carcinogenesis a switch to the lymphangiogenic phenotype may occur at the stage of CIN 3... - Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and SykFarhad Abtahian
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 299:247-51. 2003..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals... - CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesisAntonio Manzo
Rheumatology Unit, Guy s, King s, and St Thomas School of Medicine, London, United Kingdom
Am J Pathol 171:1549-62. 2007.... - Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cellsChao Nan Qian
Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
Cancer Res 66:10365-76. 2006..e., vasculature reorganization in the SLN) can be initiated by a primary tumor before and independent of the physical presence of metastatic cancer cells... - The role of the lymphatic system and its specific growth factor, vascular endothelial growth factor C, for lymphogenic metastasis in prostate cancerLutz Trojan
Department of Urology, University Hospital Mannheim, Mannheim, Germany
BJU Int 98:903-6. 2006.... - Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomasNoora Vainionpää
Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, FI 00014, Helsinki, Finland
Cell Tissue Res 328:317-28. 2007..The distribution of the laminin alpha5 chain and Lutheran glycoprotein proposes a difference between normal and carcinoma lymphatic capillaries... - Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancerNathalie Audet
Department of Otolaryngology, Wharton Head and Neck Centre, Princess Margaret Hospital, University of Toronto, Ontario, Canada
Arch Otolaryngol Head Neck Surg 131:1065-70. 2005.... - Increased nuchal translucency is associated with jugular lymphatic distensionMonique C Haak
Department of Obstetrics and Gynaecology, VU Medical Center, Amsterdam, The Netherlands
Hum Reprod 17:1086-92. 2002..Disturbance in timing of endothelial differentiation might be a common denominator in the origin of NT, linking cardiovascular and haemodynamic abnormalities... - Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver diseaseAllister J Grant
Liver Research Labs Centre for Immune Regulation and the Department of Pathology, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
Am J Pathol 160:1445-55. 2002..This study provides further evidence for the existence of portal-associated lymphoid tissue and is the first evidence that ectopic CCL21 is associated with lymphoid neogenesis in human inflammatory disease... - VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumorsMirjami M-T Mattila
Department of Anatomy, Institute of Biomedicine and Medicity Research Laboratory, University of Turku, Turku, Finland
Int J Cancer 98:946-51. 2002..These data suggest that VEGF-C has an important role in lymph node metastasis of breast cancer even at its hormone-dependent early stage... - Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient miceJoseph S Palumbo
Division of Hematology Oncology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Cancer Res 62:6966-72. 2002..These studies suggest that therapeutic strategies focusing on hemostatic factors may be effective in controlling solid tumor metastasis, particularly if used for the treatment of micrometastatic disease... - Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanomaOddbjørn Straume
Department of Pathology, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
Clin Cancer Res 9:250-6. 2003..In addition, our data suggest the presence of low-grade intra-tumoral lymphangiogenesis in melanoma and a stimulating role of bFGF in lymphangiogenesis... - VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedemaYoung Sup Yoon
Department of Vascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
J Clin Invest 111:717-25. 2003..This novel therapeutic strategy may merit clinical investigation in patients with lymphedema... - Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survivalSoheil S Dadras
Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Am J Pathol 162:1951-60. 2003..Our results reveal tumor lymphangiogenesis as a novel prognostic indicator for the risk of lymph node metastasis in cutaneous melanoma... - Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinomaFrancis T Hall
Department of Otolaryngology Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
Arch Otolaryngol Head Neck Surg 129:716-9. 2003..The antimetastatic potential of targeting these lymphatics may be of potential therapeutic benefit in the future... - Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veinsMarika J Karkkainen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
Nat Immunol 5:74-80. 2004..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development... - Visualization of lymphatic vessels through NF-kappaB activityMarcia R Saban
Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center OUHSC, 940 SL Young Blvd, Rm 605, Oklahoma City, OK 73104, USA
Blood 104:3228-30. 2004..They also provide a working model for detecting lymphatic vessels and evoke testable hypotheses regarding the role of lymphatic vessels in health and disease... - PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasisRenhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Cancer Cell 6:333-45. 2004..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis... - Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammationPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
J Clin Invest 115:247-57. 2005..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases... - Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imagingArvind P Pathak
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Res 65:1425-32. 2005.... - Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumorsVivien Schacht
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Am J Pathol 166:913-21. 2005.... - Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancerZofia Von Marschall
Department of Hepatology, Gastroenterology, Endocrinology and Metabolism, Charite University Medicine Berlin, CVK, D 13353 Berlin, Germany
Int J Oncol 27:669-79. 2005..Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease... - Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophagesKazuichi Maruyama
Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Invest 115:2363-72. 2005..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis... - Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancerNigel J P Beasley
Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
Cancer Res 62:1315-20. 2002..017), but no obvious correlation with intratumoral lymphatics. Our results provide new evidence that proliferating lymphatics can occur in human cancers and may in some cases contribute to lymph node metastasis...