David G Jackson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis
    David G Jackson
    MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    APMIS 112:526-38. 2004
  2. ncbi request reprint Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 282:33671-80. 2007
  3. doi request reprint A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium
    Thomas D Nightingale
    Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 284:3935-45. 2009
  4. pmc Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function
    Suneale Banerji
    Medical Research Council Human Immunology Unit, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Biol Chem 285:10724-35. 2010
  5. ncbi request reprint Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction
    Suneale Banerji
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Struct Mol Biol 14:234-9. 2007
  6. doi request reprint A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
    Steven Clasper
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Cancer Res 68:7293-303. 2008
  7. doi request reprint Cell traffic and the lymphatic endothelium
    Louise A Johnson
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Ann N Y Acad Sci 1131:119-33. 2008
  8. doi request reprint Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Int Immunol 22:839-49. 2010
  9. pmc Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
    Nicholas W Gale
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Mol Cell Biol 27:595-604. 2007
  10. doi request reprint Immunological functions of hyaluronan and its receptors in the lymphatics
    David G Jackson
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK David
    Immunol Rev 230:216-31. 2009

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis
    David G Jackson
    MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    APMIS 112:526-38. 2004
    ....
  2. ncbi request reprint Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 282:33671-80. 2007
    ..These findings suggest that LYVE-1 can function independently of hyaluronan and have implications for the use of LYVE-1 as a histological marker for lymphangiogenesis in human pathology...
  3. doi request reprint A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium
    Thomas D Nightingale
    Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 284:3935-45. 2009
    ..These results reveal unexpected complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo...
  4. pmc Distinctive properties of the hyaluronan-binding domain in the lymphatic endothelial receptor Lyve-1 and their implications for receptor function
    Suneale Banerji
    Medical Research Council Human Immunology Unit, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Biol Chem 285:10724-35. 2010
    ..These results reveal that elements additional to the extended Link module are required to stabilize HA binding in Lyve-1 and indicate important structural and functional differences with CD44...
  5. ncbi request reprint Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction
    Suneale Banerji
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Struct Mol Biol 14:234-9. 2007
    ..Measurements by NMR indicate that the conformational transition can be induced by hyaluronan binding, providing further insight into possible mechanisms for regulation of Cd44...
  6. doi request reprint A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
    Steven Clasper
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Cancer Res 68:7293-303. 2008
    ..These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis...
  7. doi request reprint Cell traffic and the lymphatic endothelium
    Louise A Johnson
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Ann N Y Acad Sci 1131:119-33. 2008
    ..Here we review the current knowledge of leukocyte trans-lymphatic endothelial migration and its role in the development of an immune response...
  8. doi request reprint Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Int Immunol 22:839-49. 2010
    ..These results imply a direct role for CCL21 in lymphatic transmigration that involves the selective use of integrin activation in inflammation...
  9. pmc Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1
    Nicholas W Gale
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Mol Cell Biol 27:595-604. 2007
    ..These results indicate that LYVE-1 is not obligatory for normal lymphatic development and function and suggest either the existence of compensatory receptors or a role more specific than that previously envisaged...
  10. doi request reprint Immunological functions of hyaluronan and its receptors in the lymphatics
    David G Jackson
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK David
    Immunol Rev 230:216-31. 2009
    ....
  11. ncbi request reprint Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1)
    Remko Prevo
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Biol Chem 279:52580-92. 2004
    ..These properties support a role for stabilin-1 as a rapidly recycling scavenger receptor and argue against a role in cell adhesion or lymphocyte homing...
  12. doi request reprint Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma
    Daniel Royston
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Pathol 217:608-19. 2009
    ..These findings raise the exciting prospect of future biomarkers of lymphatic metastasis and identify potential targets for new generation anti-tumour therapies...
  13. pmc An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
    J Exp Med 203:2763-77. 2006
    ..These results reveal a CAM-mediated mechanism for recruiting leukocytes to the lymph nodes in inflammation and highlight the process of lymphatic transmigration as a potential new target for antiinflammatory therapy...
  14. doi request reprint Blocking development of a CD8+ T cell response by targeting lymphatic recruitment of APC
    Denise Teoh
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 182:2425-31. 2009
    ..These results reveal lymphatic entry as an important step that may be rate limiting in the development of immunity and reconfirm its potential as a target for localized immunotherapy in inflammation and tissue rejection...
  15. ncbi request reprint The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1
    David G Jackson
    MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Trends Cardiovasc Med 13:1-7. 2003
    ..This article considers the biology of LYVE-1 and outlines how recent research into this molecule is providing new insights into the nature of lymphatics and their role in tumor metastasis...
  16. ncbi request reprint Lymphatic markers, tumour lymphangiogenesis and lymph node metastasis
    David G Jackson
    MRC Human Immunology Unit and University of Oxford, Oxford, UK
    Cancer Treat Res 135:39-53. 2007
  17. ncbi request reprint Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44
    Peter Teriete
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    Mol Cell 13:483-96. 2004
    ..Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies...
  18. doi request reprint Immunohistochemical methods for measuring tissue lymphangiogenesis
    Steven Clasper
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Methods Mol Biol 467:79-91. 2009
    ..This chapter focuses on the use of these markers for the immunohistochemical analysis of lymphangiogenesis in both frozen and paraffin-embedded tissue sections and discusses current protocols and their associated problems...
  19. ncbi request reprint Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer
    Cory S M Williams
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Pathol 200:195-206. 2003
    ....
  20. ncbi request reprint Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1)
    Lutz Trojan
    Department of Urology, University Hospital Mannheim, Mannheim, Germany
    J Urol 172:103-7. 2004
    ..Normal blood vessels were additionally quantified in BPH and PCa...
  21. ncbi request reprint Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  22. pmc An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
    Jeffrey T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 21:1505-13. 2002
    ..On the basis of our findings, we propose that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype...
  23. ncbi request reprint Structure function relationships in the lymphatic system and implications for cancer biology
    Marlys H Witte
    Department of Surgery, University of Arizona, Tucson, AZ, USA
    Cancer Metastasis Rev 25:159-84. 2006
    ..Therefore, in cancer biology, attention to the multifaceted structure-function relationships within this vast, relatively unexplored system is long overdue...
  24. ncbi request reprint High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
    Petri Bono
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Clin Cancer Res 10:7144-9. 2004
    ..LYVE-1, a lymphatic endothelium-specific hyaluronan receptor, is a novel lymphatic vessel marker that is expressed on lymph vessel endothelial cells of both normal and neoplastic tissues...
  25. ncbi request reprint Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis
    Philippe O Van Trappen
    Department of Gynaecological Oncology, Cancer Research UK Translational Oncology Laboratory, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    J Pathol 201:544-54. 2003
    ..These results suggest that in cervical carcinogenesis a switch to the lymphangiogenic phenotype may occur at the stage of CIN 3...
  26. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
    ..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals...
  27. pmc CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis
    Antonio Manzo
    Rheumatology Unit, Guy s, King s, and St Thomas School of Medicine, London, United Kingdom
    Am J Pathol 171:1549-62. 2007
    ....
  28. ncbi request reprint Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 66:10365-76. 2006
    ..e., vasculature reorganization in the SLN) can be initiated by a primary tumor before and independent of the physical presence of metastatic cancer cells...
  29. ncbi request reprint The role of the lymphatic system and its specific growth factor, vascular endothelial growth factor C, for lymphogenic metastasis in prostate cancer
    Lutz Trojan
    Department of Urology, University Hospital Mannheim, Mannheim, Germany
    BJU Int 98:903-6. 2006
    ....
  30. ncbi request reprint Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas
    Noora Vainionpää
    Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, FI 00014, Helsinki, Finland
    Cell Tissue Res 328:317-28. 2007
    ..The distribution of the laminin alpha5 chain and Lutheran glycoprotein proposes a difference between normal and carcinoma lymphatic capillaries...
  31. ncbi request reprint Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancer
    Nathalie Audet
    Department of Otolaryngology, Wharton Head and Neck Centre, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Arch Otolaryngol Head Neck Surg 131:1065-70. 2005
    ..To examine the relationship between intratumoral lymphatic vessel density and clinical and pathological variables in patients with head and neck squamous cell carcinoma...
  32. ncbi request reprint Increased nuchal translucency is associated with jugular lymphatic distension
    Monique C Haak
    Department of Obstetrics and Gynaecology, VU Medical Center, Amsterdam, The Netherlands
    Hum Reprod 17:1086-92. 2002
    ..Increased NT is seen in a diversity of fetal malformations. The mechanism explaining the abnormal fluid accumulation and the transient nature of NT remains unexplained...
  33. pmc Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease
    Allister J Grant
    Liver Research Labs Centre for Immune Regulation and the Department of Pathology, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Am J Pathol 160:1445-55. 2002
    ..This study provides further evidence for the existence of portal-associated lymphoid tissue and is the first evidence that ectopic CCL21 is associated with lymphoid neogenesis in human inflammatory disease...
  34. ncbi request reprint VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
    Mirjami M T Mattila
    Department of Anatomy, Institute of Biomedicine and Medicity Research Laboratory, University of Turku, Turku, Finland
    Int J Cancer 98:946-51. 2002
    ..These data suggest that VEGF-C has an important role in lymph node metastasis of breast cancer even at its hormone-dependent early stage...
  35. ncbi request reprint Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice
    Joseph S Palumbo
    Division of Hematology Oncology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 62:6966-72. 2002
    ..These studies suggest that therapeutic strategies focusing on hemostatic factors may be effective in controlling solid tumor metastasis, particularly if used for the treatment of micrometastatic disease...
  36. ncbi request reprint Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma
    Oddbjørn Straume
    Department of Pathology, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Clin Cancer Res 9:250-6. 2003
    ..In addition, our data suggest the presence of low-grade intra-tumoral lymphangiogenesis in melanoma and a stimulating role of bFGF in lymphangiogenesis...
  37. pmc VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
    Young Sup Yoon
    Department of Vascular Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Clin Invest 111:717-25. 2003
    ..This novel therapeutic strategy may merit clinical investigation in patients with lymphedema...
  38. pmc Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Pathol 162:1951-60. 2003
    ..Our results reveal tumor lymphangiogenesis as a novel prognostic indicator for the risk of lymph node metastasis in cutaneous melanoma...
  39. ncbi request reprint Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma
    Francis T Hall
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Arch Otolaryngol Head Neck Surg 129:716-9. 2003
    ..To examine the relationship between lymphatic vessel density and clinical and pathological variables in patients with well-differentiated papillary thyroid carcinoma...
  40. ncbi request reprint Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development...
  41. ncbi request reprint Visualization of lymphatic vessels through NF-kappaB activity
    Marcia R Saban
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center OUHSC, 940 SL Young Blvd, Rm 605, Oklahoma City, OK 73104, USA
    Blood 104:3228-30. 2004
    ..They also provide a working model for detecting lymphatic vessels and evoke testable hypotheses regarding the role of lymphatic vessels in health and disease...
  42. ncbi request reprint PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cancer Cell 6:333-45. 2004
    ..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis...
  43. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  44. ncbi request reprint Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging
    Arvind P Pathak
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 65:1425-32. 2005
    ....
  45. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
    ....
  46. ncbi request reprint Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
    Zofia Von Marschall
    Department of Hepatology, Gastroenterology, Endocrinology and Metabolism, Charite University Medicine Berlin, CVK, D 13353 Berlin, Germany
    Int J Oncol 27:669-79. 2005
    ..Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease...
  47. pmc Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
    Kazuichi Maruyama
    Ocular Immunology Group, The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2363-72. 2005
    ..The novel finding that CD11b+ macrophages are critical for the development of inflammation-dependent lymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis...
  48. ncbi request reprint Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer
    Nigel J P Beasley
    Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom
    Cancer Res 62:1315-20. 2002
    ..017), but no obvious correlation with intratumoral lymphatics. Our results provide new evidence that proliferating lymphatics can occur in human cancers and may in some cases contribute to lymph node metastasis...