Christopher L Jackson

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Animal models of spontaneous plaque rupture: the holy grail of experimental atherosclerosis research
    Michael E Rosenfeld
    Department of Pathobiology, University of Washington, Box 353410, Seattle 98195, USA
    Curr Atheroscler Rep 4:238-42. 2002
  2. pmc The fat-fed apolipoprotein E knockout mouse brachiocephalic artery in the study of atherosclerotic plaque rupture
    Andrew R Bond
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Biomed Biotechnol 2011:379069. 2011
  3. pmc Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse
    Helen Williams
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Atherosclerosis 210:94-9. 2010
  4. ncbi request reprint Assessment of unstable atherosclerosis in mice
    Christopher L Jackson
    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 27:714-20. 2007
  5. ncbi request reprint Is there life after plaque rupture?
    C L Jackson
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, U K
    Biochem Soc Trans 35:887-9. 2007
  6. ncbi request reprint Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    Cardiovasc Res 71:586-95. 2006
  7. pmc MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
    Helen Williams
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Research Floor Level 7, Upper Maudlin St, Bristol BS2 8HW, UK
    Cardiovasc Res 87:137-46. 2010
  8. pmc A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice
    Jason L Johnson
    Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    Arterioscler Thromb Vasc Biol 31:528-35. 2011
  9. ncbi request reprint Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Bristol, England
    Circulation 113:2435-44. 2006
  10. ncbi request reprint Destabilizing role of cathepsin S in murine atherosclerotic plaques
    Kenneth J Rodgers
    Bristol Heart Institute, University of Bristol, United Kingdom
    Arterioscler Thromb Vasc Biol 26:851-6. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Animal models of spontaneous plaque rupture: the holy grail of experimental atherosclerosis research
    Michael E Rosenfeld
    Department of Pathobiology, University of Washington, Box 353410, Seattle 98195, USA
    Curr Atheroscler Rep 4:238-42. 2002
    ....
  2. pmc The fat-fed apolipoprotein E knockout mouse brachiocephalic artery in the study of atherosclerotic plaque rupture
    Andrew R Bond
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Biomed Biotechnol 2011:379069. 2011
    ..The purpose of this review is to highlight the reasons why we should be looking to the apolipoprotein E knockout mouse to further our understanding of plaque rupture...
  3. pmc Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse
    Helen Williams
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Atherosclerosis 210:94-9. 2010
    ..TG2 is also expressed within plaques that develop within the brachiocephalic arteries of apolipoprotein E (apoE) deficient mice...
  4. ncbi request reprint Assessment of unstable atherosclerosis in mice
    Christopher L Jackson
    Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 27:714-20. 2007
    ..These considerations lead us to a number of general recommendations...
  5. ncbi request reprint Is there life after plaque rupture?
    C L Jackson
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, U K
    Biochem Soc Trans 35:887-9. 2007
    ..Interventions that strengthen the plaque, such as pravastatin therapy, do not alter remodelling parameters but instead allow for more outward remodelling before a rupture is caused...
  6. ncbi request reprint Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    Cardiovasc Res 71:586-95. 2006
    ..We have therefore investigated the effects of a broad-spectrum MMP inhibitor, RS-130830, on plaque development and stability. This compound inhibits a wide range of MMPs at concentrations below 20 nmol/L...
  7. pmc MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
    Helen Williams
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Research Floor Level 7, Upper Maudlin St, Bristol BS2 8HW, UK
    Cardiovasc Res 87:137-46. 2010
    ..We previously showed that cell-cell contacts mediated by N-cadherin reduce VSMC apoptosis. This study aimed to determine whether matrix-degrading metalloproteinase (MMP)-dependent N-cadherin cleavage causes VSMC apoptosis...
  8. pmc A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice
    Jason L Johnson
    Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    Arterioscler Thromb Vasc Biol 31:528-35. 2011
    ..In this study, we investigated the influence of a greater than 10-fold selective synthetic MMP-12 inhibitor on plaque progression in the apolipoprotein E knockout mouse model of atherosclerosis...
  9. ncbi request reprint Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Bristol, England
    Circulation 113:2435-44. 2006
    ..We hypothesized that overexpression of tissue inhibitor of metalloproteinase (TIMP)-1 or TIMP-2 would attenuate atherosclerotic plaque development and instability in high fat-fed apolipoprotein E-knockout (apoE(-/-)) mice...
  10. ncbi request reprint Destabilizing role of cathepsin S in murine atherosclerotic plaques
    Kenneth J Rodgers
    Bristol Heart Institute, University of Bristol, United Kingdom
    Arterioscler Thromb Vasc Biol 26:851-6. 2006
    ..Therefore, we investigated the possibility that the lysosomal proteinase cathepsin S may be involved in atherosclerotic plaque destabilization...
  11. ncbi request reprint Coronary artery disease progression is associated with increased resistance of hearts and myocytes to cardiac insults
    Anabelle Chase
    Faculty of Medicine and Dentistry, Bristol Heart Institute, University of Bristol, Bristol, UK
    Crit Care Med 35:2344-51. 2007
    ..To investigate whether coronary artery disease alters vulnerability of hearts and myocytes to cardiac insults. To address this issue, we developed an experimental model of coronary artery disease...
  12. ncbi request reprint Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques
    J L Johnson
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Arterioscler Thromb Vasc Biol 18:1707-15. 1998
    ..Activation of MMPs by mast cell-derived proteases may be an important mechanism in atherosclerotic plaque destabilization...
  13. pmc Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury
    Ben Littlejohns
    Bristol Heart Institute, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 9:e100579. 2014
    ..However, the effect of high-fat diet without obesity and associated co-morbidities is presently unknown...
  14. pmc Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, United Kingdom
    Proc Natl Acad Sci U S A 102:15575-80. 2005
    ..These data demonstrate that MMPs are directly involved in atherosclerotic plaque destabilization and clearly show that members of the MMP family have widely differing effects on atherogenesis...
  15. ncbi request reprint Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries
    Alastair L Miller
    Bristol Heart Institute, University of Bristol, Bristol, UK
    Metabolism 53:760-5. 2004
    ..69, P <.003). These data suggest that even modest homocysteinemia has a deleterious effect on the function of healed endothelium in mouse arteries. This may account for its adverse influence on chronic cardiovascular disease...
  16. ncbi request reprint Delayed recovery of receptor-mediated functional responses to acetylcholine in mouse isolated carotid arteries following endothelial denudation in vivo
    Alastair L Miller
    Bristol Heart Institute, University of Bristol, Bristol, UK
    J Vasc Res 40:449-59. 2003
    ....
  17. ncbi request reprint Ruptures of delight? A new mouse model of plaque rupture
    Christopher L Jackson
    Arterioscler Thromb Vasc Biol 26:1191-2. 2006
  18. ncbi request reprint Defining and defending murine models of plaque rupture
    Christopher L Jackson
    Arterioscler Thromb Vasc Biol 27:973-7. 2007