Andrew P Jackson

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK Electronic address
    Curr Biol 26:161-72. 2016
  2. pmc The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK
    Nucleic Acids Res 42:7113-31. 2014
  3. pmc A cell-surface phylome for African trypanosomes
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England, United Kingdom
    PLoS Negl Trop Dis 7:e2121. 2013
  4. pmc Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 109:3416-21. 2012
  5. pmc The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    PLoS Negl Trop Dis 4:e658. 2010
  6. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
  7. pmc Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Evol Biol 7:54. 2007
  8. doi request reprint Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 9:e0003975. 2015
  9. pmc Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    BMC Genomics 8:432. 2007
  10. pmc The evolution of amastin surface glycoproteins in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
    Mol Biol Evol 27:33-45. 2010

Detail Information

Publications13

  1. doi request reprint Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK Electronic address
    Curr Biol 26:161-72. 2016
    ..This new evidence defines the parasitic innovations of trypanosomatid genomes, revealing how a free-living phagotroph became adapted to exploiting hostile host environments. ..
  2. pmc The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool L3 5RF, UK
    Nucleic Acids Res 42:7113-31. 2014
    ..Hence, VESA2 proteins are abundant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently different to those of VESA1, suggesting that their functions are distinct. ..
  3. pmc A cell-surface phylome for African trypanosomes
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England, United Kingdom
    PLoS Negl Trop Dis 7:e2121. 2013
    ..All data can be accessed at: http://www.genedb.org/Page/trypanosoma_surface_phylome...
  4. pmc Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 109:3416-21. 2012
    ....
  5. pmc The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    PLoS Negl Trop Dis 4:e658. 2010
    ..b. gambiense and the reference genome. We sought to identify features that were uniquely associated with T. b. gambiense and its ability to infect humans...
  6. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis...
  7. pmc Tandem gene arrays in Trypanosoma brucei: comparative phylogenomic analysis of duplicate sequence variation
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Evol Biol 7:54. 2007
    ..This report presents the first account of the tandem gene arrays in the T. brucei genome, employing several related genome sequences to establish how variation is created and removed...
  8. doi request reprint Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax
    Andrew P Jackson
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 9:e0003975. 2015
    ..These unique features may yet explain the species differences in life cycle and could, in the form of bloodstream-stage proteins that do not undergo antigenic variation, provide targets for therapy. ..
  9. pmc Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    BMC Genomics 8:432. 2007
    ..The duplicated region may be browsed online at http://www.genedb.org/genedb/tryp/48dup_image.jsp..
  10. pmc The evolution of amastin surface glycoproteins in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
    Mol Biol Evol 27:33-45. 2010
    ....
  11. pmc Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
    ..coli. By comparing rhs repertoires across the Enterobacteriaceae, this study provides a robust explanation of rhs diversification and evolution, and a mechanistic model of how rhs diversity is gained and lost...
  12. pmc Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    BMC Genomics 9:594. 2008
    ..Various coding regions were sequenced to provide a preliminary insight into the bodonid genome sequence, relative to trypanosomatid sequences...
  13. pmc Origins of amino acid transporter loci in trypanosomatid parasites
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Evol Biol 7:26. 2007
    ..This study provides a comprehensive phylogenetic account of the origins of these genes, redefining each locus according to a positional criterion, through the integration of phyletic identity with comparative gene order information...